Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
Chinese researchers at Shandong University have engineered the probiotic strain Escherichia coli Nissle 1917 to synthesize and deliver the anticancer drug Romidepsin directly within breast‑tumor tissue in mice. The bacteria colonized the tumors, releasing the drug locally and achieving tumor‑inhibiting effects comparable to, or better than, conventional dosing while reducing systemic toxicity. Four engineered strains matched the efficacy of the drug, and one outperformed it with lower side effects. The study, published in PLOS Biology, highlights a potential live‑vector strategy for targeted solid‑tumor therapy, though human trials remain pending.
When I was at the Brigham/Harvard I saw how we billed different insurance levels as well as the uninsured. The uninsured got screwed the worst. Always. Different payers pay remarkably different prices for the identical things. It all comes down...
Cancer survivorship is increasingly recognized, yet cognitive impairment—often called "brain fog"—remains invisible in most oncology workflows. Studies show up to 75% of patients experience cognitive changes during treatment, with roughly 35% continuing months or years afterward. The gap stems from...
President Trump’s TrumpRx website claims to offer the world’s lowest prescription‑drug prices, but a New York Times analysis finds the opposite. The site lists only a few dozen negotiated U.S. prices, omitting widely used drugs such as statins and many high‑cost cancer...
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Lexapro (escitalopram) is a widely used SSRI that commonly triggers mild side effects such as nausea, insomnia, and headaches during the first week of treatment. Most of these effects diminish after one to two weeks, but patients are advised not...
A study published in Gastroenterology demonstrates that stress during early life rewires gut‑brain pathways, increasing the risk of chronic digestive disorders. Mouse experiments showed sex‑specific motility changes and identified separate neural, hormonal, and serotonin mechanisms. Large human cohorts—over 40,000 Danish...
The U.S. National Institutes of Health announced a pivot away from agency‑directed solicitation calls toward a greater reliance on unsolicited research proposals, a change unveiled in Bethesda, Maryland. The shift, made under the agency’s new leadership following the 2025 presidential...
On March 18, 2026, White House officials—including two former Trump administration aides—intensified a campaign to pass legislation that would lock U.S. drug prices to the lowest rates paid by peer nations. The push, aimed at lowering costs for patients, met...
The Centers for Medicare & Medicaid Services (CMS) announced on March 16 that it will transition to a secure, centralized independent dispute resolution (IDR) gateway for Medicare payment and coverage disputes in the second half of 2026. The new platform...
How about we ask @govofco how much more reinsurance is costing Colorado? And don’t give me the bs talking points about the average premium reduction, babes.
Yesterday one of my co-conspirators messaged to let me know that over 7k pregnant people and 20k children have health coverage because of the policy we passed years ago…Cover All Coloradans I have so many feelings that I can’t fully figure...
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Hydrocodone remains the most prescribed opioid in the U.S., with 83.6 million prescriptions in 2017 and 6.3 million misusers. Withdrawal typically starts 8–24 hours after the last dose, peaks on days two to three, and subsides within a week for most patients. Symptoms...
Fraser Health has deployed an artificial‑intelligence tool within its Meditech Expanse platform to automate discharge summary creation. The pilot, involving roughly 60 clinicians, cut average drafting time from 12.5 minutes to 5.5 minutes per patient. Users report the draft‑and‑review workflow...
OpenText unveiled its AI‑powered Fax Aviator at HIMSS, aiming to modernize healthcare fax workflows. The solution claims up to 85% labor savings by automating extraction, classification, and routing, and can process 2‑3 times more faxes without additional staff. Features such...
Health Secretary Wes Streeting’s NHS digital transformation faces warnings of nurse burnout. A Society of Occupational Medicine study of 339 nurses found digital technology stress significantly drives emotional exhaustion and burnout. While AI and digital tools can improve disease management...
An Italian neuroimaging study of 260 inpatients found that adverse childhood experiences (ACEs) are associated with poorer white‑matter integrity, especially in patients with bipolar disorder. In bipolar patients, higher exposure to physical abuse, emotional abuse, and neglect correlated with widespread...
Inspire Medical Systems reported a 12% rise in fourth‑quarter revenue to $269 million and a 14% increase for the full year, reaching $912 million, driven by both existing and new center growth. The company widened its 2026 revenue outlook to $950‑$1 billion, reflecting...
Zymeworks reported Q4 2025 revenue of $106 million, up from $76.3 million, while net loss narrowed to $81.1 million as operating expenses fell. The company highlighted Phase III zanidatumab data showing median PFS over one year and overall survival beyond two years in first‑line...
West Pharmaceutical reported Q4 2025 revenue of $850 million, up 7.5% reported and 3.3% organically, pushing full‑year net sales past $3 billion with 4% organic growth. Adjusted EPS rose 12% to $2.04 and free cash flow surged 70% to $469 million for the...
The Scottish Parliament rejected the Assisted Dying for Terminally Ill Adults Bill, voting 57 to 69 against it. The legislation would have made Scotland the first UK nation to legalise assisted dying, featuring strict safeguards such as dual‑doctor certification and...
No evidence that medicinal cannabis effectively treats anxiety, depression, or PTSD - according to the largest review of cannabinoids ever conducted.
PACS Group reported a $5.29 billion revenue in 2025, marking almost 30% year‑over‑year growth and expanding to 323 facilities in 17 states. CEO Jason Murray said the internal billing investigation is closed, while a federal probe continues without adding new risks....
The U.S. Federal Trade Commission announced it is closely monitoring how pharmaceutical companies respond to the upcoming patent cliff affecting numerous blockbuster drugs. FTC antitrust director Dan Guarnera said the agency’s “laser focus” on healthcare will target any anticompetitive conduct...
Unionization in U.S. nursing homes has altered staffing mixes without affecting overall care quality. Six years after a union vote, facilities added 0.34 LPN hours per resident day (4.2 % increase) while RN hours dropped 0.041 per resident day (9.1 % decline),...
Zymeworks will present Phase 1 data on its folate‑receptor‑alpha ADC ZW191 and preclinical results for a novel pan‑RAS inhibitor ADC platform at the AACR Annual Meeting. The oral presentation will detail dose‑escalation safety and efficacy in advanced solid tumours, while...
ORIC Pharmaceuticals announced that two preclinical abstracts on its PRC2‑targeting agent rinzimetostat (ORIC‑944) have been accepted for poster presentation at the 2026 AACR Annual Meeting. The data show rinzimetostat, an allosteric EED inhibitor, maintains potency against EZH1‑overexpressing complexes and key...
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On 17 March the National Health Laboratory Service (NHLS) in South Africa lost access to its TrakCare information system after a power outage at its Johannesburg head office, revealing the absence of backup power. NHLS provides diagnostic pathology for over 80 %...
The Centers for Medicare & Medicaid Services issued guidance allowing insurers to reallocate unspent Section 1303 segregated abortion premiums to general revenue after the coverage year ends. This ends years of accumulated “abortion funds,” which analysts estimate could total between...
Sutter Health and Allina Health have signed a Letter of Intent to merge, creating a nonprofit system that spans Northern California, Minnesota and Wisconsin. The combined entity will include 39 hospitals, over 400 care sites, 18,000 physicians and 88,000 staff,...
Hospice providers face a turbulent 2026 outlook as regulatory scrutiny intensifies, staffing shortages deepen, and demand for end‑of‑life care surges. CMS has placed Georgia, Ohio, Arizona, California, Nevada and Texas under enhanced oversight to combat fraud, casting a shadow over...
A BMJ study of more than 600,000 Veterans Affairs patients with type‑2 diabetes found that glucagon‑like peptide‑1 (GLP‑1) drugs significantly lowered the risk of developing substance‑use disorders, including alcohol, cannabis, nicotine, cocaine and opioids. The analysis compared GLP‑1 therapy with...
A new analysis of the Multi‑Ethnic Study of Atherosclerosis (MESA) links each additional daily serving of ultra‑processed food to a 5.1% rise in incident cardiovascular disease (CVD). Participants in the highest consumption quintile faced a 66% higher CVD risk compared...
On March 17, 2026, House members introduced the bipartisan Physicians and the Healthcare Workforce Act, which would waive the $100,000 H‑1B filing fee imposed on foreign‑trained health‑care workers by a 2025 presidential proclamation. The legislation also bars any new H‑1B...
The American Hospital Association (AHA) placed an advertorial in The Wall Street Journal on March 17, emphasizing that hospitals are the heart of U.S. communities because they deliver care whenever and wherever needed. The piece outlines current challenges—rising costs, system complexity,...
So it's time for an update on me playing around with Retatrutide. This is typed from mobile, so forgive any typos or missing words. First, I stopped using it about 2 weeks after post below. I didn't run out. I'm just...
Parents in England are scrambling to secure meningitis vaccinations for their children after a deadly outbreak in Kent that has claimed two lives and left 13 seriously ill. The surge in demand has exhausted vaccine inventories, leaving many pharmacies unable...
Our bottleneck for some of the biggest change ahead may be humans. I shared the story of Paul Conyngham and his dog Rosie on my Instagram when it broke. When I read the coverage, my shock was less that ChatGPT...
Inclined infant sleepers were banned in the United States in 2019 after the Consumer Product Safety Commission recalled millions of units following multiple infant deaths. A March 2026 study in Pediatrics found that 51 infants died in these products between...
Researchers at Worcester Polytechnic Institute created a machine‑learning model that scans MRI images and achieved 92.87% accuracy in distinguishing Alzheimer’s disease or mild cognitive impairment from healthy brains. The algorithm highlighted volume loss in the hippocampus, amygdala and entorhinal cortex...
An individual with mid‑range testosterone (488 ng/dL) plans a TRT protocol of 160 mg testosterone cypionate split twice weekly and 50 IU hCG weekly. They seek guidance on expected physiological changes, timeline, potential side effects such as hair loss, and whether the hCG...
A NIH‑backed multicenter trial of 140 pregnant adults found that weekly injectable extended‑release buprenorphine achieved significantly higher rates of illicit opioid abstinence than daily sublingual buprenorphine, while also reducing serious maternal adverse events. The study, published in JAMA Internal Medicine,...
Healthcare technology is accelerating, but clinicians’ trust remains the linchpin for successful deployment. Senior Executive Changemaker Awardee Kassaundra McKnight-Young stresses that vendors must partner closely with clinicians to build reliable, workflow‑friendly tools. Such collaboration aims to streamline clinical processes and...
Kassaundra McKnight‑Young, Chief Nursing Informatics Officer at Zebra Technologies, urges emerging healthcare leaders to partner directly with bedside clinicians. She stresses that understanding clinicians’ day‑to‑day technology needs is essential for creating people‑centered solutions. By listening to care teams, leaders can design...
In France, women who give birth are routinely prescribed pelvic floor rehab. They get about 10 sessions with a physiotherapist covered by the government. This has been standard since the 1980s. In the US, you get a 6 week...
BEING WITH DYING: Professional Training Program for Clinicians in Compassionate Care of the Seriously Ill and Dying (In Person 2026) May 8-15 50 CME's for clinicians https://t.co/nt2OWCudf6
Kern County Public Health has deployed a new AI‑enabled, five‑lead portable electrocardiogram that delivers 12‑lead diagnostics to EMTs. Within weeks of the Feb. 1 rollout, Hall Ambulance EMTs used the device to identify a myocardial infarction in a home patient, enabling...
Cigarette smoking in the US falls below 10% of the population for the first time. https://t.co/JReSJgZA85
Hospital of the Future — Advancing smart, connected care through data-driven innovation. Join me for a deep @DigitalDHealth dive with @StephenKonya @jconleymd, Manish Ladha, and Casey Granak This Thursday at 10am PST / 1pm EST for our https://t.co/YGpenFx8zW Studio Series Register here-->...
This week's Editor's Choice highlights a study by Valette and colleagues that evaluates a feedback system to improve gait and perception when using a knee prosthesis. @rlvalette Learn more in Science #Robotics: https://t.co/pWQ3r6aGLs https://t.co/xqUZp2YyCH
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY
