Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Consumer epigenetic "biological age" tests promise a single number that reflects a person’s true health trajectory, but they actually measure DNA methylation patterns correlated with chronological age. Research‑grade clocks can predict mortality risk, yet the kits sold to patients lack validation, show large result variability, and provide no actionable clinical guidance. Physicians who adopt these tests risk replacing evidence‑based diagnostics with unreliable metrics, undermining patient trust. The article urges clinicians to reject the hype and rely on proven health‑span biomarkers.
Ronda Rousey and Gina Carano will headline a Netflix‑broadcast MMA showdown on May 16, 2026, reigniting debate over the so‑called “over‑35 curse.” Sports‑medicine experts warn that sarcopenia, slower recovery and weaker connective tissue increase injury risk for fighters past their...
If you’re over 30, lifting weights is NOT optional. It’s your insurance policy for life.
The new Huberman Lab episode is out: The Best Vitality & Health Protocols | Dr. Rhonda Patrick (@foundmyfitness) 0:00 Rhonda Patrick 2:40 Competition, Jumping Rope, Rope Flow 6:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 12:30 Cognitive & Physical Benefits of Exercise, Serotonin &...
Sam Shethar, an amateur strongman who deadlifts 880 lb, shares a step‑by‑step roadmap for lifters stuck at intermediate plateaus. He argues that flawless form—flat back, proper hip hinge—trumps raw intensity and recommends temporarily shedding weight to refine technique. Complementary movements such...
Athletes increasingly rely on dietary supplements to boost performance, recovery, and overall health, but product safety and efficacy vary widely. Experts advise selecting third‑party certified supplements, such as Informed Sport or NSF Certified for Sport, to ensure they are free...
Sleep profiles predict injury in runners 🩼💤 This new study profiled 425 recreational runners based on their sleep habits including… ⏰ Sleep duration ☑️ Sleep quality 🚨 Sleep problems Investigating associations with injury history, whilst controlling for factors including training volume 🔍 Results 📊 Runners were...
British triathlete Kat Matthews secured the $200,000 Ironman Pro Series prize by pairing rigorous training with disciplined sleep habits, aiming for at least eight hours nightly. She adjusts workouts when rest falls short, a strategy echoed by fellow elite athletes...
Nestlé Research and the University of the Philippines demonstrated that a daily blend of 500 mg taurine, 1.3 mg vitamin B6, 0.2 mg vitamin B9 and 2.4 µg vitamin B12 improves motivated, goal‑oriented performance in healthy adults. In a double‑blind, crossover trial with 45 participants, the supplement...
A mouse study published in Cell Host & Microbe shows that the gut virome—primarily bacteriophages—modulates carbohydrate metabolism by activating immune pathways. Disrupting the virome with an antiviral cocktail caused sharp blood‑glucose spikes in mice fed a high‑carbohydrate diet, while enriching...
Apogee Therapeutics reported that its experimental long‑acting eczema biologic, zumilokibart, achieved sustained skin‑clearance in a mid‑stage trial. Seventy‑five percent of patients receiving the drug every three months and 85 % of those dosed every six months maintained an EASI‑75 response after...
Researchers analyzed RNA‑seq data from Caenorhabditis elegans and identified a broad decline in collagen gene expression with age, pinpointing 16 collagens consistently downregulated across multiple studies. Meta‑analysis of 66 datasets revealed that collagen expression is up‑regulated in 84% of long‑lived...
Assistant health editor Ava Durgin tested a 12‑lb weighted vest during identical one‑hour walks to see if it boosts calorie burn. Over two weeks, the vest produced virtually identical distance, step count, and calorie estimates compared to unweighted walks. The...
Turning your thermostat down to 15°C (about 59°F) at night is one of the simplest, most evidence-based “sleep performance hacks” available and it works because it directly supports your body’s natural biology. Your core body temperature needs to drop by around...
The benefits of not eating three hours before bedtime extend beyond improving sleep; but are also harnessed in protecting the natural increase in parasympathetic activity at that time. @foundmyfitness on the Huberman Lab podcast out now https://t.co/O8b2YunpVT
In this AMA episode, Dr. Peter Atiyah tackles a wide array of practical health questions, covering how health priorities shift across the decades, the hierarchy of chronic disease risk, and the most useful consumer health metrics. He discusses the role...
Public discussions around “sugar” are often dominated by extreme claims, from strong health warnings to recommendations for athletes to consume sugar-rich gels and drinks. This blog examines what “sugar” actually is: https://t.co/8dQmKzXO90
I've been saying this for the longest time, and including fecal pH in my grant applications, too I predict that we'll see a significant correlation for fecal pH with neurodegenerative diseases in future papers...
In this AMA sneak‑peek, Dr. Peter Atiyah fielded listener questions on practical longevity strategies, covering how health priorities shift across the 20s, 40s, and 60s+, the hierarchy of chronic disease risk (cardiovascular, cancer, neurodegeneration, metabolic), and the most useful consumer...
Therapeutic effects of vitamin D and intermittent fasting on metabolic associated steatotic liver disease in rats "These findings support their potential as complementary, non-pharmacological strategies for MASLD management and warrant further translational investigation." https://t.co/n4BtHrrcOU
Been experimenting with bicarb for the last year as well as seeing how extra calories impact my performance Full write up can be found on Endurance Essentials https://t.co/WLuX7VNkAv
Researchers introduced K‑4, a novel AMPA‑receptor positive allosteric modulator, which produced rapid and sustained antidepressant‑like effects in treatment‑resistant depression rat models. Bulk RNA‑seq revealed that K‑4 markedly down‑regulated NADPH oxidase‑1 (NOX‑1) in the medial prefrontal cortex and lateral habenula. Pharmacological...
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏
A low-volume, low-frequency combination is able to maintain muscle fascicle lengths after eccentric-only training in humans. This suggests that maintenance of sarcomeres and myofibrils works slightly differently. https://t.co/kSamQXyhZh
Resveratrol, a polyphenol found in red wine and berries, activates SIRT1 and AMPK pathways, positioning it as a potential longevity and neuroprotective agent. Clinical trials show 200‑500 mg daily improves cerebral blood flow, hippocampal connectivity, and memory performance in older adults....
7 Drugs. 30,000 Mice. 20 Years. The Only Longevity Compounds With Real Evidence. https://t.co/BzdoDZeicb @agingroy https://t.co/uM5QMpIAS6
The effects of time-restricted feeding on early phases of carcinogenesis in rat liver and colon https://t.co/hZQUZAwXV5
Recent research links glycine deficiency to disrupted sleep, elevated oxidative stress, and heightened fever responses. Glycine acts on NMDA receptors in the suprachiasmatic nucleus to lower core body temperature, facilitating sleep onset, while also serving as the rate‑limiting substrate for...
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty 🌟Performance on the 6-minute walk test improved in a dose-response fashion 🌟Improved 6-minute walk test distance correlated with patient-reported outcomes 🌟The percentage of study subjects classified as frail decreased...
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial “Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome. Given the excellent safety and efficacy...
A new international consensus study published in the Journal of Clinical Medicine finds integrated psychological treatment for dual disorders outperforms separate treatment. Researchers from the University of Barcelona, CEU Cardenal Herrera, Bellvitge University Hospital and European University of Madrid reviewed...
Wow... Power training and longevity Araújo et al. followed 3,899 people — mostly middle-aged and older adults — for a median of nearly 11 years. They compared two metrics head-to-head: muscle strength and muscle power. Men in the lowest power category were...
Strength training might be the single most potent habit for aging gracefully and extending lifespan. It certainly appears to be one of the best methods to prevent the need for joint replacement surgery. After 30 years of practice, there’s no...
Researchers found that strict adherence to the MIND diet can slow structural brain aging by up to 2.5 years, while a separate analysis linked reductions in biological age to a 23% lower stroke risk and healthier white‑matter. Together the findings...
Every 1% BMI Drop Cuts Cancer Risk Every 1% drop in BMI lowers your cancer risk. The data now proves it in the real world. As a medical school professor, I have taught for years that obesity drives cancer through metabolic dysfunction....
Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial 🗣️A clinical trial reports that a single dose can significantly improve physical strength and key signs of aging in older adults with frailty. https://t.co/5mw5r64imb https://t.co/uI88QpTEIa
A large retrospective analysis of over 19,000 patients with cancer, type 2 diabetes and brain metastases found that those prescribed GLP‑1 receptor agonists such as Ozempic or Wegovy experienced a 37% reduction in three‑year mortality compared with matched controls. The survival...
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial https://t.co/8Ex1caVyLp
Your Thymus and Your Healthspan https://t.co/ENhIn2A2l3 High vs Low Thymic Health Scores and Outcomes https://t.co/oOz9sOK8RV
Emerging research highlights oxidative stress—not sugar—as a primary driver of insulin resistance. Excess reactive oxygen species, fueled by high‑omega‑6 seed oils and visceral fat, disrupt the insulin‑receptor cascade and GLUT4 transport. The instability of polyunsaturated fats during cooking creates oxidized...
Glucose sensors promise personalised fuelling insights. But do they deliver? Three days to go, last chance to register : https://t.co/eN6PetWMGW https://t.co/jDTUsQhle2
Some interesting match-ups. Metabolic health is beating circadian optimization by a wide margin. Psilocybin and multivitamin are neck and neck. @bryan_johnson's Blueprint is getting destroyed by sauna.
Eli Lilly reported that its investigational triple‑agonist retatrutide lowered HbA1c by up to 2 percentage points and produced an average 16.8 % body‑weight loss over 40 weeks in the TRANSCEND‑T2D‑1 Phase 3 study. The results, presented as the strongest dual‑action outcome for diabetes and obesity...
Athletes recovering from injuries, intense training, and tournaments here’s a few strategies to help you heal & recover for the week ahead and beyond‼️ 👉Antioxidants & healthy fats 👉7-10 g creatine monohydrate 👉Leucine rich foods (aim for 1.8-2.0g/kg/bw/protein/day) 👉Zinc, vitamin D, choline, glutamine, and...
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice https://t.co/k0vERH4LSg
A two‑decade study of nearly 90,000 adults found that regular consumption of flavonoid‑rich foods—such as berries, apples, citrus, black tea and moderate red wine—significantly lowers age‑related frailty, physical decline, and mental health issues. Women with the highest intake saw up...
Are Aging Clocks Based on Routine Clinical Indicators Trustworthy and Applicable? A Systematic Review and Critical Appraisal https://t.co/JU53JV0gnv
Strong work👏 This is less Watson and Crick, and more Turing and Wiener, where biological form and function emerge from information processing #Burr If biology is information processing, then aging can be understood as information loss #shannon
The American College of Sports Medicine released its first resistance‑training update in 17 years, issuing a 2026 Position Stand grounded in 137 systematic reviews and over 30,000 participants. The new guidelines discard long‑standing myths—such as training to failure, the necessity...
Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study https://t.co/tsJ5qJLBap https://t.co/4EvBWDftJ4
