Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
In this episode Chris Kresser reviews a new American Journal of Clinical Nutrition study of over 5,000 Chinese adults aged 80+, which found vegetarians and especially vegans were 19‑29% less likely to become centenarians than omnivores, with the effect driven by underweight elders. He explains that animal foods provide bioavailable protein, B12, heme iron, zinc, EPA/DHA, and other nutrients crucial for aging bodies, while plant foods supply fiber, vitamin C, and phytonutrients, highlighting the synergistic benefits of mixed diets. Kresser argues that optimal nutrition is age‑specific and that a balanced omnivorous pattern, similar to traditional diets, supports longevity better than strict plant‑only regimens.
Temporal interference (TI) stimulation uses two high‑frequency electrical currents that intersect to generate a low‑frequency envelope capable of modulating deep‑brain activity without surgery. Early human pilots have reported seizure suppression and better sleep in epilepsy, improved motor learning after stroke,...
looking forward to concluding next week's NAD for Health conference in Copenhagen with a talk on Known Knowns and Known Unknowns in NAD Coenzyme Research.... see you there https://t.co/hLAnAq7Fay
Injectable peptides such as BPC‑157, GHK‑Cu and TB‑500 have surged in popularity among biohackers despite lacking regulatory approval. The Guardian podcast explores why these grey‑market compounds have become mainstream, featuring insights from journalist Adrienne Matei and Imperial College peptide researcher...
The episode with Dr. Jenna Gillen explores how exercise timing and nutrition jointly shape post‑prandial glycaemic control. It explains that muscle contractions during brief, low‑volume interval sessions can blunt glucose excursions and, over time, enhance insulin sensitivity. The discussion highlights...
Breast cancer risk can be mitigated through lifestyle choices and proactive screening, according to oncologist Margaret E.G. Thompson. Regular physical activity helps regulate estrogen and insulin, while maintaining a healthy weight reduces hormone-driven tumor growth. Limiting alcohol consumption further lowers...
The International Osteoporosis Foundation has launched Build Better Bones, a multilingual, user‑centered website that supports self‑management for people with osteoporosis and their caregivers. Developed through design‑thinking and agile methods, the platform offers evidence‑based guidance on exercise, nutrition, home safety, and...
The remarkable benefits of 5 min per day of meditation. Which is simply, sitting quietly and observing your own thoughts, stress, etc. not clearing the mind etc. As explained by @RichieJDavidson on the Huberman Lab podcast out now. https://t.co/c9kiY8lycp
A systematic review published in Lancet Psychiatry, analysing 54 randomized controlled trials from 1980‑2025, found no evidence that medicinal cannabis treats depression, anxiety or PTSD. The paper highlights modest benefits for conditions such as epilepsy, multiple sclerosis spasticity, pain and...
Simple nutrients, serious science. March 2026 is turning into a good month for longevity research on everyday supplements. First, a Nature Medicine paper (COSMOS trial) showing daily multivitamins modestly slowed epigenetic aging clocks (GrimAge and PhenoAge) in older adults: around...
Omega-3s improve recovery from exercise. A new study reveals a potential mechanism. Men who supplemented with 2.5 grams of EPA + DHA per day for 8 weeks lost less strength after muscle-damaging exercise vs. those taking a placebo. This was attributed in part...
Women over 40 are often warned against jumping exercises, yet new research shows plyometrics dramatically improve bone mineral density and reduce fracture risk. Studies in *Current Osteoporosis Reports* and *BMC Musculoskeletal Disorders* confirm that adding high‑impact drills to strength routines...
I did placenta encapsulation with my first baby due to my prior midwife's recommendation, but I no longer do it or recommend it. Here's why. The only placebo-controlled trials on it (UNLV) found no meaningful benefit for mood, fatigue, bonding, or iron...
Researchers have mapped how senescence spreads between human brain cell types via the senescence‑associated secretory phenotype (SASP). Using DNA‑damage‑induced cultures and conditioned‑media assays, they identified cell‑type‑specific SASP signatures that drive secondary senescence in neighboring astrocytes, endothelial cells, microglia, oligodendrocytes and...
Hyperbaric oxygen therapy (HBOT), once confined to treating decompression sickness and serious medical conditions, is now being repackaged as a high‑end wellness service. Proponents claim it enhances cognition, slows skin aging, and extends lifespan, yet peer‑reviewed studies do not substantiate...
Researchers at Google used AI to analyze smartwatch data from 1,165 users, combining heart‑rate, sleep and activity metrics with routine lab results to detect insulin resistance. The model identified the condition with 76% accuracy using only clinical data, rising to...
Sleep remains a top performance metric, prompting many to turn to over‑the‑counter aids. Melatonin acts as a circadian‑time‑setter, helping those with jet lag or shift‑work schedules fall asleep a few minutes faster, though dose accuracy varies widely. Magnesium supports relaxation...
What's the best way to improve the lactate threshold? When's it best to push or pull it up? I give you my 5 steps to improving LT in my latest deep dive video. Link below:
Researchers published in Aging Cell report that vascular injury induces misshapen nuclei in smooth muscle cells, accelerating cellular senescence. Human femoral arteries post‑angioplasty and rat carotid injury models both displayed nuclear dysmorphism linked to prelamin A buildup. The study identifies...
Memory Loss Starts in the Gut As a medical school professor, I was taught that memory loss is a brain problem. New research from Stanford says it's a gut problem. Scientists just identified a 3-step pathway from gut to brain that drives age-related...
Researchers at Sanford Burnham Prebys unveiled TLPath, a machine‑learning model that infers telomere length from routine histopathology slides. The system was trained on 5,263 whole‑slide images covering 18 organs from 919 individuals and can predict telomere shortening in 11 tissue...
The post argues that regular walking—especially a dedicated daily walk—delivers outsized health, longevity, and mental benefits. Research cited shows 7,000‑10,000 steps a day cut premature‑death risk, while 12,000 steps can reduce mortality by up to 55 %. Speed matters: brisk cadence...
The new Huberman Lab episode is out: Science-Based Meditation Tools to Improve Your Brain & Health | Dr. Richard Davidson 0:00 Richard "Richie" Davidson 3:33 States of Mind vs Traits 9:06 Wakeful Brain Activity vs Deep Sleep 11:55 Sponsors: David & Eight Sleep 14:31 Brain...
Phenibut, a GABA‑analogue originally developed in Russia, is marketed as a nootropic for anxiety, stress relief, and sleep enhancement. The compound crosses the blood‑brain barrier, raising GABA levels and producing calm focus, but it also carries risks of tolerance, dependence,...
Structure Therapeutics announced that its daily oral GLP‑1 obesity pill produced an average 16% body‑weight reduction versus placebo after 44 weeks in a Phase 2 trial. The result outperforms Eli Lilly’s orforglipron, which showed about 11% loss over 72 weeks, and rivals...
Researchers identified insulin‑like growth factor binding protein‑7 (IGFBP7) as a circulating factor that limits exercise adaptation in older adults. Plasma proteomics from a year‑long high‑intensity interval training trial showed higher IGFBP7 levels predicted smaller fitness gains. In mice, genetic deletion...
Heart‑rate variability (HRV) measures the time interval between heartbeats and reflects autonomic nervous system balance. Wearable devices such as Apple Watch and Fitbit now provide daily HRV readings using ECG or photoplethysmography. Low HRV can signal stress, poor sleep, illness,...
A model that predicts cellular age from Cell Painting microscopy images alone. No DNA methylation needed. The model captures morphological aging hallmarks across nuclear and cytoplasmic compartments, correlates with chronological age AND epigenetic clocks. The promise: screen for rejuvenation compounds...
Epigenetic aging happens at different rates in individual cells within the same tissue. Using single-cell DNA methylation analysis, Hagit Masika, Tommy Kaplan, Howard Cedar, and colleagues show polycomb CpG island methylation creates 'young' vs 'old' cell subpopulations even at fixed...
Recent research indicates hormone replacement therapy (HRT) can enhance weight loss when combined with tirzepatide and lower osteoporosis risk when started early in menopause. A meta‑review of over one million women found no safety signals, prompting the FDA to drop...
A study in Alzheimer's & Dementia found that late-life methionine restriction reduces Alzheimer’s pathology and neuroinflammation in mice by activating the liver–brain FGF21–FGFR1 signaling pathway, independent of metabolic improvements. 🧠 https://t.co/A9kEqNv8pO
Beyond the Weight Loss: The Effects of Semaglutide on Standard and Diet-Induced Obese Mice 🤔"..semaglutide improved glucose metabolic health inboth diet groups..while chronic semaglutide treatment appeared to exertanxiolytic effects in obese mice, opposit[e] effects were observed in lean animals.." https://t.co/doU6EkwT7z
Obicetrapib, a next‑generation CETP inhibitor, has demonstrated potent LDL‑C, apoB, and Lp(a) reductions in a large phase III lipid trial. A pre‑specified biomarker sub‑study reported a marked attenuation of p‑tau217 progression, especially among APOE4/4 carriers, hinting at a potential Alzheimer’s‑related benefit....
Eating chilis may be good for your memory. Capsaicin (from chilis) partially rescued the memory decline by restoring the gut-brain (vagus-hippocampus) communication. Aging microbiome disrupts the gut-brain communication and memory function. https://t.co/gAEPdmhPDB
I've cut my social media use by 50% and I feel 100% better. Did it with one simple rule: 2 hrs deep work for every hour on social media. You earn an hour on social media ONLY after two hours...
The article distills six evidence‑backed strategies for extending healthspan, ranging from dietary composition and the off‑label use of metformin to regular moderate exercise, cognitive challenge, and optimal sleep. It highlights genomic instability as the core driver of aging and notes...
There is an opportunity to strengthen this whole #diet and #nutrition area by showing how data, AI, and predictive analytics could identify who most needs these interventions and personalize them. #health #wellness https://t.co/X1HwREhhdS
Association between Low-carbohydrate Diets and 10-year Atherosclerosis Cardiovascular Disease Risk: Data from the National Health and Nutrition Examination Survey https://t.co/NavY2Ldwip https://t.co/Is80ZwaTXu
The WASHOUT study, presented at the EAU26 congress, found that one in ten emergency‑department patients presenting with visible blood in urine (hematuria) dies within three months. A diagnostic scan—CT or cystoscopy—performed within 48 hours cut mortality risk and accelerated cancer detection,...
We can all argue opinions on this. But nowhere do we say RT is the primary thing folks need to do for health. There are many other studies that show RT (and AT) positively affect health
The effect of continuous or intermittent calorie-restricted diet on body composition and 2 resting energy expenditure in patients with type 2 diabetes "both diets appear promising, with a lower 60 dropout rate in ICR suggesting greater feasibility..." https://t.co/sPAkTrVK40 https://t.co/C82NXBEddG
Since eccentric contractions produce passive mechanical tension, they stimulate sarcomerogenesis, which we observe as increases in muscle fascicle length in humans. Isometric contractions at short or moderate muscle lengths do not. https://t.co/7wVgBzjELC
#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D. https://t.co/tezM4gAKI9
Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial https://t.co/hpjHcUsbtP https://t.co/Kf2yZhbmVe
So great to see the OG work that helped spark the longevity revolution taken to the next level: New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell Is this relevant to...
Low-dose epigallocatechin gallate combined with L-theanine effectively alleviate obesity and metabolic dysfunction-associated steatotic liver disease by remodeling gut homeostasis and avoiding its hepatotoxicity https://t.co/rRnmHMr0An https://t.co/8DyZbmkAwg
Solve Aging: Biophytis and LynxKite are expanding their alliance to use graph-based AI to speed discovery of new longevity drugs, aiming to map complex aging biology and surface novel targets for age-related disease. The “AI x longevity” stack is quietly...
Well. Here the good “Dr” isn’t entirely wrong. But his believers are getting the wrong message. If you’re avoiding whey protein because “it spikes insulin,” you’re optimizing for the wrong variable. Yes, leucine stimulates beta cells directly. Yes, insulin...
GLP-1 drugs for extending healthspan? Intriguing but we're a long way off from evidence Discussed at length in Super Agers as a candidate drug beyond lifestyle + factors @TheEconomist gift link https://t.co/A2dpfcnApF https://t.co/3gY8iACeGs
Dietary EPA shows superior efficacy over DHA in chronic sleep deprivation-induced cognitive decline by disrupting the crosstalk between intestinal ferroptosis and gut-derived Aβ production 🧠👨🏻⚕️ 🔗https://t.co/rqUO058bO9 https://t.co/Kr137l2BvH
