Mitochondrial Transfer Advances Stem Cell Therapies
The progress of mitochondrial function and transfer in stem cell regulation and therapy https://t.co/rltLeBPkHU https://t.co/WreIarDoAo
Elite Sports Research Fuels Health and Longevity Breakthroughs
This World Cup Highlights the potential of science and technology in elite sports. https://t.co/5hAZybS1eM Biomedical breakthroughs often come from studying disease. But understanding how elite athletes optimize physical, cognitive, and emotional performance, and recover from injury may unlock strategies to improve health,...
Finding Freedom While Embracing Our Personal Narratives
Can We Be Free of Our Stories? Why do the stories we tell ourselves create so much suffering? And if stories are central to creativity and self-expression, is it possible to be free without abandoning them? Watch Rupert’s latest video here...
Magnesium Modestly Improves Insomnia, Benefits Those Most in Need
Can a cheap mineral capsule really move insomnia? The largest RCT to date says: a little -- and most in people who need it. Schuster et al. (Nature and Science of Sleep, 2025) ran a double-blind, placebo-controlled trial: 155 adults with...
One‑Shot CRISPR Cures Hereditary Angioedema in Phase 3
A life-threatening inherited disease, hereditary angioedema, with striking benefit from one-shot CRISPR genome editing. Phase 3 randomized, double-blind trial results @NEJM today https://t.co/pT4fVgZcNP https://t.co/TveFMeK9ia
Meet mLOC: The Hidden Bridge Powering Lactate Metabolism
Let me tell you about the mLOC Everybody talks about mitochondria nowadays…Lactate is becoming mainstream as well… However, almost nobody has heard of the molecular machinery that connects the two. It is called the mLOC, the mitochondrial lactate oxidation complex. This network of proteins...
Microglia Fuel Learning by Boosting Brain Glucose Transport
Building memories is energetically expensive. New research reveals that microglia help meet this demand by orchestrating a neuroimmune metabolic circuit that boosts glucose transport to active brain regions, fueling neuronal protein synthesis required for learning. During motor learning, microglia release CYR61,...
Internalized Stress Predicts Five-Year Memory Decline in Elders
The way you internalize stress may determine how harmful it becomes. Among older adults, the strongest psychosocial predictor of memory decline over 5 years was stress internalization: - more perceived stress - more hopelessness - less conscientiousness Social support, activity engagement, and community cohesion were...
Smart Add‑on Turns Car Seat Into Automated Baby Bouncer
Smart Device Turns Any Baby Car Seat Into an Automated Bouncer by @gigadgets_ #Innovation #EmergingTech #Technology #Tech https://t.co/95FoJC4pro
Little Baobab Serves Delightful Senegalese Set Menu
For today’s @ftweekend at Little Baobab, a delightful restaurant inside the Africa Centre serving a Senegalese set menu. It’s a room you want to be part of. https://t.co/X3VSrrdz70? https://t.co/rru0VGydXl
Cambridge AI‑Designed Super‑Antigen Shows Broad, Long‑Term Protection
The University of Cambridge says it successfully tested a vaccine with an AI-designed antigen 🧬 💉 The “super-antigen” could provide long-term protection against a wide range of diseases spread by humans. https://t.co/URHxKcCg1h https://t.co/mDYHro2mfO
DNA Damage Drives SIRT1 Relocation, Sparking Epigenetic Aging
Good question. Back in the 2000s, Phillip Oberdoerffer, a postdoc in our lab, published that DNA breaks cause epigenetic drift in mammals, not just yeast, consistent with the Information Theory of Aging Summary of the 2009 study ICYMI: One of the...
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Tiny Tweaks in Sleep, Activity, Diet Extend Lifespan
Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study https://t.co/5q1WnJhN78
Rank Your Meetings by Stress Using Oura Data
Used Fable 5 to connect my @ouraring with my Google calendar to see which people stress me out the most. 🤣 Saw this yesterday and had to build my own. It was as easy as screenshotting the X post and letting...
DNMT3A Mutations Drive Hyper‑methylation, Accelerating Age‑related Diseases
Getting to the root of age-related diseases. By studying a rare accelerated aging genetic disorder, gain-of-function mutations of DNMT3A were found to be causal. DNA hyper-methylation was then linked to stem cells dysfunction and multiple age-related diseases (blood, bone, metabolic). Work...
One Gene Can Halt Cellular Aging, Hinting at Reversal
Scientists like Hayflick once viewed replicative senescence as a complex, multifactorial form of cellular wear and tear. So when a single gene manipulation (telomerase expression) was shown to prevent replicative senescence, it came as a surprise. Aging is more...
Boosting SIRT6 Reverses Liver Aging and Restores Youthful Genes
This study suggests that increasing SIRT6 can reverse age-related changes in liver cells, restoring a more youthful gene expression pattern by reducing inflammation, improving metabolism, and rejuvenating chromatin structure. https://t.co/eEUz3KACvO
IL‑17/IL7R Identified as Central Immune Disease Drivers
Interleukin-17 (IL-17 and its receptor, IL7R) is emerging as a key mediator in many immune-related diseases. Today @SciImmunology a superb review https://t.co/QjRc9cr9Wl https://t.co/86y5bM46p5
Scientists Rush Trials Amid Growing Bundibugyo Outbreak
As the Bundibugyo outbreak continues to grow, researchers are scrambling to start clinical trials of antivirals and monoclonal antibodies to see if any work against the virus. Here's my story on this race, with Stephanie Nolen. Gift link: https://nyti.ms/4eEZHqR
Prime Video's Evolution and the Bundling Boom Unpacked
listen to this week's @Variety "Strictly Business" podcast --> Mike Hopkins on Prime Video’s Evolution, the Bundling Boom, How MGM Changed Amazon, the Future of Bond and No Regrets on ‘Melania’ https://t.co/HA5WhmDAEK via @variety
Aging Linked to Loss of Cellular Information, Not Damage
NEW PREPRINT: Scientists may have found direct evidence that aging is driven by the loss of cellular information, not just the accumulation of damage For decades we've focused on what aging cells accumulate. This paper focuses on what they lose:...
Ofirnoflast NEK7 Inhibitor Shows Promise in Lower‑risk MDS
MDS Oral - Clinical - OFIRNOFLAST NEK7i in LR MDS - Bafna #EHA2026 #MDSsm #leusm https://t.co/6b7pX0rR8g
Ron Howard: Audiences, Not Studios, Will Judge AI Films
Ron Howard Thinks Audiences Will Decide Whether AI Films Succeed: ‘What Are We Invested In?’ https://t.co/4lxkKG2p2r via @variety
Morning Sunlight Advances Sleep Timing and Boosts Quality
New in BMC Public Health (2025): every extra 30 minutes of morning sunlight before 10 AM was associated with sleep schedules shifting 23 minutes earlier and improved sleep quality. This is observational data -- it shows association, not causation. But the...
Anxiety: Primarily a Physiological Process, Not Just Mental
I have a PhD in healthcare research and work as Head of Science at a gut & anxiety relief app. Here's what most anxiety content misses — and what actually helps: 1. Anxiety is often a physiological process disguised as a...
Cycling Cuts Epigenetic Age by Seven Months
Consistent endurance exercise may be one of the most powerful ways to slow down biological aging. Six months of cycling (about 4.5 hours/week) reduced GrimAge by 7 months relative to the expected trajectory of normal aging. GrimAge is an epigenetic clock...
Markiplier Announces New Film Following Iron Lung Success
@markiplier confirms that he’ll make another movie after the success of his indie horror movie Iron Lung
Movement Beats Rest: Prevent Chronic Injury Now
“Just rest” is the WORST medical advice that exists. Rest and wait is how a short-term injury quietly becomes a years-long problem. Muscles waste, capacity tanks, and the nervous system turns up the volume on pain. Movement isn’t the enemy. Avoidance is.
Harvard Unveils First Evidence‑Based Longevity Report
Pathways to Longevity Harvard Medical School's first Special Report dedicated to longevity science.👨⚕️ 250+ comments and 100+ reposts from across the field since launch. Evidence-based longevity reaching a mainstream audience, on medicine's terms. 🔗https://t.co/LkYEpplFjK
Tart Cherry Supplements Show Mixed Recovery Benefits in Soccer
Polyphenol supplements for recovery in football ⚽️ This new systematic review compiled data from 8 RCTs with a combined total of 166 adult male football (soccer) players to see the effects of polyphenol supplements on recovery 📚 Here are the...
Olivia Rodrigo Swaps Pop‑Punk Angst for New‑Wave Romance
This Olivia Rodrigo album lives up to expectations. Read all about it here... Olivia Rodrigo Trades Pop-Punk for New Wave — and Angst for True Love (for Half an Album) — in the Excellent ‘You Seem Pretty Sad for a...
Firefly Aerospace Wins Collier Trophy for Moon Landing
Firefly Aerospace receives the Collier Trophy for the Blue Ghost 1 lunar landing in a ceremony tonight in DC. https://t.co/cGuK6iK5FX
Extinct Virus Recreated Cheaply Sparks Call for Screening Laws
In 2017 a researcher reconstructed an extinct virus from roughly $100,000 of mail-ordered DNA. Which is exactly why I signed a letter asking Congress to require synthesis screening alongside the CEOs of leading frontier labs.
From Self-Optimization to Collective Joyful Longevity Raves
From self-optimization to collective joy at scale By @TinaWoods 🏆 Note for readers: Dr. Woods is not only a global thought leader on healthspan, the exposome, & joyspan, she is also a talented DJ. Her “Longevity Rave” events come highly recommended 🪩 https://t.co/D0vRHnvjc4...
Metformin Restores NCoR1, Delays Primate Gut Aging
The aging gut, mapped at single-cell resolution in primates. NCoR1 decline = barrier failure + chronic inflammation + stem cell lineage shift away from absorptive cells. Metformin restores NCoR1 and delays intestinal aging in NHPs. Li et al., Nature Aging 2026 https://t.co/OLdXp99EiG
Stop Chasing Happiness; Seek Peace in Discomfort
Screw happiness. Chasing it is what makes you miserable. Unhappiness isn't inherently bad. Sometimes life hurts and things are heavy. Sometimes you feel bad for completely valid reasons. The goal should never be to feel good all the time. The goal is to...
Epigenetic Drift and Stress Trigger Senescence, Accelerating Aging
Nice review about how epigenetic drift and cell stress can cause cellular senescence to drive aging and disease https://t.co/40OXfSTDhV
World’s Most Luxurious Expedition Cruise to Antarctica
This is NOT a regular cruise. This is Seabourne Venture - the world’s most luxurious expedition cruise ship - where you sail into places most people only see on maps … and do it in absolute comfort and style. Icebergs, silence, infinity…...
Adult Brain Can Still Grow Neurons, Boosting Memory
Emerging research suggests that the adult human brain may retain a limited ability to generate new neurons throughout life, and enhancing this process could help preserve memory, cognitive function, and resilience against age-related decline and Alzheimer’s disease. https://t.co/qYi3RkkLwU
Grantmaking Shifts Post‑Trump: Climate Funding Evolution
The longtime leader of one of America’s top 50 grantmaking foundations speaks about how its giving and the climate giving field at large have changed since Trump’s election. Michael Kavate Reports: https://tinyurl.com/3j3ds5m7 Related IP Resources: The Schmidt Family Foundation -https://tinyurl.com/436yuast Climate Change Grants -https://tinyurl.com/mvh59bw7 Grants...
Feed the Cats Fuels Record‑breaking Hurdler Success
“This young man is a product of tremendous genetics, but using Feed the Cats in the past 3 years, he went from high 14’s in hurdles to the fastest hurdler in TN, ever.” ~Coach Caleb Ingram, Rockvale (2023) “This Kid would’ve...
Luhrmann
My review of the re-release of Strictly Ballroom (1992) (dir. Baz Luhrmann) is up here: https://t.co/Suij20mxDr
A Warm Welcome Elevates Innovative French Cuisine
Plenitude Every once in while you have an experience when the company, a genuinely warm welcome, comfort of a chair in a room energetic with technically perfect - professional and playful service. You just know what’s to follow before the first...
New Insights Reveal Cellular Senescence’s Role in Aging
We're learning a lot about cellular senescence, how to track it, and its role in aging and disease. Cover and commentary @CellCellPress https://t.co/bFma1UocnS https://t.co/7ZRfmmFL5Z
Just Minutes of Walking Beat Hour-Long Cardio for Glucose Control
The lie I taught in medical school: you need an hour of cardio to move the needle on blood sugar. The data says the opposite. A 2022 meta-analysis in Sports Medicine (7 controlled trials) found 2-5 minutes of light walking after meals...
Daily Multivitamin Slows Brain and Biological Aging
A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent...
Longer Meal Gaps Boost Overnight Glucose Control
How to choose your time restricted eating window for better glucose control? In adults with obesity, longer gaps between the last meal and sleep—and between waking and the first meal—were linked to lower overnight glucose levels and improved glycemic control. Aligning...
Use Knicks Game to Teach Kids Grit and Resilience
Last night's @nyknicks game is such a good opportunity to talk to your kids about grit and resilience and what my kid's 5th grade teacher calls "fighting to the finish." Let me explain.
Planetary Energy Imbalance Jumps 40% Since 2021
Thank you Big Oil and enablers. The data is out: Our planetary energy imbalance has surged 40% since 2021, hitting 1.12 Watts per square meter. We are physically forcing extra heat into our system at a horrifying rate. What this...