Today's Biohacking Pulse
Study Links Common Cognitive Supplement L‑Tyrosine to Shorter Lifespan
Researchers analyzing data from over 250,000 UK Biobank participants found that genetically higher L‑tyrosine levels are associated with a reduced lifespan, particularly in men who lived about one year less on average. The Mendelian randomization approach isolated tyrosine’s effect, showing it to be more detrimental than its precursor phenylalanine.
PapB Enzyme Enhances Ozempic; Endoscopic Procedure Cuts GLP‑1 Weight Rebound
Scientists at the University of Utah introduced PapB, an enzyme that macro‑cyclizes GLP‑1 peptides, potentially extending Ozempic’s efficacy. At the same time, a European‑based endoscopic duodenal mucosal resurfacing (DMR) trial demonstrated that patients maintained more than 80% of their weight loss after stopping tirzepatide, sparking debate over broader GLP‑1 use.
Targeting Senescent Cells as a Treatment for Chronic Obstructive Pulmonary Disease
Researchers have introduced BCLXL-PROTAC, a proteolysis‑targeting chimera that degrades the anti‑apoptotic protein BCLXL in senescent lung cells. In primary small‑airway epithelial cells and fibroblasts from COPD patients, the compound induced caspase‑3‑mediated apoptosis and lowered classic senescence markers such as p21,...
Senescent Macrophages Are Important in Liver Aging and Liver Disease
Researchers identified a distinct p21‑positive, TREM2‑positive senescent macrophage population that accumulates in aging and fatty livers. These cells drive chronic inflammation through a senescence‑associated secretory phenotype linked to type I interferon signaling. In mouse models, senolytic agents that selectively eliminate these...
AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD
In this episode, Dr. Robert Lovekin talks with Dr. Daniel Ives, founder of Shift Bioscience, about moving from hypothesis‑driven aging research to data‑driven, AI‑powered approaches. Ives explains how his early focus on mitochondrial DNA mutations as the primary cause of...
Symptom-Based Approach Treats Opioid Withdrawal in Newborns with Minimal Drug Exposure
An NIH‑funded OPTimize NOW trial compared symptom‑based, as‑needed opioid dosing with traditional scheduled tapering for newborns with moderate to severe neonatal opioid withdrawal syndrome (NOWS). Among 383 infants cared for under the family‑centered Eat‑Sleep‑Console model, the symptom‑based group was ready for...
How Personalizing Nutrition Can Manage Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) affects roughly 2.4‑3.1 million Americans and costs the U.S. economy about $50 billion each year. New research highlights that the typical Western diet—rich in refined sugars, vegetable oils, and ultra‑processed foods—disrupts the gut microbiome, increases intestinal permeability, and...
Balanced Longevity Research Shows Real Human Impact
Longevity Science Is Overhyped. But This Research Really Could Change Humanity. We were delighted to have @susandominus with us at the last academy meeting earlier this year. She does gives a balanced take on the latest rejuvenation science. This...
Omega‑3 Index: Key Biomarker for Health and Performance
Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance https://t.co/mBkHB6BlIs
Noninvasive Skull Sensor Prevents Brain Injuries in Critically Ill ICU Patients
A Brazilian startup, brain4care, has validated a non‑invasive skull sensor that monitors intracranial compliance in real time. In a five‑year study of critically ill neuro‑ICU patients, adding the sensor to standard guideline‑based care cut mortality from 37.3% to 5.9% and...
Resistance Training Plus Polyphenols Boost Aging Health
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals https://t.co/mDL393xerp @GeroScienceAGE https://t.co/qr3yxiZuHB
Optimal Nightly Sleep: 7‑8 Hours for Health
Sleep is essential for good health. Do you know how many hours of sleep are recommended each night?🤔 Is it 5, 6, 7 or perhaps 8 hours? You'll find the answer in this video. 📹 https://t.co/q1o9q3o11h #sleep #Health #lifestylemedicine #HealthCoach #MedTwitter #Wellness...
Drugging the Undruggable: Cancer's Slipperiest Targets Finally Meet Their Match
Researchers at the University of British Columbia and BC Cancer have unveiled a novel drug design strategy that tightly binds intrinsically disordered proteins, long deemed undruggable. The new compounds exhibit binding affinities up to a million times stronger than previous...
Bacteria-Resistant Coating on Catheters Reduces Infection and Need for Antibiotics
A clinical trial of Camstent's bacteria‑resistant polymer‑coated catheter showed a one‑third drop in catheter‑associated urinary tract infections (CAUTIs) and more than a 50 % reduction in antibiotic use versus standard catheters. Long‑term patients using the coated device reported zero symptomatic CAUTIs...
How Virtual Reality Therapy Could Change the Way Mental Disorders Are Treated
Virtual reality (VR) is emerging as a powerful adjunct to cognitive‑behavioral therapy, allowing clinicians to immerse patients in realistic anxiety‑provoking scenarios such as public speaking or flying. A recent literature review in Psychology Research and Behavior Management confirms that VR‑enhanced...
Metabolic Illness Can Nullify Calorie Deficits, Study Shows
came across a reddit post from someone who stopped losing weight and gained a bunch back while being in "a deficit". turns out they had a metabolic illness that was the issue, as soon as they started treatment they started...
HIIT Boosts Brain Health in Heart Disease Patients
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients “the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more...
Allyson Felix Targets 2028 LA Olympics in Bold Comeback Bid
Allyson Felix unveiled "Project Six," a plan to qualify for her sixth Olympic Games in Los Angeles in 2028 at age 42. The former 11‑medal sprinter says the comeback is a "once‑in‑a‑lifetime homecoming" and a test of human potential, sparking...
Thanks to GLP-1s, Obesity Experts Are Trying to Understand ‘Food Noise’
New GLP-1 obesity drugs such as Ozempic, Wegovy, Mounjaro and Zepbound have been found to silence the internal “food noise” that drives constant thoughts about eating. Patients describe a dramatic reduction in cravings and mental chatter about food after starting...
Prevention Beats Treatment: NYC Smoking Ban Saves Lives
"How can medicine save the most lives?" Most people ask this rhetorically. @Farzad_MD and Tom Frieden took it literally. From banning smoking in NYC bars to cutting teen smoking in half in 5 years, this is what happens when you stop treating diseases...
Maine Wild Blueberries Proven to Boost Heart and Gut Health, Study Finds
A University of Maine study led by nutrition professor Dorothy Klimis‑Zacas validates that daily consumption of wild blueberries reduces vascular inflammation and enhances gut health. The research shows the berries contain twice the antioxidants, 72% more fiber and 33% more...
The Longevity Economy Is Built for the Rich
The episode examines the $6 trillion "longevity economy"—the booming market built around anti‑aging and wellness innovations—and highlights how its benefits are disproportionately accessible to the wealthy. It outlines macro trends driving investment in longevity, critiques the uneven distribution of cutting‑edge therapies,...
Shared Pathways Link Gut Aging and IBD; Target Early
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging "this article highlights both the shared and distinct pathways driving gut dysfunction in aging and IBD, and underscores the importance of early recognition and targeted...
A Robust Senescence Response Helps Wounds Heal
Scientists compared wound healing in young (2‑month) and old (24‑month) mice and found that a rapid, temporary surge of senescent cells in the young animals accelerates closure. The younger mice displayed sharp up‑regulation of senescence markers p16, p21 and SA‑β‑gal,...
This Dangerous Pregnancy Complication Is Common. A New Treatment Might Help
A novel blood‑filter that removes excess soluble Flt‑1 reduced the protein by roughly 17% in a pilot study of 16 women with early‑onset preeclampsia. The intervention modestly lowered blood pressure and proteinuria, allowing pregnancies to extend a median of 10...
ACC Endorses Universal CRP Screening for Heart Risk
I've been waiting for this for a long time... The American College of Cardiology now recommends universal screening for a marker I've been writing about since 2011 - and most doctors still don't order it. The American College of Cardiology now highlights inflammation...
Injury Prevention Is Simply Optimized Performance Through Discipline
“Injury prevention is performance optimization in disguise.” These 7 words delivered Friday by Dan Fichter was a revelation; an epiphany of why a Feed the Cats approach creates HEALTHY athletes… seemingly bulletproof. When we get fit by repeating low-dose, performance-level work...
Cellular Rejuvenation Has the Potential to Reverse Aging
Researchers have identified a natural cellular rejuvenation process that resets embryonic cells to a youthful state within two weeks, effectively erasing parental age markers. Over the past two decades, labs have revived skin cells from 90‑year‑olds and rejuvenated diseased mice,...
Transformational Coach Emmanuela Launches Global 'Breath of Life' Program to Foster Inner Calm
Transformational coach Emmanuela has launched a global Breath of Life program that uses breathwork to counter chronic stress and burnout. The initiative targets high‑performers, parents, and professionals worldwide, promising measurable shifts in emotional regulation and presence.
Study Links Centenarians' Children Diet to Lower Chronic Disease Risk
Scientists at Tufts University report that offspring of centenarians who follow diets high in fish, fruits and vegetables and low in sugar and sodium have markedly reduced risks of stroke, dementia, type‑2 diabetes and cardiovascular disease, based on a 20‑year...
UT Southwestern Study Links Refeeding Phase to 41% Lifespan Boost in Worms
UT Southwestern scientists discovered that the metabolic response to refeeding after a 24‑hour fast extends Caenorhabditis elegans lifespan by about 41%, highlighting the refeeding phase—not the fast itself—as the key driver of longevity. The finding could reshape human dietary recommendations...
New Guide Shows Habit‑Stacking Can Accelerate Health and Wellness Goals
A guide released on Yahoo outlines how habit‑stacking can speed health and wellness progress, citing UCLA Health, Cleveland Clinic and Wharton experts. The piece highlights practical steps, early research and why motivation alone often falls short.
Pilot Study Finds 300 Mg NMN Cuts Post‑Exercise Inflammation in Young Men
Researchers in Taiwan reported that a six‑day regimen of 300 mg NMN lowered key inflammatory cytokines in young men after intense blood‑flow‑restriction resistance training. The crossover trial suggests NMN could become a targeted supplement for athletes and biohackers seeking faster recovery.
Dartmouth Researchers Launch Smartphone Study to Predict Alzheimer’s Risk in Williamstown Seniors
Dartmouth Medical School researchers began a pilot study with 23 Williamstown seniors, part of a nationwide 200‑person trial, to test the RealVision smartphone app that analyzes walking, speech, eye‑tracking and smiling to flag early Alzheimer’s risk. The effort showcases big‑data...
Carbs Aren’t One Tank: Muscle Glycogen Drives Performance
Let me dump some carbs on you... Someone said yesterday that thinking about CHO intake in terms of stores, output and "bonking" is the "old way" of looking at carbs in sport. That pissed me off. So, let's start with... Only those with...
Sodium Fuels Glucose Uptake, but Excess Clogs Absorption
Yes, it is a confounding factor, but a necessary one. To get carbs from the gut across the intestinal wall requires the SGLT1 transporter... Sodium-Glucose-Linked-Transporter Sodium is the driver, glucose is a passenger. So, you do need ample sodium to get high levels...
How to Build a Fueling Strategy Around the Glycemic Index
The glycemic index (GI) measures how quickly carbs raise blood sugar and has evolved from a diabetic tool to a performance‑focused nutrition metric. Low‑GI foods such as whole grains, legumes, and vegetables provide steady energy and support long‑term metabolic health,...
Cold Plunge Activates Vagus Nerve, Cuts Inflammation
Are you a cold plunge person — or does the idea make you want to close the app? For the full 10percenthappier podcast episode with Dr. Kevin J. Tracey — neurosurgeon, president and CEO of the Feinstein Institutes for Medical Research,...
Low Post‑Surgery Klotho Predicts Inflammation and Cognitive Decline
Lower levels of the anti-aging protein Klotho after surgery were strongly linked to higher inflammation and worse cognitive function in patients with postoperative cognitive dysfunction (POCD). This suggests Klotho could be a useful early biomarker—and possibly a treatment target—for predicting...
Study Links Vitamin E and Riboflavin to Hormone Levels and Muscle Mass in Infertile Women
Researchers published a cross‑sectional study of 97 women seeking infertility treatment in Spain, finding that higher vitamin E intake correlates with elevated anti‑Müllerian hormone (AMH) and that riboflavin consumption is positively associated with muscle‑mass percentage. The findings highlight nutrition as a...
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Pinealon Boosts Sleep, HRV, and Lowers Resting Heart Rate
Pinealon has been an awesome peptide for sleep: +1 hr sleep + HRV (up to 105-110) - RHR (down to 40-43) Thanks to @AbudBakri for these. https://t.co/YcwfPO9ebD
Study Finds Exercise Variety Cuts Mortality Risk, Extending Lifespan
Researchers analyzing data from the Nurses' Health Study and the Health Professionals Follow-Up Study report that a varied exercise regimen, not just higher volume, is linked to a markedly lower risk of death. The finding challenges the prevailing biohacker focus...
Skipping After‑Dinner Snacks May Drive Early TRF Benefits
From 2.6M time-stamped diet records, we identified 5 clusters of commonly consumed items: Breakfast | All-day | Lunch | Dinner | After-dinner After-dinner: popcorn, beer, wine, ice cream. So when people stop eating early, they also (inadvertently) cut out this cluster—potentially explaining some...
Longevity Medicine’s New Vanguard: 11 Innovators Poised to Drive an $8 Trillion Market
Business Insider unveiled its 2026 Rising Stars of Longevity, naming 11 innovators whose AI‑driven diagnostics, biotech breakthroughs and gerotherapeutics aim to capture a market expected to grow to $8 trillion by 2030. The list, vetted by experts like Andrea Maier and...
Evidence for MLKL to Be Important in Hematopoietic Stem Cell Aging
Researchers have identified the RIPK3‑MLKL signaling axis as a central driver of hematopoietic stem cell (HSC) aging. Activated MLKL accumulates in HSC mitochondria, impairing self‑renewal and lymphoid differentiation without causing necroptotic cell death. The study links multiple stress responses—such as...
Heart‑Metabolic Risks Accelerate Cognitive Decline in Indian Seniors
Cardiometabolic-Inflammatory Risk Factors and Cognitive Decline Among Older Indians—Report From a Nationally Representative, Longitudinal Study 'Longitudinal data provided by LASI-DAD study shed light on how cardiometabolic risk factors may influence decline of cognitive function and development of dementia in older adults...
AI Accelerates Longevity Science at London Tech Show
AI is reshaping longevity science faster than ever. At the Health + AI Insiders Tech Show, I'll be discussing how computational biology is transforming our understanding of ageing. 📍 London | 29 April 2026 🔗 Complimentary tickets: https://t.co/4XipXYfWcc
Abdominal Contractions May Drive Brain Fluid Flow, Aiding in Neural Waste Clearance
A new study in Nature Neuroscience shows that abdominal muscle contractions compress vessels linked to the spinal cord, nudging the brain within the skull. This subtle motion drives cerebrospinal fluid flow, helping to wash away neural waste. Researchers demonstrated the...
Static Stretching Boosts Flexibility and Pain Tolerance Alike
Long-term static stretching produces improvements in flexibility (by increasing stretch tolerance) but also increases pain tolerance more generally (as measured by pressure-pain thresholds). This shows that stretch tolerance and pain tolerance are very similar in nature. https://t.co/XEAOVCPQWi
Post‑marathon Reflections: Shoes, Fuel, and Doping Insights
I have some morning-after thoughts on that 1:59:30 performance and the marathon generally, ranging from shoes to doping via fuel, so let's see how it goes. And we'll explore them (and your thoughts) in the next podcast. So here goes......