AI Simulates Patient Tumors, Transforming Oncology Research
@Ronalfa is speaking at @SynBioBeta in May and you probably already know who he is if you've been paying any attention to the AI x bio space. Ron spent years at @RecursionPharma as SVP of Research and acting CSO, helping build one of the most ambitious tech-bio platforms in the industry, shepherding programs across rare disease, neuroscience, oncology, and immunology from discovery into the clinic. Recursion went on to land landmark deals with @Roche, @genentech, @sanofi, and Bayer. Ron was one of the architects of how that science got built. Then he left to found @NOETIK_ai — and made a bet that the real unlock in oncology wasn't another drug. It was building AI that actually understands human tumors at the patient level. The result is OCTO: a virtual cell foundation model trained on hundreds of millions of spatially resolved human tumor and immune cells. Instead of running experiments in mice and hoping they translate, Noetik lets you simulate how a patient's tumor will behave, which patients will respond to a given therapy, and why. In January, @GSK licensed it for $50M. That's right. Not a drug, not a clinical asset, a model. Agenus is using it to identify responders to their lead IO combination. @Stanford's Bio-X called Ron one of the most important physician-scientists working at the intersection of technology and medicine. If you are wondering where biopharma partnerships are heading and the people defining that shift. You'll find your answers on stage at SynBioBeta May 4 - 7th in San Jose. A ticket link is available in the replies.
AI Adoption Soars, Governance and Risk Lag Behind
AI adoption is accelerating across global organizations, improving productivity, but governance frameworks and risk management systems remain incomplete and inconsistently implemented. https://t.co/RlW0ELL0fT
OpenAI Repo Merges AI Contributions, Codex Stays Anonymous
I explained in today’s @Pragmatic_Eng newsletter: That’s a repo where OpenAI is merging external contributions. Some are made by Claude Code, some with GitHub Copilot, some with Codex. Codex doesn’t add itself as a contributor - on purpose - that’s...
Apple’s Siri Upgrade: Bigger AI Vision, Delayed Rollout
Two things investors should keep in mind as Apple works to do something unique in AI: 1️⃣ The scope of their AI ambitions is bigger than last year’s WWDC comments. It's now expected to include conversational AI and using Siri as...
Claude Code Defaults to Grok 3; Upgrade to 4
FYI for some reason Claude Code will always default you to use Grok 3 and not Grok 4.1 but you should use Grok 4.1 or Grok 4.2 (but that one is more expensive)
Apple's Privacy Focus Limits AI Ambitions, Favors On-Device Models
I’ve argued that Apple is constrained by what it can do with AI by its privacy narrative. Apple *has* trained foundation models, and they have a proprietary ~3BN LLM available on device via Foundation Models Framework. They also offer other...
Tax Revenue From Data Centers Should Cushion AI Job Losses
Americans fear AI-related job losses and resent data centers powering that potential displacement. @MarkWarner says communities should use tax revenue from data centers to soften the blow of this economic transition. https://t.co/F8TsvpEI5n via @techcrunch
AI Benefits Evolve to Year‑Round Support with Guardrails
Contributor Spotlight: LaJoi McClendon — AI-powered benefits moving beyond enrollment to year-round support, with the right guardrails. Read LaJoi's take on p. 26 of our eBook. https://t.co/x6mbQ6zZKz #AI #Talent https://t.co/udEnGmVMon
New AI Platform Uncovers Hidden Cancer Targets, Raises $10M
Most cancer drugs go after the same targets: EGFR. PD-L1. HER2. Not because they’re the best targets. Because they’re the only ones we’ve been able to see. RyboDyn Inc. is going after what’s been invisible. The San Diego team, led by Imad Ajjawi, PhD,...
Top Experts Reveal Keys to Enterprise AI Adoption
Great listen about enterprise AI adoption from two of the smartest minds on the topic
Apple’s Open Siri Boosts Revenue, Justifies AAPL Overweight
Macro: Apple opens Siri to third‑party AIs (iOS27), shifting to an open AI platform and unlocking subscription revenue. Key risks: execution and regulation. Insight: overweight AAPL. — Viktor Kopylov, PhD, CFA More insights: t.me/si14Kopylov
OpenAI’s Promised Rapid Shifts Clash with Economic Weight
"Please expect a very high rate of change from us" Sam Altman told us six months ago. But OpenAI isn't a plucky startup. It's a giant, deeply tied to our current and future economy. Maybe take a breather on the changes...
Missing AI Signals Cost Billions; Claim Your Market
OpenAI killed Sora. Disney found out 30 minutes before and pulled a billion-dollar deal the same day. The signal was real. AI video was exploding. But while OpenAI chased it, Anthropic took 73% of first-time enterprise buyers. Seeing a signal is step...
User Reports Sidebar Assistant Failure After Restart
hello @perplexity_ai gang, any idea why the sidebar assistant isn't working? have restarted my computer and comet https://t.co/QhGiTOTnuy
CIOs Shift to Variable AI Budgeting Amid Token Volatility
#CIOChat Q4: Endgame: If more IT workloads consume tokens, budgeting shifts from fixed to variable, a major $ issue. How are CIOs adapting financial models like FinOps for AI, chargebacks, or automated guardrails? How do you manage volatility while still enabling...
Small, Niche AI Models Crumble on Out-of-Distribution Challenges
Small AI models and specialized vertical AI models are very brittle. Any unusual situation or out-of-distribution issue and they break down. You also won’t get emergent leaps or good problem solving. They still have uses, but benchmarks don’t do a good...
American Startups Missing Huge Open-Source AI Opportunity
Frankly I’m shocked that not many more American startups and big tech have noticed the massive opportunity and gap in the market for American open-source AI https://t.co/93mzlvoD53
AI “Slop” Is Simply Early‑stage Generated Content
what people call "ai slop" is just AI generated content that's not good enough yet
Claude Code Speeds Terminal Workflow, but Lacks Input Alerts
Switched to using Claude Code in the terminal more. It feels faster and more natural. But I miss one simple thing: notifications when it needs input.
AI Text and Images Reach Human‑Like Realism
the uncanny valley is over for text and photos. I can't tell the difference. Video next. What happens after that?
Treat AI Failures as Observability, Not PR Issues
Hallucinations, bad decisions, and dangerous actions are observability problems before they become PR problems. #DevSecOps #AI https://t.co/tRGwCPc4Mb
Five Ironwood TPU Optimization Strategies for ML Engineers
A developer’s guide to training with Ironwood TPUs https://t.co/eFGnybvR0G < it's really five optimization strategies for ML engineers. Check it out.
Apple Opens Siri to Rivals, Sparking Privacy Concerns
So how does the $AAPL privacy angle work here? Do external apps now get access to the data on my phone? So much for the local modeling pitch. *APPLE TO OPEN UP SIRI TO RIVAL AI ASSISTANTS IN STRATEGY SHIFT
AI Token Spend Hard to Forecast, Value Unclear
A1) It’s very challenging to forecast spend on AI tokens or connect spend to value. #CIOchat
AI Token Usage Hidden; Teams Need Clear Visibility
#CIOChat Q1: AI token spend is now embedded in everyday work, such as copilots, agents, but often without clear visibility. Where is token consumption growing most in your org? How are you making it measurable/visible at team and workload levels? https://t.co/tnw9OYIb9f
AI Agents Drive Observability Surge, Boost Datadog
Macro: SaaS selloff from AI agent hype. Key: AI agents amplify telemetry, boosting observability demand. Risk: agent errors and trust slow adoption. Buy Datadog — AI-monitoring tailwind. — Viktor Kopylov, PhD, CFA. More insights: t.me/si14Kopylov
New Study Exposes AI Sycophancy in Scientific Research
The problem of AI sycophancy addressed in the new issue: @ScienceMagazine cover and original research by @chengmyra1 and colleagues https://t.co/P8112DRIIH https://t.co/7natpzaVpG
AI Agents Bring Expertise to Democratized DeFi
Here's the thing about DeFi We democratized access but not expertise Agentic finance changes that AI agents that understand yield farming, risk management, and optimal execution paths Finally, the promise of financial inclusion meets actual capability
AI Boom Persists Despite Market Stress, Not a Bubble
The Mag 7 notwithstanding, the AI playbook (led by memory stocks and data centers, with software lagging behind) has not been materially impacted by the stress in the broader market. To me this strongly suggests that the AI boom continues...
Grok Adopts ChatGPT’s Fake‑enthusiasm Voice, Users Protest
noooo... Grok suddenly started doing the Chatgpt FeFe voice (fake enthusiasm for everything) make it stop @elonmusk https://t.co/xWAvzaztwt
Google Expands AI Search Globally, Boosting Engagement
JUST IN: Global availability expands Google’s AI‑driven search ecosystem, driving higher engagement and data collection across diverse markets. https://www.pulse.bot/saas/blogs/search-live-is-expanding-globally-a50b1072-674e-4e09-a3b2-479e6cebec68/ SaaS
FERC Chair Urges Tech Firms to Power AI Data Centers
The @FERC chairman publicly prodded tech companies on Thursday to engage more as they race to power a massive buildout of AI data centers. https://t.co/S9mmfJEQsk via @axios https://t.co/BIishr9Acl
AI Threat Looms: Universal Risk Within Decade
From Associated Press interview on “The AI Doc”: “I honestly think if 99% of people on the planet were just to understand the basics of what’s going on here, they would say, ‘That doesn’t sound good,’” Harris said. “The film is...
AI Is Redefining Hiring: Hire Engineers Already Obsessed
A candidate used AI to ace the coding test. The team couldn't tell the difference. This is the new hiring reality for SaaS founders 👇 On this week's SaasRise Mastermind, we broke down the biggest challenges SaaS CEOs are facing...
Production-Ready Vector RAG: Blueprint for Every Pipeline Layer
How to Build a Production-Ready Vector RAG 🧠🔎 RAG isn’t just “embeddings + LLM.” It’s a pipeline — and every layer matters. Here’s the practical blueprint 👇 1️⃣ Ingest & Preprocess Data Collect from search, docs, web, internal systems. Clean,...
AI Agents Finally Get Production-Ready Integration Layer
AI agents just got their missing piece. 47,000 actions. 250+ apps. One integration layer. This is the infrastructure that makes agents actually useful in production.
GitHub Defaults to Using Copilot Data for AI Training
GitHub will use your Copilot data to train AI models by default. Microsoft is a $3 trillion company. They can afford to ask. https://t.co/f7coXc6GcI
AI Can Strengthen Politics If We Choose Wisely
I absolutely love this. AI is an incredible tool. There's every reason to believe that we *could* use it to strengthen and improve our institutions, our politics, and our political process. To do so, we have to make some wise...
AI Agents: Future Economic Players or Mere Tools?
Are AI agents going to be real economic actors — or just tools? We break down the competing visions. https://t.co/9SSDq5hVSn
AI‑Driven Benefits Platform Raises $30M to Transform HR
Origin Secures $30 Million Series A+ to Scale AI‑Powered Global Benefits Platform Origin’s financing highlights a growing consensus that AI can unlock efficiency in traditionally manual HR functions. By centralising disparate benefits data, the platform not only cuts costs but also...
Claude Automates Stack Setup, Making Deployment Effortless
Struggling to get a production stack together? Just get Claude to do it. Need to pay for it? Just get Claude to do it. Bit by bit autonomy is coming.
AI Governance Rises Globally—Readiness No Longer Optional
48 hours this week: US: constitutional protections for AI outputs. Europe: enforceable compliance requirements. Scotland: five-year national AI strategy. Three continents. One conversation. The governance infrastructure is being built. Your company's readiness isn't a factor.
China's S1 Humanoid Robot Operates Retail Kiosks
Meet S1: The Humanoid #Robot Running Retail Kiosks in China by @CyberRobooo #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/cm3OJSAIR2
Finance Ops Drives 45% AI Agent Market Surge
the ai agents market grew from $8.29 billion in 2025 to $12.06 billion in 2026. that's 45.5% year over year. and finance operations is the number one entry point. 33% of enterprise leaders are piloting agentic ai in finance ops first, ahead...
Can AI Master Empathy: State or Language?
Can AI "learn" empathy? Is empathy an inner social state or a set of linguistic strategies? https://t.co/REyUpNkS7H
AI Agents Trigger Payment Wars Among Tech Giants
Stripe. Coinbase. Visa. Everyone is building for AI agents. Now LIVE on Unchained, we unpack the battle for the payment layer of the agent economy. https://t.co/meE1SvxnF0
AI: Handy Shortcut, But Overuse Breeds Hidden Complexity
AI is a shortcut. So it’s useful. But it’s lazy. So it speeds execution. But it hides complexity. So you want to use it. But definitely not overuse it. So the user of AI often loves it. But the reader of AI often hates it.
AI Becomes Society’s New Horizontal Infrastructure
This is so well put. AI will be as ubiquitous in future societal advances and catastrophes as electricity or books. It's just a new, horizontal part of society's infrastructure.
Right Data & Context Transform Zero‑Shot AI
Very much agree with this Cowork zero shot is meh When connected to the right data and fed with deep, detailed context: it’s remarkable And once set up, the MCP and Skills architecture make it quite usable
Twitter Leverages AI for Real‑Time SEO, Threads Lags
The difference between Twitter and Threads right now: Threads: AI can’t do SEO research for you it doesn’t have access to real time data. Twitter: I just hooked up Claude to SEMrush MCP and setup 5 skills to handle all my...
