Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
A comprehensive review of 113 clinical trials involving nearly 8,000 participants reports moderate gains in muscle strength, lower osteoarthritis pain, and enhanced skin elasticity and hydration from hydrolysed collagen supplements. The findings give the first robust, quantitative backing to a product category that has long been marketed on anecdotal claims.
I’ve had the privilege of practicing in the same region for nearly 25 years. I’ve gotten to know many of my patients well. Some thrive despite the years; many don’t. Long ago, that observation started to quietly shape how I...
Diana Nyad, now 76, completed the iconic 110‑mile Cuba‑to‑Florida crossing in 53 hours, matching the time she logged at age 64 and reaffirming the world record she set in her 60s. Her achievement spotlights how disciplined training and mental toughness...
Legal psilocybin retreats in Oregon have documented therapeutic benefits for dozens of participants, including 70‑year‑old Martha Stem, who said the experience helped her confront decades of trauma. The trend underscores a growing convergence of regulated psychedelics and meditation as an...
A research team led by Liu Guanghui at the Chinese Academy of Sciences released a comprehensive map of inflammatory aging across multiple organs and introduced two anti‑aging strategies—a betaine‑based small‑molecule and engineered FOXO3‑edited stem cells. The work was named one...
Herbalife Ltd. announced a $55 million acquisition of assets from UK‑based Bioniq, adding a biomarker‑powered supplement engine to its portfolio. The deal, slated to close in Q2 2026, aims to scale personalized nutrition through the company’s global distributor network.
Loss of epigenetic information as a cause of mammalian aging “we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA...
Can supplements really improve sleep? This session reviews the evidence on melatonin, magnesium, tart cherry, glycine and more. Sign up: https://t.co/0PJC4DLDwV https://t.co/CHqyc8krh7
Rex Maurer of the University of Texas posted a 3:32.96 in the 400‑meter individual medley, establishing a new American record while capturing the NCAA national championship. The performance underscores a shift toward race‑pace training and deeper talent pipelines in U.S....
Hematopoietic (stem) cells—The elixir of life? "In this perspective article, we discuss the evidence that supports that rejuvenating or delaying aging of the blood system has a beneficial and systemic impact on human health..." @FEBS_Letters https://t.co/Y9sYcwXp1A @FEBSJournal
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target 👉 “By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing,...
A comprehensive review of decades of exercise research published on March 28, 2026, concludes that late‑afternoon sessions coincide with the body's highest temperature and optimal hormonal environment, delivering the greatest strength and endurance benefits. The findings challenge the long‑standing debate over morning...
I wonder if we could find similar signatures in chronic diseases, such as diabetes, chronic infections, or autoimmune diseases? Would the Information Theory of Aging also rationalize these diseases equally based on equivalent observations?
Scientists led by Farnaz Shamsi identified the SLIT3 protein system that constructs the nerve and blood‑vessel networks essential for brown‑fat thermogenesis. Published in Nature Communications, the work links SLIT3 activity to metabolic health in over 15,000 human tissue samples, positioning...
Oura’s chief medical officer, Dr. Ricky Bloomfield, disclosed that the ring’s Symptom Radar feature nudged four young women to seek care, leading to early‑stage lymphoma diagnoses. The finding underscores a shift from fitness tracking to actionable health alerts.
A UC Health‑wide hypertension algorithm was embedded in electronic health records for roughly 90,000 patients, raising the proportion of controlled blood pressure from 68.5% to nearly 74% by mid‑2025. The stepwise, clinician‑guided tool, called the UC Way Hypertension Medication Algorithm,...
The British Heart Foundation warned that popular gut‑friendly foods such as kimchi, sauerkraut, kombucha and fruit smoothies can pose hidden cardiovascular risks due to added salt, sugar, and low fiber. Cardiology dietitian Michelle Routhenstein clarified that while probiotic strains may...
Senescent immune cells protect against damage, inflammation and disease 🤯 In mice, p16-expressing immune cells delay age-related organ deterioration and preserve tissue homeostasis. More evidence of the physiological roles of senescent cells? https://t.co/UtBKDF00P1
In a recent interview, former two‑time NFL Pro Bowler Julius Thomas, Psy.D., outlined a new framework that ties mental‑training techniques to longer, healthier lives. He argues that chronic stress at the cellular level and low‑grade inflammation are the hidden culprits...
Biohackers World announced a two‑day conference in Los Angeles on March 28‑29, 2026, slated to draw about 1,500 researchers, founders and enthusiasts. The event will shift the biohacking conversation toward everyday habits, supportive technology and environmental design. Organizers say the...
Training for life means deliberately resisting the narrowing that accompanies aging without training. It means building and maintaining the full spectrum of physical capacity: aerobic base, strength, power, rotational core, lateral movement, balance, and landing mechanics. Not because any single...
Want to build muscle effectively? 💪 Muscle hypertrophy happens when protein synthesis outpaces breakdown driven by smart training, nutrition, and recovery. 1. Resistance Training Gradually increase weight, reps, or difficulty over time. • Aim for 10–20+ weekly sets per muscle group (spread...
A comprehensive 2026 guide reviews 13 magnesium supplements, ranking them by bioavailability, purity, synergistic cofactors, and real‑world results. The methodology, based on four years of personal testing and biometric tracking, disqualifies low‑absorption oxide products. Top picks include RnA ReSet ReMag...
A new paper says lifespan gains will be small due to our biology That’s true - if we don’t change. But if we can change our biological age, the equation changes In 1700, we couldn’t imagine moving faster than a horse. Biology...
Magnesium, an essential mineral involved in over 300 enzymatic processes, is increasingly recognized for its broad health benefits ranging from neuroplasticity to cardiovascular support. Recent analyses highlight that modern diets and lifestyle factors leave the majority of adults deficient, despite...
A clinical trial of Dzeny’s AI‑assisted therapist showed participants’ anxiety scores fell 43% in eight weeks, a result comparable to conventional cognitive‑behavioral therapy. The study, led by psychologist Valentina Lipskaya, also reported gains in burnout, mood and quality of life,...
Researchers analyzing daily food logs from 112 overweight adults in a 12‑week behavioral program found that participants who ate the same foods repeatedly and kept daily calories steady lost 5.9% of body weight, versus 4.3% for those with varied diets....
Neuroscientists from the University of Lübeck, together with mental coach Thomas Baschab, released a documentary that tracks a swimmer, an air‑traffic‑controller trainee and an e‑sports professional to map how the brain sustains concentration. The study identifies neural signatures of the...
The University of Texas at San Antonio has opened a precision clinical trial to evaluate rapamycin in non‑smoking, independently living seniors. Researchers hope the study will provide hard data on dosing and safety, moving the longevity drug from hype to...
Researchers at Toronto Metropolitan University discovered that a 24‑minute session of music combined with auditory beat stimulation (ABS) significantly reduces anxiety symptoms in adults already taking medication. In a randomized trial of 144 participants, the 24‑minute condition outperformed a 12‑minute...
The episode outlines the top ten hidden factors that speed up aging, ranging from smoking and UV exposure to sugar, chronic stress, poor sleep, chronic inflammation, sedentary behavior, excessive alcohol, ultra‑processed foods, and social isolation. Each factor is explained in...
You’ve probably heard that longevity is 20% genetics and 80% lifestyle But that would make it an outlier because almost every other human trait is closer to 50% genetic Dr. Uri Alon is a physicist and systems biologist whose recent research suggests...
As a medical school professor, I've watched GLP-1 drugs transform diabetes and obesity treatment. Now a Nature Cancer review reveals they may suppress cancer too. GLP-1 drugs reduce insulin resistance, lower inflammation, and cut body weight -- three of the biggest...
In a recent episode of Longevity by Design, Dr. Uri Alon presents a systems‑biology model that likens the body to a village where houses generate garbage, trucks clean it up, and a threshold determines collapse. The framework links the balance of...
Mindbodygreen is recommending brief movement and mentally engaging breaks during long periods of sitting after a Karolinska Institute study of 20,000 adults showed a 14‑23% lower dementia risk for active sitting versus a 24% higher risk for TV watching. The...
Related to another post from yesterday... Most athletes could afford to spend at least 6 months of every year capped at 75% MHR. You won't do that, because you'll get bored and distracted (probably by something you read here) But you'd be a...
A new study by King’s College London tracked healthcare workers with type 2 diabetes across night, day and rest shifts, revealing that night‑shift schedules impair diet quality and increase blood‑glucose variability. Participants relied on vending‑machine snacks and faced up to 22‑hour...
Instead of only short bursts of movement, add walks that last 15+ minutes. Among people averaging <8,000 steps/day, those who got most of their daily steps from walks lasting 15+ minutes had the lowest cardiovascular risk and among the lowest mortality...
Neurodegeneration leading to dementia could affect up to 152 million people worldwide by 2050. A recent meta‑analysis of more than 540,000 older adults found cataract surgery reduces the risk of cognitive impairment or dementia by roughly 25 % compared with untreated cataracts,...
A patient asked me yesterday why so many orthopedic surgeons seem to be in good shape. I told her... Because we know what happens to the human body when we're not. We see it every day. The loss of muscle that...
Researchers at Kochi University of Technology and the Shizuoka Institute of Science and Technology reported that, after an acute stressor, the human brain takes roughly 60 minutes to transition from a salience‑network‑driven alarm state to a default‑mode‑network‑driven reflective state. The...
The U.S. Food and Drug Administration approved Novo Nordisk’s 7.2 mg semaglutide injection, branded Wegovy HD, just 54 days after filing. The fast-track decision, the fourth under the National Priority Voucher program, expands dosing options for weight‑loss and metabolic biohackers.
In this episode, Dr. Uri Alon explains his systems‑biology view of aging using a vivid village metaphor: houses (cells) generate garbage (damage) while a fixed fleet of trucks (the immune system) removes it, leading to overload and a robustness threshold...
As a medical school professor, I used to teach that aging is gradual wear and tear. But a Vanderbilt study in Nature Cell Biology reveals something far more disturbing. Your cells are actively dismantling themselves through a process called ER-phagy. Starting early...
For nearly 40 years I've used my body to test ideas about training intensity, HIIT, monitoring, etc. I seem to be paying for those sins now with big atrial fibrillation challenges. This distracts me a bit, but hey,...
When I started Don't Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies. Psychedelics were no where to be found. A wild turn of events that they're now front and center for us....
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
In the era of molecular and organ clocks and marked inter- and infra-individual variability of the aging process, we need to move beyond chronological age. "biologic measures predict outcomes more robustly than chronologic age" @NEJM https://t.co/DKmIfdJJUF https://t.co/d5Gc6xGKqn
Long post. What my training week looks like… and why it looks like this. Sometimes understanding the science and theory helps anchor the methodology. Link for there 👇 https://t.co/2Xzne078WC
Ever since I travelled to Moscow in 1986 as a 20y old student in search of secrets, "periodization models" have spun in my head. This review helped slow the spin. Revisiting Tradition: Why the Traditional Periodization Still Shapes Modern Sport...
