Matcha tea curbs sneezing in allergic rhinitis mouse model
An early‑access study published in npj Science of Food showed that mice engineered to have allergic rhinitis sneezed fewer times after receiving oral matcha tea two to three times weekly for over five weeks and a dose before allergen exposure. The reduction occurred without changes in IgE, mast cell, or T‑cell activity, suggesting a novel anti‑sneeze mechanism.

The Longevity.Technology UNLOCKED episode highlights the mouth as a pivotal gateway to overall health, linking nasal breathing, oral microbiome, and dental habits to inflammation, sleep quality, and metabolic function. Clinicians Dr. Aoife Stack and Dr. James Goolnik argue that chronic mouth breathing deprives the body of nitric oxide and disrupts posture, while frequent snacking creates a persistent acidic environment that erodes enamel. Simple interventions—nasal breathing, adequate hydration, reduced snacking, tongue scraping, and xylitol gum—can restore oral balance and signal broader systemic improvements. The discussion reframes dentistry as preventive medicine rather than reactive treatment.
Sitting for over 8 hours daily raises mortality risk. Stand up. Now. (And get a standing desk)
Estradiol is not just a reproductive hormone. It is an anabolic signal. It drives muscle protein synthesis. It activates satellite cells after training. It controls how your body responds to the stress of a hard workout. When it declines, the same...
A 30‑year longitudinal study of more than 1,000 women found that those with polycystic ovary syndrome (PCOS) performed worse on cognitive tests and showed reduced white‑matter integrity at midlife. The researchers controlled for BMI, smoking, alcohol use, income, diabetes and...

Adding 5 g of glycine to 25 g of glucose lowered the glucose response by >50% compared with glucose alone, without increasing total insulin secretion. PMID: 12450897 Why glycine is a blood sugar and glycation powerhouse: https://t.co/fEVjzefmyI https://t.co/dPaspTRBHF
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
Researchers have shown that mild, repeated stressors such as hypoxia can trigger cellular maintenance programs, notably autophagy, which delays senescence and extends organismal lifespan. Under low‑oxygen conditions, oxygen‑dependent histone demethylases are inhibited, leading to increased histone methylation and stabilized chromatin...
This is common sense. You don't get healthier/fitter from the exercise stressor. You get healthier/fitter from the supercompensation effect of the body during *recovery*. No recovery. No fitness. You need both.

In our blog we discuss four potential applications: https://t.co/i88WCldGot • Preventing hypoglycaemia during exercise • Improving pre competition fuelling strategies • Learning how different foods influence glucose levels • Understanding glucose regulation during sleep and stress
The article reviews the emerging field of comparative biogerontology, emphasizing that while the hallmarks of aging have been mapped in laboratory models, their relevance across the vast diversity of animal species remains unclear. It argues that integrating molecular insights from...

Recent research and expert commentary overturn the long‑standing low‑fat dogma, emphasizing that total fat intake of 20‑35% of calories is acceptable and that the type of fat matters more than the amount. Saturated fats can remain in the diet for...
Health Roadmap Updates: 1. Clinical evidence for every suggestion — guideline tags + DOI references 2. Per-field unit switching (SI / conventional) 3. Fixed LDL suppression bug and HDL threshold rounding 4. Cleaner inputs https://t.co/wwMaIyXtzB
A study in *Brain Medicine* shows that eight weeks of voluntary wheel running in adult male rats reshapes the gut microbiota, notably decreasing the tryptophan‑metabolizing genera Alistipes and Clostridium. The microbial shift coincides with altered serum metabolites, including a rise...
Researchers at Icahn School of Medicine created the first sex‑specific atlas of GLP‑1 expression in the mouse brain using RNAscope, mapping the peptide across 25 nuclei. The atlas shows pronounced differences between females and males, especially in hindbrain nuclei of...
David Creel, PhD, RD, a clinical psychologist and dietitian at the Cleveland Clinic, emphasizes that lasting weight‑loss hinges on behavioral psychology rather than isolated diet or exercise prescriptions. He outlines a framework that blends collaborative communication, self‑monitoring, skill‑building, and relapse‑prevention...
Exercise is generally safe for most cancer patients and can be a powerful adjunct to treatment. Medical oncologists emphasize that even modest activity—walking, yoga, or light strength work—helps lower inflammation, fatigue, and improves sleep and mood. The American Cancer Society...
Researchers at the Chinese Academy of Sciences unveiled a ferritin‑based biomimetic platform called FACE that links CD71 on CAR T cells to CD71 on leukemia cells, strengthening cell‑cell engagement without re‑engineering the CAR. In patient‑derived xenograft models, FACE‑augmented CAR T...
Duke University researchers discovered that resident tissue macrophages (RTMs) are essential for maintaining intraocular pressure (IOP) in mice. Fluorescent tagging showed that selective removal of RTMs clogged the eye's outflow pathway, causing fluid buildup and elevated IOP, while depletion of...

PCSK9 in Vascular Aging and Age-Related Diseases Comprehensive summary of PCSK9's regulatory functions in vascular aging, highlighting potential therapeutic targets for combating age-related cardiovascular diseases. https://t.co/uo3PaSJLCb https://t.co/w8UZgIduPV
A UCL‑led study shows that a 12‑week cycling program improves aerobic fitness and amplifies the post‑exercise surge of brain‑derived neurotrophic factor (BDNF) in previously inactive adults. Participants underwent VO₂ max testing and cognitive assessments; after training, the BDNF spike following a...
Delayed‑onset muscle soreness (DOMS) is a normal response to new or intensified workouts, appearing within hours and peaking 12‑36 hours later. The article outlines four evidence‑based strategies to lessen the discomfort: staying properly hydrated, performing dynamic warm‑ups, incorporating post‑exercise stretching and...
An international team genetically deleted the ENA1 gene from Saccharomyces boulardii, a common probiotic yeast. In immunosuppressed mice, the ENA1‑deficient strain showed no mortality, raising survival from 30‑40% to 100% compared with wild‑type isolates. The edit also reduced osmotic stress...
Researchers at King's College London identified genetic markers that determine whether donor microbes persist after fecal microbiota transplantation (FMT). By tracking biosynthetic gene clusters in 86 healthy adults over a year, they distinguished stable clusters that remain long‑term from transient...
Researchers at Rice University and Baylor College of Medicine used a non‑editing CRISPR system to activate the PPARGC1A gene, boosting mitochondrial production in human cardiomyocytes. The technique safely increased cellular energy output, as shown by higher oxygen consumption in cell...

The article follows triathlete Georgie Rutherford’s stage 2C melanoma, linking her diagnosis to insufficient sunscreen during extensive outdoor training. Dermatologists highlight that 90% of non‑melanoma skin cancers and 86% of melanomas are UV‑related, and a 2024 study shows frequent outdoor exercise...

Nearly 90 secs off his 5k… in just a few weeks Ross was already training when he came to me. He also owns a busy cafe in Dublin so didn’t have endless hours to train So we designed a plan that hit the mark...
Sleep Awareness Week is a great reminder that getting better rest starts with understanding how we actually sleep. What I find fascinating is how wearable technology is turning sleep into something we can truly measure and improve. Today’s smartwatches and health...

The documentary "Forever Young" arrives as the longevity field moves from lab breakthroughs to public policy and everyday life. Featuring top geroscientists from the Buck Institute, Harvard and Stanford, the film argues that lifestyle and environment outweigh genetic destiny in...
A decade‑long study of 235 cognitively normal adults tracked plasma levels of 14 complement proteins every two years. Five factors—C4, C4b, Factor I, Factor D and Properdin—showed progressive deviations only in participants who later developed Alzheimer’s disease. These peripheral changes...

We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport...

Ozempic (semaglutide) is FDA‑approved for type‑2 diabetes but has become a popular off‑label weight‑loss drug, prompting shortages and easy online access for paying patients. Experts stress it should be reserved for individuals with diabetes or obesity who have failed diet...
A much needed effort that @Danbelsky and I have now been funded for to support the FAST initiative ($8 million over 18 months): https://t.co/aZsaZuEpoo The goal of this is to provide a set of biomarkers that will tell a person if...

New research reveals frailty can begin decades before old age, with many people in their 30s and 40s already in a pre‑frail state. Around 10 % of those in their 50s show early signs, rising to about half of individuals in...

Researchers conducted a double‑blind, placebo‑controlled trial with 1,000 participants averaging 70 years old, giving half a daily multivitamin (Centrum Silver) and the other half a placebo. After two years, analysis of five epigenetic aging clocks indicated the supplement group aged...

Researchers at the University of Iowa recorded intracranial EEG from 14 participants before and after a 20‑minute stationary‑bike workout, finding a rapid increase in high‑frequency hippocampal ripples that spread to cortical regions involved in learning. This is the first direct...
A while back I encouraged folks on twitter to get bloodwork 2x a year. A doctor friend of mine started arguing with me. "No need for this. If there are no symptoms, why look for problems?" I asked him when the last time...
In my view, the competing forces when it comes to health/longevity... 1/ Having sufficient reserves (both energy and muscle) so that you're not frail. 2/ Having very strong aerobic/metabolic fitness. These start to go against each other as you age. For example, for an...

The Dutch method proposes sleeping with curtains open to let natural morning light reset the body’s clock. A recent study confirms that exposure to sunlight before 10 a.m. improves sleep quality and mitigates the fatigue caused by daylight‑saving time shifts. Unlike...
Stable GLP‑1 receptor agonists such as Exendin‑4 and Ozempic improve beta‑cell viability by modulating gene expression. Researchers at the Salk Institute discovered that these drugs induce phosphorylation of Med14, a core subunit of the Mediator transcription complex. Phosphorylated Med14 enables...
I’ve had a few ask why this matters. It depends. If you’re a new runner just trying to get in shape, this doesn’t really matter. For those who are training for a race and trying not to blow up on...
The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T...

The article pairs Jeff Galloway’s run/walk method with treadmill training to accelerate speed gains. It outlines three treadmill‑based workouts—the Hill Climber, Interval Sandwich, and Sprint Ladder—each targeting different energy systems. Coach Michelle Baxter stresses a solid aerobic base before attempting...
On 15% BF... A lot of talk on whether 15% BF (for men) is "normal" at the moment. Statistically... No, not normal. Yes, optimal. The 10-step process to getting there... Step 1/ A 250-500 kcal deficit each day. Steps 2 - 10/ See step 1. Things...

How New Longevity Tech Could Help You Reach 100 Daily biometrics, smart scales and AI companions are quietly rewriting the rules of aging. https://t.co/lAmYntfSP5 https://t.co/YYo4tWkgMg
Most people are now comfortable with the idea of “reading” the nervous system, hormone, sleep tracking, etc., but writing to the nervous system, obviously is the next step. The eyes are going to be the entry point b/c they are...
Sleep masks that induce sleep (exist not released yet), glasses to ramp up specific brain states etc (early versions look promising), and vagal micro stim with specificity… have tried several, and the engineers behind the soon to come tech are...

CNS fatigue occurs during exercise due to supraspinal and spinal mechanisms. Supraspinal is likely global in nature, while spinal is not. Differences between contralateral muscle fatigue and entirely non-local muscle fatigue may help separate the two fatigue mechanisms. https://t.co/Ytl8WnBxFU
Check out this article I was apart of @MensHealthMag where I discuss currently approved FDA drugs that are potential geromedicines and our work on centenarians. https://t.co/e95XvnY9fb

Why is it vital for humanity to fight aging? Why are common longevity worries not big problems? My new review: https://t.co/tIcXYBFE7U a preprint of a book chapter for the upcoming radical longevity book that many in the field have contributed to. https://t.co/NFTYSMALzD

Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb