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The study introduces an operator‑based framework to assess pathway identifiability when metabolite coverage is incomplete. It aligns condition‑specific pathway graphs using a Johnson‑Lindenstrauss stabilized fused Gromov‑Wasserstein (JL‑FGW) operator and quantifies ambiguity via a composite functional that blends transport entropy, alignment instability, and structural risk. Measurement prioritization is formulated as an optimization over this functional’s sensitivity, yielding a next‑best metabolite estimator without exhaustive enumeration. Synthetic and real‑world evaluations show low regret versus baselines and tractable runtimes for curated and genome‑scale models.
What if we could use technology to identify wildfires, then extinguiwh them before they spread? That’s what Crossfire, a research team, is trying to accomplish with drones. There’s a multi-million dollar contest awarding the best wildfire-dousing tech. #wildfire #drones #tech #fire
Taxonomists documented 309 new freshwater fish species in 2025, the highest annual count since 2017 and the third‑highest since records began in 1758. The discoveries span five continents, with Asia leading (165 species) followed by South America and Africa. Many...
Willem Drost’s 1654 tronie *Man With a Plumed Red Beret* was sold at TEFAF Maastricht through Agnews Gallery to the privately‑held Leiden Collection. The painting, once owned by the Rothschild family and recovered by the Monuments Men after World War II,...
Dolly Parton made her first major public appearance of the year at Dollywood's 41st‑season kickoff, addressing recent health setbacks and the loss of her husband, Carl Dean. She confirmed postponing her Las Vegas residency and other engagements to focus on...
Fans of Drake have spotted an Instagram profile called @quilteddiamonds that appears to be a new burner account, featuring 115 posts and a single follower – the rapper himself. The account’s minimal activity and exclusive connection to Drake have sparked...
Buick is reportedly evaluating a new sedan for the U.S., potentially built on GM's Alpha II platform that underpins the Cadillac CT4 and upcoming CT5. The brand has not offered a domestic sedan since the Regal ended production in 2020, though...
Therapists who can sit with men’s anger, regret, and aggression without flinching are essential for genuine therapeutic breakthroughs. Men quickly assess whether a clinician can handle their raw truth; when they sense steadiness, they begin to disclose suppressed emotions. The...
The Brooklyn Museum announced photographer and collage artist Keisha Scarville as the winner of its sixth UOVO Prize, awarding her a $25,000 unrestricted cash grant. Scarville will mount a solo show titled “Where Salt Meets Black Water” at the museum’s...
Have you ever noticed how much newborns sneeze? It's because they're clearing their nasal passages. Newborns have tiny little nostrils and breathe almost exclusively through their nose for the first few months. Every little bit of dust, milk, or mucus makes...
Shinedown’s eighth studio album, “Ei8ht,” arrives on May 29 via Atlantic Records, featuring 18 tracks that the band describes as a double‑album. The record, a year and a half in the making, sees bassist Eric Bass taking the production helm,...
Zubin Mehta, born in Bombay to the founder of India’s first symphony, rose from Vienna studies alongside Claudio Abbado to early posts in Liverpool and Montreal. He later led the Los Angeles Philharmonic, gaining worldwide attention for his energetic conducting...
A noticeable resurgence of Apple’s discontinued iPod line is underway, driven largely by Gen Z listeners seeking a break from algorithm‑driven streaming and smartphone overload. Google Trends and eBay data show searches for classic iPods and iPod Nano up 25%...
Experts explain that both walking and running satisfy the CDC’s 150‑minute weekly activity recommendation, but each offers distinct advantages. Walking provides a low‑impact, beginner‑friendly option that can be intensified with hills, weighted vests, or intervals, supporting cardiovascular health and chronic...
Seoul’s design scene is spotlighted in a new travel guide that pairs expert recommendations with curated itineraries for design‑focused visitors. The guide highlights four key neighborhoods—Sogyeok‑dong, Seongsu‑dong, Jeong‑dong and Hongdae—alongside boutique hotels, high‑end restaurants and concept stores that showcase the...
Backcountry Discovery Routes (BDR) is set to unveil the Ozarks BDR‑X, a 480‑mile loop that begins and ends in Jasper, Arkansas. The route weaves through the Boston Mountains, Ozark‑St. Francis National Forest, and features iconic spots like the Arkansas Dragon...
The article reviews Daniel Constantinou’s book *The Holy Grail and Her Knights*, arguing that humanity thrives when women lead with compassion and men step back from power. It claims that female leadership would end wars because mothers would never send...
Director Lee Sang-min returns to horror with his solo feature debut, “Salmokji: Whispering Water.” The film follows a film crew investigating a mysterious figure captured at the remote Salmokji reservoir, where they encounter escalating supernatural phenomena. Starring Kim Hye‑yoon alongside...
Clare McAndrew’s latest annual art market report confirms a rebound, with total sales reaching an estimated $59.6 billion in 2025 – a 4 percent rise over the prior year. The recovery is most pronounced in the auction segment, which has rebounded strongly since...
Sara Blackard announces her debut poetry collection, *My Uterus Is in Her Chaotic Era*, which candidly chronicles her perimenopause journey. The book blends humor, raw emotion, and lyrical insight to give voice to a phase often left unspoken. Blackard markets...
Knowing your destination lets you self-prioritize and make decisions about what you're doing and how you're doing it. But, it's also bigger than that. You want to make sure the direction you're headed in still feels right-that you still believe...
The American Hospital Association will host a webinar on March 19 at 1 p.m. ET to examine how health‑care leaders are strengthening the clinical workforce. The session will focus on improving retention, physician well‑being, and coverage stability across hospitals. Attendees will...
Six years ago today, on Friday, March 13, 2020, I sent the email switching all my clients to telehealth. Some of them didn’t want to do online sessions; they said they’d rather wait a little, until things blew over. I...
We’ve reimagined the way our Gemini models power @GoogleMaps. Here are some use cases you can try (and the advancements that make them possible): “Find a well-lit pickleball court that’s usually less busy on Tuesday nights” ➡️ Maps performs multi-step reasoning across...
Netflix’s animated hit *K‑Pop Demon Hunters* has become the platform’s most‑watched original, surpassing 500 million views and sparking a new wave of Korean travel. In the three months after its June 2025 release, global flight bookings to South Korea jumped 25 % and...
A dietitian‑led case series of four critically ill patients with advanced pressure ulcers implemented personalized enteral nutrition, targeting progressive energy and protein goals, glycemic control, and selective immunonutrient supplementation (arginine, glutamine, HMB). Over several weeks to months, each patient showed...
The Milpa diet revives a Mesoamerican polyculture of maize, beans, squash and chili, combined with traditional processing like nixtamalization, to create a nutrient‑dense, bioactive‑rich food system. Agroecologically, the intercropping maximizes land equivalent ratio, cuts water use and curtails deforestation, while...
A methanol extract of the traditional plant *Gnaphalium affine* (GAE) markedly reduced weight gain, visceral fat, and metabolic dysfunction in high‑fat diet mice. The treatment restored antioxidant defenses, improved glucose tolerance, and reinforced intestinal tight‑junction proteins. Multi‑omics revealed GAE reshaped...
Researchers used patient‑derived organotypic slice cultures from nine head and neck squamous cell carcinoma (HNSCC) tumors to test short‑chain fatty acids (SCFAs) and an immunonutrition (IN) blend containing glutamine, alanine and omega‑3 fatty acids. IN alone or combined with SCFAs...
A one‑month early time‑restricted eating (eTRE) regimen in 21 male patients with metabolic syndrome led to significant reductions in weight, BMI, fasting glucose, insulin and HOMA‑IR. Neuroimaging revealed increased fractional anisotropy in the left anterior thalamic radiation and cortical thinning...
World Sleep Day. We're marking it the best way we know how: with data. We just released https://t.co/wj0FotCsjN. 10.2 million nights from 23 countries. One year of continuous measurement. Some findings confirmed what we expected. Others didn't. - REM sleep peaks in...
...an exclusive inside report from last night's Kevin Feige USC dedication that brought out Ryan Coogler & Shawn Levy...Plus: SOMETHING IS KILLING THE CHILDREN: the novel. And VISIONQUEST finds its composer. https://t.co/PrULgqINGy
Legendary surfer Gerry Lopez has partnered with North Action Sports (NSP) to launch the Pelican, a lightweight foilboard built for the Foil Drive electric‑assist system. The board features a rounded, forgiving shape and a subtle nose vee that promotes quick...
To survive in the current workplace we need to be more thoughtful and intentional about how we manage ourselves. That means we cannot be on autopilot. https://t.co/SanqGOwq3T https://t.co/Lf8czbZW9b
Install positive emotions in your neural circuity. Consistently focus on kindness, compassion, generosity, joy, patience, and optimism. https://t.co/zjc850yFse
China’s Shanghai Academy of Spaceflight Technology unveiled an “economical lunar cargo transport” concept at the CACE 2026 exhibition. The cylindrical lander family would deliver 120 kg to 5,000 kg using a methane‑liquid‑oxygen engine, marking a shift from hypergolic propellants. The system is positioned...
In my Substack today, where to get pollo huaxmole, made with those green seedpods you see in Mexican markets. [link in first comment] https://t.co/k5GapZkTAi
🎉 Want a fun way to kick off or wrap up your book club? 🗣️ I shared ideas like an author visit for a final session Q&A. 📚 I also mention study guides as a planning tool, including my free EdTech Essentials...
Jessica Chapel’s March 13, 2026 guide showcases 15 hand‑picked Airbnbs that sit within walking distance of Portugal’s premier surf breaks, from Nazaré’s giant waves to the Algarve’s quieter points. Each property was selected for Superhost status, guest ratings, amenities, design and proximity...
A hospital room can feel very small. But the mind doesn’t have to stay there. At Cedars-Sinai, we’re using VR to help patients explore beautiful places beyond the four walls of the hospital room. Not to escape life… but to contemplate its beauty in...
Alright, Alice 24-0001 petunia bits co-culturing with Agribacterium strain Gv3101 carrying a PcUBI4::RUBY::THSP construct. Testing out this ubiquitin promoter for stable transformation to avoid silencing. These will bake at 30°C until Monday and then transfered to selection. 🤞 https://t.co/SO1EKELMgU
A study in Nutritional Neuroscience shows that rats exposed to a high‑fat, high‑sugar (Western) diet during gestation and lactation retain metabolic imprints into adulthood. Even after months on a healthy diet, these animals exhibit elevated blood glucose and protein levels....
For the sixth year in a row, Hollywood enters the Academy Awards in some stage of an existential crisis. https://t.co/jozy6DM9bL
NAD⁺ as a central hub regulating the hallmarks of aging: Mechanisms and therapeutic implications https://t.co/Mw45GF0QhL https://t.co/pvAGRxXQZv
Researchers from Harvard and the University of Cincinnati have quantified how tree‑climbing snakes stand nearly upright, raising up to 70 percent of their body length off the ground. By filming brown tree snakes and juvenile scrub pythons moving between perches, they...
Fashion outlet The Cut has compiled a spring‑ready list of 14 blazers, ranging from $75 Amazon basics to $429 designer pieces. The selection emphasizes fit, versatility, and inclusive sizing, covering oversized, cinched‑waist, and double‑breasted silhouettes. Brands featured include Gap, Uniqlo,...
Brazil’s *The Secret Agent* has earned two Oscar nominations – Best Picture and Best International Feature – marking a historic moment for the nation’s cinema. Actor Wagner Moura becomes the first Brazilian male to receive an acting nomination, recognized for his...
Visionary hotelier Rami Fustok has listed his 5,500‑square‑foot, art‑filled London residence for about £5,000 (≈$6,600) per week. The apartment occupies New River Head, a former early‑20th‑century civic building in Clerkenwell, retaining grand boardroom spaces, high ceilings and Doric columns. It...
In 1976 Wild Cherry turned a casual audience comment into the hit "Play That Funky Music," capturing the seismic shift from hard‑rock to disco. The single surged to #1 on the Billboard Hot 100 and cracked the top ten in multiple...
A new study shows Earth’s rotation is slowing faster than in any of the past 3.6 million years, lengthening the average day by about 1.33 milliseconds per century. Researchers linked this unprecedented slowdown to rising sea levels caused by melting glaciers and...
