Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Dr. John Pandolfino at Northwestern Medicine has created a digital twin of the esophagus to guide myotomy surgery for achalasia patients. The virtual model reproduces pressure and motion, runs millions of simulations, and recommends the optimal surgical cut. A 400‑patient clinical trial now compares standard surgery with twin‑guided procedures, aiming to reduce reflux and diverticulum formation. The approach could extend to other tube‑like organs, reshaping personalized surgery and reducing reliance on animal models.
Running itself isn’t harmful to knees, but sudden mileage spikes, weak supporting muscles, and abrupt terrain changes can overload the joint. Research shows runners often have healthier cartilage than sedentary people, yet three conditions—patellofemoral syndrome, iliotibial band syndrome, and patellar...
The Power of Zero - Why CAC Scoring Changes Everything for Heart Disease Risk https://youtu.be/XVNLubDAE-M https://www.innerscopic.com/
As a medical school professor, I've watched patients take vitamin D for years with zero improvement in their blood levels. Now a Vanderbilt clinical trial explains why: they're missing magnesium. Key findings: > Magnesium RAISED vitamin D in people who were deficient > But...
In this episode, host Molly Eastman talks with Dr. Melissa Sauners, a chiropractor and nervous‑system alignment specialist, about how women (and anyone) can quickly downshift their nervous system to achieve deeper, more restorative sleep. Dr. Sauners explains that chronic over‑stimulation...
Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort https://t.co/x0zpRxwOXX
Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study https://t.co/8DUSdzlf4e
A Bayesian adaptive trial with 99 trauma‑exposed healthcare workers showed that a brief, guided Tetris‑based imagery‑competing task significantly reduced intrusive memories at four weeks and maintained benefits over follow‑up. The authors stress that the intervention targets a specific PTSD symptom...
Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging https://t.co/3mjdKHKcPc
As a medical school professor, I tell my students: muscle isn't vanity. It's a longevity organ. A new JAMA Network Open study of 5,000+ women ages 63-99 just proved it: > Every 7kg increase in grip strength = 12% lower mortality > Faster...
Researchers led by Dr. James Murrough and Dr. Emma Guttman‑Yassky identified the Th2 immune pathway as a contributor to major depressive disorder. Using proteomic profiling and computer modeling, they repurposed dupilumab—an IL‑4 receptor antibody approved for eczema—to target this pathway....
The impact of time-restricted feeding on energy and macronutrient intake among elite Jordanian football players: a randomized controlled trial "TRF did not significantly improve energy or macronutrient intake compared to the standard diet. Both groups exhibited persistent energy and carbohydrate deficits...
It’s flabbergasting that some get offended over the plain fact that running more makes you faster. It’s science ⤵️
A team at Gladstone Institutes and the San Francisco VA has launched HIV‑seq, a virus‑specific single‑cell RNA‑sequencing platform that isolates active HIV reservoir cells from patients on antiretroviral therapy (ART). The method captured 25 treated‑patient cells and over 1,000 cells from...
We lose many abilities as we age. One is the ability to change direction and remain stable. This drill, done once a week, helps. This isn’t about speed. The cones are only 12-15’ apart. This is about the transition from...
Dehydration not only affects your brain and exercise performance - it also makes you look older Skin dehydration and dryness have been seen to be closely related to the degree of skin wrinkles and deeper furrows. The lower the skin hydration, the...
Loaded carries are presented as a postural resistance tool rather than a simple transport exercise, emphasizing total‑body rigidity under load. The "Tall and Wide" cue system—head up, shoulders spread, pelvis neutral—creates a stacked, pillar‑like structure that maximizes spinal alignment. Variations...
"A series of WBC sessions improved carbohydrate metabolism and modulated adipokine and sirtuin profiles, with the most pronounced effects observed in individuals with elevated BMI. However, this effect generally may require a longer treatment series." The effect of whole-body cryostimulation treatments...
Bright light therapy influences glymphatic system function in individuals with subthreshold depression: a randomized clinical trial Highlights 👇👨🏻⚕️” 🔘 Bright light therapy (BLT) influences glymphatic function in subthreshold depression. 🔘 BLT enhanced brain functional activity of the prefrontal cortex. 🔘 BLT links glymphatic system...
![[Comment] Aldosterone Synthase Inhibition in Resistant Hypertension: Promises and Unknowns](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/0a5065acfb3787a2e2e6999bae6248e9.webp)
Resistant hypertension affects up to 20 % of hypertensive patients and carries heightened cardiovascular risk. Recent phase‑3 studies of aldosterone synthase inhibitors such as baxdrostat and lorundrostat have demonstrated significant ambulatory blood‑pressure reductions, positioning them as potential fourth‑line agents beyond traditional...
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis https://t.co/tLGUiinPPl
Useful story here for someone. I can't take DHEA because it's banned by WADA. But I can take pregnanolone. And that boosted not just my DHEA-S back to levels in my 20s, but also boosted my testosterone with tripping up my estradiol.
![[Comment] Offline: The Silent Torment of Casey Means](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/d29724c6236ef051403e50259273b915.webp)
Casey Means, a former ENT surgeon and author of *Good Energy*, was nominated by President Trump for U.S. Surgeon General and faced a Senate confirmation hearing dominated by vaccine questions rather than her metabolic‑health agenda. She argues that nine in...
Impact of creatine supplementation on menopausal women’s body composition, cognition, estrogen, strength, and sleep https://t.co/8ZqpAr94uG
As if we needed more evidence...resistance training is the primary intervention for preventing and reversing the age related loss of muscle mass https://t.co/zljKrp6tnp
![[Perspectives] Hadiza Shehu Galadanci: Strengthening Maternal Health in Nigeria](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/52b082cc64194e1f91a2de11b6fecc8d.webp)
Professor Hadiza Shehu Galadanci, director of the Africa Center of Excellence for Population Health and Policy, highlighted the urgent need to tackle postpartum haemorrhage (PPH) in Nigeria. She noted that while prevention and treatment methods exist, the majority of the...
Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging? https://t.co/Tg5ZSIfZB2 https://t.co/Tl6nluUA0s
NEW: Marketing suggests CGM can optimise meals, stabilise energy, and personalise fueling. But what does the science actually show? https://t.co/B3MRb4lyXM Secure your early-bird spot now for £15 https://t.co/g9C0i7QJgO
![[Comment] Why Investing in Women's Health Is a Societal Imperative](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/e85a106906bfc6e377921705c114243b.webp)
The commentary highlights that women experience nine additional years of poor health—25% more than men—primarily between menarche and menopause. Female‑specific conditions such as fibroids, endometriosis, and menopause‑related issues affect the majority of women, curtailing school attendance and workforce participation. Recent...
Intermittent fasting for adults with overweight or obesity "...Compared to regular dietary advice, intermittent fasting may result in little to no difference in weight loss or quality of life. Intermittent fasting may result in little to no difference in adverse events,...
Continuous glucose monitoring offers interesting possibilities for athletes, but it is not a perfect fuel sensor. It may help detect falling glucose levels early and prompt an athlete to eat before hypoglycemia becomes a problem. Read now: https://t.co/uNfQi7HiW8 https://t.co/gVQz8Fqjbu
![[Comment] Hypofractionated Nodal Radiotherapy in Breast Cancer: Time for an Updated Standard of Care?](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/51ee4beaf110fc3e1c92723294b3d34e.webp)
The Lancet comment revisits hypofractionated nodal radiotherapy for breast cancer, highlighting its historical association with lymphoedema and brachial plexopathy due to high doses and poor protocol control. Early adoption of hypofractionation was driven by capacity constraints rather than trial evidence,...
Ambient Temperature and Adult Obesity: Evidence from U.S. County-Level Panel Data "The results indicate that higher ambient temperatures are associated with higher adult obesity rates, even after accounting for correlated environmental conditions..." https://t.co/ewEuMdqr3O
Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection https://t.co/Xv3xItlP20
A large observational study of 98,261 U.S. veterans with type 2 diabetes found that using GLP‑1 receptor agonists together with six to eight healthy lifestyle habits lowered major adverse cardiovascular events (MACE) by 43% compared with low‑habit, non‑GLP‑1 users. Both the...
that’s a high level question MO the specific value of NR relates to the tissue distribution of NMRK1 and NMRK2 NR kinase 2 is strongly upregulated in conditions of NAD decline including heart failure and peripheral neurodegeneration
Researchers found that low‑oxygen environments cause red blood cells to multiply and increase GLUT1 expression, turning them into a powerful glucose sink. In mice, chronic hypoxia improved glucose tolerance and reversed hyperglycemia, an effect replicated by the experimental drug HypoxyStat...
A cross‑sectional analysis of 23,475 adults identified 7 hours 19 minutes (≈7.3 h) of nightly sleep as the sweet spot for insulin sensitivity, measured by estimated glucose disposal rate (eGDR). Sleep durations shorter than this point showed lower eGDR, while longer sleep was linked...
A mouse study found that a high‑fat, low‑carb ketogenic diet normalized blood‑sugar levels in hyperglycemic mice and, when combined with aerobic training, restored their peak oxygen consumption (VO2max). The diet shifted metabolism toward fatty‑acid oxidation and ketone utilization, eliminating muscle‑remodeling...
A new study in Nature Communications shows that a high‑fat, high‑sugar diet during early life permanently alters hypothalamic circuits that regulate appetite in mice, even after the diet is discontinued. The research links these lasting changes to the gut microbiome...
The British Journal of Cancer published an observational study of 1.8 million adults followed for 16 years, finding that vegetarians had significantly lower risks of pancreatic, prostate, breast, kidney, and multiple myeloma cancers. Conversely, the same cohort showed almost double the...
Those of us who have been taking 5-10g (20-30g in the “loading” (we now know not needed) of creatine daily and lifting low volume, heavy 3-4x per week for the last 30+ years will tell you: sometimes the science does...
Alaskan ultra‑endurance rider Lael Wilcox is shaving her head to eliminate a ten‑minute daily grooming routine, translating into 13 hours saved over her 78‑day Around‑the‑World record attempt. She will launch the bid on June 7, aiming to beat Mark Beaumont’s 78‑day, 18,000‑mile...
3 Essential Questions Everyone must answer for Self Directed Health: 1) What’s your margin for safety? (Do you need RCT data? Are you OK with preclinical only? “Anecdata” only?) 2) Do you want to be in the experimental or control group? 3)...
What's your excuse for not strength training? Why are people at all ages suddenly becoming more fit than they’ve ever been in their lives? Could it be that they are learning that strength training is a key to health and longevity? (see you...
Human Growth Hormone May Be Detrimental When Used to Accelerate Recovery from Acute Tendon-Bone Interface Injuries https://t.co/L4EOFMKjys
AGE products shorten lifespan on a CR diet Ha, I wonder if @bryan_johnson watched my video on it 5y ago: https://t.co/h5FppnQpk9
Assuming this is real it may have something to do with their “must pay by Venmo to the following name” (at least that’s how it used to be). FDA is easing up on some aspects of peptides but gray market...
Targeting aging hallmarks in brain health within the framework of preventive medicine: mechanistic insights into naringenin's role in longevity, synaptic function, and cellular homeostasis https://t.co/JPiEz5VnQe https://t.co/C0EYPRepwy
Yep. Do what works for you. If I’m exercising in the first hour or two after waking, I’ll go straight to caffeine otherwise I delay. Coleman:
