Know What's Happening in Biohacking
Know What's Happening in Biohacking
High‑Altitude Hypoxia Slashes Blood‑Sugar Spikes in Mice
A mouse study found that exposing animals to low‑oxygen (8% O₂) conditions triggers red blood cells to take up far more glucose and convert it into a molecule that eases oxygen release, effectively acting as a glucose sink. The hypoxic mice showed markedly smaller blood‑sugar spikes after glucose injections, and the effect persisted even after they returned to normal air.
A recent Bicycling article outlines a practical checklist for lowering resting heart rate (RHR), emphasizing at least 150 minutes of moderate‑intensity cardio or 75 minutes of vigorous activity each week. It adds endurance rides, interval training, stress‑reduction practices, a whole‑food diet, and adequate hydration as complementary levers. The piece also provides a timeline, noting modest drops of 1‑3 bpm in the first two weeks and up to 5‑10 bpm after three months of consistent effort. Wearable devices are recommended for tracking progress and maintaining motivation.
Repeated head impacts in contact sports have been linked to lasting damage of the blood‑brain barrier (BBB), a finding that may underlie chronic traumatic encephalopathy (CTE). Researchers scanned 47 retired athletes using an MRI contrast agent that only enters brain...
Renowned nutritionist Ann Louise Gittleman sat down with internal‑medicine physician Dr. Ana Maria Mihalcea to discuss blood‑based evidence of lingering effects from COVID‑19. Dr. Mihalcea uses dark‑field microscopy to examine patient samples, reporting that no post‑pandemic blood appears truly normal,...
New AI‑driven analyses of thousands of CT scans reveal that thymus health strongly correlates with longevity, cardiovascular disease risk, and lung cancer incidence. The studies show individuals with a robust, non‑involuted thymus live longer and experience fewer major health events....
Azalea Therapeutics, a spinout from Jennifer Doudna’s lab, reported in Nature that its in vivo CAR‑T approach can generate functional CAR‑T cells directly within mice and eradicate both solid and hematologic tumors. The technique uses infused gene‑editing particles that precisely...
Exactly. Everyone talks about tapering the load for performance. Few talk about tapering the load for stability. At a constant load, Fatigue plateaus much quicker than fitness (half-life of ~7 days) This means, if you hold the load constant, you don't just get faster...
From a clinical perspective, patients are not asking for abstract years. They are asking for time with family, time in full cognition, time in independence, and time living on their own terms. That is why geroscience should be judged not...
A recent hands‑on test shows Dirtea Pure Essential Creatine eliminates the gritty taste and filler concerns that plague many powders. The reviewer reports smoother mixes, steady energy and better recovery, positioning Dirtea as a standout as the creatine market expands...
Less than one-quarter of the population performs resistance training on a regular basis. Time is considered the primary barrier to participation. It shouldn't be. An emerging body of evidence shows that as little as two 30-minute resistance training...
Communication breakdown: senescent cells in interorgan communication of aging: Trends in Endocrinology & Metabolism By the great @MattYousefzadeh https://t.co/PcavJgfq5z
Researchers have engineered microscopic capsules made from red blood cell membranes that encase single, healthy mitochondria and can be injected into animals. In mouse models of Parkinson‑like disease and Leigh syndrome, the capsules restored neuronal function, improved motor activity, and...
Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty "This review explores how IF may exert immunoregulatory effects through metabolic remodeling, cellular stress responses, and inflammatory signaling..." https://t.co/CxfUNppvST
One of the more interesting matchups in round 1 of Longevity March Madness: Sauna vs. @bryan_johnson's Blueprint. Can the million-dollar protocol upset the favorite, or will it be sent home early? Let the people decide: https://t.co/TBjYekZE8A https://t.co/j986aHGBwp
In a recent "Longevity by Design" episode, Dr. Terrie Moffitt of Duke University explains how early‑life mental health and self‑control shape the biological pace of aging, drawing on the 50‑year‑long Dunedin Study. The research shows that mental disorders in youth...
I posted five years ago about how to use the Acumobility ball for upper extremity health and performance, so it seems long overdue for me to share one of the ways we’re using it a bit further down the...
The mistake people make re meditation: they presume we should feel peaceful while doing it. It’s about observing your stress & learning to not react to it (in the same way exercise is a stressor that triggers an adaption). Meditation...
Recent research frames autophagy as a double‑edged sword in aging, proposing a threshold model where modest autophagic flux preserves mitochondrial health and blocks senescence, while excessive autophagy sustains the metabolic needs of established senescent cells. Above the damage threshold, autophagy...
Researchers at Duke Health and the University of Minnesota have validated a blood test that uses six piRNA molecules to predict whether adults 71 and older will survive the next two years, achieving up to 86% accuracy. The finding could...
In this episode, Dr. Gil Blander talks with Dr. Terry Moffitt, a leading psychologist behind the 50‑year Dunedin Multidisciplinary Health and Development Study, about how early‑life mental health influences the biological pace of aging. Dr. Moffitt explains the study’s unique...
A recent double‑blind trial of 94 resistance‑trained adults found that caffeine’s strength‑boosting effect hinges on the CYP1A2 gene. Fast metabolizers (AA genotype) experienced 4‑12% higher propulsive velocity, while slow metabolizers (CC genotype) saw only marginal gains. The study administered 3 mg...
LAST CHANCE for EARLY-BIRD: https://t.co/eN6PetWMGW How to avoid the biggest mistake athletes make with continuous glucose monitoring? https://t.co/LeoLb5ds7u
A randomized, double‑blind pilot trial examined 8‑week consumption of a fermented milk protein beverage versus an equivalent non‑fermented milk protein drink and a protein‑free placebo in 44 prepubertal boys who play soccer. Both fermented and non‑fermented milk protein groups showed...
Exciting new work in @CellCellPress: a detailed single-cell multiomics atlas of 36 cell types during brain aging in mice. This level of resolution is what we need to track how and why the epigenome changes with age 🧵 https://t.co/w5eSYG8aIf
On December 30, 2025, researchers announced a nanotechnology‑based drug delivery platform that can transport chemotherapy agents directly to cancer cells while sparing healthy tissue. The system, detailed in Science Times, uses engineered nanoparticles that exploit the enhanced permeability and retention...
On March 14, 2026, a team of researchers at the University of Maryland unveiled a sensor‑filled pair of underwear that clips onto the garment and continuously measures hydrogen gas—the chemical signature of intestinal flatulence. The “Smart Underwear” records each emission...
So it's time for an update on me playing around with Retatrutide. This is typed from mobile, so forgive any typos or missing words. First, I stopped using it about 2 weeks after post below. I didn't run out. I'm just...
Researchers using intracranial EEG recorded a surge in hippocampal ripple activity after participants completed a 20‑minute moderate cycling session. The increase in high‑frequency ripples, which are linked to memory consolidation, was stronger in participants with higher heart rates, indicating intensity‑dependent...
Researchers at Worcester Polytechnic Institute created a machine‑learning model that scans MRI images and achieved 92.87% accuracy in distinguishing Alzheimer’s disease or mild cognitive impairment from healthy brains. The algorithm highlighted volume loss in the hippocampus, amygdala and entorhinal cortex...
The Spring 2025 Alzheimer’s Association Research Roundtable highlighted a shift toward early detection and prevention of Alzheimer’s disease, emphasizing new biomarkers that can identify pathology years before symptoms appear. The meeting underscored the U.S. POINTER trial’s evidence that multi‑domain lifestyle interventions...
An individual with mid‑range testosterone (488 ng/dL) plans a TRT protocol of 160 mg testosterone cypionate split twice weekly and 50 IU hCG weekly. They seek guidance on expected physiological changes, timeline, potential side effects such as hair loss, and whether the hCG...
A NIH‑backed multicenter trial of 140 pregnant adults found that weekly injectable extended‑release buprenorphine achieved significantly higher rates of illicit opioid abstinence than daily sublingual buprenorphine, while also reducing serious maternal adverse events. The study, published in JAMA Internal Medicine,...
A new Cochrane review claims intermittent fasting "doesn't work." But it only measured weight loss - not insulin sensitivity, autophagy, inflammation, or gene expression. Here's what the science actually shows. The 2026 Cochrane systematic review analyzed 22 randomized controlled trials and...
Recent research suggests that not all sitting is detrimental; specific sitting postures and practices can actually safeguard cognitive function. Studies indicate that mindful, upright sitting improves cerebral blood flow and reduces stress hormones, both of which are linked to better...
GIP preferentially enhances glucose storage and triglyceride deposition in healthier subcutaneous fat, particularly under conditions of hyperinsulinemia and hyperglycemia. Tirzepatide contains a GIP agonist. https://doi.org/10.2337/db10-0098 https://www.gatlan.com/ @GatlanHealth
Working on a new article for my Substack. Those of us working with elite athletes have relied on our good old friend VO₂max for decades. It’s essential, but it’s not the full picture. Now that VO₂max has re-emerged in the world of longevity,...
A Northwestern University study involving 39 overweight adults found that abstaining from food for at least three hours before bedtime improves cardiometabolic markers without altering calorie intake. Over a seven‑and‑a‑half‑week trial, participants who kept a 3‑hour night fast showed lower...
![Train This Close to Failure for Optimal Gains [2 New Studies]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://mennohenselmans.com/wp-content/uploads/2026/03/Thumb.jpg)
Two recent studies examined strength‑trained athletes performing bench presses and squats with varying velocity‑loss thresholds to gauge proximity to failure. Results showed a clear trend: the nearer to failure, the greater the muscle hypertrophy, while strength gains were inconsistent and...
“A lot of people tend to drift up in distance as they age, thinking, “well, if I can’t go faster, I’ll just go longer.” I believe dropping down is underrated and probably provides more bang for your buck as you...
Researchers using Saccharomyces cerevisiae showed that replicative senescence is triggered when a single shortest telomere falls below a critical length, which both initiates senescence and promotes genomic instability that can transiently enable cells to escape it. 🧬 https://t.co/TOUeXB4L3v
The United States faces a transplant shortage of over 100,000 patients, prompting research into xenotransplantation using genetically engineered pig organs. Recent cases—David Bennett’s pig heart in 2022, Lawrence Faucette’s in 2023, and Tim Andrews’ pig kidney in 2025—demonstrate feasibility, with...
Thank you @drgabriellelyon for the opportunity to sit down and discuss HIIT, VO2max, Zone 2, Fatmax, and applications for health. https://t.co/p6VplkCgVS
Healthy Life Extension: The “North Star” of Geroscience🌟| @AgingJrnl 🩺 - David Barzilai MD PhD | @agingdoc1👨⚕️ 🔗https://t.co/JqhGgOe3nA https://t.co/ieBQZ6pAQd
Researchers at the National University of Singapore have demonstrated that a purified betacyanin‑rich extract from red dragon fruit peel can be incorporated into wheat bread at a 0.75% level, enhancing antioxidant activity and slowing starch digestion. The fortified loaf maintains...
Did you know humming producing nitrous oxide which is anti-inflammatory, anti-viral and a vasodilator for the blood vessels? It also tones the vagus nerve and improves heart rate varialbity, a marker of good health. Inhale and then hum as...
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY
A Japanese crossover study found that a single 70 mL dose of concentrated beetroot juice containing 400 mg of nitrates improved post‑sprint agility in male soccer players. Participants performed three sets of six 20‑meter all‑out sprints and then completed sensor‑based agility tests,...
Creatine supplementation and healthy ageing: https://t.co/NDGrsIncs2 This blog outlines the potential role of creatine for combating age-related changes in skeletal muscle and bone health, as well as cognitive function and memory. https://t.co/gVxO9C1mit
You should placebo yourself into thinking you’re on steroids. Athletes given a placebo they thought was Dianabol added ~8.5 kg to their bench, ~7 kg to their military press, and ~16 kg to their squat in 4 weeks compared to when...
A growing number of women are sourcing the experimental GLP‑1 drug retatrutide, dubbed “reta,” from Instagram peptide sellers to lose a few pounds without traditional dieting. The drug, still in Phase 3 trials, targets three hormone receptors and is being micro‑dosed...
NAD for Health: Opportunities & Challenges 2026 This international conference will explore a central question in aging research: can manipulation of nicotinamide adenine dinucleotide (NAD⁺) metabolism enhance human healthspan and prevent age-related diseases? https://t.co/bEtQPmUnSh
