When You Eat Impacts Metabolism as Much As What
As a medical school professor, I was trained to focus on WHAT patients eat. But this massive meta-analysis says WHEN may be just as important. 41 randomized controlled trials. 2,287 participants. Published in BMJ Medicine. The finding: time-restricted eating improved nearly every metabolic marker -- body weight, BMI, fat mass, waist circumference, blood p... https://pubmed.ncbi.nlm.nih.gov/41586347/ IntermittentFasting #MetabolicHealth #TimeRestrictedEating #Longevity #HealthLongevitySecrets
Maximize Strength and Hypertrophy with Minimal Training Time
No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review 👉"This review shows how acute training variables can be manipulated, and how specific training techniques can be used to optimize the training response: time ratio in...
AI Empowers Chemists, Accelerating Novel Drug Discovery
The life of a chemist is about to change dramatically as we move away from tedious trial-and-error and deeper into the comfort of the prompt window. We don't need fewer medicinal chemists; we need more high-novelty drugs on the market...
Alpha‑Lipoic Acid Shows Promise for Ischemic Heart Failure
Efficacy of Alpha-Lipoic Acid in Patients With Ischemic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Study | @JACCJournals https://t.co/nW9SbwEDfy https://t.co/qsemjmMb9k
GLP‑1 Therapies Show Promising Cardiovascular Benefits
GLP-1 and the cardiovascular system "This Review summarizes the effects of GLP-1 and GLP-1RAs in the CV system..." https://t.co/Sy7Jjb96WD https://t.co/v3T01fIcOs
Billionaires Fund Headless Human Clones for Organ Farms
Billionaire-backed scientists aim to grow 'headless humans' to farm their organs... and help biohackers live for longer https://t.co/uQOzEtBapf https://t.co/HYZCMCOPy3
Uric Acid Predicts Sex‑Specific Cognitive Decline in Seniors
Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study https://t.co/vl5LLY6mBc
Aging Meets Disease Criteria: Measurable, Pathological, Treatable
Apparently aging isn’t a disease because it’s “natural,” therefore it should be managed, not treated I disagree. Aging has causes, biomarkers, clear pathology, and is modifiable If something can be measured & treated, it should be considered a disease https://t.co/a2a2cNdobC
Regeneration, Not Just Slowing, Could Reverse Aging
New Paper - Evidence suggests regeneration may be a natural and achievable biological process worth prioritizing over merely slowing aging—ideally beginning in midlife (around 40–60) to postpone decline, with the potential to reverse aging later in older individuals. Insights from...
Current Evidence on NAD⁺ Supplements Remains Inconclusive.
NAD⁺ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence https://t.co/au5YIC11Hw https://t.co/fMsAOSQF6f
Day 1 of 96‑Hour Fast: No Hunger, Full Energy
24 hours of the 96 hour water fast are now complete. Been super easy so far. Shocked at how I’m not hungry. Good workout this morning still + a long walk after. LMNT, sparkling water, & black coffee have helped for...
Your Nervous System Signals Sleep Deprivation; Get a 7‑day Reset
This isn't about judgment. It's about physiology. If 3 or more of these describe you, your nervous system is trying to tell you something. Comment Sleep Fix and I'll send you my 7-day sleep Reset. Save this so you remember you're not...
Three 20‑second Sprints Match Weekly Cardio VO2 Gains
Just 3 all-out sprints for 20 sec repeated 3x a week can result in the same VO2 max gains (+19%) as 45 min of steady cardio once a week. The difference: 20 min less time spent on training. Caveat: done on sedentary...
Nutrition Hacks to Boost Sleep and Performance
Can you improve sleep with nutrition? Learn how to optimise sleep for better recovery, adaptation and performance. https://t.co/SabVAOeY5n https://t.co/cASn0WvTvT
High‑Dose Psilocybin Outperforms Nicotine Patches Sixfold
One large psilocybin dose beat nicotine patches by 6x odds for smoking cessation. 82 otherwise-healthy cigarette smokers, 42 received a single high-dose 30mg/70kg psilocybin session, and 40 initiated an 8- to 10-week course of nicotine patch treatment. At 6 months; participants were 6x...
Train First, Then Count Protein: Nutrition Follows
Prioritize training over protein count obsession (yes nutrition still matters but putting training first anchors the nutrition aspect). @foundmyfitness on the Huberman Lab podcast out now https://t.co/vQ9eIWHyF8
Load Choice Doesn’t Matter for Muscle Growth—Pick What Works
There is strong evidence that similar hypertrophy can be achieved across a wide range of loading schemes (~5 to 30+ repetitions), provided sets are performed close to muscular failure. That said, some data suggest fiber type–specific differences, with heavier loads...
Gene Therapy Turns Aging Into Editable Code
Gene therapy isn't just targeting diseases anymore—it's targeting aging itself. The hallmarks of aging are becoming editable code. Longevity Escape Velocity isn't a fantasy. It's an engineering problem. And we're solving it.
Gyms Transform Into Future Longevity Centers
Gyms are evolving to integrate services that are looking beyond near-future fitness and into longer-term benefits. The concept of longevity has gained traction in recent years, and gyms are tapping into this trend. In this article, by analysing real-life trends and examples,...
Exercise Beats Optional: Key for Prostate Cancer Survival
As a medical school professor, I can tell you: the textbooks got this one wrong. We taught that once you have prostate cancer, exercise is nice but optional. New data says it may be the most powerful tool in your arsenal. 828...
Lifespan Extension Doesn't Guarantee Morbidity Compression, Study Shows
“These findings challenge the assumption that lifespan extension necessarily compresses morbidity, highlighting the need to consider lifespan, healthspan, and CoM as endpoints when evaluating anti-aging interventions. We do not claim that life-extending interventions categorically fail to achieve CoM; rather, we demonstrate...
Fitness Industry Misreads Post‑Workout CNS Fatigue
The fitness industry misunderstands post-workout CNS fatigue more than any other physiological concept. Learn how it actually works in this week's free Patreon article. https://t.co/L5B5n6Ltt0
Top Epigenetic Clocks Predict All-Cause Mortality Risk
I'd still rather measure the actual biomarkers, but the best epigenetic clocks (PhenoAge, GrimAge, DunedinPACE) are consistently associated with all-cause mortality risk Another study was just published showing this: https://t.co/RZntDTn02c
Inflammation Not Inevitable With Age, Environment Matters
Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations 🐒"These results parallel recent findings from humans in demonstrating that chronic inflammation is not a natural consequence of aging but may rather be driven by environmental contexts that are mismatched to the evolutionary...
Raw Honey: Natural Remedy Boosting Immunity, Gut, and Performance
Benefits of Raw Honey: 🍯 Contains polyphenols, which help protect cells from damage and reduce inflammation. 🍯Studies show it can be as effective as some over-the-counter cough medications for reducing cough frequency and severity. 🍯 Its antibacterial properties make it effective for treating...
96-Hour Water Fast: Gut Reset, Mental Challenge
Began my 96 hour water fast today with my last meal at lunch. Why am I doing it? Sounds like a fun challenge. Feel like I often eat when i’m not hungry but it’s something to do. It’s a physical reset for...
Elevated CAC: A Crucial Risk for Endurance Athletes
Fantastic thread on the ⬆️ CAC commonly found in endurance athletes. 🫀 IMHO, this is key 👇
Red‑Light Therapy: The Real Science Behind the Hype
The surprising science behind red-light therapy — and how it really works. People are buying helmets, face masks, vests and beds that emit long-wavelength light. Beneath the hype, there is some interesting biology. https://t.co/JWV80QOuQU
Open Review Flags Flaws in Telomere‑river Longevity Study
The incredible study using "Rivers of telomeres" to rejuvenate tissues and extend lifespan in mice is now undergoing open peer-review. I did a review, pointing out issues with the methods and the lifespan curves. They're looking for more reviewers. https://t.co/KOiR4F85sT
Roundback Lifts: Use Wisely to Prevent Injuries
Roundback lifting: should you avoid it altogether, or should you purposefully do it to safeguard against injuries?
Longevity Depends on Daily Habits, Not Quick Hacks
We’ve gotten longevity all wrong. Not the goal of longevity, but the way we’re trying to achieve it. That’s the point of the new book Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity, by @drjordanmetzl, a...
Exercise Raises Plaque Yet Cuts Heart Risk
Regular exercise reduces the likelihood of plaque accumulation in the arteries However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression The fascinating thing is that despite the higher plaque, those people still have lower rates of cardiovascular disease...
Higher Phenotypic Age Accelerates Cancer Survivors' Mortality Risk
The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999–2018 "Our findings reveal a significant linear correlation between PhenoAgeAccel and both all-cause and cancer-specific mortality in cancer survivors." https://t.co/Rt7v8ECOB6
Vitamin D Guidelines Miscalculated; Sunlight, Not Pills, Solves Deficiency
The Vitamin D Lie Your Doctor May Still Believe The official recommendation was based on a mathematical mistake. The "normal" level on your lab report may be dangerously low. And the best fix isn't a pill — it's free https://x.com/robertlufkinmd/status/2036754584954167391
Detraining Can Boost Speed via Fiber Shift
Some S&C resources claim that speed is lost quickly during detraining. In fact, speed tends to increase during detraining (probably due to fiber type shifts back to type IIX). https://t.co/jn4vRuAvSR
D+Q Senolytic Linked to Brain Demyelination, Prompting Safety Concerns
The recent study showing D+Q causes demyelination in brain cells leads to more questions than it answers: (I only read the abstract cause paper new & paywalled.) D+Q has been used a lot in mice & humans. Why hasn't this been noticed...
Exercise Protects Blood‑Brain Barrier, Slowing Alzheimer’s
New on exercise —the best medicine vs age-related chronic diseases, a review @Cell_Metabolism https://t.co/z9RpD0SlYW —salutary effect on the blood brain barrier (BBB) vs Alzheimer's and brain aging gift link https://t.co/jmhJwXGWms by @GretchenReynold —original research on BBB integrity via liver produced exercise factor @CellCellPress https://t.co/3tSN8knpYF
Simple Daily Microsteps Boost Brain Health, Prevent Dementia
Dr. Tommy Wood's new book “The Stimulated Mind” is out today, and it gives people a practical toolkit to improve their cognitive function on a day-to-day basis while decreasing their long-term risk of dementia. “Every one of us has the ability to dramatically improve...
Choose Exercise by Goal, Not One‑Size‑Fits‑All
The relative effects of different exercise modes on physical and metabolic health in older adults: A network meta-analysis "Current evidence does not identify a single “best” exercise modality for improving VO2max/VO2peak in older adults. Modality selection may be better guided by...
Perimenopause Is a Metabolic Shift, Not Just Hormones
Perimenopause is not just a hormonal event. It's a metabolic one. Estrogen decline affects muscle, bone, tendons, cardiovascular capacity, and insulin sensitivity — often simultaneously. Most women aren't told this. Most training advice doesn't account for it. Here's what the evidence...
Exercise Fuels Brain Health Through BDNF and Metabolism
Exercise doesn't just strengthen your body — it changes your brain. Resistance training and aerobic activity promote BDNF production, improve brain glucose metabolism, and appear to reduce the risk of cognitive decline. The muscle-brain connection is one of the most important...
Food Evolves Into Programmable Bioactive Layer for Health
There’s a shift happening in food that most people are still underestimating. Food is no longer just fuel. It is becoming a programmable layer on top of human biology. For decades, we’ve treated nutrition as static inputs. Calories in, calories out. Macros, vitamins,...
Melatonin Controls Glutathione, Master Antioxidant, and Cell Recycling
Glutathione is often called the master antioxidant, but it’s actually regulated by melatonin (PMID: 20868358) Besides sleep, melatonin also regulates inflammation, immunity, antioxidant activity, and autophagy the process of cell recycling https://t.co/auPkyCsXLp https://t.co/JagmihM101
10 Minutes of HIIT Boosts Brain and Impulse Control
Dr Rhonda Patrick on the benefits of brief, even 10 minutes, of high intensity exercise on cognitive function, including impulse control. @foundmyfitness https://t.co/cWoeLXolL0
Introducing a Noninvasive Test for Endothelial Function
I’m excited a new noninvasive way to evaluate endothelial function. Stay tuned for a deeper dive as I test it on myself. https://www.vendys2.com/drlufkin VENDYS_2
Data Reveals Individualized Sharpening Benefits for Athletes
For example... Step into my brain, but please remove your shoes... How do I go about deciding when/if to begin sharpening an athlete prior to their A Race? I run a mixed effects model (comparing to population norms) to determine the relative performance...
Seven‑Domain Framework Elevates Person‑Centered Longevity Care
The Longevity Medicine Patient Experience Framework: A Seven-Domain Model for Optimizing Person-Centered Longevity Medicine "By operationalizing a patient-experienced, person-centered approach, this framework offers potential solutions to common challenges in longevity medicine, including care fragmentation, accessibility barriers, and poor patient engagement. It...
Oxygenated Water Boosts Cycling Performance, Study Shows
Can oxygenated water improve athletic performance? In this blog, Dr Nick Tiller and I discuss findings from a study showing oxygenated water improves cycling performance... Read here: https://t.co/buFBG5adMw https://t.co/wXVLIQ80Xl
Ketone Supplement May Shield Soldiers From Training Head Impacts
Neuroprotective effects of ketone monoester supplementation 🧠 This new study recruited 354 US military service members engaging in airborne training 🪖 Participants consumed either… 1️⃣ Ketone monoester 2️⃣ Placebo …before and during Improved Swing Landing Trainer (ISLT) training 🪂 Cognitive, balance, blood-based biomarkers were assessed 🔍 Results...
GLP‑1 Weight Loss Risks Muscle Loss without Proper Monitoring
We are prescribing powerful weight loss drugs without measuring the most important metric: muscle mass. Physical therapist Maureen McBeth has tested the body composition of countless patients who lost 50 pounds on GLP-1s. The results? Dangerously low skeletal muscle and exceptionally...