Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Recent open‑access review maps the human virome’s role in aging, highlighting how gut and circulating viruses influence immunity, inflammation, and metabolism. Age‑related virome changes include expansion of bacteriophage families, reactivation of latent herpesviruses, and altered viral diversity, with centenarians displaying a distinct, more diverse virome signature. The authors note persistent gaps due to technical biases, incomplete databases, and the vast “viral dark matter” that hampers functional interpretation. Emerging tools like targeted antiviral platforms could clarify viral contributions to healthspan.
What's your excuse for not strength training? Why are people at all ages suddenly becoming more fit than they’ve ever been in their lives? Could it be that they are learning that strength training is a key to health and longevity? (see you...
Apple has reduced the price of its Watch Series 11 to the lowest level since launch, making the health‑focused smartwatch more accessible. The latest iOS 26 update introduces blood‑pressure notifications and a new sleep‑score metric, enhancing its comprehensive wellness suite. Industry analysts...
Chris Masterjohn, a nutritional scientist and mitochondrial biologist, launched Mitome, a consumer‑focused platform for mitochondrial health testing. In a conversation with Razib Khan, he critiqued the COVID‑19 response, alleging authorities overstated certainty and faced attempts at censorship. Masterjohn also argued...
20/20 BioLabs has launched OneTest for Longevity, a lab‑developed blood test that combines inflammatory biomarkers, lifestyle data, and AI to deliver personalized aging and chronic disease risk insights. The platform leverages IBM's watsonx.ai and the University of South Carolina's Dietary...
The team led by Inkyung Jung and Yarui Diao introduced scHiCAR, a trimodal single‑cell technology that simultaneously captures transcriptome, epigenome, and 3D genome architecture. By integrating AI, the method achieves ultra‑high throughput at roughly $0.04 per cell and was used...
The article ranks eight creatine supplements deemed optimal for women, evaluated by a registered dietitian. Each product is broken down by dosage, form (powder, capsule, stick pack), flavor options, and third‑party certifications such as NSF Certified for Sport or Informed...
Recent studies suggest that persistent inflammation in the gut, lungs and skin may trigger Alzheimer’s disease. Vaccinations such as Shingrix have been shown to cut dementia risk by about 17 percent, likely by dampening inflammatory pathways. Lifestyle measures—including a Mediterranean...
Scientists discovered that the ratio of polyunsaturated to monounsaturated fatty acids in the diet determines T‑cell susceptibility to ferroptosis, a form of iron‑dependent cell death. Mice fed diets with low PUFA/MUFA ratios showed higher ferroptosis resistance, leading to stronger humoral...
Alzheimer’s disease now affects 55 million people worldwide, with 10 million new cases each year, prompting researchers to explore upstream triggers beyond genetics. Texas A&M scientists have shown that chronic circadian disruption in animal models drives microglia into a stress‑primed, inflammatory state,...
A narrative review on the therapeutic potential of stem cells in neurodegenerative diseases: advances, insights, and challenges 👉"Stem cell therapy offers regenerative potential for neurodegenerative diseases. 👉Mesenchymal stem cells (MSCs), induced pluripotent stem cells, and neural stem cells show promise through neuroprotection...
The article explains that gut microbiome composition is tightly linked to aging, with older individuals showing reduced diversity and more inflammatory bacteria. Experiments in mice demonstrate that transplanting youthful microbiota can reverse age‑related inflammation, while diet, fiber, and exercise can...
Researchers have identified flavin‑containing monooxygenase‑2 (FMO‑2) as a shared downstream effector in several long‑lived mitochondrial mutants of Caenorhabditis elegans, including clk‑1, isp‑1 and nuo‑6. RNA interference or genetic loss of fmo‑2 shortens the extended lifespan of these mutants, confirming its...
Sauna use has surged as a wellness trend, prompting scientific scrutiny of its health impacts. Large Finnish cohort studies show that bathing 4‑7 times weekly cuts cardiovascular disease risk by up to 60% and improves blood pressure, cholesterol, and arterial...
The pharmaceutical industry has finally delivered an oral GLP‑1 weight‑loss pill, with Novo Nordisk launching an oral version of Wegovy earlier this year. Eli Lilly’s oral GLP‑1 candidate, orforglipron, is expected to receive approval imminently. Oral formulations overcome the injection barrier that...
Boosted Brain Cells Erase Dementia-Linked Proteins “At nearly six months of age, when untreated mice normally have brains saturated with harmful plaques, brains of treated mice were plaque-free. Meanwhile, older mice with plaque-saturated brains at the time of treatment saw a...
PEP protects against age-related inflammation, puts the brake on the aging process in mice, high levels in humans correlate with low inflammation So what is PEP, you ask? phosphoenolpyruvate, from glucose metabolism, a, master regulator, blocks cGAS-STING https://t.co/glMvaHSjOq https://t.co/MSVMBJbHm4
Garrya Mù Cang Chải is launching a data‑driven well‑being concept for 2026 that moves beyond traditional spa stays to structured, results‑focused programmes. Guests will complete a digital pre‑arrival assessment and receive a dedicated Wellbeing Trainer who tailors itineraries around sports...
Retrotransposon Activation in the Aged and Alzheimer’s Disease Brain Examined by Nanopore Long-read DNA Sequencing "...we report somatic retrotransposition events in the aging and demented brain..." https://t.co/zkRCMO1Plh
ppl have been asking for head to head comparisons of NR v NMN in humans the data show that at 1.2 g/day, NR had 2.3x the blood NAD-boosting activity versus NMN the paper and the details in this 🧵 https://t.co/7KuP6LXyia
Researchers from Kyoto University and INSERM identified tanycytes as a previously unknown conduit that clears tau protein from cerebrospinal fluid into the bloodstream. In rodent and cellular models, blocking vesicular transport in these cells dramatically slowed tau efflux and worsened...
A Master Class on Sleep, with plenty of practical tips Eric Topol with Guest Professor Yo-El Ju https://t.co/sKY9e7Tinq https://t.co/Gofntnw02o
Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies https://t.co/Q3yGX1Xd8j
A new observational study of nearly 22,000 chronic‑migraine patients found that those who started GLP‑1 receptor agonists for diabetes or obesity experienced fewer severe migraine events than peers on the preventive drug topiramide. Over a 12‑month follow‑up, GLP‑1 users had...
Advance in neuroprotective effects of proanthocyanidins (PCs): Structure, absorption, bioactivities, mechanism, and perspectives https://t.co/AMfxcjo4m6 https://t.co/oTMCLW0CKL
Healthspan Horizons just launched out of the Buck Institute's Price Lab. It's a federated, privacy-preserving research platform aimed at making healthspan measurable and actionable through AI and systems science. The Flagship White Paper is worth a read👨⚕️ https://t.co/OoxuurRJNE | @BuckInstitute
A Finnish study of 64 sedentary adults with metabolic syndrome showed that a six‑month program to reduce sitting time by roughly one hour a day cut daily sedentary behavior by an average of 41 minutes. Participants who achieved at least...
Links between autophagy and healthy aging "Identification of autophagy modulators holds promise to improve healthspan..." https://t.co/PJjbfpeYTg https://t.co/tXreB5m4cw
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition @BrunetLab https://t.co/n9bsJPSJQT https://t.co/9vvH3eEU0e
Scientists delivered naked Cldn11 messenger RNA directly into the testes of genetically infertile male mice, restoring Sertoli cell function and enabling spermatogenesis. The treatment produced viable sperm that generated healthy offspring via in‑vitro fertilization, without permanent germline alteration. The approach...
Exciting news in the world of longevity via deep technology. Congratulations to @khoslaventures and @lightspeedvp on this historic investment. IMHO, Science may be bigger than OpenAI
Ergostane steroid, as one of the major contributor to cranberry derived extracellular vesicle nanoparticles, restores ovarian function of murine premature ovarian failure https://t.co/CFcjDvzMnU https://t.co/le7VTHjEKa
The CONTEXT Framework reframes health optimization by prioritizing the circumstances surrounding an intervention over the intervention itself. It breaks decision‑making into seven coordinates—Client, Objective, Now, Terrain, Execution, eXchanges, and Tracking—to ensure each supplement, protocol, or technology aligns with the user’s...
Exercise and enriched environments help protect brain barrier from stress-linked depression, finds study https://t.co/BcXFdEXP3f https://t.co/02j702A4Zq
UT San Antonio has been given a $38biin ARPA-H grant to study the health benefit effects of three drugs in humans, namely, rapamycin, dapagliflozin and semaglutide …🧵 https://t.co/fAX14ngoyD
British biotech Vesalic reports a breakthrough that links amyotrophic lateral sclerosis (ALS) to a systemic metabolic dysfunction detectable in blood extracellular vesicles (EVs). The company says the EVs carry a toxic lipid cargo that harms motor neurons, and its blood‑based...
Air filtration at home and work is an easy health win. In my house and office, each room has an air filter and monitor. I try to maintain pristine air quality 24/7. Air pollutants PM2.5, PM10 and poisonous gases like...
This week I modeled in Paris Fashion Week. I am a meme for Immortality.... why was I there? Something significant is happening. By the time something appears on a runway in Paris, it usually means the concept has already crossed...
In this AMA episode, host Dawn Cornegas and IHMC CEO Dr. Ken Ford field listener questions on a wide array of topics, from astronaut training in NASA's Neutral Buoyancy Lab to the latest research on supplements like urolithin‑A and anti‑aging...
Creatine isn’t just for adults. I give my son 2.5 g/day. There are (albeit few) studies in kids and adolescents showing creatine can improve performance. For example, trials in adolescent soccer and basketball players report improvements in power, jumping, sprint/anaerobic performance,...
Finished a seven day social media fast. It feels like the most effective longevity therapy I've done. Everything got better: mood, sleep, energy, presence, judgment, relationships, and optimism. Evidence shows a seven day fast produces a reduction of anxiety (16%),...
The author presents an evidence‑based nightly routine designed to preserve sleep architecture, hormonal balance, and skin health. By integrating personalized supplement timing, environmental controls, and regular lab‑driven adjustments, the protocol consistently yields 60 minutes of deep sleep and comparable REM,...
Indices of Sleep Health Are Associated With Timing and Duration of Eating in Young Adults - Journal of the Academy of Nutrition and Dietetics https://t.co/RztLzXUScr
2026 aging/longevity conferences mostly have announced dates now. A few date just announced. Here's what the schedule looks like at the moment. Next up is Longevity Global's Longevity Innovation Forum in San Diego next week. https://t.co/mIDmfQD38H I'll be there & speaking. https://t.co/4mRLXJmGgg
Neuropathic pain affects 7-10% of all people globally. New 🐁 study finds resveratrol alleviates neuropathic pain associated with restoration of mitochondrial dynamics 👏 https://t.co/zJ8LvwZ9UP https://t.co/hdCK7UgqBj
Did you know... That the daily 💩 weight of an average hunter-gatherer was ~4-5x the daily 💩 weight of a modern human? #FixYourFiber
Wrist temperature as a sleep marker in actigraphy: Chronobiology International: Vol 43, No 2 https://t.co/HElT9CO7XS
One of the most overlooked benefits of morning bright (sun)light, exercise & caffeine is how it reduces the duration of any cortisol peaks in response to stress (should they happen) later in the day… and it’s ability to reduce nighttime...
Before you bullish-on-peptides folks inject melanotan, make sure you do a web search to look at some before and after photos…! Here is a case where unless there’s a *real clinical need* I highly recommend you intelligently use sunlight instead.
Quickly becoming one of our most popular episodes ever. Merges western medicine (guest is practicing MD) and eastern practices for brain, plasticity, long duration stress resilience. @HealthyGamerGG on Huberman Lab podcast out now:
