Organelles Drive Aging: Metabolic Engines and Signaling Hubs
Cellular organelles play a central role in aging by acting as both metabolic engines and signaling hubs that coordinate processes within and between cells. Their dynamic interactions influence lifespan, health, and even inheritance, making them key targets for interventions aimed at promoting longevity. https://t.co/hL9XBRQEmR
Self‑driving Robot Labs Spark Debate on Replacing Biologists
Will self-driving ‘#Robot labs’ replace biologists? Paper sparks debate by Ewen Callaway @Nature Learn more: https://t.co/CfOHJ2PcV3 #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/utwGlUIRVV
Biomarkers Reveal Burnout Impact on Emergency Care Staff
Burnout and Biological Biomarkers in Emergency and Acute-Care Healthcare Workers: A Systematic Scoping Review with Evidence Mapping https://t.co/q7ajNKrk8t
Co-Authored Nature Communications Paper on Innovative Research
Just realized we never posted this @NatureComms article from last year. Was honored to join @Lijing_Cheng & colleagues on this interesting project: https://t.co/ERIVtjY69r
Aging Evolves: Unveiling the Longevity Bottleneck Hypothesis
Fantastic video on the evolution of ageing and the longevity bottleneck hypothesis 🚀 Thank you @EonsShow @PBS for the brilliant work 🙏 https://t.co/GjHMlIn3hg
Dark‑sector Beings Miss Our Hidden Spiral Galaxy
We're invisible to dark energy and dark matter. To dark-sector creatures, the Milky Way is a big bulbous ellipsoid. It might take a renegade dark-sector scientist to deduce that there is a thin spiral of stars - invisible to them...
Climate Change Threats Outweigh AI Job‑Displacement Hype
Climate change is far more of a threat than AI displacement of jobs, it’s just not cool to talk about anymore. AI displacement of jobs is a marketing pitch, climate change is actually real.
P‑tau217 Blood Test Predicts Alzheimer’s Risk Early
Good summary of p-tau217, the breakthrough blood test to predict risk of Alzheimer's in people well before onset of symptoms @ScienceMagazine https://t.co/qVJtYR4bnz https://t.co/OhjLExTroG
O‑1 Model Beats GPT‑4 and Doctors in Triage
New @ScienceMagazine The o-1 reasoning model (text only, from @OpenAI, releasedSept 2024) exceeded performance cf GPT-4 and physicians for clinical vignette management reasoning and in a real-world emergency department assessment for initial triage @AdamRodmanMD @PeterBrodeurMD @arjunmanrai @jonc101x https://t.co/tPZqZAE8cd
Soyuz‑5 Launches From Baikonur on Debut Flight
The first Soyuz-5 rocket, designed to replace Zenit, reported lifting off from Baikonur Cosmodrome in Kazakhstan on its inaugural test mission. FLIGHT DETAILS, UPDATES: https://t.co/roiCzko73d https://t.co/WKcx7PubdF
Pregnancy Often Widens Feet, Many Stay Larger
One thing that might surprise you about pregnancy is that your foot size can go up by half a size. This happens to a lot of women. Relaxin loosens the ligaments in your feet while the extra weight flattens your arch. One...
Depression Linked to Faster Brain Aging and Suicide Risk
Major Depressive Disorder (MDD) is associated with increased risk of suicide. New study of people ~40-50 finds associations between suicide & accelerated brain aging, suggesting altered "neural development, signaling & neurogenesis." https://t.co/Fjgx1yH690 https://t.co/ARKfWDTbin
ISS Spacewalk to Install Sun‑Watching Teragerts Telescope May 27
TASS now confirms that the installation of the Teragerts experiment is planned during a spacewalk aboard the International Space Station on May 27. The Sun-watching telescope was delivered to the outpost with Progress MS-33: https://t.co/OewEuTieGZ https://t.co/P7IADBZ8L2
Intel Expands Into Three Quantum Computing Modalities
This is significant news. Intel now has their toes in three types of quantum computing modalities, to varying degrees: - Silicon spin - Neutral atoms - Photonics
Mitochondria Shape Immune Landscape: Clinical Insights
Mitochondria orchestrated immune microenvironment and response in health and disease-clinically relevant outlook and recommendations https://t.co/bI64EK9zdf https://t.co/0UV2mkcRiP
Kids Taste Food Much Bitterer Than Adults
You and your child are not tasting the same food. Babies have taste buds spread across the roof of their mouth, the back of their throat, and down into their epiglottis, all in much higher density than adults. Kids are also...
2026‑27 Temperature Forecasts Rise Amid Strong El Niño
I've updated my 2026 and 2027 annual temperature forecasts in light of the strong El Nino forecast (and 2026 data to-date) over at the Climate Brink, as well as methodological changes for more robust uncertainties. Both are now higher than they...
Nearly 60 Nations Convene in Colombia for Energy Transition
Nearly 60 nations, save the largest polluters, gathered in Colombia this week to discuss the energy transition. https://t.co/eYIniZphK2
New Science Shows Pluto No Longer Qualifies as Planet
The science case for why Pluto still isn’t a planet Sure, we lived in a simpler time when we had 9 planets, including Pluto. But we've learned a whole lot since 1929, and can't in good conscience ignore it to suit our...
Register Now for UCLA Quantum Device Design Workshop
Friendly reminder to register (if you have not already) for the upcoming Quantum Device Design Workshop at UCLA June 15–18.
Chip‑scale EPR Achieved by Ultra‑fast Optical Frequency Sweep
What happens when you shrink EPR onto a chip and sweep 1400 THz/s instead of the magnet field itself? https://spectrum.ieee.org/epr-spectroscopy-free-radicals-chip?share_id=9416801
Irisin Hormone Reverses Obesity and Insulin Resistance
Irisin, a hormone released by muscle during exercise, reverses obesity and insulin resistance in mice -- without cutting food intake or causing muscle loss. As a medical school professor, I find this striking. We have spent a decade asking how to...
Key Factors That Truly Impact Aging After 40
I’m a bioscientist studying aging. 🧬 If you’re 40+, this is what actually matters ↓
DNA Nano‑Ring Precisely Captures and Orients Membrane Proteins
A new DNA nano-ring platform enables precise capture and orientation of individual membrane proteins, advancing the study of these vital cellular gatekeepers and opening new possibilities in medicine, imaging, and synthetic biology. nanotechnology
VR Engages Brain Areas that Build Our Reality
Virtual reality activates the same brain regions responsible for constructing our sense of reality, suggesting that the immersive experience of "being there" in VR and perceiving the real world may share common neural mechanisms. virtualreality
Diet‑Microbiota‑Polyamine Axis Drives Intestinal Aging
The Diet–Microbiota–Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications https://t.co/UJwPyVroBn https://t.co/xQTAAszA0w
New GLP‑5 Study Is Only Mouse
A friendly reminder, just because that new Nature study on a quintuple agonist (LOL GET READY FOR "GLP-5" discourse) is out today: It's a study on MICE. MICE TESTING IS NOT HUMAN TESTING. IT'S JUST MICE.
Qubit Pharma Teams Up with Singapore’s Quantum Hub
A fantastic partnership between @qubit_pharma and the Centre for Quantum Technologies in Singapore (@quantumlah)! Excited to be part of this journey and looking forward to the breakthroughs ahead.
Year Two Funding Crisis: Grants Dry, Competition Rises
With federal research funding cuts, the first year of Trump 2.0 was tough. Year 2 is in some ways grimmer, a @statnews survey shows. Bridge funding is drying up, existing grants are ending & competition for fewer new grants is...
Better Prediction of Type 1 Diabetes Boosts Prevention Prospects
A jump in our ability to predict Type 1 autoimmune diabetes should help future preventive strategies @NatureGenet https://t.co/ako2Ic46QW https://t.co/XbW26qu5LE
Akeso’s ASCO Plenary Raises Questions on Lung Cancer Data
This week's Biotech Scorecard: An #ASCO26 mystery: What does Akeso’s primo plenary spot say about its ivonescimab lung cancer survival data? $SMMT If the news was good, we'd have heard by now, right? Or, is Akeso just being ultra conservative?...
Testing Claude's Bioinformatics Skills via BioMysteryBench
Evaluating Claude’s bioinformatics research capabilities with BioMysteryBench "Send us your interesting benchmarks, innovative uses of AI for science, and interactions with AI that prompted you to rethink what could be possible in your field at scienceblog@anthropic.com. " https://t.co/SDC3eHsmRJ
High Accuracy in Omics May Be Illusory
The pitfalls of class prediction in omics 🧵 1/ You think you’ve built the perfect omics predictor. The accuracy is high. The p-value is low. But is it real—or just a story your data whispered back? https://t.co/LGNWQMKOfv
Venter and Collins Bookend 1993 Nature Genetics, Predicting Genome Wars
My last friendly encounter with the late Craig Venter, at @CHI_Healthtech @TriConference in 2023 (photo credit @calimagna). The slide shows photos of Venter and Collins bookending the inaugural @NatureGenet conference in DC in 1993, foreshadowing the Genome Wars. https://t.co/26oVPO3rAn
Sevabertinib Shows
EGFR’s Poor Sibling {Editorial} [April 15, 2026] @DCarboneMD @NEJM https://t.co/DjV4gAtKMk #lcsm #PrecisionMedicine RE: #NCT05099172 Sevabertinib in Advanced HER2-Mutant Non–Small-Cell Lung Cancer https://t.co/63kCdZ6JOJ
Identify Organ Source From Single‑Cell RNA‑Seq Data
One example they give: “Which human organ is this cell type single-cell RNA-seq dataset derived from?”
Soyuz‑5 Launch Window Opens Amid Ongoing Ground Issues
HINTS & RUMORS: The Soyuz-5 launch window is now open for today but the personnel in Baikonur apparently still working through issues...
Menstrual Hormones Don’t Alter Protein Metabolism in Active Women
Is protein metabolism affected by menstrual cycle hormones? 🧐 This new study recruited 40 healthy active females… 🩸 15 x eumenorrheic (normal cycle) 💊 13 x oral contraceptive users 👉 12 x IUD users Participants markers of protein metabolism were tested in low- (follicular /...
Arianespace Completes 32‑satellite Amazon Leo Separation
.@Arianespace reports successful separation of 32 @AmazonLeo satellites after 12-part separation sequence. This is the 2nd of 18 Ariane 64 Amazon Leo launches planned. https://t.co/lxdVhmkiEb
Northwestern Chemist Launches Science-Driven Biotech Blog
New biotech blog by a Northwestern medicinal chemist -- debut post is a well-written, science-focused take on $CCCC. Check it out: https://t.co/4Pc5wUUKlO
Low RHR & High HRV Signal Longevity
There's a proverb that you only have a certain number of heartbeats in your life Low resting heart rate (RHR) and high heart rate variability (HRV) are good signs of good heart health and fitness Low RHR and high HRV are...
Earth Approximates Inertial Frame, Foundations of Relativity
The thread below is an example both of mind numbing idiocy and why on-line content is essentially useless because of A.I. and / or old fashioned ‘creative’ editing. The physics here is that to a good approximation over a short...
ADHD Isn't Caused by Low Dopamine, Says Science
The Truth About ADHD and Dopamine KEY POINTS The social media trend describing ADHD as "low dopamine" is not based in science. Dopamine-seeking isn't an explanation for ADHD symptoms. "Dopamine detox" isn't a real way to treat ADHD, and withholding things that bring...
Calcium Supplements Linked to Higher Cardiovascular Event Recurrence
Association Between Calcium Supplementation and Recurrence of Cardiovascular Events in Patients With Cardiovascular Disease: A Population‐Based Cohort Study 👉 “Caution should be exercised” https://t.co/ynmqMB4Zd0
Exercise Proven to Reduce Biological (Epigenetic) Age
What is the most established intervention linked to lower biological (epigenetic) age? Exercise A new systematic review @LancetLongevity of 44 studies, >145,000 participants https://t.co/agmAazwDxs
Gene Editing Swaps Whole Genes, Fixes 1,000 Mutations
A new genome editing technique enables efficient replacement of entire genes, allowing correction of up to 1,000 mutations simultaneously by inserting large DNA segments without causing toxic double-strand breaks. genetherapy
Vaccines May Reduce Alzheimer Risk and Slow Aging
I'm getting two vaccines next week: Tdap and shingles. The Tdap because Kate's family has a newborn and we're visiting. Shingles for the potential longevity benefits. Data we're looking at: 1. Lower Alzheimer risk with vaccination in 1.6 million people,...
CCDC6‑RET Fusion Recycles ADP, Drives Rapid Tumor Activation
The fusion protein CCDC6-RET, implicated in lung and thyroid cancers, can self-activate rapidly and uniquely reuse ADP as an energy source, offering new insight into tumor adaptability and potential therapeutic strategies. cancerbiology
AI Flags Low‑GC Flu Strains, Warning of Pandemic Risk
A new AI classifier analyzes influenza A virus genomes to identify strains with reduced GC content, signaling a higher risk of sustained mammalian transmission and supporting earlier detection of potential pandemic threats. publichealth
Veterinary Diclofenac Poisoning Drives India's Vulture Collapse
The cause of the vulture collapse in India is interesting - a widely-used veterinary NSAID, diclofenac, turns out to be highly toxic to vultures when they eat carcasses of animals that had consumed it. (Diclofenac (AKA Voltaren) is also widely...