Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
The CNBC Cures Summit opened with Becky Quick urging families and innovators to accelerate rare‑disease research. Speakers highlighted a widening gap between rapid scientific breakthroughs—gene therapies, AI‑driven diagnostics, and modular “nodal biology”—and an aging regulatory framework. Leaders from Biogen, the FDA, Congress, and patient foundations called for modernized trial designs, stable bipartisan policy, and clearer reimbursement pathways. The event underscored that while the science is ready, systemic reforms are essential to deliver cures to patients.
The hardest conversation I have in my office isn't about surgery. It's about time. A 58-year-old sat across from me with knee pain. She’s otherwise healthy, but menopause has been rough on her. Her MRI shows some cartilage changes — age-appropriate,...
Plasma Lactate as a Marker for Metabolic Health : Exercise and Sport Sciences Reviews https://t.co/6IeA9Y9FGQ
Researchers have unveiled a novel HIV‑cure strategy that forces dormant virus particles to reveal themselves to the body’s innate immune system. The method employs a STING‑pathway agonist to coax latent proviruses into producing viral RNA, which then triggers a potent...
Understanding how supaspinal CNS fatigue works during exercise is essential to optimal strength training programming. See more in this week's free Patreon article. https://t.co/s5U5Z5gR8G
Is it time to start exposing high schoolers to the aging/longevity field: basic reasons it's important & a worthy potential career area? High schools have career days where adults jobs & careers. I just did a 1hr intro to aging &...
The article debunks long‑standing myths about menopausal hormone therapy (MHT) by highlighting how the 2002 Women’s Health Initiative (WHI) trial was misapplied to all women. It explains that the WHI tested an older cohort using a specific estrogen‑progestin combo, leading...
Insulin has an inverse U-shape during aging, so by itself low values may be optimal, but also indicative of B-cell failure Adding HbA1c provides more context. If it's low with low insulin this is potentially good news Also check liver enzymes, to...
University of Arkansas researchers have demonstrated that rice proteins can be extracted and incorporated into vegan cheese formulations, achieving roughly 12% protein content and closing a key nutritional gap in plant‑based cheeses. The study identified four protein fractions—albumin, globulin, glutelin...
Anita Zaidi calls for urgent research to close the knowledge gap in women’s health, highlighting the deadly impact of pregnancy complications like pre‑eclampsia. More than 700 women and 6,500 newborns die daily from these conditions, with the highest toll in...
In a recent episode of Longevity by Design, Dr. Gil Blander interviews Dr. David Allison, director of the USDA Children’s Nutrition Research Center, to dissect common misconceptions in weight, exercise, and nutrition science. Allison emphasizes that reproducibility and transparent methodology...
A large retrospective study of over 600,000 U.S. veterans found that patients prescribed GLP-1 receptor agonists for diabetes were 14% less likely to develop new substance-use disorders compared with those on SGLT-2 inhibitors. The analysis also showed 30% fewer drug-related...
The Backpacking Light podcast’s Episode 144 examines how trail steepness reshapes hiking difficulty, revealing that metabolic cost does not increase linearly with slope. It highlights that mild downhill grades (‑5 % to ‑10 %) are most energy‑efficient, while steep uphill (≥20 %) and downhill (≤‑25 %)...
Acetyl‑L‑Carnitine (ALCAR) is a bioavailable form of L‑carnitine that readily crosses the blood‑brain barrier, delivering energy‑boosting fatty acids to mitochondria and supporting acetylcholine synthesis. Clinical studies show ALCAR can improve memory, mood, and fatigue, and it performs comparably to antidepressants...
A Northwestern University study found that playing puzzle‑linked soundtracks during REM sleep can nudge lucid dreamers toward solving previously unsolved problems. Researchers used targeted memory reactivation on 20 participants, cueing them with brief instrumental clips associated with difficult puzzles. Seventy‑five...
A dermatologist explains that there is no such thing as a healthy tan, emphasizing that any UV exposure triggers skin damage that accumulates from childhood into later years. Daily use of broad‑spectrum SPF 50 sunscreen is sufficient for most office workers,...
In this episode the host explores the emerging link between chronic fatigue—including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—and gut health, emphasizing how gut dysbiosis may drive persistent exhaustion. They explain the gut microbiome as a complex ecosystem, using a garden metaphor...
The article explores the psychological battlefield elite lifters face after major injuries, emphasizing that physical healing alone is insufficient without a structured mental strategy. It outlines an identity shift from performance‑based self‑worth to broader personal value and introduces the “Spiral...
In this episode, Dr. Robert Lovekin interviews author David Etheridge about his book *We’re Not Sick, We’re Being Sold*, which argues that the food and pharmaceutical industries have distorted nutrition advice, leading to widespread chronic disease. Etheridge shares his personal...
Weight training performed through a full range of motion does not automatically provide comprehensive mobility. While heavy squats and deadlifts can improve certain joint angles, they often fall short on deep hip flexion, ankle dorsiflexion, and thoracic extension. Targeted mobility...
A new Lancet study of over 135,000 adults in the US, Sweden, Norway and the UK found that adding just five minutes of moderate‑to‑vigorous activity each day could prevent roughly 10% of premature deaths. The researchers also modeled the impact...
Omega‑3 supplementation trials produce mixed results due to differences in dose, population risk, and chosen endpoints. High‑dose EPA/DHA studies in secondary‑prevention cohorts with elevated triglycerides, such as REDUCE‑IT, show significant cardiovascular benefit, whereas lower‑dose primary‑prevention trials like VITAL and ASCEND...
The post argues that chronic cortisol elevation, not cortisol itself, drives stress‑related health issues by keeping the HPA axis overactive. It highlights the vagus nerve’s role in shifting the nervous system toward parasympathetic dominance, measurable through heart‑rate variability (HRV). Gentle,...
Washington state lawmakers introduced HB 2303 to prohibit employers from requiring or coercing employees to receive subdermal microchip implants. The bill cleared the House and a Senate Labor and Commerce Committee with bipartisan backing and now heads toward final enactment....
Cortical Labs in Australia has upgraded its biocomputer, built from lab‑grown human neurons, to play the first‑person shooter *Doom*. The new CL1 platform translates visual game data into electrical stimulation patterns that the neuronal network can interpret, achieving adaptive, real‑time...
Researchers have built microbial community‑scale metabolic models that simulate how specific probiotic strains behave in an individual’s gut. Using baseline microbiome data, the models predicted engraftment with 75‑80% accuracy and linked bacterial growth to health outcomes such as improved post‑meal...
The article introduces a step‑by‑step system for building "bulletproof" knees by embracing the knees‑over‑toes position rather than avoiding it. It blends Louie Simmons’ concentric sled‑drag techniques with Charles Poliquin’s eccentric reverse step‑up methodology, culminating in chain‑loaded squats that match the athlete’s...
The article argues that systematic sleep tracking is a powerful productivity lever, positioning sleep as the energy foundation for high performance. It outlines a low‑tech sleep journal as an entry point, then contrasts it with wearables that capture stages, heart‑rate...
In this AMA episode, host Peter Atiyah answers listener questions on practical longevity strategies, covering strength metrics (relative strength, grip, lower‑body power), starter exercise routines for time‑pressed beginners, and the role of complex movement for brain health. He emphasizes normalized...
The transient receptor potential vanilloid‑1 (TRPV1) is a heat‑sensing ion channel that also responds to capsaicin, acidic pH and a range of dietary compounds. Genetic variants shift activation thresholds, influencing how intensely people experience spicy foods, pain, and migraines. TRPV1...
The brain houses about 20‑25% of the body’s cholesterol, yet it relies on local synthesis because circulating cholesterol cannot cross the blood‑brain barrier. Although some patients report transient brain fog on statins, large observational studies generally show neutral or even...
Scientists at the University of Southern Denmark discovered that restricting dietary methionine and cysteine triggers thermogenesis comparable to chronic cold exposure, leading to significant weight loss in mice. Over a week, mice on the amino‑acid‑restricted diet burned 20% more calories...
The 80/20 training model prescribes 80 % low‑intensity and 20 % moderate‑to‑high intensity work, a formula that not only drives personal bests but also cuts injury risk for endurance athletes. By eliminating the “moderate‑intensity rut” (Zone X), the approach reduces chronic nervous‑system fatigue....
University of Tilburg associate professor Mirela Habibovic introduces the “stress spectrum” in a concise video, explaining how stress ranges from low to high levels. She argues that short‑term spikes in stress can sharpen focus, boost motivation, and enhance performance, while...
A new five‑minute, high‑impact workout targeting bone health uses heel drops, squat jumps, and box‑drop jumps to deliver forces up to four times body weight. A 2024 meta‑analysis of 18 studies found jump training can improve hip bone mineral density...
The 2024 Endocrine Society guidelines discard the notion of a vitamin D deficiency and limit supplementation to four specific groups: pregnant people, adults over 75, children under 18, and individuals with prediabetes. The series argues that robust evidence shows vitamin D pills...
Johns Hopkins researchers, led by Adam Charles, secured a four‑year, $2.7 million NIH grant to build an AI‑enhanced optical imaging system that can record brain activity 20 to 50 times faster than current methods. The platform will translate voltage spikes and...
Candida species normally coexist harmlessly on mucosal surfaces, but immune disruption can trigger a shift to opportunistic infection ranging from mild thrush to invasive candidemia with mortality over 30%. Genetic variants in innate and adaptive pathways—such as CARD9, Dectin‑1, and...
A longitudinal study of more than 5,000 Chinese adults aged 80 and older found that non‑meat eaters were less likely to become centenarians than meat eaters. The disparity was confined to participants who were underweight, while those of normal weight...
NAD+ supplements contain precursors that the body converts into the essential coenzyme NAD, which supports cellular energy production. The market promotes these products as anti‑aging and energy‑boosting, but the actual molecule cannot be absorbed directly, so formulations rely on nicotinamide...
CTS coach Cliff Pittman guided Olympic marathoner Molly Seidel through her first 100 km at Black Canyon using a Minimum Effective Change model. Rather than adding mileage, the plan kept total volume steady while increasing run density and emphasizing back‑to‑back long...
The article discusses a recent study testing Maurten’s hydrogel‑encapsulated sodium bicarbonate (baking soda) on trained cyclists performing a 40‑kilometre time trial at simulated 1,850 m altitude. Results showed an average 1.2 % faster finish (63:29 vs 64:15) with baking soda, and the...
In this episode, former Navy SEAL and sleep scientist Rob Sweetman discusses how chronic sleep deprivation undermines military readiness, first‑responder health, and overall resilience. He shares his personal journey from a SEAL who was taught to ignore sleep to a...
Endurance athletes face a supplement landscape riddled with hype, hidden ingredients, and contamination risks that can jeopardize health and lead to doping violations. The article outlines a practical framework that first reduces risk through third‑party testing and simple product choices,...
Artificial intelligence has become embedded in daily sports nutrition workflows, from wearable readiness scores to automated meal‑plan generators. The technology excels when problems are well‑defined, data are accurate, and outcomes are objective—exemplified by AI‑driven endurance nutrition planning and real‑time analysis...
In Watts Doc #62, hosts dive into how cyclists can design and run their own n=1 training experiments, covering the fundamentals of hypothesis formulation, data collection, and analysis. They walk listeners through selecting variables, establishing baselines, and using tools like...
Bell peppers are low‑calorie, nutrient‑dense vegetables that provide high levels of vitamin C, vitamin A, fiber, and antioxidants. Research links compounds such as beta‑cryptoxanthin and anthocyanins to reduced cancer risk, improved brain health, and better digestion. Nutrient content varies by color, with...
In this episode, Dr. Jason Fung, a nephrologist and author of *The Obesity Code* and the upcoming *The Hunger Code*, explains why the simplistic "calories in vs. calories out" model fails to address weight gain. He introduces the body‑fat thermostat...
Emerging research redefines depression as an inflammatory disorder linked to gut health. Cytokine‑driven inflammation often originates from increased intestinal permeability, allowing endotoxins to reach the brain. Short‑chain fatty acid butyrate and specific probiotic strains, notably Bacillus coagulans, have shown promise...
Sulforaphane, a sulfur‑rich isothiocyanate found chiefly in broccoli, acts as a potent antioxidant and anti‑inflammatory agent by activating the Nrf2 pathway. Clinical trials have documented up to 34% behavioral improvement in autism spectrum disorder and neuroprotective effects in Alzheimer’s mouse...
