Real-World Safety of Second-Line Diabetes Drugs in Elderly
A 2026 Nature Communications study examined real‑world safety of second‑line diabetes drugs in patients 65 and older after metformin. Using electronic health records and claims data, the researchers compared sulfonylureas, DPP‑4 inhibitors, SGLT2 inhibitors and GLP‑1 agonists with propensity‑score matching. The analysis found sulfonylureas linked to higher hypoglycemia and cardiovascular events, while SGLT2 inhibitors reduced heart‑failure and renal hospitalizations, and GLP‑1 agonists showed a favorable overall safety profile. The findings support more nuanced, age‑specific prescribing decisions.
Nintendo Switch 2 Update Changes Minuscule Mario Details
Nintendo released firmware version 22.0.0 for the Switch 2, introducing a subtle redesign of Mario’s avatar icon to improve its centering. The update also adds practical features such as friend‑list notes and the ability to fast‑forward or rewind videos in the...
Dreaming of a Personal Waymo for Everyday Travel
I Really Want My Own Private Waymo (yes, that is funny… but I am serious)
AI Empowers Citizens to Make Governments Transparent and Accountable
Something I've been thinking about - I am bullish on people (empowered by AI) increasing the visibility, legibility and accountability of their governments. Historically, it is the governments that act to make society legible (e.g. "Seeing like a state" is the...
Orion Spacecraft Races Toward Historic Lunar Flyby in Artemis II Mission
NASA’s Artemis II mission entered its mid‑flight phase as Orion completed the trans‑lunar injection burn and set a free‑return path toward a historic lunar flyby on April 6. The four‑person crew will skim 4,000‑6,500 miles above the Moon’s far side, capturing high‑resolution images...
Introduction to Risk Management: A Complete Guide for Security Professionals
Dr. Erdal Ozkaya’s free guide delivers a complete, step‑by‑step introduction to cyber risk management, covering definitions, the seven core concepts, quantitative formulas, and the NIST Risk Management Framework. It shifts security teams from reactive alert firefighting to strategic decision‑making by...
AMD Ryzen 5 7600X3D $246.00 at Amazon.com or $199.99 for In-Store Pickup at Micro Center.
AMD’s 6‑core Ryzen 5 7600X3D is listed on Amazon for $246, while Micro Center offers the same chip for $199.99 with in‑store pickup. The processor features 3D V‑Cache technology that delivers a noticeable uplift in gaming and content‑creation workloads. Pricing under $200...
From Silicon Chips to Integrated Systems: Industry Shift
#Technology #Blog #Semiconductor #Manufacturing #System BLOG-321 | The Semiconductor Shift From Silicon To System: https://www.chetanpatil.in/the-semiconductor-shift-from-silicon-to-system/
Agentic AI and the Next Intelligence Explosion
The article challenges the classic singularity myth, arguing that future AI breakthroughs will be plural and socially embedded rather than a lone super‑intelligence. It draws parallels to past evolutionary transitions, emphasizing that intelligence is relational and high‑dimensional. Two concrete pathways...
A Practical Guide for AI Use by Public Sector Leaders — and Why This Matters Now More Than Ever
Alan Shark’s new book offers a five‑part roadmap for public‑sector leaders to adopt artificial intelligence responsibly. It starts with foundational concepts and five critical questions administrators must ask before deployment. Subsequent sections address governance, auditing, AI fatigue, emerging Chief AI...
Protein Monitoring Enhances EASO Obesity Care Timing
The European Association for the Study of Obesity (EASO) has released new guidance emphasizing regular protein monitoring to optimize obesity treatment timing. Clinical data show that tracking protein intake enables clinicians to adjust interventions earlier, boosting weight‑loss efficacy. The recommendation...
Salesforce Agentforce Executive Eric Eyken-Sluyters Departs After 23 Years to Join Rival AI Startup Sierra
Salesforce veteran Eric Eyken‑Sluyters, who led the company’s flagship AI agent platform Agentforce, resigned after 23 years to become president of field operations at rival AI startup Sierra. Sierra, valued at roughly $10 billion, builds AI‑driven customer‑service agents that directly compete...
Measuring Fitness: Insights on Individual Phage Particles
Recent research is moving phage stability assessment from bulk plaque assays to single‑particle analysis, revealing that up to 99% of produced virions quickly become non‑infectious. Advanced microfluidics, liquid‑handling robotics, and high‑resolution imaging now track individual phage fates under stress, exposing...
This Free Tool Does Everything Snipping Tool Does and About Ten Things It Doesn't
Greenshot, a free Windows screenshot utility, matches the core functions of Microsoft’s Snipping Tool while adding a robust built‑in editor, obfuscation options, and extensive export capabilities. Users can capture full screens, windows, or custom regions, then annotate with speech bubbles,...
How Scalable Is Agentic AI for Growing Businesses
Enterprises increasingly rely on Non‑Human Identities (NHIs) to power automated processes, yet many still lack comprehensive management. Effective NHI governance—covering discovery, access control, and continuous threat monitoring—delivers risk reduction, compliance assurance, and operational efficiency. Agentic AI adds scalability by automating...
Use Practical Law Templates for Lawyer-Approved Contracts
Want a contract drafting secret? Use the SEC public agreements as a starting point. Or get a subscription to practical law. Thats where the real templates live. If you use a template from practical law, your lawyer will be impressed. Because...
US Warehouse Launch: Faster Shipping, No Tariffs
🇺🇸 We are now in the USA 🇺🇸 We’ve finally (after filling out and signing a billion forms) opened a warehouse in the US. No more tariffs, no more import duties, no more nasty surprises - just quick shipping 🙌🏻 Check...
Space42 and Viasat: Contract Close for 2800 Satellites
Space42 and California‑based Viasat are on the verge of signing a contract to build a 2,800‑satellite low‑Earth‑orbit (LEO) mega‑constellation under the Equatys joint venture. The fleet, slated for launch between 2029 and 2030, will operate at three altitude bands and...
Meta Launches Prescription-Friendly AI Glasses with Ergonomic Design
Meta expanded its line of AI glasses with new options designed for prescription wearers. 👓 Called Blayzer and Scriber, the glasses support nearly all prescriptions and come in two designs built for all-day wear. They include ergonomic features like overextension hinges, interchangeable...
AI Agents Going Mobile Within Two Months.
The next two months in AI agents. At Pokee's hackathon in San Francisco today. It makes a very powerful agentic platform. More on that later tonight when the Hackathon concludes. Founder/CEO @ZheqingZhu (Bill) Zhu told me the next move...
23 WTO Members Including the US, UK, Japan, and Mexico Form Their Own E-Commerce Duty-Free Agreement After Global Talks Collapse
A coalition of 23 WTO members—including the United States, United Kingdom, Japan and Mexico—has signed a separate pact to keep electronic transmissions such as digital downloads and streaming free of customs duties. The agreement follows the collapse of WTO‑wide talks...
Larger Context Windows Enable Human‑like AI Agent Design
As AI models get better at handling tools, and as context windows get bigger without as much rot, you can start to design agents more similar to how people work instead of having to mitigate the model limitations with weird...
Are Employers Using Your Data To Figure Out the Lowest Salary You'll Accept?
MarketWatch highlights a growing practice called “surveillance wages,” where employers use personal data—such as payday‑loan history, credit‑card balances, and social‑media activity—to infer the lowest salary a candidate will accept. An audit of 500 AI‑driven labor‑management firms found that vendors serving...
Chinese AI Firms Sell US Troop Intel to Iran
"Chinese firms market Iran war intelligence ‘exposing’ U.S. forces" @washingtonpost https://t.co/NP7gIkpzWG The private companies — some with ties to the military — are marketing detailed intelligence on movements of U.S. forces, even as Beijing seeks to keep its distance. The intelligence came...
Google Messages Still Can't Do the One Thing that Makes iMessage Actually Useful
Google Messages stops functioning the moment its primary device loses an active SIM, a limitation that starkly contrasts with Apple’s iMessage, which continues over a user’s Apple ID and email address. While the app supports RCS, Wi‑Fi messaging, and device...
Database Startup Supabase in Talks to Raise $500M at a $10B Valuation, Five Times Its Value From a Year Ago
Supabase, the San Francisco‑based backend‑as‑a‑service startup, is negotiating a $500 million financing round led by Singapore’s sovereign fund GIC. The round would value the company at roughly $10 billion, a five‑fold increase from its $2 billion valuation a year earlier. Supabase’s revenue is...
JWST Rules Out Thick Atmospheres on TRAPPIST‑1b and C
NASA's James Webb Space Telescope has measured thermal phase curves for TRAPPIST‑1b and TRAPPIST‑1c, finding no atmospheres thicker than about one bar. The data reveal extreme day‑night temperature contrasts, indicating airless or ultra‑thin atmospheres and prompting a reassessment of habitability...
Federal Agencies Ramp Up AI Enforcement Amid Policy Gridlock
AI Enforcement Accelerates as Federal Policy Stalls and States Step In Federal agencies are relying on existing authorities to regulate AI-related conduct: FTC: Section 5 of the FTC Act remains a primary enforcement vehicle for allegedly unfair or deceptive AI practices SEC:...
AI Camera That Shoots Squirrels Could Be Gold
Whoever turns this into a consumer product is going to make a fortune. AI-powered camera: 🎥 squirrel at birdfeeder? spray with water 💦🐿️ https://t.co/1zMguczpN6
Hailee Steinfeld and NFL MVP Josh Allen Welcome Baby Girl, Spotlighting Modern Fatherhood
Actress Hailee Steinfeld and Buffalo Bills quarterback Josh Allen have announced the birth of their first child, a baby girl. The couple’s private reveal and the Bills’ “Girl dad” social post have ignited conversation about how high‑profile fathers balance career...
GLP‑1s Linked to Lower Risk of Mental Illness Worsening
GLP-1s appear to reduce the odds of mental illness getting worse. Another unlooked-for benefit. Caveats: 1. This is observational, not an RCT. 2. This is reduction of odds getting worse on each of these measures. Not reduction of existing mental illness....
AI's True Value Depends on Human Action
Ignore The Doom Talk; AI’s Real Value Only Arises When Humans Step Up via @forbes https://t.co/mIjMIKN47B
Do Whatever for $200: Developers' True Shopping Cart Test
I support this, both the angle and the change. "Do whatever for $200" is the ultimate shopping cart test for developers. If you've been burning tokens on performative agentic nonsense, you've actively contributed to this change.
AI Instantly Determines Avocado Ripeness, Eliminating Guesswork
No More Guessing: #AI Checks Avocado Ripeness Instantly by @HowThingsWork_ #ArtificialIntelligence #MachineLearning #ML #Technology https://t.co/gusA3mDoQ4
Software Hurdles Keep Mass Humanoid Robots Years Away
One of many reasons I think we're still years and years away from mass humanoid robot adoption. (The software is actually my top reason.)
GLP‑1s Massively Marked up; LLMs Priced Near Cost
One observation here: GLP-1s are priced at maybe 25-50x production cost (not counting R&D). LLM usage is priced at perhaps 1x inference cost (not counting training). In any case, two great innovations that are rapidly catching on.
Vine-Like Robot Expands to Traverse Rubble and Tight Spaces
This Vine-Like #Robot Grows to Navigate Rubble and Tight Spaces by @lukas_m_ziegler #Robotics #MachineLearning #ArtificialIntelligence #ML https://t.co/UJL3YA210K
China Competition Will Accelerate US Pharma, Cut Red Tape
This is great to see. Biotech and pharma competition with China is going to force us to sharpen and accelerate processes in the US, and cut red tape. And we'll get the benefit of Chinese drugs as well. Win/win.
AI Boosts Sales Efficiency Without Adding Headcount
Scaling Without the Headcount: How AI is Redefining Sales Efficiency by @Timothy_Hughes https://t.co/DxLm3lfJ1t @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #Salesforce #SalesEnablement #Marketing #Leadership #ArtificialIntelligence #TechNews https://t.co/hlpfzxYzz1
AI Can Transform Education—We Must Rethink Institutions
AI has the potential to dramatically improve education. But we'll have to be intentional about experimenting, discovering what works, and changing how education operates to take advantage of it. I'm more bullish on the tech than the institutions.
CIOs Must Evolve: AI Drives Strategic Leadership
AI is rewriting the rulebook for leadership. 🤖📈 @Gartner_inc reveals how CIOs must evolve as AI transforms the workplace. It’s time to move beyond the hype and use AI for real strategic planning and continuous improvement. Read more here: https://t.co/XDAHd3CquP #GartnerIT #CIO #AI...
Enterprise Sales Succeed when You Map Stakeholder Incentives
Founders: Map stakeholder incentives in big deals: - Who gets promoted if this works? - Who looks bad if it fails? - Who controls the real budget? Politics matter as much as product in enterprise sales.
Who Legally Owns the AI Worker?
Who Owns The #AI Worker? The Legal Question Nobody Is Asking Yet by @beygelman @Forbes Learn more: https://t.co/yllWHQvknd #ArtificialIntelligence #MachineLearning #ML https://t.co/wIOTjHvlGj
AI-Powered Idea Lab Turns Random Thoughts Into Connections
This is my Idea Lab workflow. Allows me to dump random thoughts and ideas into AI and helps me sharpen them and make connections to other ideas. Try it yourself: https://t.co/Av2rqZ8cCp
Even a Simple “Hi” Drains 15% of Claude Quota
you accidentally say "Hi" to Claude and it burns 15% of your session cap. https://t.co/vF4CIKqUcc
Enable WhatsApp Two‑Step Verification: Simple Yet Essential
Whether you just joined @WhatsApp or have been using it for years, it's a smart idea to enable two-step verification. Here's how, step by step, and why it's not as good as 2-factor authentication, but better than nothing... https://t.co/KDT8J6yjkd #whatsapp...
AI Prosthetic Hand Adapts Through Daily Use
A Smarter Prosthetic: Esper Bionics’ #AI Hand Learns from Everyday Use by @EsperBionics #EmergingTech #Technology #Innovation https://t.co/LJXFZUA3OL
AEO Success Requires Fixing Root Cause, Not Just Content
Most of the advice circulating about answer engine optimization (AEO) treats visibility as a content challenge. Write better. Structure it cleaner. Add schema markup. That advice is not wrong, but it addresses the symptom rather than the cause. https://t.co/zrGlNWJYXy
Microsoft Takes 3.5 Years to Label AI Entertainment‑Only
Generative AI: It’s “For Entertainment Purposes Only”* *and it only took Microsoft 3.5 years to figure that out. https://t.co/GeLJRirwLa
Dreaming of AI-Generated Hour-Long Shows On Demand
I just want AI to get so good that I can get a “60 minutes” like show about any topic I want on demand
