Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
The American College of Sports Medicine released its first resistance‑training update in 17 years, issuing a 2026 Position Stand grounded in 137 systematic reviews and over 30,000 participants. The new guidelines discard long‑standing myths—such as training to failure, the necessity of varied equipment, and distinct beginner versus advanced programs—favoring consistency and goal‑specific loading. Strength training now emphasizes heavy loads (≈80% + 1RM) performed twice weekly, while hypertrophy calls for at least ten weekly sets per muscle group with eccentric focus. Power work, crucial for functional health, uses moderate loads moved quickly, especially for older adults.
Strong work👏 This is less Watson and Crick, and more Turing and Wiener, where biological form and function emerge from information processing #Burr If biology is information processing, then aging can be understood as information loss #shannon
Magnesium L-threonate (Best for Cognition): Highly bioavailable and shown in randomized controlled trials to improve memory, executive function, and focus. It supports "synaptic plasticity," helping neurons form new connections. Magnesium Glycinate (Best for Relaxation): Bound to the amino acid glycine, this form is...
Swedish biotech Atrogi has dosed the first participants in an 8‑week, first‑in‑human trial of its oral candidate ATR-258, a drug designed to promote fat loss while preserving lean muscle. The study, led by Associate Professor Morten Hostrup, targets overweight male...
People who train regularly need substantially more protein than the standard dietary allowance. Sports dietitian Sarah Gilbert notes the U.S. RDA is 0.8 g/kg, while performance nutrition experts like Raiders’ Ricky Ng recommend 1.6–2.4 g/kg for strength and endurance athletes. In addition...
A new health feature highlights that only about 2% of Americans consume enough potassium, despite its critical role in fluid balance, muscle function, and blood pressure regulation. The article lists ten potassium‑rich foods—such as tomato paste, lentils, and dried apricots—that...
Red light therapy, once a niche biohacking tool, is now entering mainstream consumer products after NASA’s 1990s experiments revealed wound‑healing benefits. Clinical research links the light’s stimulation of mitochondrial ATP production to improved collagen synthesis, muscle recovery, and potential neurological...
Wastewater Detects Colorectal Cancer Biomarkers What if your city's sewage could detect cancer before your doctor does? As a medical school professor, I find this remarkable. Researchers tested neighborhood wastewater in Kentucky for colorectal cancer biomarkers using droplet digital PCR. They detected CDH1...
There's a $101 million competition happening right now to extend human healthspan. Not in mice. Not in worms. In people. https://x.com/robertlufkinmd/status/2035318955821375489
Robert F. Schuler’s new book, *When Simple Becomes Extraordinary*, chronicles a 60‑year‑old diabetic man’s shift from 28 years of sedentary living to completing an ultramarathon. The narrative details the training regimen, dietary adjustments, and mindset changes that enabled the transformation....
Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study https://t.co/tsJ5qJLBap https://t.co/4EvBWDftJ4
Researchers found that shorter telomeres and DNA changes in kidney cells may signal faster biological aging of the kidneys and help predict risk for Chronic Kidney Disease earlier than current methods. 🧬 https://t.co/JKRM7xhOnh
The U.S. FDA granted accelerated approval to Novo Nordisk's 7.2 mg Wegovy HD, a three‑fold increase over the existing 2.4 mg dose. The higher dose showed 19% average weight loss in trials, positioning it as a potent option for biohackers seeking rapid...
Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study 🔎"Our results suggest that henagliflozin may exert anti-aging effects by influencing multiple pathways, including the IGF-1 system, glucose metabolism, the immune system, and...
A 2021 study introduced a simple equation that estimates a cyclist’s VO2 Max from a five‑minute maximal power output expressed in watts per kilogram. The formula (VO2 Max = 16.6 + 8.87 × relative power) demonstrated an adjusted R² of 0.988 when compared with traditional graded exercise tests....
Runners often lose form in the final miles, increasing fatigue and injury risk. Exercise physiologist Kate Baird recommends targeting biomechanics through periodized training, focused strength work, breathing drills, and posture correction. By integrating form‑specific workouts during off‑season blocks and practicing...
6 exercises to build bone density. Don't think you need them? You're wrong. Think you're too young? Wrong again. Think you're too old? Wrong. https://t.co/ZyqvbJDgy1
The article outlines five evidence‑based habits—soluble fiber intake, unsaturated fats, daily cardio, diverse plant foods, and strength training—that can lower apoB, a superior biomarker for cardiovascular risk. It explains apoB’s role in tagging all atherogenic lipoproteins and cites guideline targets...
Recent research highlights the eggshell membrane—not the hard shell—as a potent source of collagen, elastin, and glycosaminoglycans. Clinical trials of supplements such as Ovoderm® report measurable gains in joint comfort, reduced stiffness, and faster cartilage recovery. Parallel studies show improvements...
A recent JACC study found that using high‑efficiency particulate air (HEPA) purifiers can lower systolic blood pressure in adults, especially those with baseline SBP above 120 mm Hg. In a crossover trial of 154 participants living near highways, the real purifier reduced...
Researchers at the University of São Paulo conducted a 12‑week randomized trial comparing brief high‑intensity sprint intervals with relaxation therapy for 72 adults with panic disorder. Participants who performed intermittent sprints showed significantly lower Panic Agoraphobia Scale scores and fewer,...
Marketing suggests CGM can optimise meals, stabilise energy, and personalise fueling. But what does the science actually show? Join the webinar to learn: https://t.co/eN6PetWMGW https://t.co/aM9Fd1yXxo
Fun fact: in 2008, when we published that NAD-dependent SIRT1 suppresses cancer, almost no one believed us. How could a longevity gene suppress cancer? they asked https://t.co/aPAG3zf470
Morning people enjoy an "early riser bias" that leads managers to rate them as more conscientious, even when they work the same hours as later starters. This advantage can become a hidden trap, prompting overwork and insufficient recovery. The article...
Researchers analyzing data from the Einstein Aging Study found that older adults who experience longer periods of nighttime wakefulness exhibit slower processing speed, poorer working memory, and reduced visual memory binding. Using wrist actigraphy over 16 days and multiple daily...
Physical exercise and health-related quality of life in mid- to late-adulthood: a multi-group chain-mediation analysis https://t.co/vd6yqa45rx
A growing community of biohackers is micro‑dosing GLP‑1 agonists such as semaglutide to pursue longevity benefits. The practice, highlighted by ScienceNews, raises safety concerns and could reshape demand for obesity drugs.
A new meta‑analysis of nine randomized trials involving 4,754 patients demonstrates that intra‑operative indocyanine green fluorescence angiography (ICGFA) cuts anastomotic leak risk by roughly 40% in colorectal surgery, especially for rectal and left‑sided resections. The study, published in The Lancet...
A Chinese trial of an AI‑driven clinical decision support system (CDSS) involving 21,603 acute ischemic stroke patients across 77 hospitals showed significant improvements in care quality and long‑term vascular outcomes. Patients whose physicians used the CDSS experienced a 26% reduction...
Big v Small for longevity. Small - Most serious problems are metabolic in nature. You'll avoid them by not spending too much time in an energy surplus, i.e. not being too big. But... If shit does go bad - you do have that...
Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity https://t.co/I2ZrtJkguK https://t.co/LkH3LXzkcg
Senior cyclists are being urged to overhaul outdated fueling habits by eating before, during, and after rides. Nutrition expert Namrita Brooke recommends ingesting roughly 50 grams of carbohydrates per hour on the bike to sustain performance. She also stresses timing...
A combination of senolytics causes neuropathology in mice 👀 Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS. Senolytics under more scrutiny? https://t.co/aDosJxeyxS
FGF21 turns on SLCO4C1, which boosts cAMP signaling and helps prevent fat buildup and inflammation in the liver. https://t.co/fi6RffZKVq
Eli Lilly announced that its triple‑agonist retatrutide achieved a 1.7‑2.0 % reduction in A1C and a 16.8 % (average 36.6 lb) weight loss over 40 weeks in the TRANSCEND‑T2D‑1 Phase 3 trial. The data position retatrutide as a potential new pillar for obesity and type‑2 diabetes...
Doctors and fitness experts stress that weight‑bearing resistance training is essential for women to maintain bone density and stave off osteoporosis. A 2022 Endocrinology study links strength exercises to improved skeletal strength, especially for post‑menopausal women who can lose up...
Persimmons, an orange‑tinted fruit native to East Asia, are gaining attention as a nutrient‑dense option for athletes, especially cyclists. In the U.S., California harvested over 30 million pounds in 2019, with two main commercial types—sweet Fuyu and astringent Hachiya—available from September...
Cyclists training for a 100‑mile century often mismanage intensity, volume, and nutrition, jeopardizing performance. Coaches Pav Bryan and Samuel Thompson stress riding easy days in Zone 2, executing VO₂ max intervals, and gradually building mileage. They also warn against over‑reliance on FTP,...
SunLED’s Sunbooster SLS2000 is a $265 USB‑C‑powered infrared lamp that clips onto a laptop and delivers near‑infrared (NIR) light for two to four hours a day. The author tested the device during a New England winter and found it easy...
Cellular health depends on rigorous quality control of messenger RNA, yet these surveillance pathways weaken with age. Research in C. elegans and yeast shows that impaired nonsense‑mediated decay, nonstop decay, and no‑go decay lead to ribosome stalling, protein aggregation, and...
In the new podcast, I highlight the importance of pitchers employing high-low models to their routines in order to optimize recovery and reduce the risk of injury. Additionally, I share examples of how this structure works in the real...
There is a crucial but rarely mentioned relationship between how you use your visual system and how you perceive goals as difficult or easy. Even impacts physiology and goal attainment. Actionable.
Half‑marathon runners are advised to use heart‑rate data strategically on race day rather than ignoring it. Experts recommend staying within 70 %–90 % of one’s maximum heart rate, calculated via the Tanaka equation, and pairing this metric with a perceived exertion rating...
A large UK Biobank neuroimaging study of 14,462 adults revealed that chronic pain triggers a two‑stage remodeling of the hippocampus. Early pain is associated with modest hippocampal growth and better memory, but prolonged pain leads to volume loss, cognitive decline,...
A Swedish cohort study of 2,100 older adults found that high consumption of total and unprocessed meat was linked to slower cognitive decline and a 55% lower dementia risk among APOE ε4 carriers, while non‑carriers saw no benefit. The protective...
My latest post on the #MADcrew forum: Two athletes. Both training for endurance events. But with completely different engines. Here’s what the #PerformanceModeling data says about how @JohnGoldman and @inaki_delaparra actually work… https://t.co/oCTDk9EAjt
A new Nature study of 450,000 people finds that the APOE gene, particularly the APOE3 and APOE4 variants, accounts for 72‑93% of Alzheimer’s disease cases, and that 99% of the population carries at least one risk‑increasing allele. Lexeo Therapeutics is...
A recent Evidation survey shows roughly one in seven U.S. adults on GLP‑1 drugs are microdosing, often to curb costs or chase longevity benefits without full‑dose side effects. Clinics like AgelessRx now market low‑dose regimens, while some physicians prescribe them...
The Longevity Lifehacks series compiles a dense timeline of cutting‑edge research from early 2024 through March 2026, spanning neurodegeneration, immune modulation, and metabolic interventions. Highlights include CAR‑T cell engineering for Alzheimer’s plaque clearance, photobiomodulation to boost T‑cell responses, and multiple...
Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration https://t.co/VSJVp4MYij
