Today's Biohacking Pulse
Gut microbes may dictate cellular aging, new review suggests
A Frontiers in Aging review introduces the microbiome‑gerogene axis, proposing that gut microbes act as upstream regulators of cellular aging networks. Age‑related dysbiosis reduces key metabolites, leading to leaky gut, chronic inflammation and epigenetic drift that accelerate organ decline. The authors highlight precision interventions such as ellagitannin‑derived urolithin A and fermentable fibers to restore microbial balance.
Mediterranean Diet Boosts Mitochondrial Microproteins Linked to Heart and Brain Health
Researchers at USC's Leonard Davis School of Gerontology reported that strict adherence to a Mediterranean-style diet is associated with higher blood levels of the mitochondrial microproteins humanin and SHMOOSE. Both peptides have been linked to reduced risk of heart disease and neurodegeneration, suggesting a new biological pathway for diet‑driven longevity.
Ketone Supplement May Shield Soldiers From Training Head Impacts
Neuroprotective effects of ketone monoester supplementation 🧠 This new study recruited 354 US military service members engaging in airborne training 🪖 Participants consumed either… 1️⃣ Ketone monoester 2️⃣ Placebo …before and during Improved Swing Landing Trainer (ISLT) training 🪂 Cognitive, balance, blood-based biomarkers were assessed 🔍 Results...
New Research Links Higher B Vitamin Levels with Lower Stroke Risk
A new analysis of roughly 222,000 participants from the Women’s Health Initiative and the All of Us Research Program shows that higher dietary intake of several B‑complex vitamins—particularly B1, B2, B3, B6 and folate—correlates with up to a 20 percent lower...
GLP‑1 Weight Loss Risks Muscle Loss without Proper Monitoring
We are prescribing powerful weight loss drugs without measuring the most important metric: muscle mass. Physical therapist Maureen McBeth has tested the body composition of countless patients who lost 50 pounds on GLP-1s. The results? Dangerously low skeletal muscle and exceptionally...
CU Anschutz Pilot Shows Mindfulness Keeps 7% Weight Loss in All Participants
Researchers at CU Anschutz Medical Campus reported that all seven women in an eight‑week mindfulness pilot maintained a 7% weight loss, providing early evidence that meditation‑based training can sustain short‑term weight loss. The finding arrives as obesity rates climb and...
World Indoor Championships 2026: GB Sweep, World Records and New Champions
Great Britain captured three gold medals in a 30‑minute burst at the World Athletics Indoor Championships in Toruń, Poland, while Swiss‑born Simon Ehammer set a new heptathlon world record of 6,670 points and Christopher Morales Williams ran a championship‑record 44.76 seconds...
Gubra‑AbbVie’s ABBV-295 Achieves Up to 9.8% Weight Loss in Early Trial
Gubra and AbbVie announced that participants in a Phase 1 multiple‑ascending‑dose study of ABBV-295 lost between 7.8% and 9.8% of their body weight after roughly three months. The amylin analog was well tolerated, positioning it as a potential new class of...
Inulin Cuts Knee OA Pain, Boosts Sensitivity and Strength
Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis "Inulin and PSE each produced meaningful pain reductions. Only inulin improved pain sensitivity and grip strength, the latter paralleled by increased GLP-1, and...
Oxygenated Water Boosts Cycling Performance, Study Shows
Can oxygenated water improve athletic performance? In this blog, Dr Nick Tiller and I discuss findings from a study showing oxygenated water improves cycling performance... Read here: https://t.co/buFBG5adMw https://t.co/wXVLIQ80Xl
Sports Dietitians on the New Dietary Guidelines and What Athletes Need to Know
The 2025 Dietary Guidelines for Americans overhaul the classic food pyramid, placing protein‑dense foods at the apex and pushing grain‑based carbohydrates lower. The new guidance raises recommended protein to 1.2‑1.6 g per kilogram of body weight and emphasizes whole, minimally processed...
TFL and Gluteus Medius Leverage Peaks at Joint Extremes
With a straight leg, hip abduction moment arms alter over the joint angle range of motion such that the TFL and gluteus medius have best leverages at either end. https://t.co/d43ErC08BZ
Preparing for Major Launch: Madrid Visit with Human Longevity
Visiting Madrid with Wei-Wu He, Ph.D. of Human Longevity, Inc. @humanlongevity in preparation for the https://t.co/EABj6CYOob https://t.co/5lFqyPvmLt
#599: Does Unprocessed Red Meat Increase Diabetes Risk? – Gil Carvalho, PhD MD & Mario Kratz, PhD
In a recent podcast, Dr. Mario Kratz and Dr. Gil Carvalho dissect the contentious evidence linking unprocessed red meat to type 2 diabetes and cardiovascular disease. Observational cohorts consistently show an elevated risk, yet short‑term randomized controlled trials report largely neutral...
Greek Athlete George Kotsimpos Sets New Guinness Record with 59 One‑Leg Decline Push‑Ups
Greek fitness athlete George Kotsimpos broke his own Guinness World Record by completing 59 one‑leg decline push‑ups on unstable medicine balls in a single minute, eclipsing the prior mark of 55. The feat underscores the blend of rehabilitation, scientific training...
Russian Researchers Deploy Blood and Microbiome AI to Predict Biological Age with 6-Year Accuracy
Scientists led by Anastasia A. Kobelyatskaya and Alexey Moskalev unveiled AI models that estimate biological age from routine blood tests and gut microbiome profiles with a mean absolute error of about six years. The models, validated on 637 participants, promise...
Chronotherapy Trial Shows Timing Pain Pills to Body Clock Boosts Relief
Chinese researchers publishing in Science demonstrated that administering pain medication in sync with the body's circadian rhythm markedly improves analgesic outcomes. The findings link daytime‑heightened pain sensitivity to the hypothalamic clock and explain why 85% of chronic‑pain sufferers also develop...
Oral PCSK9 Pill Slashes LDL Cholesterol by Up to 60% in Phase 3 Trial
Enlicitide, a once‑daily oral PCSK9 inhibitor, lowered LDL cholesterol by as much as 60% in a phase 3 trial of 2,909 high‑risk adults. The results, published in The New England Journal of Medicine, could shift cholesterol management from injections to...
The Woman Rewriting Modern Fitness: How Erin Romney Is Turning Science, Longevity, and Clean Living Into a New Path Forward...
Erin Romney, a former Division I athlete, has transformed her New Orleans boutique, Romney Studios, into a science‑driven wellness hub that aligns fitness with women’s hormonal cycles and life stages. She created the Romney Method, which blends strength training, Pilates, cardio, infrared...
Biohacker Bryan Johnson Reports First‑In‑Human Psilocybin Fertility Drop
Bryan Johnson, the high‑profile biohacker, disclosed a first‑in‑human observation that two doses of psilocybin reduced his sperm motility by 51% and halved sperm morphology. He argues the metabolic benefits outweigh the fertility impact, prompting discussion among longevity researchers.
Skin Regeneration Enabled by Embryonic Healing Mechanism in Mice
Harvard researchers published a Cell study showing that mouse skin can fully regenerate by reactivating an embryonic healing program that normally shuts down after birth. They identified excessive nerve growth—hyperinnervation—driven by fibroblast‑derived Cxcl12 as the key barrier to regeneration. Genetic...
Bariatric Surgery in Adolescents 'Reprograms' Kidney Biology to Promote Recovery
A multi‑institutional study in the Journal of Clinical Investigation shows that vertical sleeve gastrectomy in adolescents with type 2 diabetes and obesity triggers profound molecular reprogramming of kidney cells, leading to functional recovery. Over a 12‑month follow‑up, participants lost weight, improved...
Improving Heart Health May Not Be Enough to Protect Against Alzheimer's Disease
A randomized trial involving 480 seniors at risk for Alzheimer’s tested whether exercise, intensive vascular risk reduction, or their combination could improve cognition over two years. While participants achieved significant cardiovascular gains—blood pressure fell 13 mm Hg and LDL dropped 24 points—the...
Higher Intake of Fruits, Veggies, Legumes, Potatoes May Cut Crohn Disease Risk
A large prospective study of 341,519 adults followed for 13.4 years found that high combined intake of fruits, vegetables, legumes and potatoes cut the risk of Crohn's disease by 56 percent (adjusted hazard ratio 0.44). The same dietary pattern showed...
Episode 193: Tommy Wood and His New Book Bust the Belief that the Adult Brain Is Fixed
In Episode 193 of STEM Talk, neuroscientist Dr. Tommy Wood discusses his new book, *The Simulated Mind*, which challenges the long‑standing belief that adult brains are fixed and inevitably decline. He explains how modern research shows the brain remains plastic...
Neuroscience of Vitality and Aging Conference in Boston
The Neuroscience of Vitality and Aging (NOVA) Conference will convene on April 25, 2026 in Boston, bringing together neuroscientists, biotech entrepreneurs, policymakers, and investors for a single‑day interdisciplinary forum. Hosted by the Aging Initiative, the event aims to bridge fragmented...
Why Scientists Are Exploring Brain Cooling as a Defense Against Altitude Sickness
Scientists are investigating selective brain cooling as a proactive defense against altitude sickness, especially high‑altitude cerebral edema. Current treatments—acetazolamide, dexamethasone, supplemental oxygen—have limited efficacy and notable side effects. Cooling helmets and cervical collars can lower brain temperature by up to...
Calf Size Predicts Lifespan: Bigger Muscles, Longer Life
A simple body measurement may predict how long you live. Calf circumference. Muscle is longevity. h/t hyderabaddoctor
Marathon Running Is Booming—And So Are Questions About Its Impact on Your Heart Health
Marathon participation is surging, yet cases like Madison DiBattista’s reveal hidden cardiac risks. A rare congenital defect discovered after severe symptoms underscores how even elite‑level training can mask serious heart conditions. Studies show marathon‑related cardiac arrests are extremely rare—about 0.54...
B‑Vitamins and Minerals Power Your Mitochondrial Engine
The mitochondria are your cells' power plants⚡⚡ You need certain vitamins, minerals, and nutrients to produce energy via the mitochondrial electron transport chain (ETC) Here's an overview of the most critical ones: 🔹B-Vitamins - Vitamin B1 (Thiamine): Required for pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. -...
When Doctors Prescribe Horoscopes: The Trouble With Biological Age Tests
Consumer epigenetic "biological age" tests promise a single number that reflects a person’s true health trajectory, but they actually measure DNA methylation patterns correlated with chronological age. Research‑grade clocks can predict mortality risk, yet the kits sold to patients lack...
Rousey vs Carano: What Age Does to Strength and Performance
Ronda Rousey and Gina Carano will headline a Netflix‑broadcast MMA showdown on May 16, 2026, reigniting debate over the so‑called “over‑35 curse.” Sports‑medicine experts warn that sarcopenia, slower recovery and weaker connective tissue increase injury risk for fighters past their...
Weightlifting After 30: Your Essential Life Insurance
If you’re over 30, lifting weights is NOT optional. It’s your insurance policy for life.
Exercise
The new Huberman Lab episode is out: The Best Vitality & Health Protocols | Dr. Rhonda Patrick (@foundmyfitness) 0:00 Rhonda Patrick 2:40 Competition, Jumping Rope, Rope Flow 6:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 12:30 Cognitive & Physical Benefits of Exercise, Serotonin &...
How to Increase Your Deadlift, According to Someone Who Pulls 880 Pounds
Sam Shethar, an amateur strongman who deadlifts 880 lb, shares a step‑by‑step roadmap for lifters stuck at intermediate plateaus. He argues that flawless form—flat back, proper hip hinge—trumps raw intensity and recommends temporarily shedding weight to refine technique. Complementary movements such...
What You Need To Know About Taking Supplements As an Athlete
Athletes increasingly rely on dietary supplements to boost performance, recovery, and overall health, but product safety and efficacy vary widely. Experts advise selecting third‑party certified supplements, such as Informed Sport or NSF Certified for Sport, to ensure they are free...
Poor Sleep Increases Runner Injury Risk
Sleep profiles predict injury in runners 🩼💤 This new study profiled 425 recreational runners based on their sleep habits including… ⏰ Sleep duration ☑️ Sleep quality 🚨 Sleep problems Investigating associations with injury history, whilst controlling for factors including training volume 🔍 Results 📊 Runners were...
Targeted Therapies and Fasting Can Prevent or Reverse Major Diseases
Heart disease is 100% preventable (PCSK9 inhib). Diabetes is reversible (3 day fasts + GLP1). Cancer is preventable (3 day fasts). Dementia is preventable (high dose creatine).
Kat Matthews Prioritizes Sleep Above Training. You Should Too
British triathlete Kat Matthews secured the $200,000 Ironman Pro Series prize by pairing rigorous training with disciplined sleep habits, aiming for at least eight hours nightly. She adjusts workouts when rest falls short, a strategy echoed by fellow elite athletes...
Timing Meals Aligns Circadian Clock, Improves Diabetes & Obesity
Time-restricted eating and circadian rhythms: A new frontier in diabetes and obesity management https://t.co/XekM37KqWt https://t.co/rsB3DZytIR
Master Timing, Not Just Load, for Peak Adaptation
Two things drive adaptation: The load… and the timing of the load. Most athletes obsess over the first. The best athletes master the second.
AI and Genomics Target Aging to Combat Chronic Disease
Aging underpins most chronic diseases and remains the biggest challenge to human health. Thank you @carninci for the opportunity to present @humantechnopole on aging, genomics and AI approaches to identify longevity targets and drugs. https://t.co/ysDGHfJeY0
Daytime Napping Not Causally Linked to Brain Health
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank https://t.co/AQI9U7Mpri
Fermented Cordyceps Broth Improves Primary Insomnia in Trial
Effectiveness of fermentation broth of Cordyceps sinensis for primary insomnia: a randomized clinical trial with digital health tool https://t.co/g5iOuzkctO
Skip Late Snacks to Boost Sleep and Parasympathetic Recovery
The benefits of not eating three hours before bedtime extend beyond improving sleep; but are also harnessed in protecting the natural increase in parasympathetic activity at that time. @foundmyfitness on the Huberman Lab podcast out now https://t.co/O8b2YunpVT
Sugar: Debunking Myths Between Health Warnings and Athlete Fuel
Public discussions around “sugar” are often dominated by extreme claims, from strong health warnings to recommendations for athletes to consume sugar-rich gels and drinks. This blog examines what “sugar” actually is: https://t.co/8dQmKzXO90
Fecal pH May Predict Neurodegenerative Disease Risk
I've been saying this for the longest time, and including fecal pH in my grant applications, too I predict that we'll see a significant correlation for fecal pH with neurodegenerative diseases in future papers...
Vitamin D and Fasting Show Promise for MASLD Treatment
Therapeutic effects of vitamin D and intermittent fasting on metabolic associated steatotic liver disease in rats "These findings support their potential as complementary, non-pharmacological strategies for MASLD management and warrant further translational investigation." https://t.co/n4BtHrrcOU
Bicarbonate and Extra Calories Enhance Endurance Performance
Been experimenting with bicarb for the last year as well as seeing how extra calories impact my performance Full write up can be found on Endurance Essentials https://t.co/WLuX7VNkAv
P7C3 Boosts NAD Enzyme, Improves Mouse Alzheimer Model
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏