Spermidine Halts Liver Fibrosis by Cell Signal Remodeling
Researchers have demonstrated that spermidine, a naturally occurring polyamine, can halt the progression of liver fibrosis by reprogramming cellular signaling pathways. In mouse models, spermidine treatment reduced collagen deposition and restored normal liver architecture within eight weeks. The study identified modulation of the TGF‑β/SMAD and AMPK pathways as the primary mechanisms behind the anti‑fibrotic effect. These findings suggest a potential low‑cost, dietary‑based therapeutic avenue for chronic liver disease.
Tech Workers Burn Out; Mental Health Support Needed Now
Tech folks need mental health support. People are working 20 hour days, 7 days a week. And still feeling like they are missing out on imp things, getting left behind, not raising enough money at high enough prices…or given too...
Canada's Provincial Park In Ontario Has Scenic Waterfalls With Fishing, Trails, And Camping
Chutes Provincial Park, a 270‑acre gem in Ontario’s Massey area, offers dramatic waterfalls, river fishing and well‑maintained forest trails. The park’s Twin Bridges Trail provides a three‑mile hike with historic markers, while its campsites range from car‑friendly to radio‑free options....
Why Regret Loses Its Sting as We Age
A new American Psychological Association study published in *Emotion* finds that adults over 60 report fewer recent regrets and experience them with far less anger and frustration than younger adults. While the total count of long‑term regrets stays roughly constant...
NBA YoungBoy Withdraws From Rolling Loud Orlando, Ken Carson Named As Replacement
NBA YoungBoy confirmed via Instagram that he is withdrawing from the Rolling Loud Orlando headlining slot, citing a need for rest from touring and travel. The announcement came just days before the festival, leaving fans disappointed. Rolling Loud responded quickly...
Rocket Lab Announces Five-Launch Neutron Deal as It Continues Aiming for Late 2026 Debut
Rocket Lab announced a block sale of five Neutron and three Electron launches to an undisclosed customer, marking its largest contract to date and surpassing the prior $190 million Haste sub‑orbital deal. The company reported a $2.2 billion backlog, with launch services...
Starz Exits Universal Pictures Pay-2 Deal After 5 Years
Starz announced it is terminating its five‑year Pay‑2 licensing agreement with Universal Pictures, ending exclusive access to Universal theatrical releases after their run on Peacock, Prime Video and Netflix. The decision, explained by CEO Jeffrey Hirsch, targets cost reduction amid...
Adidas' Hybrid Boat Shoe Knocks Sneaker-Loafers Out of the Water
adidas has launched the Climacool Boat, a hybrid sneaker‑boat shoe created with Japanese retailer Mita Sneakers. The shoe combines a full‑leather moccasin‑style upper, white contrast stitching, and a ventilated sneaker‑type outer, while incorporating adidas' adiPRENE heel cushioning. Priced at $130...
Alejandro Fernández & Banda MS to Headline the Arre Festival, Returning to Mexico City in 2026
The Arre Festival, a premier showcase of regional Mexican music, will be held Sept. 5‑6, 2026 at Mexico City’s Autódromo Hermanos Rodríguez. Headliners Alejandro Fernández and Banda MS join a diverse roster spanning mariachi, banda, norteño, tumbados and tropical styles. The festival, organized by...
Nude Meditation Sessions Continue This Spring
The Nude Meditation Series, founded by Richard Dewey and sponsored by Planet Nude, is rolling out a new spring schedule of live, clothing‑optional Zoom classes. The program offers three tiers—Fundamentals 1, Fundamentals 2, and Opening the Mind—each lasting two hours...
One Document, Whole Life: Claude, iPad, Journal
How I organize my entire life in just one document (using Claude code + iPad + journal)
Commit Fully to What You Truly Desire
Who else is going all in for the thing they want? #growth #energy #courage #mindset
High Cognitive Scores Might Predict Depressive Relapse
A new BMJ Mental Health study of 1,800 UK Biobank participants shows that, contrary to long‑standing assumptions, higher cognitive performance predicts a greater risk of depressive relapse in people with a history of major depressive disorder. Thirty‑three percent of the...
‘John Candy: I Like Me’ Composer Tyler Strickland On Using French Horn To Depict Comedy Icon “As A Soldier Going...
The documentary "John Candy: I Like Me" chronicles the life of comedy legend John Candy, directed by Colin Hanks and produced by Ryan Reynolds with participation from Candy’s children. Composer Tyler Strickland faced the challenge of scoring a film about...
How To Spot Fake Wagyu Beef A Mile Away
Wagyu beef sold in the United States often carries a loose label, allowing cross‑bred cattle with minimal Wagyu genetics to be marketed as premium meat. Genuine, pure‑bred Wagyu—primarily from Japan or Australia—commands prices above $200 per pound, with a 5‑ounce...
From Productivity to Presence: Redefining Dad Value
Dads: What’s something you value differently now as a dad? I used to measure my value by productivity. Now I measure it by presence.
Two Mechanisms Vie to Deliver First Hypoxic Ischemic Encephalopathy Drug
The article is BioCentury’s cookie policy, outlining five cookie categories—strictly necessary, functional, marketing, advertising, and analytics—and describing their purposes for site operation, personalization, outreach, and data collection. It explains how each type works, the data it handles, and the impact...
Eating Eggs Could Cut Alzheimer’s Risk by 27%
Researchers at Loma Linda University analyzed data from about 40,000 older adults over a 15‑year span and found that eating at least one egg per day was linked to a 27% lower risk of Alzheimer’s disease. Even modest consumption—1‑3 eggs...
Bottled Water Nanoplastics Are Not Simple Bottle Fragments
A new study in Advanced Science uses mid‑infrared photothermal microscopy to examine nanoplastics in bottled water one particle at a time. Researchers found 9.9 × 10⁴ particles per litre, with nanoplastics making up 64 % of the load, and identified PET as the...
Fermilab Marks Major Milestone for World-Leading DUNE Experiment
Fermilab and the Sanford Underground Research Facility celebrated the start of moving 10 million pounds of steel beams underground to build DUNE’s far‑detector structures. The steel, an in‑kind donation from CERN, marks the first time the European lab has contributed infrastructure...
Rehab and Strength Training Share Core Movements
Love these 7 rehab/prehab movements. Strength & Conditioning and Physical Therapy are the same, we just embark at different starting points. Good stuff @rehabhero
Andes Hantavirus Shows Airborne Human-to-Human Spread
The detailed investigation of a prior hantavirus human-human transmission event has evidence of airborne transmission of Andes strain: Patient 1 --> Patient 4 "did not have any physical contact and simply said “hello” to each other as they crossed paths" Patient 1 -->...
Astellas Touts Data From Early Test of Stem Cell-Derived Eye Therapy
Astellas Pharma announced early-stage data from its stem cell‑derived retinal therapy, aimed at treating age‑related macular degeneration (AMD). In a small cohort receiving the highest dose, patients showed statistically significant gains in best‑corrected visual acuity and no serious safety signals....
Backline Launches Mental Health Toolkit for Dance Music Community: ‘Seeking Help Is Not Something to Be Ashamed Of’
Backline, a nonprofit focused on mental health in the music industry, has launched a free, downloadable mental‑health toolkit tailored for EDM artists and touring professionals. The guide offers practical advice on tour packing, immune support, sleep optimization, hearing protection, venue...
Psychedelic Figures Don’t Live Longer than Researchers
Psilocybin and human longevity "All groups exceeded population life expectancy, reflecting the effect of socioeconomic advantage on lifespan, but psychedelic personalities did not outlive cancer and aging researchers." 🙂"We examined mortality among prominent psychedelic personalities, researchers, and advocates who claimed psychedelic use...
Survivor Turns Grief Into Advocacy, Humanizing Policy
“As a #suicide loss survivor, the Advocacy Forum is how I turn my grief into purpose,” said AFSP National Leadership Council Member and Advocacy Ambassador for the Nebraska Chapter Jennifer Moffett. “By sharing my stepdad’s story with congressional leaders, I...
Stress, Burnout, and Safety: OSHA’s Modern Approach to Worker Well-Being
OSHA is integrating mental wellness into its safety framework, using the General Duty Clause to address psychological hazards such as stress, burnout, and harassment. The agency’s 2024 fact sheet urges employers to embed worker input, employee assistance programs, leave policies,...
Kids Learn Faith by Watching, Not Hearing
People ask me all the time, “How do I keep my kids in the faith?” The answer is simpler than most people want it to be: your example matters more than your words. Children learn by imitation long before they learn by...
SpaceX V3 Booster Has a Full Static Fire And Is On Track for a May 15 Launch
SpaceX conducted a full‑duration, full‑thrust static fire of its Super Heavy V3 booster, firing all 33 engines simultaneously. The test confirmed that the upgraded deluge water suppression system functioned as intended. Launch trackers now list a net launch window of...
L7 Is Hitting the Road for One Final Hurrah: ‘We Are Deeply Grateful’
L7, the seminal 1990s feminist rock band, announced a 27‑date North American “Last Hurrah Tour,” marking what they describe as their final series of live performances. The trek kicks off on June 4 in Toronto and concludes on November 14 in Los...
Fathers Shape Kids' Futures and Future Therapy Conversations
As parents, we're tasked with shaping someone's childhood. The way we approach this responsibility will impact the conversations they'll have - or avoid - in therapy one day. On this @4fitfatherhood podcast episode, @mattfleekop and I dive into the critical role...
Clara Sadomba Trailblazing Zimbabwe’s Mining Industry and Empowering the Next Generation of Women
Clara Sadomba, board chair of Zimbabwe's Mining Industry Pension Fund (MIPF), outlines her top priorities: ensuring financial sustainability through diversified investments, robust risk management, and member education. She emphasizes transparency, regular reporting, and independent oversight to build confidence among miners....
Nonprofit Turns Short-Term Housing Into Disaster Shelter
The nonprofit spin-off from the short-term housing company gives people a place to land during climate catastrophes and other disasters. Wendy Paris Reports: https://tinyurl.com/dfthxkyn Related IP Resources: Grants for Humanitarian Aid -https://tinyurl.com/mmx8dzw8 Grants for Immigrants & Refugees -https://tinyurl.com/58p6mejn Donor Insights for Immigrants & Refugees -https://tinyurl.com/5n7x7vpj EmergencyHousing
Researchers Steer Electron Spin Ballistically in Graphene
Researchers at the University of Manchester have demonstrated that electrons in ultra‑clean graphene can be steered ballistically while preserving their spin orientation. Using transverse magnetic focusing, they created lens‑like trajectories that carry a clear spin signature, observable over micrometre distances....
A Bizarre 'Decapitated' Asteroid Likely Made the Moon's Largest Impact Crater. NASA's Artemis Astronauts May Land Near the Proof
A new study using high‑resolution 3‑D simulations argues that the Moon’s South Pole–Aitken basin was formed by a 260‑km differentiated asteroid that was ‘decapitated’ on impact, leaving its iron core to carve the basin’s tapered shape. The shallow, north‑to‑south impact would...
These Whales Are Screaming in the Strait of Gibraltar
A 2025 study in the Journal of Experimental Biology examined whether the critically endangered long‑finned pilot whales in the Strait of Gibraltar exhibit the Lombard effect amid intense ship noise. Researchers attached suction‑cup recorders to 23 whales, gathering 1,432 calls...
Andy Serkis' New Movie Based On A Classic Book Flopped At The Box Office
Andy Serkis’s animated adaptation of George Orwell’s *Animal Farm* opened to a weak $3.3 million domestic box office, ranking sixth for the weekend and far short of its $35 million production budget. The film faced stiff competition from $77 million blockbuster *The Devil...
Assess Grip
Do I need to work on my grip strength or are more things talenti level hard to open?
Stop Signals Delay Step Initiation Across Ages
The stop signal stepping task: how action cancellation commands disrupt step initiation in young and healthy older adults https://t.co/bjTuhURJMH https://t.co/9V14LZst7t
RAYE Calls Out ‘Nasty’ Amy Winehouse Fans Who Tear Her Down in the Name of ‘Defending’ Late Icon
British singer‑songwriter RAYE uses her new track “I Will Overcome” to call out fans who disparage her while invoking Amy Winehouse’s legacy. In a Billboard cover interview, she explains that the same verbal abuse Amy endured is being mirrored against...
Evening 5K Fuels Momentum, Topped with Sonic
All my momentum is fueled by an end of day 5k and a drink at @sonicdrivein immediately after https://t.co/5QeUMT4xej
Internet Bans Socks with Fisherman Sandals—63 Days Straight
When the internet says for the 63rd day in a row to not wear socks with fisherman sandals
Rare Ian Curtis Archives Debut in NYC Exhibition
"Ian Curtis: Insight," a free exhibition of rare archival material from the Joy Division frontman, opens June 25 at the Voltz Clarke Gallery in New York City and runs through July 22. Many items on U.S. display for the first...
Compact 1BR Maximizes Space with Dual Bathroom Access
An efficient, well designed 1BR floorplan: • Dual entrance to bathroom • Small kitchen • Hall access to Water Heater • 12' wide Living Room • Movable Island 665 square feet https://t.co/MiwnjzVMty
Only Proven Sleep Hacks Actually Improve Your Rest
I Tested Every Sleep Hack on the Planet — Here's What Actually Works https://t.co/13yp3N9anK via @YouTube
Mellissa Darlin’s Diamond Baby: Rising Star’s Journey
Talked with @applemusic’s Africa Rising star @mellissadarlin about her debut project Diamond Baby and her journey in music … 👏👏👏 Full convo on your Apple Music app https://t.co/vU3jSwnWss
Lambert and Doris Day Foundations Fund $233K Spay/Neuter Grants
Miranda Lambert's MuttNation Foundation and the Doris Day Animal Foundation have awarded $233,000 in spay and neuter grants to 63 shelters and clinics across Southern California through the It Takes Balls campaign. https://t.co/c9XD42jgE6
AI-Powered Virtual Clinic Transforms Cancer Detection and Care
There is a genuinely a revolution under way in cancer. We're solving it: from early detection (!), trial matching, and ongoing management. @Color is now an @ASCO clinic -- the first virtual-only one -- leading this revolution in screening and...
John Ford Coley to Appear on Live With Kelly & Mark Monday
Apparently John Ford Coley, one half of the duo that sang 'I'd Really Love To See You Tonight,' will appear on Live With Kelly & Mark on Monday...
AI Coach Imperfect Personalizes Daily Fitness Using Your Data
Imperfect (@imperfectco_) is an AI fitness coach that's personalized based on your health data. It adapts your training, recovery, and nutrition each day to how your body is actually responding. Congrats on the launch, and welcome back @matin (W11)! https://t.co/5N9sjEQSKG https://t.co/UL5vwXUngk