Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Researchers at Kochi University of Technology and the Shizuoka Institute of Science and Technology reported that, after an acute stressor, the human brain takes roughly 60 minutes to transition from a salience‑network‑driven alarm state to a default‑mode‑network‑driven reflective state. The finding identifies a concrete “resilience window” that could be targeted by mindfulness and other stress‑reduction techniques.
A patient asked me yesterday why so many orthopedic surgeons seem to be in good shape. I told her... Because we know what happens to the human body when we're not. We see it every day. The loss of muscle that...
The U.S. Food and Drug Administration approved Novo Nordisk’s 7.2 mg semaglutide injection, branded Wegovy HD, just 54 days after filing. The fast-track decision, the fourth under the National Priority Voucher program, expands dosing options for weight‑loss and metabolic biohackers.
In this episode, Dr. Uri Alon explains his systems‑biology view of aging using a vivid village metaphor: houses (cells) generate garbage (damage) while a fixed fleet of trucks (the immune system) removes it, leading to overload and a robustness threshold...
As a medical school professor, I used to teach that aging is gradual wear and tear. But a Vanderbilt study in Nature Cell Biology reveals something far more disturbing. Your cells are actively dismantling themselves through a process called ER-phagy. Starting early...
For nearly 40 years I've used my body to test ideas about training intensity, HIIT, monitoring, etc. I seem to be paying for those sins now with big atrial fibrillation challenges. This distracts me a bit, but hey,...
Scientists have identified a direct brain pathway—via the ventromedial hypothalamus and the Rap1 protein—through which metformin improves glucose regulation. The discovery reframes the 60‑year‑old diabetes drug as a potential low‑cost biohack for brain health and lifespan extension.
It’s interesting how quickly the conversation has shifted. Not long ago, people were hesitant about weight loss injections. Now the question is whether GLP-1s should be used… for longevity. That shift alone is worth paying attention to. Because it reflects something deeper — we’re...
Ever since I travelled to Moscow in 1986 as a 20y old student in search of secrets, "periodization models" have spun in my head. This review helped slow the spin. Revisiting Tradition: Why the Traditional Periodization Still Shapes Modern Sport...
LMNT highlighted recent behavioral research indicating that changing a single habit can trigger measurable gains across sleep quality, memory and mood. The post cites a randomized trial on phone‑free bedtime, a massive daylight exposure study, and timing‑of‑meals findings, underscoring a...
SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling "Our data suggest that SIRT6 deficiency results in proteostasis loss through nucleolar dysfunction." https://t.co/w1SfUiUxg4 https://t.co/5bqVFfS0lg
New podcast: I outline what an anconeus epitrochlearis is and how it can contribute to medial elbow pain, in throwing athletes. It’s important to consider anatomical variants in addition to medical and movement diagnoses. https://t.co/VY4K0Q0a2G https://t.co/mIa4FfK0bK
Assistant professor McKale Montgomery of TCU’s Burnett School of Medicine crossed the finish line first in the 31.1‑mile Cowtown Ultra Marathon, posting a 3:33:11 time and becoming the first woman to win the race outright. Her victory underscores the growing...
Stanford University scientists have mapped a neural‑immune pathway by which the age‑associated bacterium Parabacteroides goldsteinii provokes gut inflammation, disrupts vagus‑nerve signaling and degrades hippocampal memory function in mice. The finding suggests dietary or microbiome‑based interventions could become a lever for...
Plant-derived bioactive peptides (PBPs) are emerging as natural, sustainable supplements that mitigate exercise‑induced fatigue. They act on multiple fronts—scavenging reactive oxygen species, suppressing pro‑inflammatory cytokines, and activating AMPK pathways to accelerate glycogen replenishment. These mechanisms collectively improve muscle recovery and...
The review consolidates recent evidence on nutrition strategies that enable athletes with Type 1 and Type 2 diabetes to balance peak performance with tight glycemic control. It grades recommendations from strong (meta‑analyses) to expert consensus, emphasizing carbohydrate timing, protein intake, and targeted...
The Water Cures protocol proposes that true hydration requires an osmotic pull created by a precise salt‑to‑water ratio rather than sheer water volume. It recommends 1/8 tsp of unrefined sea salt per 16 oz of water and a “10 % rule” –...
Physician Aaron Grubner tested a simple fasting rule—no eating from 8 p.m. to 1 a.m.—while working night shifts. Over eight weeks, his weight fell from an average of 207.2 lb to 202.3 lb, a loss of about 4.9 lb (0.8 lb per week). Daily weigh‑ins showed...
Juliet Starrett, a former extreme‑water champion turned mobility entrepreneur, champions the concept of "durability"—a blend of strength and mobility—to help cyclists thrive past their 50s. She argues that aging riders must counter declining bone density and stiffness by adding two...
A 2025 Springer Sports Medicine study shows endurance athletes need 1.8‑2.0 g of protein per kilogram body weight daily—about twice the sedentary recommendation—but many fall far short. Exercise‑metabolism researcher Dr. Sam Impey warns that the gap is especially wide among recreational...
Researchers found that the cholesterol-related protein SREBP-2 can trigger apoptosis under stress by interacting with IRAK1, revealing a new mechanism for how cells self-destruct. This suggests that beyond telomeres, which signal aging through gradual shortening, cells can also initiate death...
The Economist highlights a surge in interest around VO₂ max after Norwegian triathlete Kristian Blummenfelt posted a record‑breaking score of roughly 84 ml kg⁻¹ min⁻¹. Traditionally a metric for elite athletes, VO₂ max is now being promoted by fitness influencers as a personal health dashboard. Wearable...
Rubedo Life Sciences reported positive preliminary Phase 1 data for RLS‑1496, the first human‑tested GPX4 modulator designed to clear senescent cells. The 4‑week, double‑blind study in the EU showed the drug was well‑tolerated, produced a clear dose‑response, and reduced epidermal thickness...
One of the most valuable things I’ve done in the last five years: An executive health retreat. I learned a few things: - I have the Alzheimer gene. Got on supplements to help. - I don’t have cancer. I got every organ imaged and...
Google announced today that it is rolling out the SoundHeal sensory program across its global offices to support employee mental and emotional health. The initiative reflects a growing corporate focus on holistic wellness, though details of the technology and rollout...
Executives increasingly turn to personal trainers to replace generic workout plans with customized, data‑driven programs. By aligning fitness goals with demanding schedules, trainers provide structure, accountability, and biomechanical expertise that translate hard work into measurable performance gains. The approach mirrors...
Scientists have engineered red‑blood‑cell membrane capsules to ferry healthy mitochondria into diseased cells, dramatically improving delivery efficiency. In vitro, the capsules restored mitochondrial function in mtDNA‑deficient and mutant fibroblasts, reducing pathogenic DNA fractions and boosting ATP production. In vivo, mice...
Is sun avoidance a risk factor for mortality?☀️ In this 2014 study from Sweden, sun avoidance was associated with nearly a 2x higher rate of all-cause mortality compared to the most active sun exposure habits. They did find increased risk of malignant...
Entrepreneurs are questioning the health impact of their daily coffee habit as reports of fatigue, inflammation, and anxiety rise despite unchanged caffeine intake. The article highlights that over half of commercial coffee tests positive for mold, while acrylamide formation and...
Researchers at the University of Pennsylvania identified the endothelial receptor TIE2 as a pivotal link between the MEKK3‑KLF2/4 and PI3K signaling cascades that drive cerebral cavernous malformations (CCMs). In mouse models, oral inhibition of TIE2 with the tyrosine‑kinase inhibitor rebastinib...
Researchers led by health psychologist Charlotte Hagerman at Drexel University reported that participants who ate the same meals and kept calories steady lost 5.9% of body weight over 12 weeks, compared with 4.3% for those with varied diets. The finding...
UT Health San Antonio has started a National Institute on Aging‑funded, randomized trial of rapamycin and everolimus in roughly 84 adults 65 to 90 years old. The six‑week study will assess safety, optimal dosing and biological markers of healthy aging,...
One of the simplest things you can do to set up a breakthrough season: Set a heart rate cap at AeT (~70-75%) & keep *every session* below it for the first few months of your build. Most watches will have a heart...
AstraZeneca’s in‑vivo CAR‑T platform, acquired last year, has entered a Phase I/II trial in China for relapsed/refractory multiple myeloma. Early data show a 33% overall response rate with several partial remissions, but the study also reported one death due to severe...
The article argues that extending healthspan—years lived in good health—should eclipse the pursuit of sheer longevity. It highlights the growing gap between longer lifespans and rising chronic disease burdens, urging a shift toward interventions that improve quality of life. Researchers...
As a medical school professor, I teach my students to prescribe drugs. But a landmark review in Cell Metabolism argues we should prescribe exercise first. Febbraio and Pedersen -- the scientists who coined "exercise as medicine" -- reviewed 233 studies on...
A joint analysis of the Women’s Health Initiative and the All of Us Research Program, covering roughly 222,000 men and women, shows that the highest intake of several B‑vitamins is associated with up to a 20 percent lower incidence of stroke....
As a medical school professor, I was trained to focus on WHAT patients eat. But this massive meta-analysis says WHEN may be just as important. 41 randomized controlled trials. 2,287 participants. Published in BMJ Medicine. The finding: time-restricted eating improved nearly every...
No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review 👉"This review shows how acute training variables can be manipulated, and how specific training techniques can be used to optimize the training response: time ratio in...
Output Sports has become the official HYROX365 Athlete Testing and Benchmarking Partner, unveiling the 34‑minute HYROX Conditioning Test. The protocol captures aerobic capacity, muscular endurance and power, delivering a HYROX Conditioning Score that coaches can use to benchmark athletes across...
Brown fat loses its heat-producing function with age due to epigenetic changes that reduce activity of key genes like PGC1A, with specific enhancers playing a critical role in maintaining this function. https://t.co/Dnnawd5r41
Aging may or may not be classified as a disease, but that’s largely semantics. What matters is that aging is a malleable, targetable biological process, and slowing human aging would result in massive health benefits.
Human Longevity, Inc. and the LEV Foundation announced a strategic partnership to analyze blood samples from centenarians and supercentenarians. The collaboration will use HLI's AI‑driven precision longevity platform and LEV’s expertise in lifespan extension to uncover molecular drivers of exceptional...
Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research https://t.co/OWU1Hhcreu https://t.co/IH7uKdRsa9
This adds to the building story for ergothioneine, which we covered in a deep dive (2h): https://t.co/VvaoPbC3eB
Now at 1M+ views. What struck me most here wasn’t the views. It was the engagement. People are ready to engage seriously with aging biology. Now the opportunity is to turn that energy into stronger collaboration, better translational science, and...
Brain benefits of intense exercise, including impulse control @foundmyfitness on the Huberman Lab podcast out now. https://t.co/ikb1qKevnc
"Why don't we do high-intensity early in the build?" Because high-intensity and low-intensity adaptations operate over different timeframes... https://t.co/UUH1ANwGG7
Shared and specific blood biomarkers for multimorbidity "Metabolic disturbances emerged as a key driver of multimorbidity. If confirmed, these processes could represent targets for interventions to mitigate disease accumulation." https://t.co/3nuctP2eAC https://t.co/yxk5CZHiHV
