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Tristan Maurer’s Flash Talk framed dose as the definitive multiparametric optimization (MPO) endpoint for small‑molecule drug design. He argued that dose integrates exposure, pharmacology, and mechanism‑driven effects, making it the linchpin for balancing potency, ADME, and safety. The presentation highlighted how accurate dose prediction can accelerate lead‑optimization cycles and improve projected clinical performance. Maurer also outlined technical and workflow challenges that must be overcome to embed dose modeling into discovery pipelines.
Spring style take: Knit polos have been getting all the attention the last couple of years—I think it’s time we all remember that the humble piqué polo is truly peak I wrote about the one that’s clearly the best of all...
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Denim shirts are being repositioned as a versatile spring staple, thanks to celebrity stylists and designers highlighting their transitional appeal. The article offers ten expert‑approved styling hacks, from pairing oversized shirts with mini skirts and boots to integrating them into...
Project Hail Mary opened with $33.1 million on Friday, including $12 million from pre‑release previews, marking one of the biggest opening days ever for a live‑action film that isn’t tied to an existing franchise. The Ryan Gosling‑led sci‑fi epic earned $190 million worldwide, outperforming...
The post argues that discipline falters when energy is mismanaged, not due to lack of willpower. It explains that the brain’s limited regulatory resources are depleted by repeated decisions, self‑control, and task switching. By simplifying environments, setting clear start times,...
The key to Norway's sporting success?� "It takes everything we do in the US and does the opposite. We treat child athletes like budding professionals, prodigies train like the pros they look up to. In Norway, they let kids be...
The article introduces Part 1 of a two‑part series that decodes the terminology used in Publishers Marketplace deal announcements. It explains how writers can interpret sales figures, co‑agented deals, international rights, pre‑empts, exclusives, and multi‑book agreements to gauge an agent’s performance....
A top wellness specialist explained how daily cold exposure can improve stress resilience, boost energy, and support overall health. The interview offers actionable tips for integrating cold therapy into everyday routines.
A partial shutdown of the U.S. government has caused extended TSA security queues and widespread flight delays, disrupting travel plans nationwide. While the exact magnitude of the impact was not disclosed, the slowdown highlights the vulnerability of airport operations to...
NASA moved its Space Launch System rocket from the Vehicle Assembly Building to Launch Pad 39B on Friday night, clearing the way for a possible April 1 launch of Artemis II. The rollout follows months of repairs to hydrogen and helium systems...
Employees across the U.S., Australia and the U.K. are embracing microshifting, short‑duration work bursts, and other low‑effort habits to counter rising burnout and the mental strain of constant AI‑driven idea generation. The trend reflects a broader push for autonomy, mental‑health...
Florida state officials tested 24 infant formula products and identified elevated mercury and other heavy metals in 16 of them. The findings have prompted calls for recalls, tighter regulation, and heightened consumer vigilance across the U.S. baby‑nutrition market.
A mother wrote to Slate’s Care and Feeding column describing how her husband Brad called their 9‑year‑old son Wade a “pussy” and a “disappointment.” The columnist responded that such language signals danger to the child and recommended therapy and possible...
The Maine Legislature will decide whether to renew the Land for Maine’s Future (LMF) program, a voter‑approved conservation effort that has safeguarded more than 650,000 acres. Lawmakers face a budget showdown as the state balances conservation funding with other fiscal...
Writer‑director Luchina Fisher’s documentary ‘The Dads’ premiered this week, profiling a cross‑section of American fathers as they navigate supporting their transgender and non‑binary children. The film blends personal stories with a broader look at the cultural and political pressures surrounding...
After the 2019 Kincade Fire destroyed their off‑grid residence, a Healdsburg couple rebuilt a contemporary home wrapped in fire‑resistant corten steel, equipped with deck sprinklers and a retention pond that captures 100% of stormwater. The project, designed with Faulkner Architects,...
Leading humanitarian NGOs announced a coordinated rebranding that replaces “mercy” with “motivation” in their communications, aiming to empower aid recipients. The move reflects on‑the‑ground experiences of workers like Harerimana Ismail and broader solidarity campaigns such as Cuba’s Nuestra América convoy.
Margot Robbie’s Papa Salt gin, launched in Australia in 2023 and expanded to the UK in 2024, is being rejected by several British bars because its botanical blend includes oyster shell, raising shellfish allergy concerns. The backlash has forced the...
Fitbit has integrated Google’s Gemini‑based ‘Coach’ AI into its app, extending personalized health insights to Android and iOS users. The rollout coincides with a mandatory migration to Google accounts by May 19, 2026, igniting a debate over how medical data...
Swedish biotech Atrogi has dosed the first participants in an 8‑week, first‑in‑human trial of its oral candidate ATR-258, a drug designed to promote fat loss while preserving lean muscle. The study, led by Associate Professor Morten Hostrup, targets overweight male...
Goop announced a new line of revealing, high‑slit dresses, directly leveraging the viral reaction to Gwyneth Paltrow's Armani Privé gown at the 98th Academy Awards. The move signals a swift brand‑level response to a controversy that split public opinion on...
Venice mayor Luigi Brugnaro announced that the city will close Russia's national pavilion at the 2026 Biennale if it is used for propaganda, a warning that pits cultural diplomacy against political pressure. The statement comes as the EU threatens funding...
Nick Offerman has been cast as the voice of Mr. Fish in the animated adaptation of Deborah Diesen’s bestselling ‘Pout‑Pout Fish’ books, which opens in U.S. theaters on March 20. The film brings together a star‑studded cast and an international...
On February 25, 1984, Van Halen’s synth‑driven anthem "Jump" surged to No. 1 on the Billboard Hot 100, holding the summit for five consecutive weeks. The track marked the band’s only chart‑topping single despite a catalog of enduring rock classics. Decades later, the...
Chris Barnes explained that former Cannibal Corpse bandmates view his presence as a threat, which is why they would not share the stage with him or guitarist Jack Owen. After being dismissed in 1995, Barnes founded Six Feet Under, describing it as...
Fit people don't do diets. Eating healthy isn't hard for them. It's automatic. Their body craves it. They don't avoid junk food because they love kale. They hate the way it makes them feel. Diets expire. A fit person's lifestyle...
Physical therapist Tom Dalonzo‑Baker announces a free live webinar on March 24 targeting chronic back pain. He argues that back discomfort is a symptom of deeper musculoskeletal issues rather than a spinal problem. The session promises actionable insights without surgery, medication,...
So two things quick: one of the most important things a writer has is a voice. A voice is honed, developed over time. AI can rob you of your voice because by design it's generic. Whatever is uniquely you is...
On March 7, 2026 the Bay Area Book Festival hosted a live conversation with actor‑musician Daveed Diggs about the 50th‑anniversary edition of Greil Marcus’s *Mystery Train*. The discussion was recorded and the full video is now publicly available online. The commemorative edition,...
Generative AI is rapidly entering core business functions, promising massive economic gains. Analysts estimate it could add almost $7 trillion to global GDP and boost productivity by 1.5 percentage points over ten years. Adoption is soaring, with over one‑third of firms already...
Entrepreneurs increasingly face high‑stakes speaking opportunities that can turn a single 45‑minute slot into a credibility shortcut. The article argues that intentional preparation is the key to moving from a nervous flub to a memorable, brand‑building performance. By mastering structure,...
Italian race car maker Dallara unveiled the Monoposto Stradale, a street‑legal, single‑seat hypercar. The car packs a 395‑horsepower, 2.3‑liter turbocharged engine paired with a six‑speed dual‑clutch transmission and extreme aerodynamic features. RM Sotheby’s will auction the one‑off vehicle in Monaco...
Universal’s animated hit Minions: The Rise of Gru, starring Steve Carell and Will Arnett, has launched on Netflix today. The 2022 comedy earned more than $940 million worldwide during its theatrical run. The film serves as the second prequel in the...
New Balance is launching a sandal‑inspired version of its popular 9060 sneaker, dubbed the 9060 Mule, for the summer season. The new model retains the original’s Abzorb and Abzorb SBS midsole cushioning while swapping flat laces for a quick‑lace toggle...
When you really dive into your schema structures it's like turtles all the way down. You start working on your view that you're defective by finally standing up for yourself? Whoops, you've accidentally become as punitive as your mother. Jenga, man. Healing...
The episode examines the lethal connection between diabetes, high blood glucose, and heart attacks, highlighting how chronic hyperglycemia damages the vascular system and oxidized cholesterol accelerates plaque formation. It reviews robust clinical trial data comparing an ancient plant extract to...
Whew. I don’t listen to podcasts much but I just voluntarily listened to one for the first time ever, the episode of ICYMI about Lindy West’s new book. I was trying so hard to be open but husbands just be out...
You are not too old to change your mind, walk under a sea of yellow leaves, learn something new, fall in love again, and forgive first. https://t.co/qvhfGDZdfE
People who train regularly need substantially more protein than the standard dietary allowance. Sports dietitian Sarah Gilbert notes the U.S. RDA is 0.8 g/kg, while performance nutrition experts like Raiders’ Ricky Ng recommend 1.6–2.4 g/kg for strength and endurance athletes. In addition...
Are You an Echo – on #WorldPoetryDay, the remarkable story of the forgotten woman who died in her twenties and was rediscovered to become Japan's most beloved children's poet https://t.co/zk1RX1W0Kf
These trees do not touch. Crown shyness is a phenomenon in which the crowns of fully stocked trees do not touch each other, forming a canopy with channel-like gaps. The ‘dance like’ beautiful phenomenon is most prevalent among trees of the...
A new health feature highlights that only about 2% of Americans consume enough potassium, despite its critical role in fluid balance, muscle function, and blood pressure regulation. The article lists ten potassium‑rich foods—such as tomato paste, lentils, and dried apricots—that...
This Is a Poem That Heals Fish – on #WorldPoetryDay, an almost unbearably wonderful French picture-book about how poetry works its magic https://t.co/KxUMLIeBE0
"The recent explosion of agentic AI suggests the possibility of something similar at the scale of billions of interacting minds, human and non-human alike." An essay on the Intelligence Explosion @ScienceMagazine by @profjamesevans @bratton @blaiseaguera https://t.co/Fl0DP86XWd
Red light therapy, once a niche biohacking tool, is now entering mainstream consumer products after NASA’s 1990s experiments revealed wound‑healing benefits. Clinical research links the light’s stimulation of mitochondrial ATP production to improved collagen synthesis, muscle recovery, and potential neurological...
Happy birthday Joseph Fourier, whose 1822 equation allows us to listen to mp3 audio files today: https://t.co/O7L4xdQ1oU https://t.co/Rxg4WrqWVn
You're in charge of how you feel. Today choose to be calmer, centered within, less reactive to inner and outer pressures. #mindfulness https://t.co/nmloKuejm9
I lost 100 pounds through fasting. Not willpower. Discipline. Markets teach the same lesson. The positions that hurt you most are the ones you won't let go of. Fasting is cutting what you don't need. Trading is no different. Most investors are obese...
A pleasure to chair @carlbfrey’s talk on his brilliant book, How Progress Ends, at the @oxfordlitfest who kindly also included my latest book, The Great Crashes: https://t.co/i2YoILCoDR https://t.co/ZYKZYwYpyr
Don’t let fear of losing stop you for winning …. In fact … don’t let fear of losing let you miss out on … losing with your. Buddies …. ❤️❤️❤️❤️❤️ https://t.co/XD0yuObl3P
