Know What's Happening in Biohacking
Know What's Happening in Biohacking
Creatine Boosts Brain Power, Counteracts Sleep Loss and Stress
Creatine monohydrate, long used for muscle growth, is now shown to increase brain creatine concentrations and protect cognition under sleep deprivation and stress. Clinical trials using daily doses of 10‑25 g reported improvements in processing speed and working memory, according to studies published in Nature and other peer‑reviewed journals.
Researchers sequenced DNA from 500 domestic‑cat tumors, covering 13 cancer types, and mapped mutations in 1,000 genes commonly altered in human cancers. The study found that TP53 and PIK3CA are among the most frequently mutated genes in cats, mirroring patterns seen in human oncology. Notably, cats develop spontaneous triple‑negative mammary tumors and rare pancreatic subtypes, offering a natural model for aggressive human cancers. The Ontario Veterinary College’s biobank now links with human biobank networks, enabling cross‑species trials and drug repurposing opportunities.
Recent research indicates that regular exercise can meaningfully reduce both the intensity and duration of primary dysmenorrhea. Studies show aerobic activity lowers pain scores by roughly 2.5 points on a 10‑point scale, while strength‑training and relaxation techniques often achieve the...
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A trio of exercise types—strength, aerobic, and balance—are identified as critical for extending healthy lifespan. The article outlines six equipment‑free movements, from walking to plank holds, that can be performed at home. Each exercise targets muscle mass, cardiovascular function, or...
The only sustainable path to development of longevity therapeutics is to get the potential longevity drug approved for a disease, then go for indication expansion and study it in the context of aging at different doses and regimens. To be...
A recent study in Medicine & Science in Sports & Exercise examined how perceived effort influences the physiological benefits of interval running. Seventeen runners completed three 3‑minute interval sessions at effort levels 6, 7, and 8 on a 0‑10 scale,...
A recent study in Basic & Clinical Pharmacology & Toxicology uncovers a PXR‑SHBG‑testosterone pathway that explains how common chemicals alter hormone balance. In a week‑long rifampicin trial, participants’ SHBG levels doubled, raising total testosterone but reducing biologically active testosterone and...
Harvard‑trained metabolic researcher Dr. Nick Norwitz embarked on a 30‑day “sardine fast,” consuming roughly 1,000 sardines and supplementing with oil to boost fat intake. The experiment drove his blood omega‑3 levels to an unprecedented 16%, a concentration comparable to marine...
Japan has become the first country to grant conditional approval for two regenerative medicines that use induced pluripotent stem cells—AMCHEPRY for Parkinson’s disease and RiHEART for severe heart failure. The Parkinson’s therapy implants dopamine‑producing neurons into the brain, while the...
The forum thread argues that most lifters benefit more from simple, consistent programming than from complex concepts like effective reps or intricate exercise variations. Contributors cite classic compound movements, reasonable volume, and progressive overload as the core drivers of strength...
I teach medical students about neurodegeneration. But a new clinical trial shows the most powerful brain drug might be free. Researchers at AdventHealth put 130 adults (ages 26-58) through a randomized controlled trial: 150 minutes of aerobic exercise per week vs....
Physical activity types, variety, and mortality: results from two prospective cohort studies "Higher physical activity variety was associated with lower mortality. After adjustment for total physical activity levels, participants in the group with the highest physical activity variety score (group 5),...
The Fit to Farm column stresses that everyday mobility hinges on the simple principle of “use it or lose it,” with squatting highlighted as a foundational movement for farm workers and anyone aging in place. It explains how squatting underpins...
Most everything that increases deep sleep will lessen your REM and vice versa. So do as you will with Pinealon GH secretagogues etc but be aware of this. In any case, cool-cold-warm (subjective bed temps across 6.5-8hrs of sleep) is...
Exercise increases brain-derived neurotrophic factor, supporting brain plasticity. Trends in Neurosciences, 2002. Cotman and Berchtold https://t.co/jux3TwN0fS
Alpha GPC is a highly bioavailable choline derivative that readily crosses the blood‑brain barrier, boosting acetylcholine synthesis and supporting memory, learning, and athletic performance. Clinical trials show cognitive improvements in healthy adults and Alzheimer’s patients, while athletes report enhanced focus...
Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women 👉"Elevated FSH, not low E2, is linked to cognitive decline and Aβ pathology in postmenopausal women." https://t.co/EkFxbjsao9
People are turning to heart rate variability coaches to get ahead at work, or at least not fall behind https://t.co/s6vyi0JpiB
A new longitudinal study finds that drinking two specific beverages daily—coffee and tea—correlates with an 18% lower risk of developing dementia and a slower rate of cognitive decline. The research tracked over 100,000 adults for a decade, adjusting for lifestyle...
Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats [One week after intraperitoneal administration of rapamycin (8 mg/kg) 👨⚕️] https://t.co/6JhcZYS01h https://t.co/wruacgIvFM
An intriguing case of “exceptional resilience” against dementia A 75-year-old man free of dementia despite a dominant Alzheimer’s mutation — and a possible hint for the rest of us https://t.co/lWn9gCKrEm https://t.co/jq0L2NtZ27
Penn State researchers have engineered a new class of granular aerogel scaffolds (GAS) that allow precise control of pore architecture using protein‑based microparticles. The tunable, oxygen‑rich material demonstrated superior cell infiltration and rapid vascularization in both laboratory assays and mouse...
Vigorous physical activity, incident heart disease, and cancer: how little is enough 👉"VPA of 15–20 min/week were associated with a 16–40% lower mortality HR, with further decreases up to 50–57 min/week." https://t.co/Efp99sop1h https://t.co/zqzoL6xYor
Athletes cramp for 3 common reasons: 1. Lack of hydration and minerals 2. Inadequate pre-competition fueling 3. Poor conditioning/training preparation and warm-up Low-carbohydrate diets also cause the kidneys to excrete more sodium and water, which can further increase cramping risk. My tips to prevent muscle...
In this episode of the Empirical Cycling Podcast, hosts Coley Moore, Erica, and Fabiano dissect common mistakes cyclists make when trying to improve their Functional Threshold Power (FTP) and offer practical solutions. They discuss flawed testing protocols, the danger of...
I quit alcohol 20 years ago. Here’s how that one decision changed my life👇 Early 20s, I looked fine: • Building things • Showing up to meetings • Handling stress as a young CEO But under the hood... • 212...
Nitric Oxide Signaling and Sensing in Age-Related Diseases "Nitric oxide (NO) is a key signaling molecule involved in numerous physiological and pathological processes within the human body. This review specifically examines the involvement of NO in age-related diseases, focusing on the...
In this episode, host Rizim Tom chats with Chris Bradley of MatterBio about the science of longevity, focusing on how genomic damage drives the hallmarks of aging. Bradley explains that while cells constantly renew, DNA damage from internal sources like...
All these budding exercise physiologists and strength coaches. 🤦♂️🤦♂️ This is made up slop. Walk all you want. None of your muscles are working hard when you’re walking and your adductors are firing too. Is walking enough? No. You need strength...
Low dose caffeine pouches - a novel performance strategy? ☕️ This new study recruited 19 active adults to complete 3 x physical performance testing sessions after taking either… 1️⃣ 80 mg caffeine pouch (similar to snus) 2️⃣ 80 mg caffeine gum 3️⃣ Placebo gum 💊...
Researchers documented a 75‑year‑old man, Doug Whitney, who carries a highly penetrant PSEN2 mutation that typically causes early‑onset Alzheimer’s disease, yet he remains cognitively normal. Imaging revealed massive amyloid buildup but tau pathology confined to the occipital lobe, an atypical...
Parental fasting effects on offspring immune gene expression, epigenetic patterns, and gut microbiota in a species with male pregnancy (Syngnathus typhle) https://t.co/5x9ScJ30uY https://t.co/hixjrq8Bvg
Most athletes ruin their season the same way: They increase volume AND intensity at the same time. Rule #1 of season planning: Pick one. Volume first. Intensity later. And “later” is usually much later than your ego thinks.
The American Heart Association and American College of Cardiology have lowered the systolic blood‑pressure target for older adults, now urging clinicians to aim for readings below 130 mmHg. Emerging data linking hypertension to cognitive decline have accelerated this shift, prompting more...
New study of mouse brain aging identifies a progressive drift in cellular identity, consistent with information theory (ITOA) https://t.co/OaB2p9GUgT
Association between cagemate number and risk of death in mice: a time-varying covariate analysis using Cox frailty models "...Female mice exhibited a pronounced increase in mortality rate as cage density declined..." https://t.co/pGtDArEzI0 https://t.co/5gizWZ0QYo
Foxo, a Bengaluru‑based longevity startup, offers a premium, membership‑driven health platform that combines systems biology with AI‑assisted clinical coaching. The company raised $0.5 million in a pre‑seed round led by Blume Ventures and targets high‑income executives willing to invest lakhs annually...
Overexpression of FoxO3a in the dentate gyrus alleviates CUS-induced anxiety- and depression-like behaviors and cognitive impairment https://t.co/p2t18NRkew
Dietary Advanced Glycation End Products (dAGEs): Pathogenesis and nutritional strategies for health longevity-A critical view https://t.co/RrTxgGg4UF https://t.co/ujoKGLKIRz
A randomized 12‑week trial evaluated Melonga, a smartphone app that teaches pelvic‑floor, mindfulness and cognitive‑behavioural techniques to men with premature ejaculation. Among the 66 participants who completed the study, average intravaginal ejaculation latency rose from 61 seconds to 125 seconds,...
Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework The hierarchical architecture of the EpiAge-R framework... https://t.co/YpwDdLI7wo https://t.co/Uid3kNzDHr
A completely novel axis of epigenetic aging. N6-methyldeoxyadenosine (N6medA), i.e. NOT the usual 5 methyl cytosine, increases linearly with age in human prefrontal cortex (r=0.95). Genome-wide profiling reveals age-associated ADENINE methylation changes reminiscent of classic CpG based epigenetic clocks. Abdur...
The power‑to‑weight ratio (watts per kilogram) is the premier metric for estimating a cyclist’s climbing speed, translating raw power into how quickly each kilogram of mass can be moved uphill. While absolute watts dominate on flat terrain, weight‑adjusted power shines...
Peter Abraham, a former pro cyclist now 62, attributes his continued speed and endurance to mastering three core skills: comfortable group riding, precise cornering, and a competitive mindset. Over the past 15 years he rebuilt his fitness while coaching Bicycling’s...
Ultra‑runner Pat Heine explains that training for a 200‑mile trail race can rely on short, repeatable segments rather than long mileage. By applying the “chunking” method—breaking a massive goal into manageable pieces—he builds both physical strength and mental resilience on...
Experts explain that both walking and running satisfy the CDC’s 150‑minute weekly activity recommendation, but each offers distinct advantages. Walking provides a low‑impact, beginner‑friendly option that can be intensified with hills, weighted vests, or intervals, supporting cardiovascular health and chronic...
How to know you're "ready" for a specific distance: Complete a ~2/3 (Metric) simulation at race-pace as a regular training session with... - Minimal decoupling between pace/HR - No extended recovery needs beyond that of a regular loading day. For a marathon, I think...
NAD⁺ as a central hub regulating the hallmarks of aging: Mechanisms and therapeutic implications https://t.co/Mw45GF0QhL https://t.co/pvAGRxXQZv
If avoiding sugar, consider stevia. A stevia plant extract (from Pharmingen, Korea) improved muscle metabolism, mitochondrial function, and attenuated muscle loss in obese mice while activating SIRT1. Non-ultraprocessed stevia resembles matcha powder 🍵 https://t.co/tWvBmZzk2g
Resilience is physiological & actionable: Spiking your morning cortisol increase (which is what wakes you up & is healthy) with bright sunlight & exercise, shortens the duration and the amplitude of the cortisol response to afternoon and night time stressors,...
Syringic acid is a naturally occurring molecule in grapes, olives, pumpkins & herbs with antiinflammatory, anti-microbial & anticancer properties. New study finds it prevents rodent neurotoxicity & inflammation. Not yet sold widely but will be I expect https://t.co/3XtSesFb9I https://t.co/C3RqjvK6NY
