Genentech’s Fenebrutinib Yields Positive Results in Phase III MS Trial
Genentech’s oral BTK inhibitor fenebrutinib met its primary endpoint in the Phase III FENtrepid trial for primary progressive multiple sclerosis, showing non‑inferiority to Ocrevus and a 12% risk reduction in confirmed disability progression. The drug also delivered a 26% lower risk of worsening upper‑limb function on the nine‑hole peg test and a 22% reduction on a composite functional disability measure. Safety was comparable, with modest liver enzyme elevations but no severe injury. These results position fenebrutinib as the first potential new therapy for PPMS in over a decade.
First SAFE Closing Saves Founder Money, Attorney Time
We are running out 1st SAFE closing for a startup through the 9to5 Docs platform. Founder saves $$$ and Attorney saves time. Win-win.
![[Therapeutics] Adaptive Deep Brain Stimulation in Parkinson's Disease](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/3742a25a994e69efcb711edfa308902b.webp)
[Therapeutics] Adaptive Deep Brain Stimulation in Parkinson's Disease
Adaptive deep brain stimulation (aDBS) introduces real‑time modulation of stimulation amplitude by tracking subthalamic beta activity, shifting Parkinson's therapy from fixed to physiomarker‑guided. Clinical trials report superior motor improvement, reduced stimulation‑related side effects, and markedly lower energy consumption compared with...
IRS CIO Says Agency Lost 40% of Tech Workers Last Year
The Internal Revenue Service’s Chief Information Officer disclosed that the agency shed roughly 40% of its IT workforce and almost 80% of its technology leadership last year, marking the deepest attrition in two decades. The cuts stemmed from voluntary separations,...
Chief AI Officer Alex Deer Speaks at India AI Summit
Our Chief AI Officer @alexanddeer will take the stage at the India AI Impact Summit. Date: Thursday, February 19 Time: 1:53pm IST // 12:23am PST Watch the livestream here: https://www.youtube.com/live/WgW7cC-kHgY
Wyndham Takes $160 Million Hit After European Franchisee Files for Insolvency
Wyndham Hotels disclosed a $160 million charge after its largest European franchisee, Revo Hospitality Group, entered self‑administration in January. The charge covers uncollectible receivables, asset impairments and a write‑down of the Vienna House trademark acquired in 2022. Despite the setback, the...
AI Won’t Kill SaaS; Governance Still Essential
Narratives can crush multiples faster than fundamentals change. Markets are pricing “software is dead” as if AI will commoditize SaaS overnight. But enterprises still need governance, permissioning, audit trails, compliance, uptime, and data orchestration. AI may change workflows, but it doesn’t...
Researchers Develop RNA-Activated Implant to Stimulate Nerve Regrowth After Spinal Cord Injury
Researchers at RCSI have created a 3‑D biomaterial implant that releases PTEN‑targeting siRNA to injured spinal cord neurons, reactivating growth pathways. The scaffold replicates spinal cord mechanical properties and delivers RNA particles directly to the lesion site, silencing the PTEN...
Etsy Sells Secondhand Clothing Marketplace Depop to eBay for $1.2B
Etsy announced it will sell its second‑hand fashion app Depop to eBay for $1.2 billion in cash. Depop, which posted roughly $1 billion in gross merchandise volume and 7 million active buyers in 2025, was acquired by Etsy in 2021 for $1.62 billion. The...
Mass Production Technology Developed for Ultra-High Color Purity Perovskite Emitters
Professor Tae‑Woo Lee’s team has unveiled a cold‑injection synthesis that mass‑produces perovskite nanocrystals with ultra‑high color purity at ambient temperature, eliminating the need for high‑temperature, vacuum or specialized gas facilities. The process achieves near‑100 % photoluminescence quantum yield and an external...
Solera Health Launches Behavioral Health Network with Calm and Lyra
Solera Health announced a new behavioral health network that links its HALO platform with Calm Health and Lyra Health. The service directs members to self‑guided apps or therapist‑led care based on their reported needs, expanding support beyond anxiety and depression...
Top HHS Officials Tout TEFCA Data-Sharing Framework As Central To MAHA
Top officials at the Department of Health and Human Services highlighted the Trusted Exchange Framework and Common Agreement (TEFCA) as a cornerstone of the "Make America Healthy Again" (MAHA) initiative. TEFCA, mandated by the 2016 bipartisan law, seeks to create...
UrbanToronto Webinar: State of Construction in the GTA
UrbanToronto is kicking off a free 2026 webinar series focused on the Greater Toronto Area construction market, with the first session scheduled for February 25. The inaugural webinar, titled "Exploring the State of Construction in the Toronto Region," will feature...
Geopolitical Analysis: U.S. Space Strategy in Africa Facing Chinese Competition
The Atlantic Council’s 2026 strategic analysis warns that the United States must overhaul its commercial partnership model with African nations to counter China’s accelerating foothold in the continent’s space economy. China’s 2025 handover of a telemetry, tracking and command station...
US Vaccine Policy Shift Boosts MRNA Stock Appeal
Macro: US vaccine-policy swing heightens regulatory risk; FDA will review Moderna’s flu shot. Key: public dispute, amended filing; decision by Aug 5. Risk: political oversight. Trade: Buy MRNA. — Viktor Kopylov, PhD, CFA More insights: t.me/si14Kopylov
Tech Firms Must Remove ‘Revenge Porn’ in 48 Hours or Risk Being Blocked, Says Starmer
The UK government will amend the Crime and Policing Bill to require tech platforms to delete non‑consensual intimate images, including AI‑generated deepfakes, within 48 hours of notification. Enforcement will be handed to Ofcom, which can levy fines up to 10%...
REMAX Names New President; Tech Exec Joins Offerpad Board
REMAX promoted Chris Lim, who joined a year ago as chief growth officer, to president while keeping his growth responsibilities. Lim, formerly president of Christie’s International Real Estate, will now oversee the global network, emphasizing international expansion and affiliate services....
Federal Circuit Clarifies Patent-Risk Boundaries in Government-Sponsored R&D
The Federal Circuit affirmed that AeroVironment’s UAV development under SBIR and STTR contracts is protected by 28 U.S.C. § 1498, barring patent‑infringement suits against the contractor. The court held the work was performed for the United States with government authorization, shifting any remedy...
Michigan Bills Would Regulate Automatic License Plate Readers
Michigan lawmakers have introduced a bipartisan two‑bill package to regulate automatic license plate readers (ALPRs) used by law‑enforcement and private firms. The proposals would restrict data collection, storage, and sharing, limit retention to 14 days, and require quarterly public reports...
GAO: Millions of People Can’t Understand Life-or-Death Weather Alerts
The GAO report warns that roughly 26 million Americans with limited English proficiency struggle to comprehend life‑or‑death weather alerts. Outdated alert infrastructure, insufficient staffing, and slow translation processes prevent timely multilingual warnings. GAO recommends modernizing the National Weather Service’s system with...
FDA Chief Warns U.S. Is Losing Ground to China in Early Drug Development, Calls for Faster Trial Approvals
FDA Commissioner Marty Makary warned that the United States is falling behind China in early‑stage drug development, citing slower Phase 1 trial volumes and cumbersome regulatory steps. He identified three primary bottlenecks—hospital contracting, ethical review processes, and the IND application workflow—that...
E.P.A. Plans to Loosen Mercury Rules for Coal Plants, Documents Show
The Environmental Protection Agency is set to loosen federal mercury limits for coal‑burning power plants, permitting higher emissions of the neurotoxic metal. Agency officials argue the change will cut "unwarranted costs" for utilities, estimating up to $670 million in savings between...
Winter Storm Leaves Solar Power Completely Ineffective
As badly as wind performed during recent winter weather, solar performed far, far worse. As often happens during winter storms, solar was mostly or totally useless during the times of highest demand (evening and early morning). In Florida, which was hit later...
Amazon Teams with OpenAI for Custom Shopping AI
🚨 My new exclusive at @ReadTheAisle Amazon has discussed w/ OpenAI working on custom shopping-related AI tied to Rufus, after using its own models and then Anthropic’s, according to sources briefed. The focus goes beyond Rufus’ main use of product Q&A https://t.co/60Z6WBfyvh
Nigerian Man Sentenced to Eight Years in Prison for Computer Intrusion and Theft
A Nigerian national living in Mexico was sentenced to eight years in federal prison and ordered to pay $1.39 million in restitution for a five‑year scheme that compromised Massachusetts tax‑preparation firms. Using phishing emails and Warzone RAT malware, he harvested taxpayer...
High‑Voltage DC Cuts AI Data Center Costs
High-voltage DC design targets AI data center costs #energysky -- via pv magazine global: https://t.co/xe594PCmhP
GitHub PR Navigation Speed Boost Improves Daily Workflow
GitHub issue/PR navigation is significantly faster recently. Large PRs also render so much better [on Safari, especially]. It is noticeably improving my day since I navigate between them with high frequency. Thanks to whoever made this happen. ❤️
ChatGPT Search Often Switches To English In Fan-Out Queries: Report via @Sejournal, @MattGSouthern
ChatGPT Search rewrites user prompts into multiple “fan‑out” queries for its search partners. An analysis of 10 million prompts and 20 million fan‑out queries found that 43 % of those sub‑queries run in English, even when the original prompt is non‑English. Overall, 78 %...
Replit on Databricks Reveals Why Software Stocks Slump
When start vibecoding your business apps with Replit directly on your Databricks you get why the market is so bearish on software stocks.
Vantor Precision3D Surface & Terrain Models Now on Satellite Data Explorer
Digital Surface and Terrain Models from Vantor’s Precision3D Product Line Added to Satellite Data Explorer https://t.co/wwaePneP9X 4 min read Digital Surface and Terrain Models from Vantor’s Precision3D Product Line Added to Satellite Data Explorer N… https://t.co/GyiCqb3Lrp
Quantum Simulator Reveals Statistical Localization that Keeps Most Qubit States Frozen
Researchers at Duke University used a neutral‑atom Rydberg quantum simulator to observe statistical localization, a phenomenon where most qubit configurations remain frozen despite quantum evolution. The effect, first theorized in 2020, was demonstrated in a one‑dimensional chain of rubidium atoms...
NASA Releases Multispectral Satellitegic Data via CSDA Program
NASA’s Commercial Satellite Data Acquisition Program Releases Archived and Tasked Multispectral Data from Satellogic https://t.co/5hA84hrb1m CSDA Menu CSDA Commercial Data Commercial Datasets Commercial Satellite Data Explorer Satellite Data Eval… https://t.co/QN5MKM4S4J
Solid‑state Batteries Outshine Li‑ion, Na‑ion Safety
Comparing safety profiles of lithium-ion, sodium-ion and solid-state batteries #energysky -- via pv magazine global: https://t.co/2EDdejzvGR
'Revolutionary' Mobile Imaging Pilot Program Excels at Preventing Unnecessary ED Visits
A pilot program in Ashford, England uses portable Fuji Xair imaging at patients' homes after falls. A radiographer and an advanced paramedic review 999 calls, travel to the scene, capture X‑rays and transmit them instantly to a hospital for interpretation....
If You’re Not Tracking These 10 PR KPIs in 2026, You’re Already Behind
The article outlines ten essential PR KPIs that have evolved for 2026, integrating AI-driven metrics such as Share of Search Influence and Emotion‑Weighted Sentiment. Traditional measures like Share of Voice remain core, but new dimensions assess message semantics, outlet authority,...
Trump Card Cap Adds to Clouds over US Consumer at Big Banks
U.S. banks posted robust Q4 consumer‑loan growth, but all warned that a proposed 10% credit‑card rate cap could restrict credit access and hurt borrowers. JPMorgan’s credit‑card revenue fell short of forecasts by 7.6% and the bank now expects card‑loan growth...
AI Skill Automates Faxing Healthcare Requests in 2026
It's 2026, so... I just wrote a Claude Skill that faxes a request form to my healthcare provider.
Rocket Lab, Blue Origin PR Clash Over Mars Telecom
Watching the PR comms from Rocket Lab and Blue Origin on Mars Telecommunications Orbiter has been fascinating.
PepsiCo’s First Creator-Led Product Launch Reimagines Chips for Gen Z
PepsiCo Foods unveiled its first creator‑led "Flavor Swap" snack line, teaming influencers Madison Beer, iShowSpeed and Dude Perfect with new chip‑flavor mash‑ups. The products launched exclusively on TikTok Shop with a nationwide rollout slated for March, aligning the launch with...
Two Red Flags? Move On From That Prospect
Founders: Prospect disqualification criteria: 🚩 Pain described in general terms only 🚩 Complex approval chain with no champion 🚩 First-time category purchase 🚩 'Someday' implementation timeframe 🚩 'We don't share that information' on budget If you see two flags, focus elsewhere.
Utah ‘Gigasite’ Data Center Contemplates Solar-Storage Baseload Addition
Zeo Energy Corp. has signed a non‑binding MOU with Creekstone Energy to evaluate a 280 MW solar‑plus‑storage system for the Delta Gigasite data‑center campus in Utah. The study will focus on photovoltaic generation paired with long‑duration thermal, chemical or electrochemical storage,...
Zoho's OS of Intelligence Unifies Data, Ensures Sovereignty
Zoho’s @rajuv just finished a great presentation describing @Zoho’s systems philosophy, summing up to following 3 key outcomes at #ZohoDay 2026 in Austin. - Operating System of Intelligence - Unified Business Context with live data - Sovereignty by design https://t.co/y6UWOmv1dv
Do Teachers Have the Skills to Use AI? New Test Aims to Find Out
ETS’s Futurenav Adapt AI test, a 30‑minute assessment, gauges teachers’ ability to recognize, ethically navigate, evaluate, and apply generative AI in classrooms. The test, piloted with 75 secondary teachers, delivers individual and district‑level dashboards of strengths, gaps, and equity concerns....
New Agent Framework Matches Human-Engineered AI Systems — and Adds Zero Inference Cost to Deploy
Researchers at UC Santa Barbara introduced Group‑Evolving Agents (GEA), a framework that evolves entire groups of AI agents instead of single individuals. By sharing a collective experience archive and using a reflection module, GEA combines innovations across agents, leading to...
Fortescue's Repeating Solar Tracker Model Boosts Pilbara Innovation
“Tracker, panel, rinse, repeat:” How Fortescue is driving solar innovation in the Pilbara #energysky -- via Renew Economy: https://t.co/t0Jovxaw7c https://t.co/NwSYabiAHC
Olympics Boost Spending in Italy; UK Banks Push Visa, Mastercard Rival
U.K. banks, led by Barclays, are convening to fund a home‑grown payment network aimed at reducing reliance on Visa and Mastercard, which dominate 95% of the non‑cash market. Visa data shows the Milano‑Cortina 2026 Winter Olympics sparked a sharp surge...
AI Automates Cytology, Streamlining Cell Pre‑Screening
AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses today @Nature https://t.co/ZI3F2pkMxE https://t.co/WsUcRjkHFN https://t.co/mdz1DM6xs7
The Blueprint for Commercializing Breakthrough Healthtech
AI‑driven medtech firms must prove tangible ROI for patients, providers and payers to move from lab to bedside. Brent Ness outlines three pillars—capital efficiency with payer alignment, rigorous evidence and reimbursement pathways, and operational scalability paired with strong IP—that determine...
When Electronics Become Flexible: Atom-Thin Materials for Future Devices
IISER Pune researchers have demonstrated large‑area bismuth oxyselenide (Bi₂O₂Se) nanosheets only a few atomic layers thick, grown by fine‑tuning temperature, gas flow and precursor ratios. The nanosheets were integrated onto a Kapton substrate to create microscopic flexible electronic devices. Even after...
NACHC Announces Center for Mobile Health to Advance Mobile Healthcare Delivery
The National Association of Community Health Centers (NACHC) unveiled the Center for Mobile Health, a dedicated hub to accelerate mobile health programs across community health centers. Backed by the Leon Lowenstein Foundation, Direct Relief and mobile‑vehicle firms, the Center will...
