Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine emerges as brain‑fuel supplement that counters sleep loss and stress
Creatine monohydrate, long known for muscle growth, is gaining scientific backing as a brain‑fueling supplement. Recent studies show that daily doses of 10‑25 g raise brain creatine levels and mitigate cognitive deficits caused by sleep deprivation and stress, improving processing speed and working memory.
Cat Bowen, a seasoned runner and senior editor, tested the Naturepedic Side Sleeper Pillow and found it kept its shape thanks to an organic latex‑and‑cotton fill. The pillow aligned her spine, reduced neck and shoulder tension, and led to noticeable improvements in overnight HRV scores. She reported easier morning runs and greater mobility after switching from her previous pillow and stopping Ambien. The review highlights the pillow’s durability, non‑toxic certifications, and long‑term value for athletes focused on recovery.
Began my 96 hour water fast today with my last meal at lunch. Why am I doing it? Sounds like a fun challenge. Feel like I often eat when i’m not hungry but it’s something to do. It’s a physical reset for...
Regenerative medicine promises to shift healthcare from a reactive model to proactive disease modification by targeting early biological drivers of chronic degeneration. Cell‑based therapies such as mesenchymal stromal/stem cells (MSCs) can modulate inflammation, immune signaling, and tissue repair, showing benefits...
A secondary analysis of a Danish year‑long trial examined 193 adults on the GLP‑1 agonist liraglutide with or without a structured aerobic exercise program. Participants first lost an average of 29 pounds on a very‑low‑calorie diet, then were assigned to four...
Researchers have shown that age‑related muscle loss stems primarily from a decline in the activation of resident muscle stem cells, not from their depletion. Early activation of these satellite cells is a stress‑sensitive, rate‑limiting step that becomes impaired in older...
Roundback lifting: should you avoid it altogether, or should you purposefully do it to safeguard against injuries?
We’ve gotten longevity all wrong. Not the goal of longevity, but the way we’re trying to achieve it. That’s the point of the new book Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity, by @drjordanmetzl, a...
Researchers identified a drug combination that enhances the brain's glymphatic system, improving clearance of Alzheimer‑related proteins. The regimen pairs a widely used sedative with a medication that prevents dangerously low blood pressure, showing safe and effective removal of amyloid and...
Researchers identified two conjugated polyunsaturated fatty acids, α‑eleostearic acid (α‑ESA) and its methyl ester (α‑ESA‑me), as potent senolytics that selectively eliminate senescent cells. In mouse models, short‑term dosing reduced senescence markers and SASP factors across liver, heart, kidney, and lung...
A study of more than 5,000 runners tracked via Garmin watches shows that boosting a single run by over 10% of the longest run in the past month sharply raises injury risk, up to 128% for double‑distance spikes. The findings...
NOVOS launched a randomized, double‑blind, placebo‑controlled trial of a multi‑component supplement in adults over 40, enrolling 61 participants and completing six months with 43 finishers. Early preprint data show a 2.9% improvement in flow‑mediated dilation, a 1.18 m/s reduction in pulse‑wave...
Research on astronauts reveals that microgravity accelerates bone and muscle degradation, mirroring the physiological decline seen in aging adults. In orbit, astronauts lose up to 2 % of bone mass each month and see muscle strength drop 10 % within weeks, reaching...
Former SpaceX engineer John C. Foster launched Puresteel, a plastic‑free coffee maker priced around $80. The device uses medical‑grade stainless steel and glass, eliminating polymer components that can shed microplastics into brewed water. Foster cites recent studies linking microplastic exposure...
The Frontiers in Nutrition scoping review mapped 79 studies on nutritional interventions and smart‑technology tools aimed at preserving cognitive resilience in military personnel operating in extreme environments. Nutritional supplements (42%) and personalized diets (31%) dominated the evidence base, while operational...
A 12‑week randomized trial with 60 competitive endurance athletes showed that a Mediterranean‑diet intervention markedly altered gut microbiota, boosting alpha diversity and enriching SCFA‑producing genera such as Faecalibacterium and Roseburia. Plasma concentrations of propionate and butyrate rose 42% and 58%...
A double‑blind, randomized crossover trial examined 16 elite male taekwondo athletes who received either 6 g L‑arginine, 8 g citrulline malate, their combination (14 g total), or placebo one hour before a Wingate test. The combined citrulline malate + L‑arginine condition produced a statistically significant...
A randomized, single‑blind pilot trial evaluated creatine monohydrate at 6 g and 18 g daily for four weeks in adults with post‑COVID‑19 condition (PCC) experiencing fatigue. The 6 g/day regimen produced a statistically significant reduction in Piper Fatigue Scale‑Revised scores (‑2.05 points) and...
Regular exercise reduces the likelihood of plaque accumulation in the arteries However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression The fascinating thing is that despite the higher plaque, those people still have lower rates of cardiovascular disease...
Jake Canter credited a new pressure mindset for his Olympic bronze, PRAX Performance launched an Athlete division to teach mental habits, and Joakim Noah unveiled a health‑first diet that helped him add 10 pounds of muscle in a summer. All...
Stanford Medicine and the Arc Institute reported that stimulating gut‑brain signaling and altering the microbiome reversed age‑related cognitive decline in mice, making old animals perform on memory tests like their younger peers. The finding points to a new, peripheral route...
Researchers found that a single 300 mg dose of caffeine taken an hour before a 7 a.m. workout significantly increased peak force and velocity in bench press and back squat, bringing morning strength measures up to typical evening levels. The study, involving...
The Vitamin D Lie Your Doctor May Still Believe The official recommendation was based on a mathematical mistake. The "normal" level on your lab report may be dangerously low. And the best fix isn't a pill — it's free https://x.com/robertlufkinmd/status/2036754584954167391
A commentary in Nature Reviews Cardiology, authored by researchers from Maharishi International University, UCLA and Wayne State, argues that Transcendental Meditation can lower stress‑related cardiovascular risk. The paper cites decades of trials showing blood‑pressure reductions and slower atherosclerosis progression, and...
Basecamp Research has launched the Trillion Gene Atlas, a platform that will collect and model genetic information from more than 100 million species, expanding known evolutionary diversity by roughly 100‑fold. The initiative aims to give AI models a vastly broader biological...
Women’s health experts outline age‑specific supplements that address shifting hormonal, bone and metabolic needs from the 20s through senior years. Vitamin D, calcium and iron dominate early adulthood, while magnesium, omega‑3s and vitamin K gain prominence in the 40s and beyond. In...
Researchers at Trinity College Dublin have demonstrated that a single dose of interferon‑gamma can “train” human macrophages to more effectively kill drug‑resistant bacteria such as MRSA and Mycobacterium tuberculosis. The IFN‑γ‑trained cells undergo epigenetic reprogramming, rely on glutamine metabolism, and...
The recent study showing D+Q causes demyelination in brain cells leads to more questions than it answers: (I only read the abstract cause paper new & paywalled.) D+Q has been used a lot in mice & humans. Why hasn't this been noticed...
Fantastic thread on the ⬆️ CAC commonly found in endurance athletes. 🫀 IMHO, this is key 👇
Researchers at the University of Illinois Chicago have repurposed the FDA‑approved cancer drug doxorubicin to combat drug‑resistant herpes simplex virus type 1 (HSV‑1). Using their AI‑driven platform HerpDock, they identified doxorubicin’s ability to block the PI3K‑AKT‑mTOR pathway that the virus exploits,...
The surprising science behind red-light therapy — and how it really works. People are buying helmets, face masks, vests and beds that emit long-wavelength light. Beneath the hype, there is some interesting biology. https://t.co/JWV80QOuQU
The incredible study using "Rivers of telomeres" to rejuvenate tissues and extend lifespan in mice is now undergoing open peer-review. I did a review, pointing out issues with the methods and the lifespan curves. They're looking for more reviewers. https://t.co/KOiR4F85sT
The 2026 biohacking supplement guide ranks the top product in each of 29 categories, emphasizing cellular‑level absorption, clinical dosing, and real‑world outcomes. Core recommendations include liquid magnesium (RnA ReSet ReMag), full‑spectrum minerals, electrolytes, vitamin D3 & K2, and a range of longevity...
The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999–2018 "Our findings reveal a significant linear correlation between PhenoAgeAccel and both all-cause and cancer-specific mortality in cancer survivors." https://t.co/Rt7v8ECOB6
Some S&C resources claim that speed is lost quickly during detraining. In fact, speed tends to increase during detraining (probably due to fiber type shifts back to type IIX). https://t.co/jn4vRuAvSR
Researchers used the short‑lived turquoise killifish to map immune aging, publishing a Nature Aging cover article. Multi‑omics analyses revealed systemic inflammaging, kidney‑marrow fibrosis, and accumulation of DNA‑damaged stem‑like immune cells, mirroring changes seen in mammals. Functional assays showed older fish...
New on exercise —the best medicine vs age-related chronic diseases, a review @Cell_Metabolism https://t.co/z9RpD0SlYW —salutary effect on the blood brain barrier (BBB) vs Alzheimer's and brain aging gift link https://t.co/jmhJwXGWms by @GretchenReynold —original research on BBB integrity via liver produced exercise factor @CellCellPress https://t.co/3tSN8knpYF
Dr. Tommy Wood's new book “The Stimulated Mind” is out today, and it gives people a practical toolkit to improve their cognitive function on a day-to-day basis while decreasing their long-term risk of dementia. “Every one of us has the ability to dramatically improve...
University of Florida engineers have inaugurated an interdisciplinary Human Performance Center, expanding a 2024 investment with the UF Sports Collaborative. The hub will fuse wearable sensors, AI and robotics to advance training, injury prevention and mobility for athletes, patients and...
The relative effects of different exercise modes on physical and metabolic health in older adults: A network meta-analysis "Current evidence does not identify a single “best” exercise modality for improving VO2max/VO2peak in older adults. Modality selection may be better guided by...
The article reviews a suite of office‑chair accessories designed to combat "tech neck" and improve overall ergonomics for desk‑bound workers. Items range from a $79 Purple GelFlex back cushion and an under‑$20 aluminum laptop stand to a $110 MagGo 3‑in‑1...
Exercise doesn't just strengthen your body — it changes your brain. Resistance training and aerobic activity promote BDNF production, improve brain glucose metabolism, and appear to reduce the risk of cognitive decline. The muscle-brain connection is one of the most important...
There’s a shift happening in food that most people are still underestimating. Food is no longer just fuel. It is becoming a programmable layer on top of human biology. For decades, we’ve treated nutrition as static inputs. Calories in, calories out. Macros, vitamins,...
The Oxygen Advantage® Method is a science‑based breathing system that retrains nasal, functional breathing to increase carbon‑dioxide tolerance and improve oxygen delivery, whereas mindfulness uses breath as a neutral anchor for present‑moment awareness. By deliberately lowering breathing volume and incorporating...
Perimenopause is not just a hormonal event. It's a metabolic one. Estrogen decline affects muscle, bone, tendons, cardiovascular capacity, and insulin sensitivity — often simultaneously. Most women aren't told this. Most training advice doesn't account for it. Here's what the evidence...
Olympic downhill champion Lindsey Vonn posted a video showing six unassisted pull‑ups just 30 days after a catastrophic crash at the Milan‑Cortina 2026 Games. The milestone underscores a swift rehabilitation trajectory amid multiple fractures and a six‑hour surgery, offering a...
The 2026 review pinpoints the leading at‑home red light therapy devices, from full‑body panels like TotalSpectrum Elite 7‑Band and PlatinumLED BioMax 900 to portable units such as FlexBeam and Rouge Nano. The market is booming, with 2.5 million monthly searches and a projected valuation...
Glutathione is often called the master antioxidant, but it’s actually regulated by melatonin (PMID: 20868358) Besides sleep, melatonin also regulates inflammation, immunity, antioxidant activity, and autophagy the process of cell recycling https://t.co/auPkyCsXLp https://t.co/JagmihM101
The article challenges the notion that half‑marathon training must revolve around a very long weekly run, emphasizing that overall training volume matters more than a single mileage spike. Experts Justine Williams Roper and Lea Genders explain that the long run...
