Daytime Napping Not Causally Linked to Brain Health
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank https://t.co/AQI9U7Mpri
Calf Size Predicts Lifespan: Bigger Muscles, Longer Life
A simple body measurement may predict how long you live. Calf circumference. Muscle is longevity. h/t hyderabaddoctor
Fermented Cordyceps Broth Improves Primary Insomnia in Trial
Effectiveness of fermentation broth of Cordyceps sinensis for primary insomnia: a randomized clinical trial with digital health tool https://t.co/g5iOuzkctO
B‑Vitamins and Minerals Power Your Mitochondrial Engine
The mitochondria are your cells' power plants⚡⚡ You need certain vitamins, minerals, and nutrients to produce energy via the mitochondrial electron transport chain (ETC) Here's an overview of the most critical ones: 🔹B-Vitamins - Vitamin B1 (Thiamine): Required for pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. -...
Weightlifting After 30: Your Essential Life Insurance
If you’re over 30, lifting weights is NOT optional. It’s your insurance policy for life.
Skip Late Snacks to Boost Sleep and Parasympathetic Recovery
The benefits of not eating three hours before bedtime extend beyond improving sleep; but are also harnessed in protecting the natural increase in parasympathetic activity at that time. @foundmyfitness on the Huberman Lab podcast out now https://t.co/O8b2YunpVT
Exercise
The new Huberman Lab episode is out: The Best Vitality & Health Protocols | Dr. Rhonda Patrick (@foundmyfitness) 0:00 Rhonda Patrick 2:40 Competition, Jumping Rope, Rope Flow 6:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 12:30 Cognitive & Physical Benefits of Exercise, Serotonin &...
Sugar: Debunking Myths Between Health Warnings and Athlete Fuel
Public discussions around “sugar” are often dominated by extreme claims, from strong health warnings to recommendations for athletes to consume sugar-rich gels and drinks. This blog examines what “sugar” actually is: https://t.co/8dQmKzXO90
Fecal pH May Predict Neurodegenerative Disease Risk
I've been saying this for the longest time, and including fecal pH in my grant applications, too I predict that we'll see a significant correlation for fecal pH with neurodegenerative diseases in future papers...
Vitamin D and Fasting Show Promise for MASLD Treatment
Therapeutic effects of vitamin D and intermittent fasting on metabolic associated steatotic liver disease in rats "These findings support their potential as complementary, non-pharmacological strategies for MASLD management and warrant further translational investigation." https://t.co/n4BtHrrcOU
Bicarbonate and Extra Calories Enhance Endurance Performance
Been experimenting with bicarb for the last year as well as seeing how extra calories impact my performance Full write up can be found on Endurance Essentials https://t.co/WLuX7VNkAv
Poor Sleep Increases Runner Injury Risk
Sleep profiles predict injury in runners 🩼💤 This new study profiled 425 recreational runners based on their sleep habits including… ⏰ Sleep duration ☑️ Sleep quality 🚨 Sleep problems Investigating associations with injury history, whilst controlling for factors including training volume 🔍 Results 📊 Runners were...
P7C3 Boosts NAD Enzyme, Improves Mouse Alzheimer Model
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏
Low-Volume, Low-Frequency Training Preserves Muscle Fascicle Lengths
A low-volume, low-frequency combination is able to maintain muscle fascicle lengths after eccentric-only training in humans. This suggests that maintenance of sarcomeres and myofibrils works slightly differently. https://t.co/kSamQXyhZh
Set Night Thermostat to 15°C for Deeper Sleep
Turning your thermostat down to 15°C (about 59°F) at night is one of the simplest, most evidence-based “sleep performance hacks” available and it works because it directly supports your body’s natural biology. Your core body temperature needs to drop by around...
Only Seven Proven Longevity Compounds After Massive Mouse Trials
7 Drugs. 30,000 Mice. 20 Years. The Only Longevity Compounds With Real Evidence. https://t.co/BzdoDZeicb @agingroy https://t.co/uM5QMpIAS6
Time‑restricted Feeding Curbs Early Liver and Colon Cancer in Rats
The effects of time-restricted feeding on early phases of carcinogenesis in rat liver and colon https://t.co/hZQUZAwXV5
Stem Cell Dose Boosts Walk Test, Cuts Frailty
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty 🌟Performance on the 6-minute walk test improved in a dose-response fashion 🌟Improved 6-minute walk test distance correlated with patient-reported outcomes 🌟The percentage of study subjects classified as frail decreased...
Single Stem Cell Dose Boosts Strength, Reverses Frailty
Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial 🗣️A clinical trial reports that a single dose can significantly improve physical strength and key signs of aging in older adults with frailty. https://t.co/5mw5r64imb https://t.co/uI88QpTEIa
Allogeneic Stem Cells Safely Boost Function in Frail Adults
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial “Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome. Given the excellent safety and efficacy...
Lifestyle Program Slows Aging and Boosts Function in Frail Seniors
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial https://t.co/8Ex1caVyLp
Higher Thymic Health Scores Predict Longer Healthspan
Your Thymus and Your Healthspan https://t.co/ENhIn2A2l3 High vs Low Thymic Health Scores and Outcomes https://t.co/oOz9sOK8RV
Muscle Power Predicts Mortality Far Better than Strength
Wow... Power training and longevity Araújo et al. followed 3,899 people — mostly middle-aged and older adults — for a median of nearly 11 years. They compared two metrics head-to-head: muscle strength and muscle power. Men in the lowest power category were...
Strength Training: Key to Longevity and Joint Health
Strength training might be the single most potent habit for aging gracefully and extending lifespan. It certainly appears to be one of the best methods to prevent the need for joint replacement surgery. After 30 years of practice, there’s no...
Every 1% BMI Drop Lowers Cancer Risk
Every 1% BMI Drop Cuts Cancer Risk Every 1% drop in BMI lowers your cancer risk. The data now proves it in the real world. As a medical school professor, I have taught for years that obesity drives cancer through metabolic dysfunction....
Do Glucose Sensors Really Deliver Personalized Fuel Insights?
Glucose sensors promise personalised fuelling insights. But do they deliver? Three days to go, last chance to register : https://t.co/eN6PetWMGW https://t.co/jDTUsQhle2
Metabolic Health Tops Circadian; Sauna Beats Blueprint
Some interesting match-ups. Metabolic health is beating circadian optimization by a wide margin. Psilocybin and multivitamin are neck and neck. @bryan_johnson's Blueprint is getting destroyed by sauna.
Nutrition Essentials for Faster Athletic Injury Recovery
Athletes recovering from injuries, intense training, and tournaments here’s a few strategies to help you heal & recover for the week ahead and beyond‼️ 👉Antioxidants & healthy fats 👉7-10 g creatine monohydrate 👉Leucine rich foods (aim for 1.8-2.0g/kg/bw/protein/day) 👉Zinc, vitamin D, choline, glutamine, and...
Multiple Drugs Fail to Extend UM-HET3 Mouse Lifespan
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice https://t.co/k0vERH4LSg
Routine Clinical Aging Clocks Show Limited Trustworthiness
Are Aging Clocks Based on Routine Clinical Indicators Trustworthy and Applicable? A Systematic Review and Critical Appraisal https://t.co/JU53JV0gnv
Aging Is Information Loss in Self‑Organizing Biology
Strong work👏 This is less Watson and Crick, and more Turing and Wiener, where biological form and function emerge from information processing #Burr If biology is information processing, then aging can be understood as information loss #shannon
SGLT2 Inhibitors Boost Survival in Frail Seniors
Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study https://t.co/tsJ5qJLBap https://t.co/4EvBWDftJ4
Short Telomeres Reveal Accelerated Kidney Aging, Predict CKD
Researchers found that shorter telomeres and DNA changes in kidney cells may signal faster biological aging of the kidneys and help predict risk for Chronic Kidney Disease earlier than current methods. 🧬 https://t.co/JKRM7xhOnh
Henagliflozin Shows Potential Anti‑Aging Effects in Diabetes
Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study 🔎"Our results suggest that henagliflozin may exert anti-aging effects by influencing multiple pathways, including the IGF-1 system, glucose metabolism, the immune system, and...
Choose Magnesium Type: Cognition, Calm, or Stress Support
Magnesium L-threonate (Best for Cognition): Highly bioavailable and shown in randomized controlled trials to improve memory, executive function, and focus. It supports "synaptic plasticity," helping neurons form new connections. Magnesium Glycinate (Best for Relaxation): Bound to the amino acid glycine, this form is...
Sewage Surveillance Detects Colorectal Cancer Biomarkers Early
Wastewater Detects Colorectal Cancer Biomarkers What if your city's sewage could detect cancer before your doctor does? As a medical school professor, I find this remarkable. Researchers tested neighborhood wastewater in Kentucky for colorectal cancer biomarkers using droplet digital PCR. They detected CDH1...
$101 Million Contest Aims to Extend Human Healthspan
There's a $101 million competition happening right now to extend human healthspan. Not in mice. Not in worms. In people. https://x.com/robertlufkinmd/status/2035318955821375489
Bone‑building Exercises Work at Any Age
6 exercises to build bone density. Don't think you need them? You're wrong. Think you're too young? Wrong again. Think you're too old? Wrong. https://t.co/ZyqvbJDgy1
Science vs Marketing: CGM's Real Impact on Meals
Marketing suggests CGM can optimise meals, stabilise energy, and personalise fueling. But what does the science actually show? Join the webinar to learn: https://t.co/eN6PetWMGW https://t.co/aM9Fd1yXxo
SIRT1: Longevity Gene Proven to Suppress Cancer
Fun fact: in 2008, when we published that NAD-dependent SIRT1 suppresses cancer, almost no one believed us. How could a longevity gene suppress cancer? they asked https://t.co/aPAG3zf470
Exercise Boosts Quality of Life in Mid‑to‑Late Adulthood
Physical exercise and health-related quality of life in mid- to late-adulthood: a multi-group chain-mediation analysis https://t.co/vd6yqa45rx
Stay Moderate: Avoid Excess, Keep Some Reserve
Big v Small for longevity. Small - Most serious problems are metabolic in nature. You'll avoid them by not spending too much time in an energy surplus, i.e. not being too big. But... If shit does go bad - you do have that...
Endometriosis Impairs Egg Quality—Strategies Boost Longevity
Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity https://t.co/I2ZrtJkguK https://t.co/LkH3LXzkcg
Senolytic Combo Damages Mouse White Matter, Triggers Oligodendrocyte Dysfunction
A combination of senolytics causes neuropathology in mice 👀 Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS. Senolytics under more scrutiny? https://t.co/aDosJxeyxS
FGF21 Activates SLCO4C1 to Curb Liver Fat
FGF21 turns on SLCO4C1, which boosts cAMP signaling and helps prevent fat buildup and inflammation in the liver. https://t.co/fi6RffZKVq
Pitchers Use High‑Low Models to Boost Recovery, Prevent Injuries
In the new podcast, I highlight the importance of pitchers employing high-low models to their routines in order to optimize recovery and reduce the risk of injury. Additionally, I share examples of how this structure works in the real...
How Your Vision Shapes Goal Difficulty Perception
There is a crucial but rarely mentioned relationship between how you use your visual system and how you perceive goals as difficult or easy. Even impacts physiology and goal attainment. Actionable.
Endurance Athletes Reveal Divergent Physiological Engines
My latest post on the #MADcrew forum: Two athletes. Both training for endurance events. But with completely different engines. Here’s what the #PerformanceModeling data says about how @JohnGoldman and @inaki_delaparra actually work… https://t.co/oCTDk9EAjt
Epigenetic Age Acceleration Links to MRI Aging Markers
Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration https://t.co/VSJVp4MYij
Single-Cell Clocks Offer Precise Insight Into Aging
Single-cell aging clocks: A precision tool for dissecting and targeting the aging process https://t.co/5e47qWtZwH https://t.co/ImfBb45luO