
MindImmune secures $5M ADDF grant to target immune pathways in Alzheimer’s
MindImmune Therapeutics received a $5M investment from the Alzheimer’s Drug Discovery Foundation to advance its lead candidate MITI‑101. The therapy seeks to block CD11c‑positive innate immune cells from entering the brain, tackling neuroinflammation instead of amyloid or tau. The Cambridge‑based biotech aims to offer a novel treatment route for Alzheimer’s disease.
A recent early‑access study published in npj Science of Food reports that oral matcha consumption reduced sneezing in mice engineered to exhibit allergic rhinitis. The mice received matcha tea two to three times weekly for over five weeks and a dose before allergen exposure, resulting in fewer sneezes without altering IgE, mast cell, or T‑cell activity. Researchers traced the effect to suppressed activation of the brainstem sneezing center, as indicated by lower c‑Fos expression. The findings point to a non‑immune pathway through which matcha may alleviate hay‑fever symptoms.
Researchers at UC Irvine examined the fasting hormone asprosin in more than 4,000 postmenopausal women from the Women’s Health Initiative. They found that women with the highest baseline asprosin levels gained significantly less weight over three years compared with those...
University of Queensland and University of Minnesota researchers identified distinct ATP patterns in the brains and blood cells of young adults with major depressive disorder. The study found that resting cells produce higher ATP levels but cannot increase energy output...
Researchers at Brown University, Rhode Island Hospital, and VA Providence demonstrated that simultaneous electrical stimulation above and below a spinal cord lesion can restore both leg movement and spatial sensory feedback in people with complete spinal cord injuries. In a...
A study by Linköping University interviewed 14 adults who recovered from long‑term fatigue conditions such as post‑COVID‑19, exhaustion disorder, and CFS/ME. Participants described a common recovery trajectory that began with hopelessness, followed by self‑directed learning about their symptoms, and a...

A recent randomized control trial published in the American College of Sports Medicine journal demonstrates that adding plyometrics and strength work can dramatically improve endurance performance for well‑trained runners. The study enrolled 28 male athletes, split into a running‑only group and...

Zeke Emanuel, a physician and health-policy veteran, has published Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life, shifting his focus from system-level reform to practical, evidence-based advice for patients. Drawing on frustration with hype from...
I used to walk under 4,000 steps per day—and I was miserable. I thought everything had to be done at my desk. Now I take 20,000 steps a day—and it's the *single* best thing I've done for my health & creativity. Here are...
Using the sauna after aerobic exercise improves VO₂ max more than training alone. People who performed 30 minutes of cycling and then sat in a sauna for ~15 minutes afterward saw greater gains in their VO₂ max after 8 weeks of...

Dr. Amy Shah, MD and nutrition expert, fields a rapid‑fire series of internet‑sourced questions in WIRED’s “Women’s Health Support,” covering everything from menstrual‑related mood swings to the systemic under‑research of female physiology. She explains that the precipitous drop in estrogen and...

I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. + Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable...

Study shows nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication (GLP-1 agonists, metformin, naltrexone). https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827069 https://www.gatlan.com/ @GatlanHealth

The podcast revisits hormone replacement therapy (HRT) and testosterone replacement therapy (TRT) through the lens of contemporary cardiovascular data. It argues that the lingering fear surrounding HRT stems from the 20‑year‑old Women’s Health Initiative (WHI) trial, which used older hormone...

Energy and Exercise I've been writing about this a lot since the start of the year. Here's a snapshot from Bek's recent bike test from Elias' lab in Helsinki Don't get wrapped up in the exact numbers - it's the concept I...

Time-restricted eating as a potential strategy for healthy lifespan: an evaluation of current evidence https://t.co/wuXCFoZi1f https://t.co/mgFWzcFmSZ

The video asserts that oral administration of most peptide therapeutics fails, highlighting a fundamental limitation in the market. It explains that peptide size, exemplified by insulin's 52‑amino‑acid chain, leads to enzymatic degradation in the gastrointestinal tract, making injection necessary; only peptides...

The video introduces BPC‑157, a multifunctional peptide touted as essential for midlife women dealing with joint degeneration and gut dysfunction. Host Kyal Van Der Leest and a chiropractic doctor explain how the peptide’s primary action—restoring tight‑junction integrity in the intestinal...
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Registered dietitian Nisha Melvani highlights kale as the top vegetable for longevity, citing its dense mix of antioxidants, fiber, and anti‑inflammatory compounds. The leafy green delivers vitamin C, vitamin K, calcium, magnesium, and glucosinolates that collectively support immune function, bone strength, and chronic‑disease...
A joint study by the Wharton Neuroscience Initiative and Slalom examined how individual chronotypes—natural sleep‑wake rhythms—affect creative performance. Using the Morningness‑Eveningness Questionnaire and a divergent‑thinking task, researchers found that employees generated more ideas and higher‑quality concepts when work aligned with...

High‑intensity interval training (HIIT) is gaining traction among cyclists as a time‑efficient way to boost aerobic power, mitochondrial function, and race‑day performance. Recent studies show that two weekly HIIT sessions can raise VO₂ max and peak power by 2‑4 % in well‑trained...

Researchers at Friedrich‑Alexander‑Universität Erlangen‑Nürnberg successfully vitrified mouse brain slices and, in a limited trial, an entire mouse brain, preserving neuronal structure and function after rewarming. By using a high‑concentration cryoprotective agent cocktail, they avoided ice crystal formation, maintained synaptic architecture,...

The video outlines a dietary approach to reducing cortisol, the primary stress hormone, by highlighting ten specific foods that naturally modulate its production. Key insights include dark chocolate’s polyphenols, green tea’s L‑theanine, vitamin‑C‑rich berries, omega‑3‑laden fatty fish, and the combined benefits...

The video explains how a modest 5‑gram dose of glutamine can curb neuroinflammation, double neuronal autophagy, and rejuvenate mitochondrial function. It frames brain autophagy as the physiological basis for mental clarity, focus, and the "hunter mode" sensation that many experience...

In this Huberman Lab episode, Dr. Alex Marson explains how cutting‑edge biology is turning the immune system into a programmable weapon against cancer. He walks listeners through the fundamentals of innate and adaptive immunity, the random generation of T‑cell receptors,...

Dr. Jason Fung frames obesity as a malfunctioning "fat thermostat," arguing that the body’s set‑point for stored fat is governed by hormonal homeostasis rather than simple calories‑in‑calories‑out math. He likens this internal regulator to a room thermostat that can be...