Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
A three‑level meta‑analysis of 65 randomized trials (3,293 adults) examined exercise combined with intermittent fasting (EX + IF). Compared with exercise alone, fasting alone, or no intervention, EX + IF produced modest but significant reductions in body mass, BMI, body‑fat percentage, waist circumference and visceral fat, while preserving fat‑free mass. Cardiometabolic benefits included lower total cholesterol, triglycerides, LDL‑C, interleukin‑6 and improved fasting glucose, insulin and HOMA‑IR, plus a small rise in VO₂ max. Dose‑response modelling identified 45–60 minute sessions, four times weekly, over 14–30 weeks as the most effective protocol.
A double‑blind, crossover trial involving 44 healthy adults tested a four‑week supplement containing taurine, vitamin B6, B9, and B12. The blend raised blood taurine and B‑vitamin levels and produced a roughly 12% increase in motivated performance on a monetary incentive force...
A recent review highlights hawthorn (Crataegus spp.) as a promising natural agent for restoring lipid metabolic homeostasis. The plant’s rich flavonoids, phenylpropanoids, and terpenoids suppress hepatic lipogenesis, boost fatty‑acid β‑oxidation, and improve insulin signaling. Additional benefits arise from gut‑microbiota remodeling...
Your ankle is a window into your heart. A new study found that patients with a thickened Achilles tendon were nearly twice as likely to experience a major cardiovascular event within three years of a coronary stent procedure. An observational study...
🍉NWW “4-2-1; Chew- Nibble- Sip” Fueling Strategy™ to optimize athletic performance: Pick a food from each category on game or training day 👇 4⃣Hrs. out CHEW ✔️25-30g protein ✔️50-75g carbs ✔️20-30 oz fluid 2⃣Hrs.. out NIBBLE ✔️10-15g protein ✔️20-30 g carbs *as needed ✔️10-15 oz...
The Conversation compares peanut, almond and cashew butters, emphasizing that health benefits depend more on ingredient purity than the nut type. All three provide monounsaturated and polyunsaturated fats, protein, fibre and essential minerals, but commercial brands often add oils, salt,...
Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline "These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes." 🧠 https://t.co/YUCjeay0kr
Gut Microbiota Manipulation by Probiotic Lacticaseibacillus paracasei DG I1572 as New Therapeutical Strategy to Counteract Vascular Inflammaging https://t.co/91dumlTNgU https://t.co/tkL0m8P6nd
Researchers at RIKEN have engineered protein‑based artificial kinetochores that compete with natural chromosome kinetochores for microtubule attachment during meiosis. By lowering the overall pulling force, these constructs keep weakened chromosome pairs together in aged mouse oocytes, restoring accurate DNA segregation....
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models https://t.co/U8LALaiz9D https://t.co/67rsM0g0pP
I’ve done 4 72+ hour fasts with no calories. Will do them quarterly for the rest of my life. I think it will dramatically improve metabolic health and reduce cancer risk. (Your body eats the cells that are weak and likely to morph...
Sauna culture is booming, highlighted by the inaugural Seattle Sauna Festival where enthusiasts gather for heat‑based rituals. Researchers cite repeated sauna sessions—four to seven times weekly—as linked to lower cardiovascular mortality, reduced blood pressure, and improved cholesterol. Emerging studies also...
Intestinal interoceptive dysfunction drives age-associated cognitive decline "We leverage this pathway to define interventions that enhance memory in aged mice, such as phage targeting of Parabacteroides, GPR84 inhibition and restoration of vagal activity. These findings indicate a key role for interoceptive dysfunction...
Researchers have demonstrated that mesenchymal stromal cells (MSCs) can actively internalize isolated, functional mitochondria through endocytic pathways. The study shows that the internalized organelles retain structural integrity and boost cellular proliferation, stress tolerance, and oxygen consumption. Chemical inhibition of endocytosis...
Instead of "healthspan," we should be thinking about "Peakspan." How long can you maintain ~90% of your peak physical or cognitive function? According to a new paper, different systems reach their “Peakspan” at very different times. Fluid cognitive abilities like processing speed...
Researchers at Massachusetts General Hospital, in partnership with Full Circles Therapeutics, have introduced a circular single‑stranded DNA donor platform called INSTALL that enables kilobase‑scale gene insertion without triggering the cGAS immune sensor. The method combines a short double‑stranded DNA segment...
A large observational study of over 258,000 adults linked improvements in the biological‑chronological age gap to a 23% lower risk of stroke and a 13% reduction in white‑matter hyperintensity volume. Researchers estimated biological age from routine blood biomarkers and tracked...
Women entering perimenopause and postmenopause face a heightened hypertension risk, with roughly 41% developing high blood pressure after menopause. A new study in Mathematical Biosciences uses a mathematical model to show estrogen’s vasodilatory effect as the primary mechanism protecting premenopausal...
Heat exposure through sauna bathing is associated with reduced cardiovascular mortality. JAMA Internal Medicine, 2015. Laukkanen et al. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2130724
For runners aged 50 and older, incorporating cross‑training is essential to sustain performance and prevent injuries. Experts advise at least two low‑impact or strength‑training sessions each week, such as cycling, swimming, yoga, or Pilates. These activities engage complementary muscle groups,...
Even small amounts of stair climbing can provide great health benefits Climbing 6–10 flights/day (~60–100 steps) is associated with: - 10% lower all-cause mortality - Lower cardiovascular disease risk - Better metabolic health - Improved cognitive function Nobody deliberately climbs stairs - stairs add incidental physical...
In this episode, host Ashley Vance talks with Nabiha Saklayen, co‑founder and CEO of Celino, about induced pluripotent stem cells (iPSCs) and their rapid evolution from a Nobel‑winning discovery to emerging therapies. They discuss how iPSCs can be reprogrammed from...
Life Biosciences has secured FDA IND approval for ER-100, the first partial epigenetic reprogramming therapy to enter human trials. The gene‑therapy delivers OCT‑4, SOX‑2 and KLF‑4 to retinal ganglion cells via a single intravitreal injection, aiming to reset age‑related epigenetic...
A recent early‑access study published in npj Science of Food reports that oral matcha consumption reduced sneezing in mice engineered to exhibit allergic rhinitis. The mice received matcha tea two to three times weekly for over five weeks and a...
Researchers at UC Irvine examined the fasting hormone asprosin in more than 4,000 postmenopausal women from the Women’s Health Initiative. They found that women with the highest baseline asprosin levels gained significantly less weight over three years compared with those...
As a medical school professor, I teach students that vitamin D does far more than build bones. This new study shows just how much more. Researchers found that vitamin D supplementation significantly improved glucose tolerance, lowered fasting blood sugar, and reduced...
University of Queensland and University of Minnesota researchers identified distinct ATP patterns in the brains and blood cells of young adults with major depressive disorder. The study found that resting cells produce higher ATP levels but cannot increase energy output...
Me, during a patient appointment, going over probiotic strains that are evidence-based for mood/anxiety: "I feel like I'm casting Harry Potter spells right now" 🪄
An international team led by the Turku Bioscience Centre discovered that applying sound‑wave vibration to vocal‑fold cancer cells restores cellular movement and markedly reduces tumor aggressiveness. The mechanical stimulation lowered levels of the oncogenic protein YAP, both in cultured cells...
Ketogenic diets for endurance performance in trained athletes 🥑 This new meta-analysis compiled data from 33 studies (409 athletes) to establish the effects of… 1️⃣ Low carbohydrate (≤130 g/day or ≤25% total energy) 2️⃣ Ketogenic diet (<50 g/day or <10% total energy) …on aerobic...
Honored to have contributed to the updated ACSM Position Stand on Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults. This was a major undertaking that synthesized findings from all related systematic reviews to develop recommendations...
Researchers report that fenofibrate, a PPARα agonist approved for hyperlipidemia, extends lifespan and reverses cellular senescence in several mouse models, including D‑galactose‑induced, 18‑month‑old, and SAMP8 strains. The drug reduces age‑related lipid accumulation and restores mitochondrial function by up‑regulating CPT1C, a...
Researchers at Brown University, Rhode Island Hospital, and VA Providence demonstrated that simultaneous electrical stimulation above and below a spinal cord lesion can restore both leg movement and spatial sensory feedback in people with complete spinal cord injuries. In a...
Recent research suggests that a simple daily habit—applying moisturiser—may help slow age‑related cognitive decline. The study followed 200 adults over 65 for three years, comparing a group that moisturised their forearms and lower legs twice daily with a control group...
The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases "Cellular senescence and SASP drive chronic inflammation and vascular dysfunction central to atherosclerosis pathogenesis, with senescent endothelial cells, VSMCs,...
The role of circular RNAs in mediating the protective effects of exercise against muscle degeneration and aging https://t.co/pdRwgTkuCj https://t.co/EaEhZfDCNi
A study by Linköping University interviewed 14 adults who recovered from long‑term fatigue conditions such as post‑COVID‑19, exhaustion disorder, and CFS/ME. Participants described a common recovery trajectory that began with hopelessness, followed by self‑directed learning about their symptoms, and a...
The @abundance360 Day 3 is at full force, covering one of the most important topics for humanity: how do we extend human healthspan & achieve LEV. We have a powerful lineup of speakers, including my friend @davidasinclair ! https://t.co/SLfeDlbo5f
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging https://t.co/gtpKOmoxDS
Urinary incontinence affects more than one‑third of women over 40 and up to half of post‑menopausal women, while men see higher rates after prostate surgery. The blog outlines a 12‑week biohacking plan that blends functional pelvic‑floor exercises, targeted nutrition, evidence‑based...
A little #ProjectUnreasonable predictive modeling this morning - Training Load + Time In Zone vs predicted VO2max. Still a whole lot of pretty aerobic colors ahead for @JohnGoldman https://t.co/noj8ztob5u
Our muscles influence the health of our brains in ways we are only beginning to understand. The muscle-brain connection. Post #3 in my series. https://t.co/IPMvZ5weLG
Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects) https://t.co/TcG9GjMVg7 @IJMS_MDPI https://t.co/gxCC9SsO7z
Everyone obsesses over VO₂max. But this paper found heart rate recovery to be more strongly tied with metabolic health metabolites than VO₂max. Peak capacity is nice. But how well you recover after a hard effort may tell us more about your metabolic health.
When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk https://t.co/aCEQF1vYep @Cells_MDPI https://t.co/yu0DOE04dp
Sterilization and contraception increase lifespan across vertebrates "... the hormonal drive to reproduce constrains adult survival across vertebrates, regardless of the environment in which an animal resides." https://t.co/gO0UflzgbW
Codon bias coevolves with longevity "Our finding is in harmony with the notion that one of the most important hallmarks of aging is loss of proteostasis, manifested in the accumulation of abnormal, misfolded proteins." https://t.co/6P7dB4KQXA
Correct. There will likely be no RCTs on BPC. Unless a new variant can perform better and be patented and Rx’d… and THATs happening.
Targeting Lifestyle in CNS Inflammatory Demyelinating Diseases: Insights from Diet and Exercise as Potential Disease Modifiers https://t.co/UyTxyZ85Ez @BrainSci_MDPI https://t.co/xTbie198cv
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis 🫀 Author conclusion: Melatonin supplementation “significantly ameliorated” multiple Cardiometabolic Risk Factors. https://t.co/SapRrA0RDa
