Rapamycin Lessens Age‑related Motor Decline, Varies by Sex
Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice 👉"Our results are consistent with the idea that rapamycin’s beneficial effects are mediated, at least in part, by reducing oxidative stress and ER stress-mediated apoptosis... https://t.co/b8EZwrDTXP
Natural SIRT1 Activators May Shield Early Alzheimer’s Microglia
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis? 🗣️"We will describe how SIRT1 can represent a key molecular link and an appealing target to harness microglial neuroprotective potential as...
Atrial Fibrillation Impairs Brain Waste Clearance, Predicts Worse Outcomes
Heart-Brain Axis Atrial fibrillation leads to reduced brain glymphatic flow, decreased washout of waste metabolites. https://t.co/2PNjoDl4Om Today #ACC26 @JAMACardio Serum Neurofilament (sNfl), a marker for brain cell injury, is associated with adverse CV events and mortality in patients with atrial fibrillation https://t.co/fWNg8zks0C
MRK's Sotatercept Shows Inverse Dose Response in 6
$TENX $TECX 🤔 $MRK sotatercept high dose *missed* stat sig on 6MWT in P2 (and it wasn’t particularly close). The low dose hit stat sig (barely) and was the dose taken to P3. What to make of a...
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative Lay Summary: "The role of interleukin-6 receptor (IL6R) blockade in reducing chronic-disease risk and improving longevity is uncertain. In a study of 38 807 postmenopausal women followed for...
Weekly Science Roundup: Quantum Uncertainty, Magnets, Sprinkler, Funding
🧪⚛️ Science items for the week, including causal uncertainty in quantum mechanics, magnets, the reverse sprinkler problem, and some funding talk. https://t.co/93lsIoh8xP
GLP‑1 Drugs Now Help Psoriatic Arthritis Beyond Weight Loss
The list of conditions for which GLP-1 drugs provide benefit independent of weight loss keeps growing. Add psoriatic arthritis #AAD26 @AADskin https://t.co/kJej6osXTS
Ivory‑billed Woodpecker: Decades of Misidentifications Confirm Extinction
Is this bird extinct? The Ivory-billed Woodpecker hasn’t been seen since 1944, despite numerous claims over the decades. All claims can only be deduced to people mistakenly identifying its close cousin, the Pileated Woodpecker. Every year, thousands of eager birders flock...
SGLT2 Inhibitors Help HFrEF Mice via Off‑Target Effects
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice “The beneficial effects of SGLT2i treatment in gKO mice conclusively demonstrate that in a physiologically relevant preclinical model of HFrEF, SGLT2i can exert therapeutic benefits via off-target pharmacology.3...
Brain Health Is a Dynamic System, Not Static
“There is no such thing as proof in biology… 🤔 …at any given moment we’re just one well-designed experiment (or one we’ll-phrased question) away from having to completely reevaluate the way we see the world.” 🔬 - @DrRagnar 🧠
More Ring Shots, Featuring Ghostly Jane for Reference
You guys liked the last batch of Ring photos so much, here’s a couple more from another angle. Standard Sam wasn’t in frame, so we’ve added in Ghostly Jane for reference. https://t.co/a5vqFxvfgc
Apple Pesticides: Dose Determines Risk, Not Presence
Here’s an engaging X (Twitter) post tailored to that specific BfR article: Is your apple really “poisoned”? 🍎 A compelling read from German Federal Institute for Risk Assessment unpacks the myth vs reality of pesticide residues—reminding us that “the dose makes the...
Writing Genomes Opens Post‑Darwinian Era of ABI
Artificial Biological Intelligence (ABI) In a post-Darwinian era of being able to write genomes, the implications—both for good and harm—are profound. In conversation with @AdrianWoolfson on his new book On the Future of Species https://t.co/2OahzzxAAa
Edge Computing in Space Cuts Data Transfer Overhead
Generically, it’s an IT arch that distributes computing so processing is closer to where the data is generated, which makes data xport more efficient and versatile. In this case, it means processing data in space, on the Ring, vs dumping...
Published Errors Survive; Faulty Experiments Kill
You can publish a paper with wrong data. You can't make a working drug with a wrong experiment. I wrote about HeLa contamination a few days ago. Then an Oxford researcher told me his story. https://t.co/77vvQQ8kq0
Discussing Artemis II and Florida Launch Experience on Bloomberg TV
Joining @BloombergTV This Weekend at 9:45amET to talk about Artemis II and my trip to Florida/KSC @davidgura @EenaRuffini @LisaMateoTV
Certain Cleaning Agents Can Cut PV Output by 5.6%
Fraunhofer CSP warns some cleaning agents may reduce PV module performance by up to 5.6% #energysky -- via pv magazine global: https://t.co/yfOWVCOjSx https://t.co/PM69r9Hgdg
Two Artemis II Live Events Today: Crew Talk & Update
Two Artemis II media events today (Sunday, Mar 28): 11:30 am ET with the crew, 2:00 pm ET status update. Watch on NASA's YouTube channel.
AI Foundation Models Expand From Language to Biology
How AI foundation models are moving from language into the biology of living systems and plant science. https://t.co/8WoCYGs5Fg
Tides Dominate Southern Ocean Internal Wave Energy Transport
Internal waves transport energy thousands of miles across the Southern Ocean, with tidal forces driving over 80% of the flux poleward and wind-driven waves carrying a smaller, equatorward component, influencing ocean mixing and climate dynamics. oceanography
Climate Crisis Ignored Yet Still Our Greatest Threat
Climate has almost disappeared from our conversation. But it remains the most pressing challenge of our times. Last week the WMO said the planet is “more out of balance than at any time in observed history.” Energy security and climate security are...
COVID Likely Zoonotic; Prioritize Broad Pandemic Preparedness
Concur that COVID was very likely zoonotic in origin. That's always been the most likely scenario, and the evidence has just grown stronger. (See below.) From a policy standpoint, I don't think it matters much. 1. Some past pandemics have originated...
Rejuvenating Blood Stem Cells Boosts Whole‑Body Health
Hematopoietic (stem) cells—The elixir of life? "In this perspective article, we discuss the evidence that supports that rejuvenating or delaying aging of the blood system has a beneficial and systemic impact on human health..." @FEBS_Letters https://t.co/Y9sYcwXp1A @FEBSJournal
Even Experts Dismiss Decades of Solid Evidence
Really interested in seeing how the supposedly smartest people rationalize ignoring a mountain of evidence that we’ve been talking about and publishing in top journals on for years
MIT's Tiny Robot Mimics Bumblebee Flight
MIT’s Insect-Size #Robot Flies Like a Bumblebee by @IntEngineering #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/xGQ1Fkrbd7
DNA Repair Drives Aging; OSK Reverses Epigenetic Decline
Loss of epigenetic information as a cause of mammalian aging “we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA...
Epigenetic Dysregulation Fuels Aging, Offers Therapeutic Target
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target 👉 “By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing,...
Can Information Theory Explain Chronic Diseases Too?
I wonder if we could find similar signatures in chronic diseases, such as diabetes, chronic infections, or autoimmune diseases? Would the Information Theory of Aging also rationalize these diseases equally based on equivalent observations?
Intranasal 5-MeO-DMT Boosts Depression Relief with SSRIs
The results of this first phase 2a clinical trial of intranasal 5-MeO-DMT administered adjunctively to SSRIs demonstrated acceptable safety and tolerability with promising improvements in depressive symptoms. https://t.co/m15DkPP4qX
Senescent Immune Cells Guard Tissues, Delay Aging
Senescent immune cells protect against damage, inflammation and disease 🤯 In mice, p16-expressing immune cells delay age-related organ deterioration and preserve tissue homeostasis. More evidence of the physiological roles of senescent cells? https://t.co/UtBKDF00P1
13-Year Study Becomes One of Cell’s Longest Papers
This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself https://t.co/Ra0CX1i5zt https://t.co/LbGXx2u4cq
Hib Vaccine Shields Against Meningitis, Pneumonia, Epiglottitis
The Hib vaccine protects against Haemophilus influenzae type b (Hib) bacteria, which can cause severe illnesses like meningitis, pneumonia, and epiglottitis. Th
Brain Mysteries Remain Unsolved After Two Decades
"Ten Unsolved Mysteries of the Brain" in Discover Magazine. I wrote this article 19 years ago. Amazingly, these are still the mysteries we face. https://t.co/SIfEB8VkUv
Researchers Prefer Automating Writing, Not Idea Generation
The researchers I know are far more likely to love this than hate it. You really think people enjoy the process of writing papers vs the actual hypothesis generation and designing & steering the research? Automate everything that can...
Psilocybin Emerges as Promising Longevity Therapy
When I started Don't Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies. Psychedelics were no where to be found. A wild turn of events that they're now front and center for us....
Microbial Phenolics Mediate Oats' Cholesterol‑lowering Power
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
PCSK9 Inhibitor Cuts Cardiovascular Events in Diabetics
In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current https://t.co/mzuI79c4IN https://t.co/16Cpxf7IBx
Supercomputer Maps Spliceosome Dynamics, Advancing Gene‑Splicing Drug Design
Supercomputer simulations of a two-million-atom human cell model have mapped the dynamic motions of the spliceosome, offering detailed insights into gene splicing mechanisms and informing future drug development. computationalbiology
Neural Network Denoises Ultrasound for Foggy Aerial Navigation
A new Science #Robotics study highlights Saranga, a deep neural network that can denoise ultrasound echolocation signals to improve aerial navigation even in dense fog, snow, or darkness. @nitinjsanket https://t.co/utyw7UGfJ9 https://t.co/ElinoMN830
Intensive LDL < 55 Mg/dL Cuts Cardiovascular Events
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) @NEJM #ACC26 https://t.co/oLnkqhawOd
Dogs Coexisted with Humans 14,000 Years Pre‑agriculture
Ancient DNA analysis shows that domesticated dogs lived alongside humans in Western Eurasia over 14,000 years ago, sharing diets and forming close bonds long before the advent of agriculture. archaeology
NASA Announces $20 B Moon Base and Nuclear Mars Ship
Now @NASA Unveils Its $20 Billion Moon Base Plan—and a Nuclear Spacecraft for Mars by @EddyTheGent https://t.co/2xGqkZeZyd https://t.co/N24jKsM0AN
AI Meets Scalable Single-Cell Data, Transforming Medicine
AI needs data. And biology is finally generating it at scale. I spoke with @10xGenomics CEO Serge Saxonov about the single-cell and spatial biology revolution — and why the convergence of AI + biological measurement could transform medicine. Read the full profile...
Combining Modest Therapies Unlocks Big Benefits, Reduces Waste
Adam, I used to think this way. Then gene therapy & IO worked. IL2 has consumed a lot of hope; but new variations make it hard to quit. Abeta worked. And synergy: combine modest drugs, unlock big benefits. Invest or...
Procrastination Driven by Threat, Freeze, and Brain Imbalance
The Neuroscience Of Procrastination: 1. Perceived Threat (Amygdala Activation). 2. The "Freeze" Response. 3. Prefrontal Cortex Underactivity. 4. The Cycle Of Relief.
Evolution Enables Shape‑Shifting Within a Single Lifetime
Just so amazing evolution found a way to change shape in a single lifespan. Some of the cell types run a few laps around the cocoon too.
New Atlas Maps All Human E3 Ligases, Unifying Research
A comprehensive atlas now defines all human E3 ligases, resolving decades of inconsistencies and providing a unified framework to advance research and therapeutic development for diseases linked to these essential enzymes. biotechnology
Molecular Anchors Boost Perovskite Solar Durability in Temperature Swings
Molecular anchors have been shown to stabilize perovskite solar cells, significantly reducing performance loss during rapid temperature changes and enhancing their durability for long-term outdoor use. solarenergy
Classifying Aging Doesn't Affect Need for Research Investment
Though authors acknowledge (as I have argued before), even *if* they are right, “classification of aging is not relevant to the importance of investing in aging research to alleviate its burden” [nor targeting it, I might add] 👨🏻⚕️
AI‑Powered Vocabulary Extraction Flattens Forgetting Curve
In 1885, Hermann Ebbinghaus made a stark discovery about the human brain. We forget 40% of new information within days, and 90% within a month. Today, we can accurately hack this forgetting curve using AI and structured data. Language apps fail because they...