Health as a Point, Disease as Trajectory in Latent Space
Latent Space as a Physiological Map: All our medical data, genomes, scans, notes are just different shadows of one underlying physiological state. Health = a point in high-dimensional space. Disease = a drifting trajectory Treatment = a vector, steering us back toward the healthy manifold. Mindbending unification from the Latent Space Hypothesis.
NASA Reveals Details of Mike Fincke’s ISS Evacuation
NASA released details of the ISS medical evacuation of astronaut Mike Fincke in January 2026 #space #astronomy #science https://t.co/Juis0InB8P
New Therapeutic Triad Accelerates Huntington's Disease Breakthroughs
“Huntington’s Disease and The Triad of Therapeutic Conviction”. Debut blog from Eric Green, CEO of Trace Neuro, explaining why and how advances are happening in HD. Genetics, cellular understanding, and enabling modalities. https://t.co/pAr9EQs5gJ
R3 Bio Engineers Whole Organs, Featured in WIRED
This is so awesome. @JohnSchloendorn and Alice Gilman at R3 Bio talk through what they’re doing at R3 Bio: building something that's never existed before. They're designing genetically engineered whole organ systems. See them featured in WIRED. @WIRED full story here: https://t.co/8z5iGXR0uK
Trump Admin Considers Repurchasing Offshore Wind Leases
The Trump administration is talking with some offshore wind developers about buying back the leases they purchased from the federal government years ago to develop energy projects along the US coast https://t.co/w6VR2H3AC3
Aging Silences Brown Fat's Heat Genes via Epigenetics
Brown fat loses its heat-producing function with age due to epigenetic changes that reduce activity of key genes like PGC1A, with specific enhancers playing a critical role in maintaining this function. https://t.co/Dnnawd5r41
Winter Power Gaps Demand Clean‑Firm Energy and Grid Scale
Solar and wind are making remarkable progress. The day/night cycle will be solved by current economic battery trends. The real long term challenge has always been winter: Those dark winter days or weeks when the wind also fails. For that...
TotalEnergies Drops 2050 Net‑zero Goal
French energy giant TotalEnergies says it will no longer aim to reach net zero emission targets by 2050 https://t.co/oJaqzNTGaQ
SREBP‑2 Links Stress to Cell Death via IRAK1
Researchers found that the cholesterol-related protein SREBP-2 can trigger apoptosis under stress by interacting with IRAK1, revealing a new mechanism for how cells self-destruct. This suggests that beyond telomeres, which signal aging through gradual shortening, cells can also initiate death...
Raw Compute and Data Will Outpace Bio
The Bitter lesson from AI applied to today's Bio AI models tells us most will be washed away with raw compute and data. Today's Startups and Academics will (mostly) fight it but that too will fall. Raw compute and data is what...
Slowing Aging: A Targetable Process for Massive Health Gains
Aging may or may not be classified as a disease, but that’s largely semantics. What matters is that aging is a malleable, targetable biological process, and slowing human aging would result in massive health benefits.
JPMorgan Clients Increasingly Focus on Climate Tipping Points
JPMorgan’s institutional clients have started paying more attention to so-called tipping points in climate https://t.co/MkV9vxVmwj
Plesetsk Launch Planned Early April to 63° Inclination
Local warnings and at least one NOTAM indicate an upcoming launch from Plesetsk between April 1 and 15 to an orbit with an inclination 63 degrees toward the Equator: https://t.co/EhSC0xsQVM https://t.co/E7nBV3xpBV
Dark Energy Keeps Universe Flat Despite Dilution
Ask Ethan: Does dark energy curve the Universe over time? Our Universe was once ruled by radiation and matter, but those densities eventually dilute. Would spatial curvature appear? Even if it did, dark energy now flattens the Universe once again. https://t.co/zF67EySaRB
GLP-1 Drugs: Brain‑targeted Cure for Obesity and Addictions
In 1992, scientists discovered a chemical in Gila monster venom that mimicked GLP-1, the hormone your gut releases to signal fullness. By tinkering with its structure, pharma companies extended its duration from two hours (the Gila monster version) to one...
Artemis II Crew Arrives at KSC for Media Q&A
Artemis II crew is enroute to KSC. Expected to land abt 2:30 pm ET. NASA's Jared Isaacman and CSA's Lisa Campbell will be there to greet them. Crew then will answer questions from the media. Full list of public...
Geoengineering Debate: Sulfur Injection as Climate Fix
Today on Volts: at this point, it is all but inevitable that global temperatures will exceed the 2° threshold & continue rising. Should we shoot sulfur particles into the stratosphere to block some of that heat? I talk with the...
NAD+ May Influence Ovarian Aging, Research Uncertain
Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research https://t.co/OWU1Hhcreu https://t.co/IH7uKdRsa9
Newborn Grip: An Ancient Primate Survival Reflex
When you put your finger in a newborn's palm, they grip it so hard it is almost shocking. It is called the palmar grasp reflex. It is strong enough that some newborns can briefly support their own body weight hanging...
Canadian Whale Scientist Observes Near‑Miraculous Sea Event
Out at sea, a Canadian whale scientist witnessed something close to a miracle /via @globeandmail https://t.co/nykQ2LNHh4
AstraZeneca's Lung Drug Scores Unexpected COPD Trial Win
AstraZeneca lung drug gets ‘surprise’ win in COPD trials https://t.co/QuRlOQtzdT @ByJonGardner $AZN $RGN $SNY $RHHBY
Cryonics: Costly, Uncertain, yet Still Seen as Worthwhile
Cryonic preservation is pricey and might never work. Some people think it’s worth it anyway.
Critics Slam NASA's Controversial Commercial Space Station Plan
No one, it seems, is happy with NASA's new idea for commercial space stations. https://t.co/SVhXpYQAnK
Avoiding Sun May Double All‑Cause Mortality Risk
Is sun avoidance a risk factor for mortality?☀️ In this 2014 study from Sweden, sun avoidance was associated with nearly a 2x higher rate of all-cause mortality compared to the most active sun exposure habits. They did find increased risk of malignant...
UCLA Health Omits Patient Polygenic Risk Scores From Study
Kudos to @UCLAHealth for assessing genomics of their patient population, published @CellCellPress today. But why weren't the results of increased polygenic risk scores (PGS) provided to the patient participants? https://t.co/F15isJfDQy https://t.co/3AW7peHa1C
China’s Research Surge Threatens U.S. Scientific Dominance
The Shocking Speed of China’s Scientific Rise When will Chinese research pull ahead of the U.S.’s? https://t.co/BBemz3lomx
New Evidence Strengthens Ergothioneine’s Health Narrative
This adds to the building story for ergothioneine, which we covered in a deep dive (2h): https://t.co/VvaoPbC3eB
Aging Research Gains Momentum: Collaboration Fuels Therapeutic Breakthroughs
Now at 1M+ views. What struck me most here wasn’t the views. It was the engagement. People are ready to engage seriously with aging biology. Now the opportunity is to turn that energy into stronger collaboration, better translational science, and...
LENG8 Ensures Quality Control of Cellular RNA Export
LENG8 has been identified as a key protein that monitors and controls RNA quality in cells, ensuring only properly processed RNA is exported from the nucleus while defective RNA is retained and degraded. molecularbiology
Intense Exercise Boosts Brain Impulse Control, Says Huberman
Brain benefits of intense exercise, including impulse control @foundmyfitness on the Huberman Lab podcast out now. https://t.co/ikb1qKevnc
In‑vivo CAR‑T Achieves 4/5 MRD‑Negative Remissions
Outstanding piece here from @leilei_wuu on AstraZeneca's in vivo CAR-T for multiple myeloma. There's data on 5 patients, which is pretty lean, but 4 come out MRD negative in two months, which is extraordinary. We're going to see a lot...
Sparse Inputs, Detailed 3D: ReCoSplat Advances Reconstruction
ReCoSplat: Reconstructing 3D Worlds From Sparse Visual Data In this episode of Artificial Intelligence: Papers and Concepts, we explore ReCoSplat, a novel approach to 3D scene reconstruction that leverages sparse visual inputs to generate detailed spatial representations. Instead of requiring dense...
Tech Experts Overestimate Their Grasp of Cancer Biology
As someone who has covered cancer drug development for 25 years, one of the few things I am sure of is that the odds of technology folks thinking they understand biology are much higher than the odds they actually do.
Metabolic Disturbances Drive Multimorbidity, Offering Intervention Targets
Shared and specific blood biomarkers for multimorbidity "Metabolic disturbances emerged as a key driver of multimorbidity. If confirmed, these processes could represent targets for interventions to mitigate disease accumulation." https://t.co/3nuctP2eAC https://t.co/yxk5CZHiHV
Prescribe Exercise Before Drugs for Chronic Disease
As a medical school professor, I teach my students to prescribe drugs. But a landmark review in Cell Metabolism argues we should prescribe exercise first. Febbraio and Pedersen -- the scientists who coined "exercise as medicine" -- reviewed 233 studies on...
When You Eat Impacts Metabolism as Much As What
As a medical school professor, I was trained to focus on WHAT patients eat. But this massive meta-analysis says WHEN may be just as important. 41 randomized controlled trials. 2,287 participants. Published in BMJ Medicine. The finding: time-restricted eating improved nearly every...
Decade-Long Quest to Break Blood-Brain Barrier Highlights Biotech Challenges
When we seeded Denali the idea was to break the curse of the blood/brain barrier. It took a decade and tons of faith and money. Biotech is hard. Curing diseases is hard. This is a good summary. ...
Asia Emerges as Testbed for Healthcare Innovation
It was a pleasure to participate in the Investment and Innovation Pathways to a Healthy Asia session at the Global Investors’ Symposium in Hong Kong. A timely discussion on where durable value is being created in healthcare across Asia, from prevention...
AI Empowers Chemists, Accelerating Novel Drug Discovery
The life of a chemist is about to change dramatically as we move away from tedious trial-and-error and deeper into the comfort of the prompt window. We don't need fewer medicinal chemists; we need more high-novelty drugs on the market...
Alpha‑Lipoic Acid Shows Promise for Ischemic Heart Failure
Efficacy of Alpha-Lipoic Acid in Patients With Ischemic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Study | @JACCJournals https://t.co/nW9SbwEDfy https://t.co/qsemjmMb9k
Mid‑circuit Measurements Add Magic, Making Adaptive FLO Classically Hard
Measurement-induced non-commutativity in adaptive fermionic linear optics We show that mid-circuit measurements of fermions with internal degrees of freedom can induce the equivalent of "magic" to free fermionic circuits and render them classically hard to sample. https://t.co/r7rZBcyLHL Fermionic linear optics (FLO) with Gaussian...
LLMs Enable DIY mRNA Vaccine for Pets
The coolest meeting I had this week with was Paul, who used ChatGPT and other LLMs to create an mRNA vaccine protocol to save his dog Rosie. It is amazing story. "The chat bots empowered me as an individual to act...
GLP‑1 Therapies Show Promising Cardiovascular Benefits
GLP-1 and the cardiovascular system "This Review summarizes the effects of GLP-1 and GLP-1RAs in the CV system..." https://t.co/Sy7Jjb96WD https://t.co/v3T01fIcOs
Quantum Battery Prototype Achieves Ultra‑Fast Charging
Scientists demonstrate quantum battery prototype with rapid charging #energysky -- via pv magazine global: https://t.co/AxphAp5wAP https://t.co/HjngLBmLdA
Billionaires Fund Headless Human Clones for Organ Farms
Billionaire-backed scientists aim to grow 'headless humans' to farm their organs... and help biohackers live for longer https://t.co/uQOzEtBapf https://t.co/HYZCMCOPy3
Uric Acid Predicts Sex‑Specific Cognitive Decline in Seniors
Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study https://t.co/vl5LLY6mBc
C1ORF112 Validated as Breast Cancer Driver After Early Prediction
Great to see a new work showing that C1ORF112 is upregulated in tumor tissues and that it promotes breast cancer proliferation. We computationally predicted C1ORF112 to be related to cancer back in 2012, and we were the first to study and...
E‑cigs Boost Quit Rates 20‑40% over NRT
Nicotine e-cigarettes are linked to quit rates 20% to 40% higher than traditional nicotine replacement therapies, with consistent evidence showing greater effectiveness for smoking cessation over at least six months. smokingcessation
DNA Confirms Galapagos Lava Heron as New Species
Genetic analysis has confirmed the Galapagos lava heron as a distinct species, overturning decades of classification and highlighting the ongoing evolutionary mysteries of the islands. ornithology
MRD‑Negative Patients Can Stop Myeloma Maintenance Therapy
Discontinuation of maintenance therapy in multiple myeloma guided by multimodal measurable residual disease negativity (MRD2STOP) - @bdermanmd et al. @ajjakubowiak #ASCO24 Abstract 106 https://t.co/FBTY7SnCxK #NCT04108624 #mmsm #mmMRD