Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
GLP‑1 receptor agonists, originally approved for type 2 diabetes and obesity, are now attracting interest as potential longevity agents. Early animal studies suggest these drugs can extend lifespan by improving metabolic health and mimicking caloric restriction. Human evidence remains anecdotal, with limited long‑term safety data and unclear impact on mortality. The growing off‑label demand raises concerns about supply, cost, and regulatory oversight.
The wellness industry loves the word "detox." Doctors prefer the word "data." In this recent episode, we look at why sauna use is linked to a 22% drop in cardiac death and a 40% reduction in all-cause mortality. Is the heat shock...
My dry sauna session today: . 38 min at 200°F . inner ear temp 102.8°F . longer duration than usual as have been experimenting with icing face and neck to avoid MMPs thermal aging, eroding collagen. The icing slows my core temp rise....
The J. Craig Venter Institute unveiled a 4D, nanoscale simulation that tracks the entire life cycle of a minimal bacterial cell, marking a milestone for synthetic biology. A new gene‑editing platform designs DNA donors that dodge immune detection, enabling safer,...
I’ve been an orthopedic surgeon for nearly 30 years, and a few patterns have become impossible to ignore. One is that many musculoskeletal problems in adults aren’t sudden injuries. They’re the moment when declining capacity and awful metabolic health finally...
Serotonin Centers announced the Serotonin Partner Program, a medical longevity model for U.S. fitness facilities. The turnkey platform lets gyms add medically supervised services—weight loss, hormone optimization, peptide and NAD+ therapies, IV metabolic support—within dedicated longevity suites. Serotonin funds, staffs,...
Researchers identified a high‑altitude Retsat Q247R mutation that enhances myelin formation under hypoxic stress and accelerates remyelination in mouse models. The variant boosts neuronal production of the vitamin‑A‑derived metabolite ATDR, which activates the RXR‑γ pathway in oligodendrocyte progenitors. Administering ATDR...
Researchers identified six circulating piwi‑interacting RNAs (piRNAs) that forecast two‑year survival in adults over 71 with up to 86% accuracy, surpassing conventional metrics such as age, cholesterol, and activity levels. The study of 1,200 participants linked lower piRNA concentrations to...
The post examines BPC‑157, a synthetic peptide derived from human gastric juice, highlighting personal anecdotes of accelerated healing for shoulder, ankle, hip and frost‑bitten fingers. It outlines the compound’s 30‑year research history, including early Croatian clinical trials that demonstrated safety...
The Coronary Artery Calcium Scan - The Heart Disease Test You've Never Heard Of There's a 5-minute heart scan… No needles. No treadmill. No contrast dye. And it predicts heart attack risk better than cholesterol alone. https://youtu.be/XVNLubDAE-M
Base training, a low‑intensity mileage buildup, is often dismissed as only for beginners, but experts say it’s a cornerstone for runners at any level. The article outlines nine scenarios where returning to a base phase—after a race, burnout, extended time...
I teach medical students that fatty liver disease (MASLD) affects 1 in 3 adults and has limited approved drug treatments. That may be changing. Hebrew University researchers found CBD and CBG -- two non-psychoactive cannabis compounds -- reversed fatty liver in mice...
A recent Neuroscience Insights review highlights citicoline, a CDP‑choline derivative, as a potent neuroprotective agent. Clinical data show consistent improvements in memory, concentration, and visual‑motor coordination for patients with mild cognitive impairment, especially of vascular origin. The bioactive also benefits...
A longitudinal study of U.S. adults aged 65 and older found that 45.15% improved either cognitive performance or walking speed over a 12‑year span. Researchers used a measure capable of detecting upward trajectories, contrary to typical aging metrics that only...
A recent study in Heliyon found that digital puzzle games significantly improve memory and concentration in adults aged 60 and older, narrowing the gap with 20‑year‑olds who do not play such games. Participants who engaged with puzzle‑type games outperformed peers...
Sports dietitian Kate Patton explains that both pre‑ and post‑workout nutrition are crucial for optimal performance and recovery. A balanced meal rich in carbohydrates and moderate protein 3‑4 hours before exercise fuels the session, while a quick carb‑protein snack 30‑60...
Singing in a choir is linked to sharper memory, faster thinking, and a younger-looking brain. Your grandma dragging you to church every Sunday might have been the original biohacker.
Heat therapy activates proteins that repair cells and protect the heart [PODCAST] http://dlvr.it/TRSXny Podcast #PrimaryCare
A Karolinska Institutet study finds that psychiatric self‑admission—where patients can directly request short inpatient stays—reduces stress and anxiety while enabling earlier intervention. Qualitative interviews show patients experience greater autonomy, improved daily functioning, and stronger relationships with relatives. The model also...
Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging https://t.co/NSDiR30N6W
In the latest podcast, I look at how adding load can actually improve movement quality for certain individuals in specific situations, as counterintuitive as it may seem. https://t.co/nAcesV7bCd https://t.co/xCCRVH5sYE
A new randomized trial (INSPIRE) led by the University of Nottingham found that daily supplementation with the prebiotic fiber inulin significantly reduced knee osteoarthritis pain and improved grip strength. Participants receiving inulin also showed higher levels of butyrate and GLP‑1,...
Get off dat ass. 8 minutes a day of vigorous exercise linked to a 36% lower mortality risk. Benefits start at 2.2 min/day. https://t.co/UQlUv8NHI7
Links between gut microbiome proteins and pace of aging, metabolic diseases, and medications @Cell_Metabolism https://t.co/Vg6vMPjnXm https://t.co/3SKNH6IEhJ
A recent review dissected four viral fitness trends—Japanese interval walking, the 75 Hard challenge, dead hangs, and Pilates—comparing their popularity on TikTok with peer‑reviewed evidence. Japanese walking showed measurable improvements in strength, aerobic capacity, and blood pressure, though adherence was modest....
Clear science. Practical guidance. Common myhts challenged. Join us to learn how to use CGM effectively and responsively with atheletes. https://t.co/q43bbIu6Me https://t.co/Yl2muIZiGN
A study presented at the European Association of Urology Congress demonstrated that a virtual‑reality (VR) consent experience significantly improves patient understanding of shockwave lithotripsy and reduces pre‑procedure anxiety. The trial involved 150 adults aged 22 to 80 at University Hospital...
![Heat Therapy Activates Proteins that Repair Cells and Protect the Heart [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://kevinmd.com/wp-content/uploads/Design-4-scaled.jpg)
Physician‑researcher Dr. Khushali Jhaveri examined the health claims surrounding infrared saunas, noting that most data derive from Finnish‑style sauna studies. A 20‑year Finnish cohort of 2,300 men showed 22‑40% lower risks of cardiac death, coronary mortality, and all‑cause mortality with...
👉 “humans now spend the majority of their adult lives in a "healthy but declined" state, characterized by a significant "functional gap." 👉 We argue that extending Peakspan and developing strategies to restore function in post-peak individuals is the functional manifestation...
What I actually tell my family about sleep (no filter) I see thousands of patients. I'm polite, professional, clinical. But at family dinners? I say what I really think. Here's the unfiltered advice I give the people I love—because sugar-coating doesn't save lives. Swipe...
Orthopedic surgeon and trail runner Howard Luks warns that many runners mistake comfortable‑feeling runs for proper base training. He explains that cardiovascular fitness (oxygen delivery) and aerobic fitness (oxygen utilization) are distinct, and easy‑day heart rates often sit in the...
When I have my clients and athletes consistently document: ✅ Sleep ✅ Training ✅ Nutrition & hydration ✅ Reading/studying ✅ Time spent on apps/video games It builds powerful self-awareness around their daily habits what’s truly serving their goals and what’s quietly holding them back. You can’t correct...
A large‑scale field trial led by Washington State University tested APIX Biosciences' nutritionally complete pollen‑replacing feed across five commercial beekeeping operations in California and Idaho. Colonies receiving the feed showed dramatically lower winter mortality—dropping from 28.8% to 15%—and emerged from...
At the 2023 New York City Marathon, medical staff treated roughly 1,500 runners at the finish‑line tent. Sports‑medicine physician Dr. Jeremy Roberts identified the five most common conditions that send marathoners to medical care: hypoglycemia, hypovolemia, hyponatremia, hypothermia and hyperthermia....
Researchers found golden spiny mouse (Acomys russatus) lives longer and retains regenerative abilities compared to its sister species. In a non‑pathogen‑free setting, aged A. russatus showed minimal frailty, reduced inflammaging, and preserved thymic structure beyond four years. Transcriptomic analysis revealed youthful...
Everything in society attacks sleep. It’s humanity's greatest risk because it strips clear thinking. Build your life around sleep. It’s worth it. Of all the longevity stuff I’ve done, I’m most proud of my learned ability to sleep. It represents overcoming...
Grease the Groove (GtG) is a neural‑focused strength method that replaces one‑off heavy sessions with frequent, submaximal reps spread throughout the day. Popularized by Pavel Tsatsouline, it leverages the spacing effect to reinforce motor pathways, improving signal efficiency without excessive...
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem disorder characterized by profound fatigue… 👉 “Low-dose rapamycin effectively reduced PEM and other key...
The PGA Tour has turned its traveling schedule into a high‑tech performance platform by deploying two 1,000‑square‑foot mobile trailers that house a full‑service gym, physical‑therapy suite and a dedicated recovery center. Senior Vice President Andy Levinson oversaw a 2019 redesign...
A recent Dutch study compared three approaches to quantifying training stress, pitting traditional objective measures against athlete‑reported subjective scores. The researchers found that subjective metrics, such as perceived exertion, aligned more closely with physiological markers of fatigue than objective data...
Cycling enthusiasts often chase daily riding streaks to build habit, boost mileage, and gain social validation. While streaks can reinforce consistency, the article highlights how relentless riding without planned rest leads to burnout, overtraining, and performance plateaus. Expert insights from...
The European Commission is set to prohibit monacolins from red yeast rice in foods and dietary supplements after EFSA declared any dose unsafe, citing risks such as rhabdomyolysis and liver damage. The draft regulation, now in WTO consultation, is expected...
Heat training, traditionally used for acclimation, now shows broader performance benefits for triathletes. A five‑week protocol—two weeks for heat acclimation followed by three weeks of continued exposure—boosts plasma volume, stimulates erythropoietin release, and raises VO₂ max, translating to faster bike...
The 4Ps of Performance Nutrition⚡️ This new review outlined an evidence-based framework for achieving optimal performance via nutrition 📝 Focusing on the following 4Ps… 1️⃣ Personalise 2️⃣ Periodise 3️⃣ Prefuel 4️⃣ Prepare Here are the details ⬇️ Personalise 🧬 👤 Tailor diet and supplement plans to the individual athlete 📊...
80 years. 724 people. One finding. The quality of your relationships predicts your health in old age more than wealth, class, or genetics. https://t.co/RhHGOhY3S8
Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide-ranging AMA https://t.co/PtZVCoRpUy
30 min key takeaways on deliberate heat exposure for health and performance. And unlike the cold plunge, nobody seems to mind the sauna. Then again, hardly anyone is doing the de-frag protocol… which is brutal but very effective. https://t.co/dFR0wVdSpn
psychedelics appear to facilitate the adoption or maintenance of physical activity habits, increase psychological flexibility, emotional resilience to acute stress, exercise and psychedelics have numerous potential complementary mechanisms https://t.co/gl4YK8bqaE
We know the microbiome plays an important role in health. Probiotics may play a role in the microbiome, but are they really as positive as they seem? This blog explores the potential of probiotics. Read now: https://t.co/EEXKgILfH7 https://t.co/5lwReH5Q2a
Two things that make marathons unhealthy IMO: 1. Inadequate preparation. 2. Inappropriate pacing (for your fitness). Both are very common, but that doesn't make running a marathon inherently unhealthy.
