Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine emerges as brain‑fuel supplement that counters sleep loss and stress
Creatine monohydrate, long known for muscle growth, is gaining scientific backing as a brain‑fueling supplement. Recent studies show that daily doses of 10‑25 g raise brain creatine levels and mitigate cognitive deficits caused by sleep deprivation and stress, improving processing speed and working memory.
Spring daylight‑saving time disrupted sleep for many Americans, prompting a rise in over‑the‑counter sleep aids. Experts warn that pills carry dependency risks and advocate lifestyle‑based alternatives. Forbes highlights three natural remedies—relaxing music, acupuncture, and a phone‑free bedroom—that research suggests can match the effectiveness of sleeping pills. The article urges readers to test these options, emphasizing safety and the need for medical consultation.
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Registered dietitian Nisha Melvani highlights kale as the top vegetable for longevity, citing its dense mix of antioxidants, fiber, and anti‑inflammatory compounds. The leafy green delivers vitamin C, vitamin K, calcium, magnesium, and glucosinolates that collectively support immune function, bone strength, and chronic‑disease...
Methylene Blue, a synthetic dye turned drug, is gaining attention as a potent nootropic that improves mitochondrial efficiency, acts as an antioxidant, and modulates neurotransmitter systems. Clinical and pre‑clinical studies show low‑dose supplementation enhances memory, mood, and offers neuroprotective benefits...
I used to walk under 4,000 steps per day—and I was miserable. I thought everything had to be done at my desk. Now I take 20,000 steps a day—and it's the *single* best thing I've done for my health & creativity. Here are...
Using the sauna after aerobic exercise improves VO₂ max more than training alone. People who performed 30 minutes of cycling and then sat in a sauna for ~15 minutes afterward saw greater gains in their VO₂ max after 8 weeks of...
A joint study by the Wharton Neuroscience Initiative and Slalom examined how individual chronotypes—natural sleep‑wake rhythms—affect creative performance. Using the Morningness‑Eveningness Questionnaire and a divergent‑thinking task, researchers found that employees generated more ideas and higher‑quality concepts when work aligned with...
I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. + Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable...
Study shows nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication (GLP-1 agonists, metformin, naltrexone). https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827069 https://www.gatlan.com/ @GatlanHealth
Johns Hopkins Medicine is heading a five‑year, $24 million NIH‑funded Hepatitis B and HIV Cure Consortium that brings together research teams from the United States, Brazil, India, Senegal and Uganda. The first year will enroll 450 participants co‑infected with HIV and chronic...
Energy and Exercise I've been writing about this a lot since the start of the year. Here's a snapshot from Bek's recent bike test from Elias' lab in Helsinki Don't get wrapped up in the exact numbers - it's the concept I...
High‑intensity interval training (HIIT) is gaining traction among cyclists as a time‑efficient way to boost aerobic power, mitochondrial function, and race‑day performance. Recent studies show that two weekly HIIT sessions can raise VO₂ max and peak power by 2‑4 % in well‑trained...
Researchers at Friedrich‑Alexander‑Universität Erlangen‑Nürnberg successfully vitrified mouse brain slices and, in a limited trial, an entire mouse brain, preserving neuronal structure and function after rewarming. By using a high‑concentration cryoprotective agent cocktail, they avoided ice crystal formation, maintained synaptic architecture,...
Researchers at Johns Hopkins found a single dose of psilocybin dramatically increased smoking cessation rates compared with nicotine patches. In a randomized trial of 82 smokers, 17 of 41 participants who received psilocybin remained abstinent after six months versus four...
Magtein, a patented magnesium L‑threonate, announced a partnership with Arnold Schwarzenegger’s Pump Club at Natural Products Expo West 2026 to promote brain‑health content through newsletters and podcasts. The collaboration seeks to translate robust clinical research—including recent findings on cognition, sleep,...
The Longevity.Technology UNLOCKED episode highlights the mouth as a pivotal gateway to overall health, linking nasal breathing, oral microbiome, and dental habits to inflammation, sleep quality, and metabolic function. Clinicians Dr. Aoife Stack and Dr. James Goolnik argue that chronic...
Sitting for over 8 hours daily raises mortality risk. Stand up. Now. (And get a standing desk)
Estradiol is not just a reproductive hormone. It is an anabolic signal. It drives muscle protein synthesis. It activates satellite cells after training. It controls how your body responds to the stress of a hard workout. When it declines, the same...
A twelve‑week randomized, double‑blind trial found that daily supplementation with 14 g arginine and 6 g fish oil improved gait speed, hand‑grip strength, and functional activity scores in older adults with sarcopenia. The intervention also lowered inflammatory markers (TNF‑α, IL‑6) and triglyceride...
Daily exogenous ketone consumption enhances cognitive function 🧠📈 This new study investigated the effects of 90 g/day (3 x 30g) ketone monoester supplementation in recreational runners Analysed outcomes included… 🏃 Running performance 🧠 Cognitive function 🔥 Metabolism 🩻 Body composition 🩸 Hemodynamics 🎭 Mood Results 📊 Ingesting ketones led to...
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis 🫀 Author conclusion: Melatonin supplementation “significantly ameliorated” multiple Cardiometabolic Risk Factors. https://t.co/SapRrA0RDa
A 30‑year longitudinal study of more than 1,000 women found that those with polycystic ovary syndrome (PCOS) performed worse on cognitive tests and showed reduced white‑matter integrity at midlife. The researchers controlled for BMI, smoking, alcohol use, income, diabetes and...
Low-cost bodyweight callisthenic-based HIIT improves blood pressure, glucose control, and TyG in older adults with metabolic syndrome https://t.co/oa7ZJpk0Ld https://t.co/xKAFxvJPIz
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial https://t.co/Xt9HqmmyGi
Researchers have shown that mild, repeated stressors such as hypoxia can trigger cellular maintenance programs, notably autophagy, which delays senescence and extends organismal lifespan. Under low‑oxygen conditions, oxygen‑dependent histone demethylases are inhibited, leading to increased histone methylation and stabilized chromatin...
Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases https://t.co/kp4LZEbZzN https://t.co/boWzW7fcjM
Time-restricted eating as a potential strategy for healthy lifespan: an evaluation of current evidence https://t.co/wuXCFoZi1f https://t.co/mgFWzcFmSZ
The article reviews the emerging field of comparative biogerontology, emphasizing that while the hallmarks of aging have been mapped in laboratory models, their relevance across the vast diversity of animal species remains unclear. It argues that integrating molecular insights from...
Adding 5 g of glycine to 25 g of glucose lowered the glucose response by >50% compared with glucose alone, without increasing total insulin secretion. PMID: 12450897 Why glycine is a blood sugar and glycation powerhouse: https://t.co/fEVjzefmyI https://t.co/dPaspTRBHF
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
The article outlines four science‑backed habits—seeking novelty, practicing kindness, brief cold exposure, and regular skin moisturisation—that can slow biological ageing. Novel experiences enrich memory encoding, making time feel slower and supporting cognitive health. Kind acts reduce inflammatory gene activity, counteracting...
This is common sense. You don't get healthier/fitter from the exercise stressor. You get healthier/fitter from the supercompensation effect of the body during *recovery*. No recovery. No fitness. You need both.
In our blog we discuss four potential applications: https://t.co/i88WCldGot • Preventing hypoglycaemia during exercise • Improving pre competition fuelling strategies • Learning how different foods influence glucose levels • Understanding glucose regulation during sleep and stress
In this episode, Christine Trimpe shares her decade‑long transformation from morbid obesity, pre‑diabetes, and chronic fatigue to a sugar‑free, metabolically healthy life. She recounts a pivotal mountain‑hike moment that sparked her resolve, the step‑by‑step quitting‑sugar plan, and how Dr. Jason...
Recent research and expert commentary overturn the long‑standing low‑fat dogma, emphasizing that total fat intake of 20‑35% of calories is acceptable and that the type of fat matters more than the amount. Saturated fats can remain in the diet for...
Health Roadmap Updates: 1. Clinical evidence for every suggestion — guideline tags + DOI references 2. Per-field unit switching (SI / conventional) 3. Fixed LDL suppression bug and HDL threshold rounding 4. Cleaner inputs https://t.co/wwMaIyXtzB
A study in *Brain Medicine* shows that eight weeks of voluntary wheel running in adult male rats reshapes the gut microbiota, notably decreasing the tryptophan‑metabolizing genera Alistipes and Clostridium. The microbial shift coincides with altered serum metabolites, including a rise...
Researchers at Icahn School of Medicine created the first sex‑specific atlas of GLP‑1 expression in the mouse brain using RNAscope, mapping the peptide across 25 nuclei. The atlas shows pronounced differences between females and males, especially in hindbrain nuclei of...
David Creel, PhD, RD, a clinical psychologist and dietitian at the Cleveland Clinic, emphasizes that lasting weight‑loss hinges on behavioral psychology rather than isolated diet or exercise prescriptions. He outlines a framework that blends collaborative communication, self‑monitoring, skill‑building, and relapse‑prevention...
Exercise is generally safe for most cancer patients and can be a powerful adjunct to treatment. Medical oncologists emphasize that even modest activity—walking, yoga, or light strength work—helps lower inflammation, fatigue, and improves sleep and mood. The American Cancer Society...
Duke University researchers discovered that resident tissue macrophages (RTMs) are essential for maintaining intraocular pressure (IOP) in mice. Fluorescent tagging showed that selective removal of RTMs clogged the eye's outflow pathway, causing fluid buildup and elevated IOP, while depletion of...
PCSK9 in Vascular Aging and Age-Related Diseases Comprehensive summary of PCSK9's regulatory functions in vascular aging, highlighting potential therapeutic targets for combating age-related cardiovascular diseases. https://t.co/uo3PaSJLCb https://t.co/w8UZgIduPV
A UCL‑led study shows that a 12‑week cycling program improves aerobic fitness and amplifies the post‑exercise surge of brain‑derived neurotrophic factor (BDNF) in previously inactive adults. Participants underwent VO₂ max testing and cognitive assessments; after training, the BDNF spike following a...
Delayed‑onset muscle soreness (DOMS) is a normal response to new or intensified workouts, appearing within hours and peaking 12‑36 hours later. The article outlines four evidence‑based strategies to lessen the discomfort: staying properly hydrated, performing dynamic warm‑ups, incorporating post‑exercise stretching and...
How New Longevity Tech Could Help You Reach 100 Daily biometrics, smart scales and AI companions are quietly rewriting the rules of aging. https://t.co/lAmYntfSP5 https://t.co/YYo4tWkgMg
An international team genetically deleted the ENA1 gene from Saccharomyces boulardii, a common probiotic yeast. In immunosuppressed mice, the ENA1‑deficient strain showed no mortality, raising survival from 30‑40% to 100% compared with wild‑type isolates. The edit also reduced osmotic stress...
Researchers at Virginia Tech discovered that a high‑fat ketogenic diet rapidly normalizes blood glucose in diabetic mice and enhances their response to aerobic exercise. Within a week, the mice’s hyperglycemia resolved, and prolonged feeding remodeled muscle fibers toward a more...
Researchers at King's College London identified genetic markers that determine whether donor microbes persist after fecal microbiota transplantation (FMT). By tracking biosynthetic gene clusters in 86 healthy adults over a year, they distinguished stable clusters that remain long‑term from transient...
Researchers at Rice University and Baylor College of Medicine used a non‑editing CRISPR system to activate the PPARGC1A gene, boosting mitochondrial production in human cardiomyocytes. The technique safely increased cellular energy output, as shown by higher oxygen consumption in cell...
Most people are now comfortable with the idea of “reading” the nervous system, hormone, sleep tracking, etc., but writing to the nervous system, obviously is the next step. The eyes are going to be the entry point b/c they are...
Sleep masks that induce sleep (exist not released yet), glasses to ramp up specific brain states etc (early versions look promising), and vagal micro stim with specificity… have tried several, and the engineers behind the soon to come tech are...
