Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
An international team genetically deleted the ENA1 gene from Saccharomyces boulardii, a common probiotic yeast. In immunosuppressed mice, the ENA1‑deficient strain showed no mortality, raising survival from 30‑40% to 100% compared with wild‑type isolates. The edit also reduced osmotic stress tolerance, a trait linked to virulence, while preserving the yeast’s ability to inhibit pathogenic bacteria and colonize the gut. Findings were published in Communications Biology, highlighting a path toward safer probiotic therapies for immunocompromised, elderly and infant populations.
Researchers at Virginia Tech discovered that a high‑fat ketogenic diet rapidly normalizes blood glucose in diabetic mice and enhances their response to aerobic exercise. Within a week, the mice’s hyperglycemia resolved, and prolonged feeding remodeled muscle fibers toward a more...
Researchers at King's College London identified genetic markers that determine whether donor microbes persist after fecal microbiota transplantation (FMT). By tracking biosynthetic gene clusters in 86 healthy adults over a year, they distinguished stable clusters that remain long‑term from transient...
Researchers at Rice University and Baylor College of Medicine used a non‑editing CRISPR system to activate the PPARGC1A gene, boosting mitochondrial production in human cardiomyocytes. The technique safely increased cellular energy output, as shown by higher oxygen consumption in cell...
The article follows triathlete Georgie Rutherford’s stage 2C melanoma, linking her diagnosis to insufficient sunscreen during extensive outdoor training. Dermatologists highlight that 90% of non‑melanoma skin cancers and 86% of melanomas are UV‑related, and a 2024 study shows frequent outdoor exercise...
Nearly 90 secs off his 5k… in just a few weeks Ross was already training when he came to me. He also owns a busy cafe in Dublin so didn’t have endless hours to train So we designed a plan that hit the mark...
Sleep Awareness Week is a great reminder that getting better rest starts with understanding how we actually sleep. What I find fascinating is how wearable technology is turning sleep into something we can truly measure and improve. Today’s smartwatches and health...
The documentary "Forever Young" arrives as the longevity field moves from lab breakthroughs to public policy and everyday life. Featuring top geroscientists from the Buck Institute, Harvard and Stanford, the film argues that lifestyle and environment outweigh genetic destiny in...
A decade‑long study of 235 cognitively normal adults tracked plasma levels of 14 complement proteins every two years. Five factors—C4, C4b, Factor I, Factor D and Properdin—showed progressive deviations only in participants who later developed Alzheimer’s disease. These peripheral changes...
A randomized clinical trial of 958 adults aged 60 and older found that a daily multivitamin‑multimineral supplement modestly slowed two epigenetic aging clocks over two years. The clocks’ rate of increase decelerated by roughly 1.5 to 2 months per year...
We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport...
Ozempic (semaglutide) is FDA‑approved for type‑2 diabetes but has become a popular off‑label weight‑loss drug, prompting shortages and easy online access for paying patients. Experts stress it should be reserved for individuals with diabetes or obesity who have failed diet...
A much needed effort that @Danbelsky and I have now been funded for to support the FAST initiative ($8 million over 18 months): https://t.co/aZsaZuEpoo The goal of this is to provide a set of biomarkers that will tell a person if...
New research reveals frailty can begin decades before old age, with many people in their 30s and 40s already in a pre‑frail state. Around 10 % of those in their 50s show early signs, rising to about half of individuals in...
Researchers conducted a double‑blind, placebo‑controlled trial with 1,000 participants averaging 70 years old, giving half a daily multivitamin (Centrum Silver) and the other half a placebo. After two years, analysis of five epigenetic aging clocks indicated the supplement group aged...
Researchers at the University of Iowa recorded intracranial EEG from 14 participants before and after a 20‑minute stationary‑bike workout, finding a rapid increase in high‑frequency hippocampal ripples that spread to cortical regions involved in learning. This is the first direct...
A while back I encouraged folks on twitter to get bloodwork 2x a year. A doctor friend of mine started arguing with me. "No need for this. If there are no symptoms, why look for problems?" I asked him when the last time...
In my view, the competing forces when it comes to health/longevity... 1/ Having sufficient reserves (both energy and muscle) so that you're not frail. 2/ Having very strong aerobic/metabolic fitness. These start to go against each other as you age. For example, for an...
The Dutch method proposes sleeping with curtains open to let natural morning light reset the body’s clock. A recent study confirms that exposure to sunlight before 10 a.m. improves sleep quality and mitigates the fatigue caused by daylight‑saving time shifts. Unlike...
Stable GLP‑1 receptor agonists such as Exendin‑4 and Ozempic improve beta‑cell viability by modulating gene expression. Researchers at the Salk Institute discovered that these drugs induce phosphorylation of Med14, a core subunit of the Mediator transcription complex. Phosphorylated Med14 enables...
I’ve had a few ask why this matters. It depends. If you’re a new runner just trying to get in shape, this doesn’t really matter. For those who are training for a race and trying not to blow up on...
Stepups are a single‑leg, low‑impact exercise that directly improves functional mobility and daily‑living tasks. Research from the Czech Republic and epidemiological studies show that superior stair‑climbing ability correlates with lower all‑cause mortality and fewer catastrophic falls in older adults. The...
The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T...
The article pairs Jeff Galloway’s run/walk method with treadmill training to accelerate speed gains. It outlines three treadmill‑based workouts—the Hill Climber, Interval Sandwich, and Sprint Ladder—each targeting different energy systems. Coach Michelle Baxter stresses a solid aerobic base before attempting...
On 15% BF... A lot of talk on whether 15% BF (for men) is "normal" at the moment. Statistically... No, not normal. Yes, optimal. The 10-step process to getting there... Step 1/ A 250-500 kcal deficit each day. Steps 2 - 10/ See step 1. Things...
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A recent nutrition guide highlights eight foods—salmon, broccoli, sweet potatoes, walnuts, egg yolks, kale, saffron, and bell peppers—that deliver key antioxidants, omega‑3s, and vitamins essential for eye health. The article cites clinical studies linking these nutrients to reduced risk of...
𝐒𝐮𝐩𝐫𝐚𝐦𝐚𝐱𝐢𝐦𝐚𝐥 𝐈𝐬𝐨𝐦𝐞𝐭𝐫𝐢𝐜 𝐑𝐃𝐋 A supramaximal Romanian Deadlift (RDL) held at the knee is an advanced strength training variation that uses loads exceeding your one-rep maximum (1RM), typically 105-125% or more, to target the posterior chain, primarily the hamstrings, glutes, erectors, and...
Experts from the National Sleep Foundation and the University of Pennsylvania stress that daytime habits are as crucial to sleep quality as nighttime routines. Exposure to natural light within an hour of waking helps reset the circadian clock, while consistent...
Modern wellness clinics are expanding beyond cosmetic services to include IV hydration therapy as a preventive health option. By delivering fluids, electrolytes, and vitamins directly into the bloodstream, these treatments aim to quickly restore balance for athletes, frequent travelers, and...
Turning 30 triggers subtle physiological shifts that affect energy, metabolism, and recovery. Hormone fluctuations, gradual muscle loss, and rising stress levels lead to slower metabolism, altered body composition, and longer post‑workout soreness. The article advises targeted strength training, increased protein...
Regular exercise is linked to slower biological aging - but only in people sleeping 7+ hours. People who slept under 6 hours and exercised actually aged faster.
Most people are now comfortable with the idea of “reading” the nervous system, hormone, sleep tracking, etc., but writing to the nervous system, obviously is the next step. The eyes are going to be the entry point b/c they are...
Researchers at Emory University used artificial intelligence to evaluate arterial calcium visible on routine mammograms, linking it to future cardiovascular events. The study examined 123,762 women without prior heart disease and found that mild, moderate, and severe breast arterial calcification...
Sleep masks that induce sleep (exist not released yet), glasses to ramp up specific brain states etc (early versions look promising), and vagal micro stim with specificity… have tried several, and the engineers behind the soon to come tech are...
CNS fatigue occurs during exercise due to supraspinal and spinal mechanisms. Supraspinal is likely global in nature, while spinal is not. Differences between contralateral muscle fatigue and entirely non-local muscle fatigue may help separate the two fatigue mechanisms. https://t.co/Ytl8WnBxFU
Check out this article I was apart of @MensHealthMag where I discuss currently approved FDA drugs that are potential geromedicines and our work on centenarians. https://t.co/e95XvnY9fb
Why is it vital for humanity to fight aging? Why are common longevity worries not big problems? My new review: https://t.co/tIcXYBFE7U a preprint of a book chapter for the upcoming radical longevity book that many in the field have contributed to. https://t.co/NFTYSMALzD
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Andrew Huberman just hosted one of the world's leading neuroscientists. Dr. David Eagleman shared the science behind brain plasticity—diving deep into how to rewire it to become a better person at any age. Here are 8 takeaways that could reshape your life:...
Sodium leads the way in controlling osmolality. That is why it sits at the centre of hydration and performance. LAST CHANCE to register: https://t.co/6IKMRNDI7X https://t.co/Khn3sEOM19
One popular idea among fitness influencers is that training blocks of light loads could increase capillary content and then permit greater muscle growth in subsequent blocks. This study shows that increasing capillarization does not facilitate hypertrophy. https://t.co/SyMoaYcHWE
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance "findings suggest that mitochondrial quality control is a key determinant of resistance to ABT263-induced and ARV825-induced senolysis, providing a possible framework for rational combination senotherapies." https://t.co/xB0wFkzIW9
A close friend called me a few months ago. Sleeping 8 hours, waking up destroyed. I told him to check his data. REM gone, light sleep up, wake-ups all night. Classic stress pattern. How many of you have felt this? Stress physically...
While recovery strategies can be effective, their success hinges on two key factors: First, there must be a genuine demand for recovery, meaning your training or athletic pursuits need to be sufficiently challenging and intense. Second, your overall lifestyle foundation has to...
I teach future physicians this uncomfortable truth: "aging" is not just time—it's biology we can potentially reprogram. NIH highlights a PNAS study where researchers screened 200 transcription factors to "reset" old human fibroblasts toward a younger gene-expression pattern. They narrowed it to...
Ave person checks their phone 186x a day. That's an interruption every 5 min. This shrinks the brain, causing lost capacity for deep reasoning and sustained thought. Deep focus strengths neural networks for complex thought.
This is unsurprising. We are swimming in signals that we haven't learned how to read yet. Modern society creates a digital ledger. Our bodies generate similar data, just waiting to be read. Anti-aging progress accelerates when we learn how...
Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵 https://t.co/AlOIwcEXEQ
DNA breaks are a potent accelerator of epigenetic drift, which some researchers think drives aging. Great work by the Gorbunova lab 👏
Microbiome depletion rejuvenates the aging brain 👉"We confirmed that antibiotic treatment improves vascular density, promotes myelination, enhances neurogenesis, and reduces microglial reactivity. Functionally, microbiome-depleted mice showed improved hippocampal memory performance." https://t.co/XYuJ2kPVbi
