Today's Biohacking Pulse
Updated 1h ago
Narrowing biological age gap slashes stroke risk and improves brain health
A large observational study of 258,000 adults found that reducing the gap between biological and chronological age lowered stroke risk by 23% and cut white‑matter hyperintensity volume by 13%. Researchers estimated biological age from routine blood biomarkers and tracked changes in about 6,000 participants over six years, suggesting that closing the age gap could protect brain health.
News•Mar 6, 2026
Garrya Mù Cang Chải Redefines Mountain Wellness for 2026
Garrya Mù Cang Chải is launching a data‑driven well‑being concept for 2026 that moves beyond traditional spa stays to structured, results‑focused programmes. Guests will complete a digital pre‑arrival assessment and receive a dedicated Wellbeing Trainer who tailors itineraries around sports science, integrative nutrition and sleep optimisation. The resort adds a 13‑step hydrotherapy circuit, upgraded suites with in‑room training stations, and regionally inspired treatments. The offering targets both restorative therapy seekers and performance‑oriented travelers in Vietnam’s northern highlands.
By TTG Asia
Social•Mar 6, 2026
Engineered Brain Cells Clear Dementia Plaques in Mice
Boosted Brain Cells Erase Dementia-Linked Proteins “At nearly six months of age, when untreated mice normally have brains saturated with harmful plaques, brains of treated mice were plaque-free. Meanwhile, older mice with plaque-saturated brains at the time of treatment saw a...
By David Barzilai, MD PhD
Social•Mar 6, 2026
Engineered IL-10 Boosts Neurogenesis and Cognition in Aging Brain
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition @BrunetLab https://t.co/n9bsJPSJQT https://t.co/9vvH3eEU0e
By David Barzilai, MD PhD
News•Mar 6, 2026
Degenerating Tanycytes Disrupt Tau Removal, Shaping Alzheimer’s Progression
Researchers from Kyoto University and INSERM identified tanycytes as a previously unknown conduit that clears tau protein from cerebrospinal fluid into the bloodstream. In rodent and cellular models, blocking vesicular transport in these cells dramatically slowed tau efflux and worsened...
By GEN (Genetic Engineering & Biotechnology News)
Social•Mar 6, 2026
Science Secures $230M Series C for Longevity Tech
Exciting news in the world of longevity via deep technology. Congratulations to @khoslaventures and @lightspeedvp on this historic investment. IMHO, Science may be bigger than OpenAI
By Alex Zhavoronkov, PhD
Social•Mar 6, 2026
Cranberry-Derived Ergostane Restores Ovarian Function in Mice
Ergostane steroid, as one of the major contributor to cranberry derived extracellular vesicle nanoparticles, restores ovarian function of murine premature ovarian failure https://t.co/CFcjDvzMnU https://t.co/le7VTHjEKa
By David Barzilai, MD PhD
News•Mar 5, 2026
Your GLP-1 Drugs May Also Have Yet Another Undiscovered Benefit
A new observational study of nearly 22,000 chronic‑migraine patients found that those who started GLP‑1 receptor agonists for diabetes or obesity experienced fewer severe migraine events than peers on the preventive drug topiramide. Over a 12‑month follow‑up, GLP‑1 users had...
By Womens Health
Social•Mar 6, 2026
Exercise and Enriched Settings Shield Brain Barrier From Depression
Exercise and enriched environments help protect brain barrier from stress-linked depression, finds study https://t.co/BcXFdEXP3f https://t.co/02j702A4Zq
By David Barzilai, MD PhD
Social•Mar 6, 2026
UT San Antonio Awarded $38B ARPA-H Grant for Drug Trials
UT San Antonio has been given a $38biin ARPA-H grant to study the health benefit effects of three drugs in humans, namely, rapamycin, dapagliflozin and semaglutide …🧵 https://t.co/fAX14ngoyD
By David Sinclair, PhD
News•Mar 5, 2026
How (and Why) to Boost Your “Metabolic Flexibility”
A Finnish study of 64 sedentary adults with metabolic syndrome showed that a six‑month program to reduce sitting time by roughly one hour a day cut daily sedentary behavior by an average of 41 minutes. Participants who achieved at least...
By Outside (Health)
Social•Mar 5, 2026
Clean Indoor Air: Simple Filter, Major Health Benefits
Air filtration at home and work is an easy health win. In my house and office, each room has an air filter and monitor. I try to maintain pristine air quality 24/7. Air pollutants PM2.5, PM10 and poisonous gases like...
By Bryan Johnson
Social•Mar 5, 2026
Runway Signals Shift: Immortality Meme Foresees New Power
This week I modeled in Paris Fashion Week. I am a meme for Immortality.... why was I there? Something significant is happening. By the time something appears on a runway in Paris, it usually means the concept has already crossed...
By Bryan Johnson
News•Mar 5, 2026
Therapeutic mRNA Reverses Genetic Infertility in Male Mouse Model
Scientists delivered naked Cldn11 messenger RNA directly into the testes of genetically infertile male mice, restoring Sertoli cell function and enabling spermatogenesis. The treatment produced viable sperm that generated healthy offspring via in‑vitro fertilization, without permanent germline alteration. The approach...
By GEN (Genetic Engineering & Biotechnology News)
Social•Mar 5, 2026
Low‑dose Creatine Boosts Performance in Kids Safely
Creatine isn’t just for adults. I give my son 2.5 g/day. There are (albeit few) studies in kids and adolescents showing creatine can improve performance. For example, trials in adolescent soccer and basketball players report improvements in power, jumping, sprint/anaerobic performance,...
By Rhonda Patrick, PhD
Blog•Mar 5, 2026
The CONTEXT Framework: Why the Best Health Interventions Fail Without Context
The CONTEXT Framework reframes health optimization by prioritizing the circumstances surrounding an intervention over the intervention itself. It breaks decision‑making into seven coordinates—Client, Objective, Now, Terrain, Execution, eXchanges, and Tracking—to ensure each supplement, protocol, or technology aligns with the user’s...
By Outliyr — High Performance Longevity
Social•Mar 5, 2026
Social Media Is a Hidden Intoxicant, Not Just Distraction
Finished a seven day social media fast. It feels like the most effective longevity therapy I've done. Everything got better: mood, sleep, energy, presence, judgment, relationships, and optimism. Evidence shows a seven day fast produces a reduction of anxiety (16%),...
By Bryan Johnson
News•Mar 5, 2026
Is Neurodegeneration a Systemic Metabolic Condition?
British biotech Vesalic reports a breakthrough that links amyotrophic lateral sclerosis (ALS) to a systemic metabolic dysfunction detectable in blood extracellular vesicles (EVs). The company says the EVs carry a toxic lipid cargo that harms motor neurons, and its blood‑based...
By Longevity.Technology
Podcast•Mar 5, 2026•39 min
Episode 192: Ken and Dawn Weigh in on ChatGPT, Ketamine, Urolithin-A, Rapamycin, and More in Wide-Ranging AMA
In this AMA episode, host Dawn Cornegas and IHMC CEO Dr. Ken Ford field listener questions on a wide array of topics, from astronaut training in NASA's Neutral Buoyancy Lab to the latest research on supplements like urolithin‑A and anti‑aging...
By STEM-Talk
News•Mar 5, 2026
At CNBC Cures, Becky Quick Leads Clarion Call for Rare Disease Research
The CNBC Cures Summit opened with Becky Quick urging families and innovators to accelerate rare‑disease research. Speakers highlighted a widening gap between rapid scientific breakthroughs—gene therapies, AI‑driven diagnostics, and modular “nodal biology”—and an aging regulatory framework. Leaders from Biogen, the...
By GEN (Genetic Engineering & Biotechnology News)
Social•Mar 5, 2026
Knee Pain Signals Years of Inactivity, Not Surgery Need
The hardest conversation I have in my office isn't about surgery. It's about time. A 58-year-old sat across from me with knee pain. She’s otherwise healthy, but menopause has been rough on her. Her MRI shows some cartilage changes — age-appropriate,...
By Howard Luks, MD
Social•Mar 5, 2026
Sleep Quality Tied to Eating Timing and Duration
Indices of Sleep Health Are Associated With Timing and Duration of Eating in Young Adults - Journal of the Academy of Nutrition and Dietetics https://t.co/RztLzXUScr
By Michael Lustgarten, PhD
News•Mar 5, 2026
New HIV Cure Approach Forces Hidden Virus Into Tripping Immune Sensor
Researchers have unveiled a novel HIV‑cure strategy that forces dormant virus particles to reveal themselves to the body’s innate immune system. The method employs a STING‑pathway agonist to coax latent proviruses into producing viral RNA, which then triggers a potent...
By Science (AAAS) News
Social•Mar 5, 2026
Longevity Conference Calendar Revealed, Forum Starts Next Week
2026 aging/longevity conferences mostly have announced dates now. A few date just announced. Here's what the schedule looks like at the moment. Next up is Longevity Global's Longevity Innovation Forum in San Diego next week. https://t.co/mIDmfQD38H I'll be there & speaking. https://t.co/4mRLXJmGgg
By Karl Pfleger, PhD
Social•Mar 5, 2026
Resveratrol Eases Neuropathic Pain via Mitochondrial Restoration
Neuropathic pain affects 7-10% of all people globally. New 🐁 study finds resveratrol alleviates neuropathic pain associated with restoration of mitochondrial dynamics 👏 https://t.co/zJ8LvwZ9UP https://t.co/hdCK7UgqBj
By David Sinclair, PhD
Blog•Mar 5, 2026
Menopause Hormone Therapy: The Myths, the Medicine, and the “Why Didn’t Anyone Tell Me?” Moment
The article debunks long‑standing myths about menopausal hormone therapy (MHT) by highlighting how the 2002 Women’s Health Initiative (WHI) trial was misapplied to all women. It explains that the WHI tested an older cohort using a specific estrogen‑progestin combo, leading...
By Dr. Gabrielle Lyon — Blog
Social•Mar 5, 2026
Hunter‑gatherers Produced Four‑to‑five Times More Poop
Did you know... That the daily 💩 weight of an average hunter-gatherer was ~4-5x the daily 💩 weight of a modern human? #FixYourFiber
By Alan Couzens
Social•Mar 5, 2026
Wrist Temperature Validated as Sleep Marker in Actigraphy
Wrist temperature as a sleep marker in actigraphy: Chronobiology International: Vol 43, No 2 https://t.co/HElT9CO7XS
By Michael Lustgarten, PhD
News•Mar 4, 2026
Rice Cheese May Be the Next Big Thing
University of Arkansas researchers have demonstrated that rice proteins can be extracted and incorporated into vegan cheese formulations, achieving roughly 12% protein content and closing a key nutritional gap in plant‑based cheeses. The study identified four protein fractions—albumin, globulin, glutelin...
By Popular Science
Social•Mar 5, 2026
Morning Sun, Exercise, Caffeine Trim Daily Cortisol Spikes
One of the most overlooked benefits of morning bright (sun)light, exercise & caffeine is how it reduces the duration of any cortisol peaks in response to stress (should they happen) later in the day… and it’s ability to reduce nighttime...
By Andrew Huberman – Huberman Lab
Social•Mar 5, 2026
Check Melanotan Results First; Prefer Sunlight over Peptides
Before you bullish-on-peptides folks inject melanotan, make sure you do a web search to look at some before and after photos…! Here is a case where unless there’s a *real clinical need* I highly recommend you intelligently use sunlight instead.
By Andrew Huberman – Huberman Lab
News•Mar 4, 2026
We Must Close the 'Shocking' Knowledge Gap in Women's Health
Anita Zaidi calls for urgent research to close the knowledge gap in women’s health, highlighting the deadly impact of pregnancy complications like pre‑eclampsia. More than 700 women and 6,500 newborns die daily from these conditions, with the highest toll in...
By New Scientist (Health)
Social•Mar 5, 2026
Western Medicine Meets Eastern Practices for Stress Resilience
Quickly becoming one of our most popular episodes ever. Merges western medicine (guest is practicing MD) and eastern practices for brain, plasticity, long duration stress resilience. @HealthyGamerGG on Huberman Lab podcast out now:
By Andrew Huberman – Huberman Lab
Social•Mar 5, 2026
Plasma Lactate: A Key Indicator of Metabolic Health
Plasma Lactate as a Marker for Metabolic Health : Exercise and Sport Sciences Reviews https://t.co/6IeA9Y9FGQ
By Michael Lustgarten, PhD
News•Mar 4, 2026
Why Most Longevity Advice Gets Weight and Exercise Wrong
In a recent episode of Longevity by Design, Dr. Gil Blander interviews Dr. David Allison, director of the USDA Children’s Nutrition Research Center, to dissect common misconceptions in weight, exercise, and nutrition science. Allison emphasizes that reproducibility and transparent methodology...
By InsideTracker Blog (Longevity/Performance)
Social•Mar 5, 2026
Supaspinal CNS Fatigue Key to Optimal Strength Training
Understanding how supaspinal CNS fatigue works during exercise is essential to optimal strength training programming. See more in this week's free Patreon article. https://t.co/s5U5Z5gR8G
By Chris Beardsley
Social•Mar 5, 2026
Introduce High Schoolers to Aging Careers Early
Is it time to start exposing high schoolers to the aging/longevity field: basic reasons it's important & a worthy potential career area? High schools have career days where adults jobs & careers. I just did a 1hr intro to aging &...
By Karl Pfleger, PhD
News•Mar 4, 2026
GLP-1 Drugs Linked to Lower Addiction Rates in Large Study of Veterans
A large retrospective study of over 600,000 U.S. veterans found that patients prescribed GLP-1 receptor agonists for diabetes were 14% less likely to develop new substance-use disorders compared with those on SGLT-2 inhibitors. The analysis also showed 30% fewer drug-related...
By Science (AAAS) News
Social•Mar 4, 2026
Low Insulin Can Be Healthy—Check HbA1c and Liver
Insulin has an inverse U-shape during aging, so by itself low values may be optimal, but also indicative of B-cell failure Adding HbA1c provides more context. If it's low with low insulin this is potentially good news Also check liver enzymes, to...
By Michael Lustgarten, PhD
Blog•Mar 4, 2026
Episode 144 | Trail Steepness Vs. Difficulty
The Backpacking Light podcast’s Episode 144 examines how trail steepness reshapes hiking difficulty, revealing that metabolic cost does not increase linearly with slope. It highlights that mild downhill grades (‑5 % to ‑10 %) are most energy‑efficient, while steep uphill (≥20 %) and downhill (≤‑25 %)...
By Backpacking Light (independent publication)
Blog•Mar 3, 2026
Acetyl-L-Carnitine (ALCAR)
Acetyl‑L‑Carnitine (ALCAR) is a bioavailable form of L‑carnitine that readily crosses the blood‑brain barrier, delivering energy‑boosting fatty acids to mitochondria and supporting acetylcholine synthesis. Clinical studies show ALCAR can improve memory, mood, and fatigue, and it performs comparably to antidepressants...
By Nootropics Expert — Blog
News•Mar 3, 2026
The Right Sounds May Turn Sleep Into a Problem-Solving Tool
A Northwestern University study found that playing puzzle‑linked soundtracks during REM sleep can nudge lucid dreamers toward solving previously unsolved problems. Researchers used targeted memory reactivation on 20 participants, cueing them with brief instrumental clips associated with difficult puzzles. Seventy‑five...
By Science News
Blog•Mar 3, 2026
How to Get Perfect Skin: A No-BS Lifter’s Guide
A dermatologist explains that there is no such thing as a healthy tan, emphasizing that any UV exposure triggers skin damage that accumulates from childhood into later years. Daily use of broad‑spectrum SPF 50 sunscreen is sufficient for most office workers,...
By Menno Henselmans Articles
News•Mar 3, 2026
The Iron Mindset: Navigating the Mental Battlefield of Major Injury Recovery
The article explores the psychological battlefield elite lifters face after major injuries, emphasizing that physical healing alone is insufficient without a structured mental strategy. It outlines an identity shift from performance‑based self‑worth to broader personal value and introduces the “Spiral...
By EliteFTS – Education
Podcast•Mar 3, 2026•36 min
We’re Not Sick. We’re Being Sold | David Etheridge
In this episode, Dr. Robert Lovekin interviews author David Etheridge about his book *We’re Not Sick, We’re Being Sold*, which argues that the food and pharmaceutical industries have distorted nutrition advice, leading to widespread chronic disease. Etheridge shares his personal...
By Health Longevity Secrets
Blog•Mar 3, 2026
Why Weight Training With Full ROM Is NOT Enough for Mobility
Weight training performed through a full range of motion does not automatically provide comprehensive mobility. While heavy squats and deadlifts can improve certain joint angles, they often fall short on deep hip flexion, ankle dorsiflexion, and thoracic extension. Targeted mobility...
By The Bioneer
News•Mar 3, 2026
New Research Shares the Simple Lifestyle Tweak to Boost Longevity
A new Lancet study of over 135,000 adults in the US, Sweden, Norway and the UK found that adding just five minutes of moderate‑to‑vigorous activity each day could prevent roughly 10% of premature deaths. The researchers also modeled the impact...
By Outside (Health)
Blog•Mar 3, 2026
#596: Why Do Omega-3 Trials Show Mixed Results?
Omega‑3 supplementation trials produce mixed results due to differences in dose, population risk, and chosen endpoints. High‑dose EPA/DHA studies in secondary‑prevention cohorts with elevated triglycerides, such as REDUCE‑IT, show significant cardiovascular benefit, whereas lower‑dose primary‑prevention trials like VITAL and ASCEND...
By Sigma Nutrition — Articles
News•Mar 2, 2026
Washington State Moves to Ban Forced Employee Microchips
Washington state lawmakers introduced HB 2303 to prohibit employers from requiring or coercing employees to receive subdermal microchip implants. The bill cleared the House and a Senate Labor and Commerce Committee with bipartisan backing and now heads toward final enactment....
By Popular Science
News•Mar 2, 2026
Computer Run on Human Brain Cells Learned to Play ‘Doom’
Cortical Labs in Australia has upgraded its biocomputer, built from lab‑grown human neurons, to play the first‑person shooter *Doom*. The new CL1 platform translates visual game data into electrical stimulation patterns that the neuronal network can interpret, achieving adaptive, real‑time...
By Popular Science
News•Mar 2, 2026
Simulations of Your Gut May Predict Which Probiotics Will Stick
Researchers have built microbial community‑scale metabolic models that simulate how specific probiotic strains behave in an individual’s gut. Using baseline microbiome data, the models predicted engraftment with 75‑80% accuracy and linked bacterial growth to health outcomes such as improved post‑meal...
By Science News