Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Recent review highlights chronic inflammation as a central driver of age‑related sarcopenia, linking pathways such as cellular senescence, oxidative stress, mitochondrial dysfunction, and gut dysbiosis. Key inflammatory cytokines—including IL‑6, CRP, and TNF‑α—disrupt muscle protein balance and serve as potential biomarkers. The authors discuss evidence that exercise, nutritional supplementation, and emerging anti‑inflammatory pharmacotherapies can mitigate muscle loss, especially in sarcopenic obesity. Understanding these mechanisms points to early diagnostic tools and targeted treatments.
![[Correspondence] Safeguarding Against Dengue Fever Risks in a More Connected World](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/0d754edb7784af3c8ea0cc186d55d361.webp)
The Lancet correspondence highlights a series of low‑tech, community‑driven interventions that have demonstrably reduced dengue fever incidence in several low‑ and middle‑income countries. Partnering with ministries, transport operators and the GX Foundation, measures such as mosquito lamps, insecticide‑treated bednets and...
![[Comment] Should We Keep Pushing a High Fluid Intake in Kidney Stones?](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/71728300caabf9cdd7e72489bb93c7ec.webp)
High fluid intake remains the cornerstone for preventing kidney stones, yet patient adherence is consistently low. Systematic reviews and a recent 2026 randomized trial confirm that adequate hydration reduces stone recurrence, but practical, behavioral, and environmental barriers limit real‑world effectiveness....
A two‑year analysis of 656 overweight adults aged 55‑75 in the PREDIMED‑Plus trial found that participants who regularly consumed virgin olive oil exhibited better preservation of cognitive function and greater gut‑microbiome diversity than those who used refined olive oil. The...
A two‑year pilot trial published in JAMA Neurology found that low‑dose oral lithium (150‑300 mg daily) slowed verbal memory decline in older adults with mild cognitive impairment. The neuroprotective benefit was most pronounced in participants who tested positive for amyloid‑beta, a...
Pickleball, a fast‑growing court sport, blends aerobic, interval and balance training, offering a comprehensive workout in a compact 20‑by‑44‑foot space. Physical therapist Jim Edwards highlights that players spend about 70 % of game time in moderate‑to‑vigorous heart‑rate zones, burning roughly 6‑10...
Sports‑medicine physician Dr. Dominic King outlines a systematic approach to running faster, emphasizing three pillars—form, agility, and power. He recommends mixing interval training, hill sprints, and shuttle runs with dedicated strength, flexibility, and breathing work. A weekly plan of two...
Which diet is the best for lowering visceral fat mass? In this 2022 randomized controlled trial, there was no significant difference between low-carb and high-carb diets if calories and protein were matched A whole food, high-carb, low-fat diet trended towards the best...
Researchers from Denmark and collaborators reported that the hormone GDF15, known for causing nausea in early pregnancy, appears to rise in response to chronic alcohol consumption and may act as a feedback signal limiting intake. Small human studies at Oktoberfest...
Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings 👉"These findings provide the first molecular evidence supporting what has long been proposed: that the OXT system functions as a fundamental long-term regulator of...
Single-cell aging clocks: A precision tool for dissecting and targeting the aging process https://t.co/5e47qWtZwH https://t.co/ImfBb45luO
Researchers from UCLA, Stanford, Utah, and Columbia have engineered T cell receptors to strengthen catch‑bond interactions with prostate cancer antigens, improving cytotoxic function. By altering just one or two amino acids in the TCR, the modified cells exhibit longer bond...
Can the Keto Diet Really Improve Mental Health? Health Secretary Robert F. Kennedy Jr. recently said that the diet could “cure” schizophrenia. We asked experts about the claim. https://t.co/s4ItEREHqW https://t.co/3CAFA8h3y2
New research published in JAMA Network Open shows that overweight older women who combine a Mediterranean‑style diet with a 30 % calorie cut and regular resistance‑focused exercise maintain higher bone density than those on diet alone. The year‑long trial of 924...
Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is...
A recent investigation identified the gut bacterium Roseburia inulinivorans as being linked to greater muscle strength in humans, with younger participants showing higher levels of the microbe. Parallel mouse experiments demonstrated that introducing the bacterium boosted grip strength, enlarged muscle...
Your menstrual cycle is the closest thing you have to a user manual for your own body. Every month your hormones shift in a predictable pattern that changes how you think, feel, create, connect, and recover. Once you see it, you...
Scientists at Washington University identified a brain‑originating leptin pathway that caused adult male mice to shed an average of 19.3% of body mass in nine days, despite identical food intake. The discovery suggests a neuro‑centric route to depleting diet‑resistant fat,...
Researchers have engineered a lipid nanoparticle (PLNP) that mimics acetylcholine to deliver TRIM11 mRNA across the blood‑brain barrier and dismantle tau aggregates. In vitro, PLNP achieved 17‑fold higher mRNA uptake than conventional LNPs, and in transgenic Alzheimer’s mice it eliminated...
Most people don't need more protein to build muscle. They need to train more. Protein isn’t the main driver of adaptation, training is. Muscle growth, strength, and metabolic health are primarily stimulated by mechanical tension and progressive overload, not just a higher...
The article explains that cycling can contribute to muscle growth but is far less efficient than dedicated strength training. It distinguishes between hypertrophy and pure strength work, noting that beginners, older riders, and clinical populations can gain noticeable strength from...
Researchers at Chalmers University decoded leg movement intentions directly from peripheral nerves of above‑knee amputees using ultrathin neural implants and a spiking neural network AI. The system accurately identified knee, ankle and toe motions and provided bidirectional sensory feedback through...
A new data-driven study of over 18,500 Ironman‑distance finishes shows that the run, not the bike, remains the most decisive leg, accounting for 41 % of final‑position variance. However, the bike’s relative importance has risen, matching or surpassing the run in...
Scientists at Washington University School of Medicine activated a newly identified brain pathway with direct leptin infusion, causing adult male mice to lose 19.3% of body mass in nine days. The loss included deep skeletal fat that normally resists diet...
Researchers analyzing Fitbit heart‑rate data from 14,489 participants in the All of Us study found that people who regularly exercised between 7 a.m. and 8 a.m. had significantly lower odds of cardiometabolic diseases. Morning exercisers were 31% less likely to have coronary...
A UK Biobank analysis of 340,924 adults tracked over 13 years found that high alcohol intake raises all‑cause, cancer, and heart disease mortality. At low to moderate levels, wine consumption was linked to lower cardiovascular death risk, while spirits, beer...
45% of Seniors Got Better With Age (Yale / Geriatrics) Nearly half of adults over 65 got BETTER with age -- not worse. And mindset was the biggest predictor. As a medical school professor, I was trained to see aging as inevitable...
Novo Nordisk has launched an oral version of its semaglutide weight‑loss drug Wegovy, expanding GLP‑1 therapy beyond weekly injections. Clinical data show the pill, dosed at 25 mg daily, achieves blood‑level exposure comparable to the 2.4 mg weekly injection, resulting in 13.6 %...
Eli Lilly’s investigational injectable retatrutide achieved a 1.9‑point HbA1c reduction versus 0.8 points for placebo after 40 weeks, while participants on the highest dose shed 15.3% of body weight compared with 2.6% on placebo. The weight loss was still progressing at...
Researchers discovered that neutrophils from older individuals adopt a senescence‑like phenotype, marked by elevated SASP factors and reduced antimicrobial metabolism. RNA‑seq of lung neutrophils after Streptococcus pneumoniae infection revealed diminished glycolysis and ROS production, impairing bacterial clearance. Aged neutrophils also...
Please stop telling people with osteoporosis not to lift anything heavy... I've heard it from docs, PTs, Trainers, etc... This might seem protective... but it's not. This risk calculation... A hip fracture in an older adult carries a one-year...
Changing your workout time of day impacts everything from mood to performance. The most common adjustment takes place when someone decides to exercise in the morning. Here are six tips for safely making a smooth transition to morning exercise: ...
Washington University researchers analyzing VA records of more than 333,000 veterans found that halting GLP‑1 drugs such as Ozempic or Wegovy eliminates the heart‑protective effect, raising major cardiovascular risk by up to 22% after two years off therapy. Continuous use...
There are definitely worse places to discuss frailty, ageing, and using AI to discover drugs that preserve health. Kick off meeting of @EU_Commission UNION Marie Curie programme. https://t.co/BwvoPYj3KC
Geroscience is for healthy life extension. We should stop pretending that lifespan and healthspan compete.👨⚕️
Researchers from Oxford and Tanzania have validated a liquid‑biopsy blood test that identifies EBV‑positive Burkitt lymphoma with 98% accuracy. The assay cut the diagnostic timeline by an average of 40 days, allowing most patients to start therapy within a week of...
Acute and chronic effects of high-intensity interval training on selected exerkine secretion in health, disease, and aging: a systematic review https://t.co/EqwyebvN62 https://t.co/yOQgxagZER
The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank https://t.co/CPfBPVRENq https://t.co/xTlj2ykr45
Researchers at Baylor College of Medicine and Tongji University discovered that early weaning reshapes the gut microbiome, triggering epigenetic changes in intestinal stem cells that enhance immune defenses. The study, published in Nature Microbiology, shows loss of DNA methylation at...
Leeches to improve testosterone and sexual function. Will look into this and see if worth doing an experiment.
Sam Conniff and neuroscientist Katherine Templar‑Lewis release "The Uncertainty Toolkit," a book that translates a 2022 UCL study on uncertainty tolerance into practical strategies. The work draws on interviews with 40 “uncertainty experts” – former prisoners, addicts, refugees and hostages...
Understanding how supaspinal and spinal CNS fatigue mechanisms work during exercise allows us to program training variables optimally . See more in this week's free Patreon article. https://t.co/6i4w1tPtdL
Dr. Amy Shah, author of *I’m So Effing Tired*, outlines seven natural strategies to combat chronic fatigue, focusing on gut‑friendly nutrition, circadian alignment, and emotional recharge. She recommends high‑fiber, nutrient‑dense foods, eliminating sugary or caffeinated drinks, and choosing lean, plant‑based...
The article explains how gut‑derived butyrate fuels intestinal L‑cells to release GLP‑1, a hormone that regulates appetite, insulin sensitivity and weight. It highlights butyrate’s ability to cross the blood‑brain barrier, dampen neuroinflammation, boost BDNF, and improve neurotransmitter balance, linking gut...
One reason why I'm tracking and attempting to optimize kynurenine levels Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway https://t.co/w1abVwROig
Scientists at Korea Advanced Institute of Science and Technology (KAIST) reported that the RNASEK enzyme degrades accumulated circular RNA, a process that slowed aging and extended lifespan in C. elegans, mice and human cell models. The discovery positions RNASEK as...
Even though the spike from oat milk could be true, see for yourself, test your own 2h glucose Not specifically for oat milk (which I don't drink), but I'm currently doing this after all meals CGM not needed, finger-prick is how I'm...
Communication breakdown: senescent cells in interorgan communication of aging: Trends in Endocrinology & Metabolism By the great @MattYousefzadeh https://t.co/PcavJgfq5z
Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty "This review explores how IF may exert immunoregulatory effects through metabolic remodeling, cellular stress responses, and inflammatory signaling..." https://t.co/CxfUNppvST
One of the more interesting matchups in round 1 of Longevity March Madness: Sauna vs. @bryan_johnson's Blueprint. Can the million-dollar protocol upset the favorite, or will it be sent home early? Let the people decide: https://t.co/TBjYekZE8A https://t.co/j986aHGBwp
