Eli Lilly secures FDA nod for oral GLP‑1 weight‑loss pill as injectable trial shows 28.7% loss
The FDA approved Lilly’s oral GLP‑1 weight‑loss drug orforglipron (brand name Foundayo), which can be taken without food or water restrictions, positioning it against Novo Nordisk’s Wegovy. In parallel, Lilly’s experimental injectable triple‑hormone agonist retatrutide delivered an average 28.7% body‑weight reduction in a Phase 3 trial, outpacing competitors.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
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Paxil (paroxetine), a short‑acting SSRI, often triggers withdrawal symptoms within two to three days of dose reduction, with effects lasting up to six weeks or longer. Over half of antidepressant discontinuers report such symptoms, including nausea, dizziness, vivid dreams, anxiety, and the characteristic “brain zaps.” Clinicians recommend a gradual taper, often switching to a long‑acting SSRI like fluoxetine, while employing lifestyle supports such as exercise, relaxation techniques, and OTC remedies. Patients must be monitored for relapse of depression or anxiety and for emergent suicidal thoughts.

Pancreatic cancer’s five‑year survival sits at just 13%, making early, expert care essential. The University of Michigan Rogel and Blondy Center emphasizes a multidisciplinary, high‑volume approach that includes surgeons, oncologists, dietitians, and palliative specialists. Patients are urged to seek centers...
The Australian Government Department of Health has launched Medicare Mental Health Check‑In, a free online service that provides low‑intensity cognitive‑behavioural therapy tools and optional telehealth practitioner support for people with mild mental‑health challenges, starting 30 May 2026. The initiative expands...
Dr Kiran Nair of ParkCity Medical Centre highlighted a growing move toward multidisciplinary obesity care during World Obesity Day, arguing that weight loss alone is insufficient. She stressed that obesity is a chronic disease requiring coordinated medical, psychological and lifestyle...
The Indian Council of Medical Research’s National Institute of Nutrition has finished a two‑year survey of 2.6 lakh individuals in 183 districts, linking diet, activity and blood biomarkers. The dataset, called DABS‑I, is the first of its kind in India and...
A post‑hoc analysis of the SURPASS‑CVOT trial finds the dual GLP‑1/GIP agonist tirzepatide lowers a broad six‑component cardiorenal endpoint by 14% compared with the GLP‑1‑only drug dulaglutide. The result, presented at ACC 2026, could reshape how biohackers approach metabolic health...
Aurinia Pharmaceuticals announced a definitive agreement to acquire Kezar Life Sciences for $6.955 in cash per share plus a contingent value right (CVR). The deal, slated to close in Q2 2026, gives Aurinia access to Kezar’s lead immunoproteasome inhibitor, zetomipzomib, and...
The Catalight Group and a coalition of health, economic and policy leaders premiered a CNBC documentary that frames value‑based care as the linchpin for brain health and a $6.2 trillion boost to global GDP. The film cites staggering productivity losses and...

The U.S. Air Force School of Aerospace Medicine’s Missile Community Cancer Study, now analyzing 148,078 cases from 1976‑2010, found statistically higher rates of testicular cancer and Hodgkin lymphoma among intercontinental ballistic missile (ICBM) personnel compared with other Airmen. Earlier phases...

A large cluster‑randomized trial of more than 21,000 acute ischemic‑stroke patients across 77 Chinese hospitals tested an AI‑powered clinical decision support system (CDSS). The tool, which combines AI‑assisted imaging with guideline‑based treatment prompts, lowered the 3‑month composite vascular‑event rate from...

The National Institutes of Health announced 15 winning teams in its Nutrition for Our Immune System Health (NOURISH) Autoimmunity Challenge, each receiving a $10,000 prize. The challenge solicited scalable, patient‑centered ideas that integrate diet, microbiome, and multi‑omics approaches to study...
The University of Ottawa Heart Institute has published an 11‑point clinical practice guideline that integrates cardiovascular, neurological and mental‑health care. The C‑CHANGE/CMAJ guideline aims to replace siloed disease protocols with a patient‑centred, whole‑person approach, and it is already being rolled...
Indian pulmonologists led by Dr. Sushil Gupta warn that chronic shallow breathing activates stress pathways, reduces focus and can cause cardiac arrhythmia. The warning comes as breath‑focused meditation apps see a surge in users seeking quick relief.
Researchers tracking 53,000 adults over eight years discovered that sleeping an extra 11 minutes each night, combined with modest increases in activity and vegetable intake, reduces the risk of heart attacks, stroke and heart failure by 10%. The findings give...
Immune Modulation, Inc. announced it is finalizing pre‑IND toxicology and pharmacokinetic studies to file an FDA submission for hypoestoxide, a plant‑derived anti‑inflammatory candidate for Parkinson's disease. The move caps a 30‑year scientific trek that began with a rainforest compound identified...
United Therapeutics reported that its TETON-1 Phase III trial met the primary endpoint, delivering a 130.1 mL improvement in forced vital capacity for idiopathic pulmonary fibrosis patients. The news lifted the stock more than 12% and set the company on a path...
Neurolief announced a $6 million milestone‑based investment from BrainsWay Ltd. following the FDA’s Premarket Approval of its Proliv™Rx at‑home brain neuromodulation system. The clearance marks the first prescription‑grade, home‑use device for adults whose depression has not responded to at least one...

The FDA has warned consumers to avoid Boner Bears Honey, a sexual‑enhancement honey sold online and in some stores, after laboratory tests revealed it contains undeclared sildenafil and tadalafil. The product was identified during an inspection of Pure Vitamins and...

The medical device landscape is accelerating across multiple fronts. Medtronic secured FDA clearance to extend its robotic platform into cranial and ENT surgeries, while Boston Scientific introduced a fluid‑management system for ureteroscopy. At‑home neuromodulation received a $6 million infusion after FDA...

So @TheCut wrote a hit piece on the @WeillCornell Alexandra Cohen hospital and of course it’s not true and worse they used photos of people who had great deliveries and some who didn’t even have a baby there. The comments...

Vietnam is fast‑tracking AI integration into its healthcare system to improve early detection of non‑communicable diseases such as cancer, cardiovascular disease, diabetes and chronic respiratory illnesses. The government and hospitals are expanding electronic health records and centralised data platforms, enabling...
Interesting. I’m surprised the graph doesn’t show those who decided self care or no care. Also interesting that emergency visits went up. Maybe that’s good? They uncovered conditions that need higher level of care? Or the AI is being cautious.
My father (and a dear friend's father) both died of this form of cancer. It is great to see the advances in cancer treatment... which will only be accelerated in the coming years (provided the luddites don't win the...

The Community Care Partnership of Maine (CCPM) has rolled out the PicassoMD digital curbside consult platform across its 22 member clinics, linking primary‑care providers with specialists in seconds. Since its October 2023 launch, more than 300 clinicians have completed over 5,700...

A JAMA Internal Medicine study of 404 influenza outbreaks in U.S. nursing homes found that administering the antiviral oseltamivir to at least 70% of residents within two days sharply reduced 14‑day hospitalizations. The retrospective cohort covered over 35,000 resident observations...

Midlife adults with irregular bedtimes face twice the risk of major cardiovascular events when they also sleep less than eight hours, according to a decade‑long Finnish cohort of 3,231 participants. The study, which used activity‑tracker data to measure sleep timing,...
The FDA has approved a higher-dose regimen of nusinersen (Spinraza) for spinal muscular atrophy, aiming to boost drug exposure and improve long‑term motor function. The approval underscores a broader industry shift toward lifecycle optimization of RNA‑targeted therapies. Simultaneously, biopharma firms...
Jonathan Lind has been appointed president of Beth Israel Deaconess Hospital‑Plymouth, effective May 4, succeeding retiring leader Kevin Coughlin. Lind previously served as president of Swedish Hospital in Chicago, where he drove ambulatory growth and achieved the highest employee‑engagement scores across...

The TV drama “The Pitt” highlighted systemic burnout in emergency medicine, showing a medical student leaving her shift despite a busy ER. Data cited in the episode reveal that roughly 60% of emergency‑room physicians and 71% of public‑health workers report...

A new Trilliant Health analysis shows that hospitals generate only about one‑third of their gross revenue from patient care, with a median of 29.9% in 2024. The share varies widely, from 8.3% to 86.6%, and is lower for for‑profit facilities...

The U.S. Food and Drug Administration ordered the Greenbrier Clinic in Sulphur Springs, West Virginia, to suspend its mammography services after an American College of Radiology review flagged serious quality concerns. The FDA’s action covers exams performed between October 28, 2023 and...
Nearly 3,000 registered nurses at six Tenet Healthcare hospitals in California ratified a three‑year labor contract with 93% support. The agreement, effective July 1 2025 through June 30 2028, includes wage increases of 11% to 18% over the term, a dedicated rapid‑response nurse at...
Retail giants are accelerating their pharmacy footprints, with Amazon planning same‑day prescription delivery in 4,500 U.S. cities by the end of 2026 and Walmart promoting 3,000 pharmacy technicians while raising wages to $22‑$40.50 per hour. Walgreens and CVS are also...

A Joint Economic Committee report finds Medicare Advantage plans are being paid roughly 20% more than Original Medicare for comparable care, largely due to aggressive coding intensity and favorable selection. These overpayments trigger a mandatory Part B premium pass‑through, adding an...

The Pentagon has asked Congress for a $200 billion supplemental defense budget, a sum that eclipses the entire annual budget of the Department of Health and Human Services. At the same time, the administration proposes an $18 billion cut to the National...

The latest CareTalk episode spotlights the growing crisis of surprise medical bills that trap millions of Americans in debt. Patricia Kelmar of PIRG breaks down patient rights under the No Surprises Act and explains how the law reshapes billing practices....
Researchers at the National University of Singapore have launched a skin‑conforming hydrogel wearable that delivers clinical‑grade ECG and blood‑pressure data while users move, classifying fatigue with 92% accuracy. The breakthrough could give biohackers and employers a continuous, objective view of...

A coalition of hospital stakeholders, including the American Hospital Association, released Long‑Term Acute Care Hospital (LTCH) Reform Policy Principles to guide Congress. The proposals aim to expand payment criteria for high‑acuity patients, improve the prospective payment system, reconsider the 25‑day...
Ontario will cut provincial funding for seven supervised consumption sites in Toronto, Ottawa, Niagara, Peterborough and London, giving them 90 days to wind down. The $378 million CAD (≈$280 million USD) will be redirected to 19 Homelessness and Addiction Recovery Treatment (HART)...
New York‑based Mantis Biotech unveiled an AI platform that builds physics‑based digital twins of humans, producing synthetic biomedical datasets for drug discovery and other high‑risk biomedical research. The startup says the technology can fill data gaps in rare diseases and...

The American Hospital Association (AHA) submitted comments to the Centers for Medicare & Medicaid Services (CMS) on a proposed rulemaking aimed at strengthening the domestic supply chain for personal protective equipment (PPE) and essential medicines. The AHA supports CMS’s plan...

HHS Secretary Robert F. Kennedy Jr announced on a podcast that the federal government will lift restrictions on 14 injectable peptides, allowing compounding pharmacies to produce and sell them without the usual FDA review. The move bypasses the scientific advisory...
BullFrog AI Holdings saw its Nasdaq‑listed shares climb 126.24% to $1.15 after announcing a commercial agreement with a leading global pharmaceutical company. The deal gives the pharma partner exclusive access to a novel target candidate for major depressive disorder and...
Southcoast Health announced the creation of an in‑house police department, deploying a 12‑officer force led by newly appointed chief Marc Duphily. The move follows five years of using Massachusetts State Special Police and is driven by a sharp rise in...

The phase III SCOUT‑HCM trial showed that mavacamten (Camzyos) significantly reduced left ventricular outflow tract (LVOT) gradients in adolescents with obstructive hypertrophic cardiomyopathy (HCM) compared with placebo. Forty‑four patients aged 12‑17 were randomized to weight‑based doses of 2 or 5 mg daily, achieving a...

The American Hospital Association (AHA) responded to CMS’s Request for Information on the Comprehensive Regulations to Uncover Suspicious Healthcare (CRUSH) initiative, urging data‑driven, low‑burden regulatory changes. It called for stronger oversight of Medicare Advantage organizations and enhanced transparency tools for...

The Centers for Medicare & Medicaid Services reported that average out‑of‑pocket premiums for Health Insurance Marketplace enrollees jumped from $113 in 2025 to $178 in 2026, a $65 monthly increase. The rise follows the expiration of the enhanced premium tax...

The Malcolm Baldrige National Quality Award for Performance Excellence was granted to two hospitals—one in New York and one in New Mexico—recognizing their superior patient safety, leadership, and operational performance. Administered by the National Institute of Standards and Technology, the...

Doctors Without Borders has condemned Gilead Sciences for refusing to sell its long‑acting HIV prevention drug lenacapavir directly to the humanitarian organization. The company had previously negotiated a limited‑supply request, while a separate deal with the Global Fund aims to...