From Kubrick’s Dream to Artemis: Moon Journey Continues
April 2, 1968, Kubrick releases 2001: A Space Odyssey. December 21, 1968, Apollo 8 orbits the Moon. July 20, 1969, Apollo 11 lands on the Moon. April 1, 2026, Artemis heads back to the Moon. https://t.co/OYK341YTa2
Oral NR/NMN Boosts Blood and Brain NAD in Two Weeks
The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation 🔎 “… oral NR or NMN in humans produces a slow but robust and sustained elevation of systemic and cerebral NAD that stabilizes after ∼2 weeks…” https://t.co/Hvp1NvRwl0
Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy
This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...
Action Builds Confidence, Not the Other Way
you dont need confidence to do things you need to do things to get confidence
Revisiting H1: Mapping Proton Structure at DESY
Spent a day at my old PhD experiment at DESY in Hamburg. This is what remains of H1 - a particle detector that mapped the structure of the inside of the proton (and I used to explore Pomerons … but...
Ringo Starr Celebrates Country‑music Renaissance at 85
Ringo Starr, your hero and mine. A joy to talk to him about his country-music renaissance with "Long Long Road," the best album ever made by an 85-year-old. Ringo had a lot to say about Nashville, the Beatles, and why...
Bernie Sanders' First‑class Seat Given to Aide
First Class Passenger Next To Bernie Sanders Downgraded To Coach Middle — Then An Aide Took The Seat - View from the Wing https://t.co/qK0cDV0O3A
Leave Work Behind: Strategies to End After‑Hours Rumination
@drlisamariebobby interviewed me for her podcast #LoveHappinessAndSuccess and asked how we can stop ruminating about work after work. https://t.co/ZnZs8XfoHS
Crypto Thriller Meets Wacky Comedy in POSITIONS Trailer
Crypto Thriller + Wacky Modern Comedy '$POSITIONS' Official Trailer https://t.co/ygVwEFEBXR #Positions #crypto #MichaelKunicki #VinnyKress #SXSW2025 https://t.co/Q6zyY9SNYF
Newborn Hiccups Are Normal, Harmless, and Self‑resolving
Newborn hiccups can be distressing to watch. It looks so uncomfortable and you feel helpless because there is nothing you can really do about it. But they are almost always benign and completely normal. Babies have been hiccuping since the womb,...
Supergirl Returns as Unstoppable Force, Hits Theaters June 26
A complete force to be reckoned with. #Supergirl - only in theaters June 26. https://t.co/N14OVMwRAx
Success Comes From Writing Relentlessly, No Matter What
Keep writing. Even when it’s hard. Keep writing through the self-doubt. Through the waning motivation. Through the publishing disappointments. Through the bad reviews. The authors who succeed in this difficult business know that perseverance and consistency matter more than anything else. They continue...
Being Right Matters Less than Handling Hurt Wisely
I had to check myself…being right doesn’t mean much if how you handle being hurt pushes away everything that matters.
Italian Burgundy Loafers: Blu Scarpa X Jake Woolf
Oh—you want loafers in the most classic shape and lovely, soft deep burgundy leather that you can wear with everything all year round? That are made in Italy? Got you. Blu Scarpa x Jake Woolf. Coming soon. https://t.co/kvQNAvmoNy
San Jacinto: Beautifully Intimidating Views During C3 Prep
Photos I took of San Jacinto while I was still prepping for C3 🫶 always beautifully intimidating
Three Artemis‑II Cubesats Show Successful Perigee‑Raise Burn
Three of the four Artemis-II cubesats have now been cataloged; orbits are 149 x 70247 km, 492 x 70228 km, and 61 x 70276 km. Suggests at least one made a successful perigee raising burn, but waiting for more data...
Charlie Duke Calls for Return to Moon via Artemis
In honor of Artemis: Yours truly with Charlie Duke, youngest living human to have walked on the moon. Let’s get back there, soon. 🌖 https://t.co/PkTaRIMwJG
One Solitary Life Outweighs All Empires and Armies
"All the armies that ever marched, and all the navies that ever were built, and all the parliaments that ever sat, and all the kings that ever reigned, put together, have not affected the life of man upon this earth...
More Efficiency, Less Free Time: The Paradox of Work
As I reflect on my workaholism, I often think about the “free-time paradox.” Despite technology made to increase efficiency and productivity, people feel more busy and stressed than ever. We fill saved time with more work. Even crazier: people with more money...
Apple Watch Pioneered Health Tech, Yet Defies Wellness Trends
As part of this week’s Apple 50 package, today’s Optimizer is all about how the Apple Watch shaped so much of modern health tech — and in some ways, stands in opposition to where wellness trends are headed. https://www.theverge.com/column/906391/apple-watch-optimizer-apple-50-health-tech-wearables
A Simple Phrase to Your Child Heals Your Inner Self
What’s the last thing you said to your child… that turned out to feel healing to your inner child? I’ll go first.
Skyscraper Action Thriller ‘Straight Shot’ Trailer Drops
Skyscraper Action Movie 'Straight Shot' Trailer with Tyrese & Lundgren https://t.co/0fazEZb68X #StraightShot #TyreseGibson #DolphLundgren #DavidARWhite #actionmovie https://t.co/tws4p4euYZ
Focus on Six Key Life Areas for Growth
The 6 Aspects of Life You Need To Start Maximizing - https://t.co/lByaJxT7mu - https://t.co/jJdqYT6Lq4 by Leon Ho
Stan's Classic Book: Essential Guide to Trend Analysis
Good rules from my good friend Stan the Man. I just spoke with him the other day. Stan is a national treasure. He calls me his "brother from another mother." If you haven't read his book, it's a classic...
Four Astronauts Witness Unseen Night‑Side Earth for First Time
Take a second and look at this image. Right now, there are four human beings seeing the full, unobstructed Earth for the first time since 1972. They are the only four people not in this picture. But it gets wilder...
Kids Remind Us How Fast Time Slips Away
Me: Do you know how old l am? 5yo: A hundred? Me: *sigh* I'm 39. 5yo: Are you almost dead? Me: It's starting to feel like it.
Psilocybin Study Shows Science Amplifies Spiritual Experience
In 1962, Harvard researchers gave psilocybin to theology students during a Good Friday service at Marsh Chapel. Many participants described it as one of the most meaningful spiritual experiences of their lives. Science didn’t diminish spirituality. It amplified it. Wishing you all a...
Happiness Grows, Yet Meaningfulness Remains Elusive Through Ages
On happiness and meaningfulness: Overall, across the world, there’s reason to believe that happiness has increased, for obvious reasons: people are living longer, they’re less poor, they’re better educated, and so on. So that would suggest, but not prove, that...
Study Overlooks Construction Heat, Skews Data Centre Impact
Looking at a viral academic study that claims to analyse local area heating effects of data centre construction on green-field sites, that does not control for the heating effects of *any* construction on green-field sites.
Walking and Running: One Continuum, Infinite Options
Walking & Running aren't separate activities. They lie on a continuum: 🚶♂️ 🏃♂️ You have all points on the range at your disposal... You can go... - All walking - A walk with 30s jog every 5 min. - A jog with walk breaks when...
Unearthing Cocteau Twins' “Sigh’s Smell of Farewell”
I wrote about "Sigh's Smell of Farewell" by Cocteau Twins for @Spin's Deep Cut Friday column this week: https://t.co/M15nWS9AqR
Evidence‑Heavy Statins Still Outpace Unproven Peptides
There is a fascinating op-ed piece in STAT from a doctor whose patient rejected a statin -- one of the most tested drug classes in existence -- but chose to take an untested peptide for cardiovascular risk. "My patient is intelligent,...
Drama Vs. Super Mario: Unmatched Quality Gap
THE DRAMA and THE SUPER MARIO GALAXY BROTHERS MOVIE: Quite possibly the widest chasm in quality of two movies ever covered on @TheBigPic. https://t.co/QbILwsfUUh
NASA's Nighttime Earth Reveal Shows Global City Lights
NASA released footage of Earth. This is Earth photographed at night time for the respective countries/ cities facing us.
Restore Your Natural Psychedelic Cycle to Prevent Addiction
Your body already does what psychedelics do. Every day, your circadian system runs a death-rebirth cycle using serotonin, melatonin, cortisol, and endocannabinoids. You're vulnerable to addiction and other mental health disorders when that cycle breaks. Recovery starts with restoring it:🧵
Artemis II Crew Captures Earth From Moonbound Journey
The Artemis II astronauts are the only living people who are not in that photo. For reference: North is down with Africa to the left and South America on the right.
Saying Yes When Your Body Says No Undermines Self
For a long time, I thrived in being someone people could rely on. Because it meant I was capable, reliable and trustworthy. Being needed and relied upon made me feel important, like I was useful and nice. But, nice‑ness isn't always kindness. Because,...
Stay Focused: Intensity Times Time Drives Success
Success = (Intensity of Focus) × (Time in Same Direction) Most people break this by: • changing direction too often • splitting intensity across too many goals
Early Taper Forces Goal Adjustments Amid Marathon Recovery
London Marathon training threw me a curveball this week. Starting taper early. Adjusting goals. Hoping to heal up in the next few weeks.
Looking Down on Others Proves You're Not Evolved
If you look down on other people for not being as evolved as you, then you're not as evolved as you think.
Relieve Lower Back Pain with Hip Mobility, Glutes, Core
Low back pain | mobility routine 4 exercises that help take pressure off your lower back, improve hip mobility, activate your glutes and strengthen your core If your hips are stiff and your core isn’t doing its job, your lower back has...
Stop Delaying—Your Future Self Is Watching Now
Your future self is watching you right now. • Waiting • Making excuses • Choosing comfort • Waiting for it to be "perfect" Wondering why you're punishing them
The Drama Pulls $1.7M, Targets $15M Debut
Impressive $1.7M THU night for #TheDrama as this looks to hit $15M+ for its debut https://t.co/k3iAPNSCNB
Eat More Fruits and Veggies for Better Health
Here's a podcast on healthy eating. The take away tip---Eat more vegetables and fruits. Take a listen. https://t.co/IP0e6tfkQD #nutrition #lifestylemedicine #pavingwellness #health #CardioTwitter #MedTwitter #medicalschools #medicalstudents #healthy #HealthyLife #WellnessJourney #wellbeing #coaching #healthcoaching #wellnesscoaching
Signed 2,000 Bookplates, Copies Available at B&N
BTS of me signing bookplates for The Meaning Of Your Life. I had to sign 2000 of these things. Luckily, Penguin attached them to the books without any extra effort on my behalf. I did write the book, after all. Signed copies...
Microplastics in Food May Accelerate Cancer Development
As a medical school professor, I never learned this in training: the plastic in your food may be fueling cancer. A new Journal of Clinical Investigation review (Feb 2026) maps how micro/nanoplastics drive cancer through 4 mechanisms: 1. Inflammation: Macrophages engulf plastic...
Building Tech Empowers Kids with Problem‑solving
I watched this seminal video with one of my 12 y/o’s this morning, who is in the process of building his own phone Me: how does that video make you feel? Him: like I can change things, I can build things. Like...
Springsteen Concert Revives Hope in Soul‑deadening Times
A good read on Good Friday: I wrote a big essay about seeing Bruce Springsteen in concert with my son this week, in my adopted hometown of Minneapolis, and the return of feeling something in a soul-deadening time. https://t.co/Y8NMqomcXX https://t.co/hNshkmHaTS
Seeing Earth From Space Reveals Our Shared Fragility
This is called the Overview Effect - the profound feeling when we view Earth from space, often described as a sudden sense of the planet’s fragility, interconnectedness, and the absurdity of political borders. We need more of that…. Maybe this...
Strong $1.7M Launch and 82% RT Score Boosted by Holiday
Very strong $1.7M pre-show launch for #TheDrama. Good Friday holiday makes THU night like a FRI night for many people. Reviews have been good overall and RT aud score is solid 82%. https://t.co/QCLfygj16i