To Accelerate Rare Disease Progress, Take a Sandbox Approach
A sandbox framework is proposed to overhaul rare‑disease drug development, allowing regulators, sponsors, patients and academics to collaborate in real time. The model groups therapies into small‑molecule, biologic and complex sandboxes, enabling a continuous IND that spans Phase 1‑3 and eliminates the need for non‑human‑primate testing of monoclonal antibodies. Model‑Informed Drug Development (MIDD) tools are embedded to maximize sparse clinical data, refine endpoints and support accelerated‑approval pathways. The approach aligns with recent FDA and NIH moves to phase out animal testing and embrace flexible regulatory engagement.
AWS Releases Updated PCI PIN Compliance Report for Payment Cryptography
Amazon Web Services has released an updated PCI PIN compliance package for its Payment Cryptography service, confirming a recent third‑party audit with zero findings. The package includes a PCI PIN Attestation of Compliance and a Responsibility Summary that outlines customer obligations. The...
Prioritizing Shortfalls
In this brief 1‑minute, 30‑second episode, NASA discusses how it is leveraging the rapid growth of the U.S. space economy to shape its own technology investment strategy. The agency highlights the importance of identifying and prioritizing “shortfalls” – capability gaps...
The New ATO Playbook: Session Hijacking, MFA Bypass, and Credential Abuse Trends for 2026
In this episode Jason Wagner outlines how account takeover (ATO) has shifted from brute‑force logins to stealthy session hijacking, MFA fatigue, and credential reuse tied to real identities. He explains that attackers now harvest active session tokens and device fingerprints,...
Retail’s Busiest Streets Are Booming with New Investment, Flagships
Transaction volume in North America’s high‑traffic urban retail corridors jumped 82% from 2024 to 2025, signaling renewed investor confidence. Major retailers such as Uniqlo, H&M and luxury houses are opening flagship stores, with New York, Los Angeles and Miami accounting for 60%...
The $42.8B Retail Media Playbook
Retail media generated $42.8 billion for Amazon in Q1 2025, driven by a server‑side ad serving architecture that delivers native ads without latency or privacy trade‑offs. The eBook outlines a modern retail media stack featuring sponsored products, zero‑impact loading, full reach, built‑in...
Retail’s Supply Chain Divide: Who Survives – and Who Won’t
Retail margins are tightening, making supply‑chain efficiency a make‑or‑break factor. Supply‑chain specialist Peter Jones splits the sector into "haves" – retailers that have invested in automated, next‑generation warehouse technology – and "have‑nots" still reliant on manual pick‑and‑pack processes. The COVID‑driven...
The Pillars of a Successful Artificial Intelligence Strategy
Digital workplace leaders must craft an AI strategy that starts with a clear vision aligned to business goals, identifies market drivers, and maps compliance and ethical risks. The strategy translates into an AI portfolio that prioritizes initiatives, balances ambition with...
The Future of Delivery: Key Trends Shaping 2026
Delivery logistics face a convergence of pressures in 2026, including AI-driven automation, stricter CO₂ emissions regulations, rising cross‑border demand, and the shift to zero‑emission fleets. Retailers and carriers must adapt to consumers who will abandon orders if delivery options are...
NATO Space Centre of Excellence Reaches Full Operational Capability as New Facility Opens
NATO’s Space Centre of Excellence has been declared fully operational following the opening of its permanent facility in France on 19 January 2026. The centre consolidates three years of institutional build‑up into a standing capability that will shape alliance thinking,...
Energy Devices for Acne in Skin of Color
Energy‑based devices such as lasers, intense pulsed light (IPL) and radio‑frequency are increasingly used to treat acne in patients with darker skin tones. Recent clinical trials show that long‑pulse Nd:YAG lasers and low‑fluence fractional lasers reduce inflammatory lesions while minimizing...
AI Creates Personalized News Podcasts on the Fly
Personalized news is in my house. I don’t know if you all are seeing what I am doing with bleeding edge AI. From @blevlabs. His AI agents “Braygents” analyze the news in ways way beyond human. I had it write me...
Show HN: SF Microclimates
Solo Founders launched a free, no‑key API that provides real‑time weather and air‑quality data for all 50 San Francisco neighborhoods. By aggregating over 150 PurpleAir outdoor sensors, the service delivers hyper‑local temperature, humidity, PM2.5 and AQI readings instead of a single...
3D Printed Polymers Mimic Atherosclerotic Blood Vessels’ Properties
Researchers have created 3D‑printed polymers that accurately mimic the mechanical behavior of atherosclerotic blood vessels, addressing a long‑standing gap in surgical training models. By integrating UV‑induced and hydrolysis‑induced degradation, the materials can evolve from healthy‑like compliance to plaque‑like brittleness, offering...
Deal Flow Quality Trumps Picking Skill for VC Success
Deal Flow Quality beats “picking skill” The figure below is a reminder that most VC chest-thumping is aimed at the wrong variable. In venture, outcomes are driven by two levers: >Pool quality (base rate): how many real winners exist in what you see >Picking...
Scale Yourself, Target Companies' Labor Budgets, Not Courses
No, don’t sell a @clawdbot course. Figure out how to duplicate yourself many times, then do that for companies. Instead of attacking consumer learning budgets, target labor budgets. It’s the biggest line item.
NASA's Webb Telescope Peers Into the Heart of the Circinus Galaxy
The James Webb Space Telescope employed the Aperture Masking Interferometer on its NIRISS instrument to capture the sharpest infrared image yet of the Circinus galaxy’s active nucleus, effectively achieving a 13‑meter virtual aperture. The data show that 87 % of the...
LLMs Introduce Critical Blind Spot in System Observability
LLMs create a new blind spot in observability - The New Stack https://t.co/jxjLTWrwLX #LLMs #LLM #GenerativeAI #GenAI #artificialintelligence
First Clawdbot Contribution Fixes iMessage Metadata Bug
My first contribution to Clawdbot is out in today’s release. 🫡 Fixed an issue where iMessage replies occasionally get prefixed with random metadata.
![What Is Human-First Marketing? [Infographic]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/592552693bf02122ca5bee9dec752a93.webp)
What Is Human-First Marketing? [Infographic]
Human‑first marketing shifts focus from product features to the personal benefits a brand delivers, emphasizing empathy and storytelling. The article warns that AI‑generated content can dilute authentic connections, making audience‑centric messaging essential for performance. Giraffe Social Media’s infographic offers practical...
Zonal Endothelial Cell Diversity Drives Renal Vascular Growth
Researchers have uncovered that endothelial cells in the kidney exhibit distinct zonal identities, each contributing uniquely to renal vascular growth. Using single‑cell RNA sequencing, the team mapped spatially resolved endothelial subpopulations and identified zone‑specific signaling pathways that promote angiogenesis. Functional...
What Is User Managed Access?
User Managed Access (UMA) extends OAuth 2.0 by letting data owners set granular sharing policies. It introduces components such as Resource Owner, Authorization Server, and Requesting Party Token to mediate consent. In enterprise SSO, UMA decouples resource data from policy logic,...
Subdued Goes Bold with Global Expansion
Italian fashion brand Subdued is teaming up with its tech partner for international expansion
The Model T Comes to Silicon Valley
The early 20th‑century assembly line slashed Model T production time by 90%, triggering a wave of consolidation that left only 44 automakers by 1929. Today, AI‑driven coding assistants are delivering comparable productivity gains—55‑81% faster development—in roughly five years. The auto boom...
Pinterest Adds Media Planner to Help You Manage Your Ad Campaigns
Pinterest has launched a native Media Planner within its Ads Manager, giving marketers a single dashboard to design, estimate, and model upper‑funnel campaigns. The tool lets advertisers explore high‑value audience segments, forecast impressions, reach, CPM and CPC by country, and...
Show HN: FaceTime-Style Calls with an AI Companion (Live2D and Long-Term Memory)
Beni AI launched a FaceTime‑style AI companion that supports two‑way voice, video, and text with live captions. The platform includes an opt‑in memory layer that preserves context across sessions and perception‑aware features such as expression detection. Users can extend functionality...
Hubble Shows Spectacularly Violent Scenes From a Massive Young Star
The Hubble Space Telescope captured vivid Herbig‑Haro objects produced by the massive protostar IRAS 18162‑2048, located about 5,500 light‑years away. Its bipolar jets blaze at over 1,000 km s⁻¹, the fastest ever recorded for a young stellar object, carving a 32‑light‑year cavity. The...
Uber and DoorDash Lose Bid to Quash NYC Tipping Law
Uber and DoorDash lost a federal bid to block New York City’s new tipping law, which forces delivery apps to present a tip option and a suggested minimum of 10% at checkout. U.S. District Judge George Daniels rejected the companies’...
AI Empowers Tech Leaders with Actionable Enterprise Tools
AI is very powerful in the hands of leaders. Here's how. Everything a Tech Leader needs to know, and some actionable advice for how to move forward. Next I'll post an Economist Style article that will be great to bring to...
Exploring CDPK Genes in Liriodendron Chinense Under Stress
Researchers have catalogued the calcium‑dependent protein kinase (CDPK) gene family in Liriodendron chinense, a prized ornamental and timber species. Twelve CDPK genes were identified, and transcriptomic profiling showed distinct up‑regulation under drought, salinity, and cold stress. Promoter analyses uncovered multiple...
AI Beats Traditional Tools in Real‑Time Crisis Analysis
I'm having @blevlabs' AI analyze what's going on in Minneapolis and even it lays out how bad things are getting. Be back in a bit with what it teaches me. By the way, his AI (a cognitive architecture) is way...
Science Fiction Writers, Comic-Con Say Goodbye to AI
Science fiction and pop‑culture institutions are tightening rules on generative AI. The Science Fiction and Fantasy Writers Association (SFWA) now disqualifies any Nebula‑Award entry that used large language models, after a brief reversal and member backlash. San Diego Comic‑Con similarly banned...
26M+ Scammed By Fake QR Codes: NordVPN
NordVPN research finds more than 26 million people may have been lured to malicious sites via fake QR codes. Scammers embed these codes in “brushing” packages, a tactic that now delivers 26 % of all malicious links. Seventy‑three percent of Americans admit...
'Put plainly...some Countries Are Already Using AI to Solve Harder Problems and Move Faster': OpenAI Wants to Make AI Usage...
OpenAI warns that AI adoption is uneven across nations, creating a capability overhang where a few countries reap disproportionate economic and technological gains. Research shows that advanced AI usage varies more by skill and infrastructure than by income, with some...
Experian, Credit Builders Alliance Partner to Improve Access for Underserved Consumers
Experian and the Credit Builders Alliance (CBA) released a study showing that adding a CBA tradeline propels 70% of previously unscored borrowers into prime or near‑prime credit within a year, far outpacing the 48% rate for the broader unscored population....
AI Enables High Earnings with Lean, Efficient Teams
So I saw a LinkedIn post from a sales executive I like a lot and have known for a long time looking for his next role. The headline: “Looking to Make The Most Money For The Least Amount of Work.”...
StepFun AI Introduce Step-DeepResearch: A Cost-Effective Deep Research Agent Model Built Around Atomic Capabilities
StepFun AI unveiled Step-DeepResearch, a 32‑billion‑parameter agent built on Qwen2.5‑32B‑Base that transforms web search into end‑to‑end research workflows. The model internalizes four atomic capabilities—planning, deep information seeking, reflection/verification, and report generation—using specialized data pipelines and long‑context training up to 128k...
Opioid Treatment’s Effects on Jail Mental Health Services
A growing number of correctional facilities are integrating opioid agonist treatment (OAT) into their mental health services, aiming to curb overdose deaths and improve psychiatric outcomes among inmates. Recent pilot programs report a 30% drop in emergency psychiatric visits and...
6 Best Employer of Record Companies in Norway
The episode outlines the top six Employer of Record (EOR) providers for hiring in Norway—INS Global, Remote, Deel, Oyster, Globalization Partners, and Papaya Global—explaining how each service handles local contracts, payroll, tax, and compliance while letting companies retain operational control....
B2BKing: A Powerful B2B & Wholesale Plugin for WooCommerce
The episode explores B2BKing, a comprehensive WooCommerce plugin that adds enterprise‑grade wholesale capabilities to WordPress stores. It walks through core features such as granular guest access restriction, tiered pricing tables, and a customizable business registration workflow that together enable hybrid...
Ask These 5 Questions to Fix Stalled Growth
5 questions to ask when your product stops growing Jason Cohen is a four-time founder (including two unicorns, one being WP Engine ), and one of the most prolific and beloved sharers of product and startup wisdom (at asmartbear.com )....
Entrepreneurs Often Run Jobs, Not Independent Businesses
Many entrepreneurs think they’re independent simply by starting their own business, but if you have a complex cap table, a bank loan that’s always on your mind, or silent (or loud) partners who see things different ways, there’s a very...
Support for FDA Action on Menopausal Hormone Therapy
The U.S. Food and Drug Administration announced a new regulatory push targeting menopausal hormone therapy (MHT), proposing stricter labeling requirements and heightened post‑market surveillance. The agency highlighted recent safety data linking certain formulations to increased cardiovascular and breast cancer risks,...
Free Weekly Newsletter Curates Top PR Campaigns and Hooks
📣 Announcing The "Trending Campaigns" Newsletter: Receive the most effective PR campaigns and coverage opportunities with the Trending Campaigns Newsletter. Trending Campaigns is a free weekly newsletter curating standout PR campaigns and timely news hooks you can use, sent every...
AI Policy Debate Misses the Real AI Assistant Shift
The policy debate over AI is overfitted to the social media wars. AI is a completely different form factor. The rise of AI assistants will make this clear.
Chandra Catalog Now Contains 1.3 Million X-Ray Detections Across the Sky
NASA’s Chandra X‑ray Observatory has expanded its Chandra Source Catalog to include 1.3 million X‑ray detections, covering the entire sky. The new release consolidates over 20 years of observations with uniform processing and improved positional accuracy. Researchers can now query the catalog...
Glossier Grew on Community, Not Ad Spend
Glossier spent $0 on ads for their first 2 years. Just UGC and community. Meanwhile you're burning budget on cold traffic. That's the gap.
Inside South Korea’s Bold Move To Accelerate Its New Space Economy
South Korea has officially designated its first nationally recognised New Space technologies, shifting the focus from pure research to commercially ready systems. The Korea Aerospace Space Administration evaluated 52 proposals, rewarding technologies that can be manufactured, sold and operated at...
Cellulose Nanofibril‐Filled Damping and Lubricating Hydrogels for Mitigating Friction‐Induced Vibration of Polyurethane Composites
Researchers introduced a multi‑crosslinked polyvinyl alcohol hydrogel reinforced with carboxylated cellulose nanofibers (MCPH) and blended it into thermoplastic polyurethane. The hydrogel supplies both hydration lubrication and reversible bonding that dissipates mechanical energy, dramatically improving the composite’s friction and damping behavior....
Will the Smartphone Survive the AI Age?
The smartphone’s reign faces its first serious test as AI giants OpenAI, Meta and Amazon unveil devices that could supplant the iPhone‑Android duopoly. OpenAI’s Sam Altman hinted at a new AI‑first hardware that would feel unlike any phone, while Meta...
