Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
University at Buffalo researchers discovered that impairment of the ceramide transfer protein (CERT) blocks ER‑to‑Golgi ceramide transport, causing ceramide buildup in the endoplasmic reticulum and triggering ER stress that drives replicative senescence. Pharmacological inhibition of CERT reproduced the senescent phenotype in human cells, linking lipid spatial organization to aging. The study highlights organelle‑resolved lipid metabolism as a potentially targetable axis in aging biology, suggesting new avenues for therapeutic intervention.
Piperine, the alkaloid extracted from black pepper, markedly improves the bioavailability of nootropic compounds by inhibiting the drug‑transporter P‑glycoprotein and the liver enzyme CYP3A4. It also acts as a monoamine oxidase inhibitor, raising serotonin, dopamine and norepinephrine levels, which can...
The episode examines the pervasive diet‑tribalism that claims any single eating plan is a flawless solution, arguing instead that all diets are trade‑off‑driven optimizations against the typical American diet, which is high in excess calories, refined carbs, and ultra‑processed foods....
Researchers at Liverpool School of Tropical Medicine have discovered a previously undescribed Treponema species strongly associated with noma, a fatal disease affecting impoverished children. Using metagenomic sequencing and machine learning on saliva samples, they identified the bacterium early in disease...
At the Arnold Classic, nutrition architect Nathan Payton guided four strongmen who finished second, third, fourth and seventh, showcasing his impact on elite performance. He relies on dry‑starch snacks like Rice Krispie treats combined with sodium to lock fluid and...
Neuroscientist David Van den Heever and his Mississippi State team recorded brain waves and motion data from novice and intermediate players, finding that successful shots correlate with stable neural activity and coordinated body mechanics. The findings suggest mental consistency is...
Houston native Carrie Bradshaw completed the January Houston Marathon in 3 hours 42 minutes 31 seconds, earning the Guinness World Record for the fastest marathon by a female with bilateral hip replacements. The achievement underscores advances in orthopedic surgery and elite endurance training.
Researchers reported that administering the metabolic hormone FGF21 boosts SIRT1 expression, which in turn activates the PINK1‑Parkin mitophagy pathway and reduces cellular senescence in intervertebral disc cells. In a rat model of puncture‑induced disc degeneration, FGF21 treatment partially restored nucleus...
IV vitamin drip clinics have surged across U.S. cities, offering premium‑styled lounges and menu‑driven infusions like “Immunity Boost” and “Glow Up.” Sessions cost roughly $150–$300 and promise quick health benefits, capitalizing on the broader wellness spending boom. However, scientific evidence...
The article highlights that only about 20% of UK women know iodine needs rise during pregnancy, despite recommendations increasing from 150 µg to 200‑250 µg daily. Early‑gestation iodine deficiency is linked to measurable drops in child IQ and thyroid hormone deficits, while...
The Art of Manliness outlines the SEEDS framework—Sleep, Exercise, Environment, Diet, and Stress—as a practical, evidence‑based approach to naturally boost testosterone. Research shows that limiting sleep to five hours can cut testosterone by 10‑15%, while 6.5‑9 hours supports optimal hormone...
The article outlines how appetite is governed by both homeostatic energy‑balance mechanisms and hedonic reward pathways, distinguishing hunger, satiation and satiety. It highlights research identifying low‑ and high‑satiety phenotypes, showing high‑satiety individuals lose roughly twice as much weight over 12...
The Formula author has released a two‑page reference called "Proven Steps for a Long, Healthy Life," offered as a free download to paid subscribers. The guide aims to cut through profit‑driven, hype‑filled health advice that dominates social media and news...
Researchers at the University of Rochester identified rhythmic brain windows that cause seven to ten attention shifts per second, linking these cycles to modern digital distraction. The findings, published in PLOS Biology, suggest a biological basis for why workers struggle...
Researchers at Sweden's Karolinska Institute reported that an hour of mentally active sitting—such as knitting, puzzles or office work—lowers dementia risk by up to 7% compared with passive screen time. The 20‑year longitudinal study of 20,811 adults links cognitive engagement...
Buffalo Bills quarterback Josh Allen has rejoined his offseason program just two months after undergoing foot surgery, signaling a rapid return to full training. At the same time, Manchester City manager Pep Guardiola has recalled England defender John Stones following...
As a medical school professor, I taught that aging was caused by DNA mutations accumulating over time. A landmark study from my friend Dave Sinclair's team in Cell just overturned that entire framework. The researchers created mice that age faster --...
The article argues that longevity‑focused beauty must move from vague claims to mechanism‑first validation, using the 12 hallmarks of ageing as a roadmap for skin. It positions peptides as the ideal modality because they can precisely modulate the mid‑layer signalling...
The effect of carbohydrate consumption during exercise - new meta-analysis 🥤 This new meta-analysis compiled data from 15 systematic reviews (262 RCTs) to establish the effects of carb consumption during exercise on performance 📚 Here is what they found ⬇️ 📈 A total...
India's Union Ministry of Ayush has launched a nationwide, evidence‑based Yoga Protocol for Non‑Communicable Diseases, targeting diabetes, hypertension, asthma and mental health. The initiative, unveiled at Yoga Mahotsav 2026, seeks to shift the health system from treatment to prevention.
A comprehensive 2026 meta‑analysis of 113 clinical trials and nearly 8,000 participants concludes that hydrolysed collagen supplements produce moderate improvements in muscle health, lessen osteoarthritis pain, and enhance skin elasticity and hydration. The findings revive scientific and consumer interest in...
Seventy‑year‑old Lynne Wawryk‑Epp of Saskatoon ran a 7:12 indoor mile at the University of Saskatchewan Sanderson Classic, eclipsing a 20‑year‑old Canadian record by eight seconds. The performance highlights the growing competitiveness of masters athletes and raises questions about training and...
Researchers analyzing more than 15,000 human fat samples have identified the SLIT3 protein as a potent enhancer of brown‑fat calorie burning. The discovery suggests a novel, metabolism‑focused avenue for obesity treatment and biohacking beyond appetite‑suppressing drugs.
In this episode of Longevity by Design, Dr. Andrea Mayer discusses the scientific evidence behind multivitamin and mineral supplements, highlighting that they may modestly improve cognition, mood, and blood pressure in at-risk or nutritionally deficient individuals, but show little benefit...
Strength training is positioned as a modifiable lever to counter frailty, using the Rockwood Clinical Frailty Scale (CFS) to tailor exercise intensity. The article outlines a three‑level prescription matrix—supported, standard, and power—matched to CFS bands, recommending 4‑6 core movements performed...
In this episode, host Sean McCormick and bio‑hacker Theo Lucier discuss the rising popularity of dry fasting—a five‑day abstention from both food and water—highlighting its purported benefits such as stem‑cell activation, gut reset, muscle preservation, and profound mental clarity. They...
Former NFL Pro Bowler Julius Thomas, Psy.D., released two interviews on The Educated Patient that argue mindset is a biological lever for longevity and outline five habits that protect health. He notes only about 7% of Americans meet all five...
The Union Ayush Ministry launched a comprehensive "Yoga Protocol for Non‑Communicable Diseases" during Yoga Mahotsav 2026, targeting conditions that cause nearly two‑thirds of all deaths in India. Developed with WHO collaboration, the protocols blend asanas, pranayma, meditation and relaxation into...
"So, coach, how do I get a really high VO2max?" Actually no one asks me that, but they do say things like... "Coach, how do I run a really fast 5K?" And, for all intents and purposes, they're the same question. My first &...
In humans, calorie restriction slows biological aging pace by ~2–3% over 2 years (CALERIE trial) https://t.co/Eg8wBzhDpQ
Researchers at Sun Yat‑sen University's National Key Laboratory of Ophthalmology published a PNAS paper revealing that the protein MTFR1L maintains mitochondrial homeostasis in the heart and can slow age‑related cardiac decline. The findings open a molecular pathway for biohackers and...
Social disconnection: from cortisol-oxytocin imbalance to endothelial dysfunction, a narrative review of mechanisms and potential interventions https://t.co/ONoBPawaNl https://t.co/0WZXKypZjo
Sleep disturbances and Alzheimer’s disease: a multiscale approach from exposome to neurobiology and precision medicine "a hypothetical integrative, stream-like model outlining how external and internal exposome factors accelerate brain aging, thereby exacerbating circadian dysregulation, orexin-mediated hyperexcitability, metabolic imbalance, and inflammaging." https://t.co/VJPZRqmM23
Neurologist Dr. Majid Fotuhi, an adjunct professor at Johns Hopkins, says generative AI is rewiring the cortex and hippocampus, challenging attention and memory. He advises a daily 20‑30‑minute brain‑exercise routine to keep cognition sharp in the AI era.
Rubedo completed a Phase 1 trial of its senotherapeutic compound RLS‑1496, reporting safety and early efficacy signals in eczema, psoriasis and sun‑damaged skin. The data, presented Friday, marks one of the few human‑centric anti‑aging read‑outs in the past year and...
University of Georgia researchers reviewed MXene‑based smart textiles that can continuously monitor body temperature, blood pressure and heart rate while also providing antimicrobial protection. The fabrics harvest solar energy, enabling built‑in power banks that could charge phones or laptops. The...
People always ask me about cardio and how much I do to stay lean. I do almost none. I walk 10k steps everyday. I do sprints (60 meter x 5 reps) 2 times a week. That is it. If you...
A Cleveland Clinic secondary analysis of a 13,000‑patient trial shows tirzepatide lowers the combined risk of heart attack, stroke, heart failure, kidney failure and death by 16% versus dulaglutide. The findings, presented at the ACC meeting, give longevity‑focused biohackers new...
You can fall asleep on the couch in 10 minutes but lie awake in bed for 2 hours. Here's exactly why and how to fix it. Your brain isn't broken. It just learned the wrong lesson about bedtime. The good news? What your...
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis? 🗣️"We will describe how SIRT1 can represent a key molecular link and an appealing target to harness microglial neuroprotective potential as...
Researchers identified the gut bacterium Roseburia inulinivorans as a factor that boosts muscle strength in both humans and mice. In a cohort of 90 young adults and 33 seniors, individuals harboring the microbe exhibited up to 29% greater grip strength...
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative Lay Summary: "The role of interleukin-6 receptor (IL6R) blockade in reducing chronic-disease risk and improving longevity is uncertain. In a study of 38 807 postmenopausal women followed for...
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice “The beneficial effects of SGLT2i treatment in gKO mice conclusively demonstrate that in a physiologically relevant preclinical model of HFrEF, SGLT2i can exert therapeutic benefits via off-target pharmacology.3...
Intensity of exercise vs volume of physical activity made a difference for lower risks of 8 diseases and all-cause mortality among 96,000 @uk_biobank participants, especially noted for immune-mediated (IMID). VPA-vigorous physical activity https://t.co/MiiJHRDwxK https://t.co/818AH12Tj4
Network pharmacology approach to unravel the neuroprotective potential of natural products: a narrative review https://t.co/LGgQeHQHwF https://t.co/OiCYu2OxZq
Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice 👉"Our results are consistent with the idea that rapamycin’s beneficial effects are mediated, at least in part, by reducing oxidative stress and ER stress-mediated apoptosis... https://t.co/b8EZwrDTXP
The 15-minute nap remains undefeated. Do it daily and you get ~1 extra hour of sleep per week. Even if you don’t fall asleep, just lying down and closing your eyes still counts as a short stress and recovery break.
