Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
Isomorphic Labs unveiled IsoDDE, a proprietary AI engine touted as an “AlphaFold 4”‑level breakthrough in drug discovery. The 27‑page technical report claims the model outperforms AlphaFold 3, the open‑source Boltz‑2, and traditional physics‑based methods in predicting binding affinity and antibody‑protein interactions. Researchers highlighted its ability to generalise to out‑of‑distribution compounds, a problem that has long limited AI‑driven chemistry. Unlike DeepMind’s earlier AlphaFold releases, IsoDDE’s architecture and training data remain undisclosed, sparking both excitement and concern in the scientific community.
The paper proposes exercise mimetics—pharmacological agents that imitate endurance training—as a novel class of antidepressants. While regular physical activity cuts depression risk by about 18 percent, adherence challenges limit its real‑world impact. Exercise mimetics activate muscle signaling pathways and alter the...
Materialise posted a mixed third‑quarter 2025 performance, with overall revenue slipping 3.5% year‑over‑year but the Medical segment hitting a record €33.3 million, up more than 10%. Software and Manufacturing revenues fell 7% and 17% amid macro‑economic headwinds, while operating cash flow...
Genentech’s oral BTK inhibitor fenebrutinib met its primary endpoint in the Phase III FENtrepid trial for primary progressive multiple sclerosis, showing non‑inferiority to Ocrevus and a 12% risk reduction in confirmed disability progression. The drug also delivered a 26% lower risk...
![[Therapeutics] Adaptive Deep Brain Stimulation in Parkinson's Disease](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/3742a25a994e69efcb711edfa308902b.webp)
Adaptive deep brain stimulation (aDBS) introduces real‑time modulation of stimulation amplitude by tracking subthalamic beta activity, shifting Parkinson's therapy from fixed to physiomarker‑guided. Clinical trials report superior motor improvement, reduced stimulation‑related side effects, and markedly lower energy consumption compared with...
Researchers at RCSI have created a 3‑D biomaterial implant that releases PTEN‑targeting siRNA to injured spinal cord neurons, reactivating growth pathways. The scaffold replicates spinal cord mechanical properties and delivers RNA particles directly to the lesion site, silencing the PTEN...
A new JAMDA cross‑sectional study of 9,473 freestanding nursing homes finds that higher Medicaid payment rates are linked to a greater likelihood of earning 4‑ or 5‑star overall, health‑inspection and staffing ratings on CMS’s Care Compare. Nearly 79% of facilities...
Nursing home operators are slowing mergers and acquisitions in 2026 as inflated asset prices and an aging facility stock raise concerns about long‑term sustainability. Leaders such as A.G. Rhodes, Diversicare and Focused Post‑Acute are prioritizing capital for modernization, data analytics...
Solera Health announced a new behavioral health network that links its HALO platform with Calm Health and Lyra Health. The service directs members to self‑guided apps or therapist‑led care based on their reported needs, expanding support beyond anxiety and depression...
Top officials at the Department of Health and Human Services highlighted the Trusted Exchange Framework and Common Agreement (TEFCA) as a cornerstone of the "Make America Healthy Again" (MAHA) initiative. TEFCA, mandated by the 2016 bipartisan law, seeks to create...
Macro: US vaccine-policy swing heightens regulatory risk; FDA will review Moderna’s flu shot. Key: public dispute, amended filing; decision by Aug 5. Risk: political oversight. Trade: Buy MRNA. — Viktor Kopylov, PhD, CFA More insights: t.me/si14Kopylov
FDA Commissioner Marty Makary warned that the United States is falling behind China in early‑stage drug development, citing slower Phase 1 trial volumes and cumbersome regulatory steps. He identified three primary bottlenecks—hospital contracting, ethical review processes, and the IND application workflow—that...
The Congressional Budget Office’s latest 10‑year budget outlook reveals that Medicare spending will be higher than previously projected, largely due to the Part D prescription‑drug benefit. CBO estimates the drug benefit adds several hundred billion dollars to federal outlays over the...
A pilot program in Ashford, England uses portable Fuji Xair imaging at patients' homes after falls. A radiographer and an advanced paramedic review 999 calls, travel to the scene, capture X‑rays and transmit them instantly to a hospital for interpretation....
AI‑driven medtech firms must prove tangible ROI for patients, providers and payers to move from lab to bedside. Brent Ness outlines three pillars—capital efficiency with payer alignment, rigorous evidence and reimbursement pathways, and operational scalability paired with strong IP—that determine...
The National Association of Community Health Centers (NACHC) unveiled the Center for Mobile Health, a dedicated hub to accelerate mobile health programs across community health centers. Backed by the Leon Lowenstein Foundation, Direct Relief and mobile‑vehicle firms, the Center will...
The FDA’s Center for Veterinary Medicine issued new guidance urging drugmakers to add explicit duration limits to medically important antibiotics used in food‑producing animals. Currently, about 28% of these drugs are administered continuously for approved indications, but the guidance seeks...
Senate health committee chair Bill Cassidy and 59 Republican lawmakers filed an amicus brief supporting Louisiana’s lawsuit that the FDA violated the 1870 Comstock Act by permitting telehealth prescribing of mifepristone. The brief argues the agency overstepped its authority, seeking...
SPT Labtech and BellBrook Labs announced a joint effort to automate a high‑throughput, cell‑based assay for VPS4B ATPase inhibitors, pairing BellBrook’s Transcreener® ADP2 fluorescence‑polarization assay with SPT’s dragonfly® liquid‑handling system. The miniaturized platform operates in 384‑ and 1536‑well formats and...
Researchers at Case Western Reserve University have shown that ultrasound‑activated nanobubbles can mechanically disrupt the dense collagen matrix surrounding solid tumors, creating a temporary “softening” effect that lasts several days. In a breast‑cancer model, the approach enabled deeper penetration of...
A new Lancet Neurology study of 22,410 ischemic‑stroke patients shows that door‑in‑door‑out (DIDO) times exceeding the 90‑minute guideline are tied to poorer functional outcomes and lower rates of endovascular therapy. Patients with DIDO intervals of 91‑180 minutes, 181‑270 minutes, and...
The Xtalks Life Science Podcast featured Joseph Sinkule, CEO of Klotho Neurosciences, discussing the company’s secreted α‑Klotho gene therapy platform aimed at age‑related neurodegenerative diseases such as Alzheimer’s, ALS and Parkinson’s. Klotho leverages a patented anti‑aging gene to develop cell‑ and...
Pfizer CEO Albert Bourla met with CMS Administrator Mehmet Oz to negotiate a "most‑favored‑nation" (MFN) drug pricing agreement, though the specific terms were not disclosed. Oz indicated that the Trump administration plans to codify such voluntary MFN deals into law...
Pfizer CEO Albert Bourla disclosed a direct collaboration with CMS Administrator Mehmet Oz on a "most favored nation" (MFN) drug pricing arrangement, though the specific terms remain undisclosed. Oz indicated that the Trump administration intends to codify such voluntary MFN...
University of Waterloo researchers demonstrated that weak magnetic fields and isotopic substitution can alter the structure of cellular proteins, specifically tubulin polymerization, in a quantum‑consistent manner. Published in Science Advances, the study bridges structural biology, biophysics, and quantum biology, revealing...
The FDA has rejected a pediatric myopia drug, citing a lack of substantial evidence for its efficacy. Pediatric ophthalmologists argue the drug, already used in compounded form, effectively slows myopia progression in children. The decision follows a series of recent,...
PeaceHealth announced a systemwide reduction of 94 positions, affecting less than 1% of its Washington workforce and including hospice staff, nurse practitioners, and administrative roles. The cuts trigger Washington's WARN Act, requiring a 60‑day notice before mass layoffs. This is...
Orthopedic surgery is rapidly adopting AI, robotic assistance, VR/AR and wearable digital tools, shifting from experimental concepts to routine practice. AI now supports imaging interpretation, predictive risk modeling, personalized surgical planning, training simulations and remote postoperative monitoring. Robotic platforms improve...
Psychiatrist Courtney Markham‑Abedi describes personal experiences of moral injury triggered by caring for vulnerable patients and the killing of immigrant activist Renee Good. She expands the concept of moral injury, originally defined for veterans, to healthcare workers, coining it as...
The U.S. Food and Drug Administration has reversed its earlier decision to decline a review of Moderna's mRNA influenza vaccine candidate. Following a Type A meeting with the company, the agency set an August 5, 2026 deadline for completing its evaluation. The...
Researchers have engineered a wet‑adhesion Janus hydrogel (WAJH) that mimics oral mucosa to treat diabetic oral ulcers. The hydrogel features an antifouling agar/polyacrylamide layer and a tannic‑acid‑rich adhesive layer, delivering adhesion energies of 15 J m⁻² and 316 J m⁻² respectively. Its antioxidant tannic...
It can take decades for new medical research to change what happens in the exam room. AI is going to massively accelerate this process. The dissemination of medical research into clinical practice is not slow because the science is slow. It...
It's 2026, so... I just wrote a Claude Skill that faxes a request form to my healthcare provider.
Dr. Jay Bhattacharya, the current NIH director, has been named acting director of the CDC, a role he will hold while continuing to lead the National Institutes of Health. He replaces Jim O’Neill, who is slated for a nomination to...
AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses today @Nature https://t.co/ZI3F2pkMxE https://t.co/WsUcRjkHFN https://t.co/mdz1DM6xs7
We're wrapping up the fact checking process for our annual Top 100 biotech VCs list and prepping for our companion webinar on VC investing in 2026. If this is a topic near and dear to your heart, be sure to...
The FDA and UTMB are hosting a free, week‑long training course on data quality and integrity for BSL‑4 laboratories from July 28 to August 1, 2025, with in‑person seats in Manhattan, Kansas and a virtual option. The curriculum covers GLP requirements, Animal Rule...
Researchers discovered that elevated circulating APOE in older mice suppresses bone regeneration by inhibiting osteoblast differentiation. Liver‑specific knockout of APOE or a single dose of a neutralizing antibody lowered serum APOE, restored Wnt/β‑catenin signaling, and markedly improved fracture callus density...
FDA chief Marty Makary says 'everything should be over the counter' unless drug is unsafe or addictive https://t.co/HiYBuxvyWC
North Country Healthcare, an alliance of three critical‑access hospitals in New Hampshire, launched the staff‑driven "Lines and Drains" project using its Meditech Expanse EHR to standardize catheter documentation and create real‑time performance dashboards. By redesigning workflows, linking orders to worklists,...
The NewCo model, where Asian biotech assets are spun out into Western start‑ups backed by Western capital, surged in 2025 with 13 new companies—more than double the six disclosed in 2024. Early 2026 already sees three additional launches, including Kidswell...
VCU Health, Virginia’s first hospital‑at‑home (HaH) provider, is showcasing its digital‑health journey at HIMSS 2026. Director David Collins will detail how lessons from the adult HaH and remote patient monitoring (RPM) programs shaped a governance framework for a new NICU RPM...
Upcoming meeting of federal vaccine panel may be postponed after HHS missed deadlines https://t.co/zfAl7owoQg via @statnews
Frist Cressey Ventures closed an oversubscribed $425 million Fund IV, lifting its assets under management close to $1 billion. The new fund zeroes in on early‑stage, AI‑native healthcare companies that can reshape care delivery. Strategic limited partners such as Cigna, MedStar Health and...
Parkland Center for Clinical Innovation is piloting an AI‑driven predictive tool that scores inpatient threat levels using EHR data, social determinants and real‑time updates, alerting clinicians through the electronic health record. The system gives staff early awareness of potentially violent...
The FDA has reversed its earlier refusal and will now evaluate Moderna’s mRNA‑1010 seasonal flu vaccine using a two‑track approach: a full Biologics License Application review for adults 50‑64 and an accelerated approval pathway for those 65 and older, contingent...
The unfounded move by @HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today @Nature Adds to successful pancreatic, renal cell, melanoma reports...
We could prevent diseases so much better but we haven't learned to listen to when biology whispers long (10 + years) in advance. A key theme in Super Agers, too. https://t.co/0pSap3f32N @NathanPriceSci @ @nrappapo @BuckInstitute example below for Type 2...
Aceclidine (Vizz®) received FDA approval in 2025 as an ophthalmic solution for presbyopia, targeting age‑related near‑vision loss. The drug acts as a pupil‑selective muscarinic agonist, inducing miosis without significant ciliary muscle activity, thereby enhancing depth of focus through a pinhole...
Another good use case for agentic AI in medicine: diagnosis of rare diseases. Exemplified by DeepRare https://t.co/XBd68V3iDl https://t.co/rBl5yn95sI
