What's happening: FDA places Regeneron's anti‑activin A antibody garetosmab under priority review
The agency has granted priority review to Regeneron's garetosmab for the rare disease fibrodysplasia ossificans progressiva, with a decision expected by August. Phase 3 OPTIMA results showed a 94% reduction in new heterotopic ossification lesions at the lower dose and a 90% reduction at the higher dose, alongside a >99% drop in lesion volume.
Also developing:

The U.S. Department of Health and Human Services has issued a December proposed rule to overhaul the Transparency in Coverage (TiC) machine‑readable files, with implementation slated for 2027. The rule would filter out payment rates that never apply to a provider, consolidate pricing to a single rate per provider network, and add provider reference sub‑files that group clinicians by NPI. It also shifts updates from monthly to quarterly to better synchronize payer data with hospital price‑transparency files. These changes aim to shrink file size, improve data quality, and make the files actionable for negotiations.
For the Nancy Guthrie case, an idea and maybe a crazy one but she had a pacemaker which often implantable devices use bluetooth such as Medtronic's. Couldn't you war-drive (drones even better) with a high gain antenna with amplifiers -...

The U.S. National Institute of Allergy and Infectious Diseases (NIAID) is stripping references to "biodefense" and "pandemic preparedness" from its website and will de‑prioritise related research. About a third of its $6.6 billion budget, roughly $2.2 billion, currently funds emerging‑pathogen and biodefense...

Seven Democratic senators reintroduced the Nurses Belong in Nursing Homes Act to restore federal staffing standards that were struck down by courts. The bill would require a registered nurse on site 24/7 and a minimum of 3.5 care hours per...

On Feb 12, HHS announced that health insurers covering roughly 165 million Americans have pledged to implement digital‑health reimbursement models modeled on CMS’s ACCESS program by Jan 1 2028. The ACCESS model adjusts payments based on measurable patient‑outcome impact, shifting from volume‑based to value‑based...

A multi‑drug‑resistant tuberculosis (MDR‑TB) ward in northern Cameroon continues to confine patients like Asta Djouma for months, despite World Health Organization guidelines that deem long‑term isolation obsolete. The government mandates hospitalization until patients test negative, separating them from families and...

The Centers for Disease Control and Prevention and the National Institutes of Health announced a new performance‑review framework that links lower ratings to easier termination. The policy reclassifies a swath of federal staff into a category with reduced civil‑service protections,...
The EPCORE NHL‑1 trial released three‑year data showing that epcoritamab (Epkinly) delivers deep, durable remissions in heavily pre‑treated large B‑cell lymphoma. Among patients who achieved a complete response, 53% remained progression‑free at the data cutoff, with a median CR duration...

A recent Chinese study finds surgery slightly more cost‑effective than radiotherapy for esophageal squamous cell carcinoma (ESCC). Using a TreeAge Pro Markov model on 196 real‑world patients, surgery delivered longer median overall survival (41.3 vs 30.4 months) and higher quality‑adjusted life...

The Identity Theft Resource Center’s 2025 Data Breach Report reveals a 79 % surge in U.S. data compromises, with 534 incidents targeting health‑care providers. Private‑practice physicians face precise, AI‑driven attacks that exploit patient records and vendor relationships. Transparency in breach notifications...
For my book Allergic, I went to Cincinnati Children's Hospital and talked to asthma experts that vehemently argued otherwise...with decades of data behind them. Young (and old) lungs especially need the cleanest air we can manage. This is one of the...

The phase III LAIS trial showed that loberamisal, a novel neuroprotectant, raised the proportion of acute ischemic‑stroke patients achieving an excellent functional outcome (mRS 0‑1) to 69.7% versus 56.4% with placebo when given within 48 hours of symptom onset. The study enrolled 997...

A bipartisan group of 100 lawmakers, led by Reps. Yvette Clarke and Michael Lawler, sent a letter to the Department of Homeland Security urging an exemption from the $100,000 H‑1B filing fee for health‑care workers. The request is backed by...

The Administration for Strategic Preparedness and Response (ASPR) has unveiled a $100 million Small Molecule Approaches for Rapid and Robust Treatment Prize to spur antiviral drug development. The competition targets viruses in the Togaviridae and Flaviviridae families, including dengue, Zika, West...

Kainova Therapeutics announced a CAD 32 million first close of its Series B financing, led by Investissement Québec and supported by existing backers. The funding brings total venture capital to about $90 million USD and will accelerate development of its GPCR‑focused drug candidates. Lead...

Riley Children’s Health’s pediatric palliative care department launched a bereavement program that uses memory‑making and legacy projects to support families after a child’s death. The initiative, developed with input from clinicians and bereaved parents, aims to create a scalable model...

The American Hospital Association hosted a webinar during its 2026 Rural Health Care Leadership Conference to guide rural providers through available grant programs. Speakers including AHA EVP Michelle Hood and Sanford Health CEO Bill Gassen highlighted practical funding strategies and...

The Centers for Disease Control and Prevention abruptly cancelled multi‑year public‑health grants that had already been awarded to jurisdictions in Democratic‑led states. The rescinded funding includes Public Health Infrastructure Grants and programs targeting HIV and other sexually transmitted infections. The...

The medical referral process is plagued by delays, miscommunication, and inappropriate specialist assignments, causing many patients to fall through the cracks. Studies show up to half of specialty referrals are never completed and over a third do not match the...

Telepsychiatry startup Talkiatry closed a $210 million Series D round, bringing total capital raised above $400 million. The funding, led by Perceptive Advisors with participation from Andreessen Horowitz and others, will support scaling its virtual psychiatry platform, which currently employs over 800 psychiatrists...

A Michigan hospital, likely McLaren Northern Michigan, is accused by internet personality Josh Clarke of allowing staff to view his medical records, take selfies in his treatment area, and conceal his presence on a notice board. Clarke’s video alleges that...

Amazon Pharmacy announced a same‑day delivery rollout to nearly 4,500 cities by 2026, adding roughly 2,000 new communities including Idaho and Massachusetts. The expansion leverages Amazon’s logistics network, Prime discounts and One Medical kiosks that let Los Angeles patients pick up...

The White House plans to rescind the 2009 EPA endangerment finding, removing federal authority to regulate carbon dioxide and other greenhouse gases. The article argues that this deregulation will shift health costs to disadvantaged communities, citing decades of research linking...

BioCentury’s editorial warns that the current director of the FDA’s Center for Biologics Evaluation and Research (CBER) is jeopardizing patient safety and destabilizing the pharmaceutical industry. The author cites the director’s handling of Moderna’s flu vaccine as a recent example...

The 2025 LeadingAge Annual Meeting highlighted the need to involve older adults directly in testing and adopting new care technologies. Louisville’s Thrive Center, partnered with CDW Healthcare and Asbury Communities, provides a functional smart‑home lab where seniors can trial solutions...
It would be highly instructive to read the pembrolizumab paper highlighted by @DrPatrick. Of course, he doesn't expect anyone to do that. This is what it says IN THE FIRST PARAGRAPH: The FDA approved pembrolizumab on May 23, 2017, for...

The National Institutes of Health announced it will not renew Linsey Criswell's term as director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Criswell's departure creates another open director position amid a growing list of leadership...

Physician wellness initiatives—pizza parties, mindfulness apps, and burnout surveys—are increasingly seen as superficial "wellness theater" that fail to address the structural drivers of physician distress. The article argues that burnout is better understood as moral injury arising from time pressure,...

Cognibotics is providing the motion‑control layer for the Vinnova‑funded CAISA project, linking AI perception and path‑planning modules in a paediatric heart‑surgery testbed. The collaboration, involving Region Skåne, Lund University and Cobotic, moves into a demonstrator phase using a 350 m² simulated...

Alrajhi Medicine, a Saudi private healthcare network, has chosen Oracle to replace its legacy clinical and enterprise systems with Oracle Health Foundation electronic health record (EHR) and Oracle Fusion Cloud Applications. The unified cloud platform will integrate patient records, finance,...

A new Health Affairs study of nearly 13,000 trauma patients shows that even insured Americans face sharp rises in medical debt and bankruptcy after serious injuries. Within 18 months, the share of patients with debt in collections grew 5.2 percentage...

The Senate Health Committee has subpoenaed Apexus, a for‑profit Texas firm that administers the federal 340B drug‑price program, to explain its earnings and business practices. Apexus reportedly generated $227 million in revenue in 2022 with profit margins above 80 percent, despite the...
.@tryprana is an AI primary doctor in your pocket that monitors you 24/7. Connect your wearables to your medical records to monitor for clinical drift. At any moment, you can instantly bring a Board-Certified MD into the chat to review your...

Seres Therapeutics, a cash‑strapped microbiome drug developer, will cut about 30 % of its workforce and suspend its lead program SER‑155, which targets graft‑versus‑host disease. The company will redirect resources toward earlier‑stage immunology candidates such as SER‑603, aiming to extend its...

Our latest paper appeared today as a cover (inside front) feature article in Advanced Functional Materials, titled “A Bioresorbable Neural Interface for On-Demand Thermal Pain Block.” The focus is on a bioresorbable, implantable form of neural electronics that supports precisely...
Earnings roundup: Neurocrine slumps, Alnylam battles skeptics and Ascendis eyes a competitor https://t.co/kU1ex80A24 by @realJacobBell $NBIX - 10% $ALNY - 4% $ASND - 2% $BBIO #biotech

Penn State researchers unveiled ZENN, a zentropy‑embedded neural network that fuses thermodynamic entropy and a data "temperature" parameter to weigh heterogeneous inputs. By separating signal energy from intrinsic noise, ZENN achieves markedly higher prediction fidelity, demonstrated by a 90% accuracy...

#TEFCA, America’s National Interoperability Network, Reaches Nearly 500 Million Health Records Exchanged as @HHSGov + @HHS_TechPolicy Leverages #Technology and #AI to Lower Costs and Reduce Burden #ASTP2026 https://t.co/0iBnnjnNR3 https://t.co/oFI2brZmfq
“Yes, the rest of the world can maintain a market for vaccines. But will it be as innovative and as vibrant as it has been? That’s a different question.” https://t.co/jB38FWfglo

Intuition Robotics’ ElliQ, a voice‑activated AI companion, is forging genuine relationships with seniors living alone, delivering up to 30 daily conversations. In New York, users who kept the robot for a month reported a 95% drop in loneliness, with many describing...
Seres to lay off staff, pause top program in latest reboot https://t.co/yJRtypSN3d by @Lilah_Alvarado $MCRB - 37%

Anterior, a clinician‑led AI platform for health insurers, closed a $40 million financing round, raising its total capital to $64 million with investors including NEA and Sequoia. The company differentiates itself through a “Forward Deployed Clinician” model that embeds medical professionals alongside...

Cracking the case: how did adenoviral vector vaccine such as the J&J's Covid induce very rare and potentially fatal clotting, bleeding? An elegant proof of molecular mimicry—genetic background + rogue antibodies https://t.co/yp6TNE8ZQC https://t.co/NhhYDvntmT @rkhamsi @TheAtlantic https://t.co/xY7f6MVkx9 @kakape @GretchenVogel1 @ScienceMagazine
Sanofi, looking for more ‘rigor,’ swaps CEO Hudson for ex-Merck KGaA chief Garijo https://t.co/SDLUYOzPuD by Kristin Jensen $SNY - 4% $MKKGY

Maven Clinic and Color Health have launched a joint oncofertility program that integrates virtual cancer care with a family‑building platform. The partnership targets the roughly 80,000 U.S. young‑adult cancer diagnoses each year, where fewer than half of patients receive fertility‑preservation...

Antimicrobial resistance (AMR) is now a global health emergency, with the WHO noting up to one‑in‑five infections in parts of Africa are drug‑resistant. While antibiotic misuse is visible, the deeper drivers are social: poverty, overcrowding, and limited clean water fuel...

Keragon has launched an AI‑powered automation platform that links more than 300 healthcare applications through conversational, no‑code prompts while maintaining HIPAA compliance. The solution lets clinical and operations staff design and deploy workflows in minutes, eliminating the traditional reliance on...

Ambience Healthcare introduced “Chart Awareness,” an AI capability that reads a patient’s full longitudinal record—including labs, imaging and prior notes—to generate richer clinical summaries. The update adds chart‑aware patient summaries, auto‑extracted diagnostic trends, and coding assistance that can substantiate complex...

Resident doctors in Scotland have overwhelmingly approved a revised pay offer, with 97.1% voting in favour and a 62.4% turnout, averting planned strike action. The British Medical Association secured a deal that provides a 4.25% pay rise for 2025‑26 and...
Bringing the innovative capabilities of @OracleHealth Clinical AI Agent to the NHS and throughout the UK underscores our commitment to empowering doctors to deliver exceptional care. By embedding advanced AI-powered capabilities into clinician workflows, we can tackle some of the region's biggest healthcare...