Senolytic Combo Damages Mouse White Matter, Triggers Oligodendrocyte Dysfunction
A combination of senolytics causes neuropathology in mice 👀 Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS. Senolytics under more scrutiny? https://t.co/aDosJxeyxS
FGF21 Activates SLCO4C1 to Curb Liver Fat
FGF21 turns on SLCO4C1, which boosts cAMP signaling and helps prevent fat buildup and inflammation in the liver. https://t.co/fi6RffZKVq
Pitchers Use High‑Low Models to Boost Recovery, Prevent Injuries
In the new podcast, I highlight the importance of pitchers employing high-low models to their routines in order to optimize recovery and reduce the risk of injury. Additionally, I share examples of how this structure works in the real...
How Your Vision Shapes Goal Difficulty Perception
There is a crucial but rarely mentioned relationship between how you use your visual system and how you perceive goals as difficult or easy. Even impacts physiology and goal attainment. Actionable.
Endurance Athletes Reveal Divergent Physiological Engines
My latest post on the #MADcrew forum: Two athletes. Both training for endurance events. But with completely different engines. Here’s what the #PerformanceModeling data says about how @JohnGoldman and @inaki_delaparra actually work… https://t.co/oCTDk9EAjt
Epigenetic Age Acceleration Links to MRI Aging Markers
Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration https://t.co/VSJVp4MYij
Single-Cell Clocks Offer Precise Insight Into Aging
Single-cell aging clocks: A precision tool for dissecting and targeting the aging process https://t.co/5e47qWtZwH https://t.co/ImfBb45luO
Calorie‑matched Low‑ and High‑carb Diets Yield Similar Visceral Fat Loss
Which diet is the best for lowering visceral fat mass? In this 2022 randomized controlled trial, there was no significant difference between low-carb and high-carb diets if calories and protein were matched A whole food, high-carb, low-fat diet trended towards the best...
Oxytocin Emerges as Lifelong Molecular Regulator of Health
Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings 👉"These findings provide the first molecular evidence supporting what has long been proposed: that the OXT system functions as a fundamental long-term regulator of...
Experts Debunk Keto “Cure” Claim for Schizophrenia
Can the Keto Diet Really Improve Mental Health? Health Secretary Robert F. Kennedy Jr. recently said that the diet could “cure” schizophrenia. We asked experts about the claim. https://t.co/s4ItEREHqW https://t.co/3CAFA8h3y2
Switch to Morning Workouts: Six Safe Transition Tips
Changing your workout time of day impacts everything from mood to performance. The most common adjustment takes place when someone decides to exercise in the morning. Here are six tips for safely making a smooth transition to morning exercise: ...
EU Launches AI‑Driven Fight Against Age‑Related Frailty
There are definitely worse places to discuss frailty, ageing, and using AI to discover drugs that preserve health. Kick off meeting of @EU_Commission UNION Marie Curie programme. https://t.co/BwvoPYj3KC
Geroscience Shows Lifespan and Healthspan Can Coexist
Geroscience is for healthy life extension. We should stop pretending that lifespan and healthspan compete.👨⚕️
HIIT Modulates Exerkine Secretion Across Health, Disease, Aging
Acute and chronic effects of high-intensity interval training on selected exerkine secretion in health, disease, and aging: a systematic review https://t.co/EqwyebvN62 https://t.co/yOQgxagZER
Psilocybin Doses Cut Sperm Motility by Half
Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is...
Use Your Menstrual Cycle as a Personal Performance Guide
Your menstrual cycle is the closest thing you have to a user manual for your own body. Every month your hormones shift in a predictable pattern that changes how you think, feel, create, connect, and recover. Once you see it, you...
Four Biomarkers Can Meaningfully Assess Coronary Artery Disease Risk
The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank https://t.co/CPfBPVRENq https://t.co/xTlj2ykr45
Train Harder, Not Just Eat More Protein
Most people don't need more protein to build muscle. They need to train more. Protein isn’t the main driver of adaptation, training is. Muscle growth, strength, and metabolic health are primarily stimulated by mechanical tension and progressive overload, not just a higher...
Testing Leeches for Boosting Testosterone and Sexual Function
Leeches to improve testosterone and sexual function. Will look into this and see if worth doing an experiment.
Mindset Boosts Aging: 45% Seniors Improve Over Time
45% of Seniors Got Better With Age (Yale / Geriatrics) Nearly half of adults over 65 got BETTER with age -- not worse. And mindset was the biggest predictor. As a medical school professor, I was trained to see aging as inevitable...
Heavy Strength Training Reduces Osteoporosis Mortality Risk
Please stop telling people with osteoporosis not to lift anything heavy... I've heard it from docs, PTs, Trainers, etc... This might seem protective... but it's not. This risk calculation... A hip fracture in an older adult carries a one-year...
Master CNS Fatigue to Optimize Training Variables
Understanding how supaspinal and spinal CNS fatigue mechanisms work during exercise allows us to program training variables optimally . See more in this week's free Patreon article. https://t.co/6i4w1tPtdL
Kynurenine Blocks Autophagy, Drives Stem Cell Aging via AhR
One reason why I'm tracking and attempting to optimize kynurenine levels Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway https://t.co/w1abVwROig
Track 2‑Hour Post‑Meal Glucose with Simple Finger‑Pricks
Even though the spike from oat milk could be true, see for yourself, test your own 2h glucose Not specifically for oat milk (which I don't drink), but I'm currently doing this after all meals CGM not needed, finger-prick is how I'm...
Senescent Cells Drive Inter‑organ Aging Signals
Communication breakdown: senescent cells in interorgan communication of aging: Trends in Endocrinology & Metabolism By the great @MattYousefzadeh https://t.co/PcavJgfq5z
Intermittent Fasting May Slow Immune Aging and Inflammation
Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty "This review explores how IF may exert immunoregulatory effects through metabolic remodeling, cellular stress responses, and inflammatory signaling..." https://t.co/CxfUNppvST
Sauna Challenges Bryan Johnson's Million‑Dollar Blueprint in Longevity Showdown
One of the more interesting matchups in round 1 of Longevity March Madness: Sauna vs. @bryan_johnson's Blueprint. Can the million-dollar protocol upset the favorite, or will it be sent home early? Let the people decide: https://t.co/TBjYekZE8A https://t.co/j986aHGBwp
Constant Load Boosts Predictability, Fuels Champion Performance
Exactly. Everyone talks about tapering the load for performance. Few talk about tapering the load for stability. At a constant load, Fatigue plateaus much quicker than fitness (half-life of ~7 days) This means, if you hold the load constant, you don't just get faster...
Geroscience Should Prioritize Healthspan, Not Just Lifespan
From a clinical perspective, patients are not asking for abstract years. They are asking for time with family, time in full cognition, time in independence, and time living on their own terms. That is why geroscience should be judged not...
Two 30‑Minute Sessions Weekly Deliver Real Strength Gains
Less than one-quarter of the population performs resistance training on a regular basis. Time is considered the primary barrier to participation. It shouldn't be. An emerging body of evidence shows that as little as two 30-minute resistance training...
Acumobility Ball Targets Quadratus Lumborum for Better Performance
I posted five years ago about how to use the Acumobility ball for upper extremity health and performance, so it seems long overdue for me to share one of the ways we’re using it a bit further down the...
Meditation Builds Stress Tolerance, Not Immediate Peace
The mistake people make re meditation: they presume we should feel peaceful while doing it. It’s about observing your stress & learning to not react to it (in the same way exercise is a stressor that triggers an adaption). Meditation...
Avoid Athletes' Biggest CGM Mistake – Last
LAST CHANCE for EARLY-BIRD: https://t.co/eN6PetWMGW How to avoid the biggest mistake athletes make with continuous glucose monitoring? https://t.co/LeoLb5ds7u
Single‑cell Atlas Maps Brain Aging Epigenome Across 36 Cell Types
Exciting new work in @CellCellPress: a detailed single-cell multiomics atlas of 36 cell types during brain aging in mice. This level of resolution is what we need to track how and why the epigenome changes with age 🧵 https://t.co/w5eSYG8aIf
One Short Telomere Triggers Senescence and Instability
Researchers using Saccharomyces cerevisiae showed that replicative senescence is triggered when a single shortest telomere falls below a critical length, which both initiates senescence and promotes genomic instability that can transiently enable cells to escape it. 🧬 https://t.co/TOUeXB4L3v
Retatrutide Drops Weight Fast, but Triggers Severe Reflux
So it's time for an update on me playing around with Retatrutide. This is typed from mobile, so forgive any typos or missing words. First, I stopped using it about 2 weeks after post below. I didn't run out. I'm just...
Optimizing Health with HIIT, VO2max, Zone 2, and Fatmax
Thank you @drgabriellelyon for the opportunity to sit down and discuss HIIT, VO2max, Zone 2, Fatmax, and applications for health. https://t.co/p6VplkCgVS
Healthy Life Extension: Geroscience’s Guiding Principle
Healthy Life Extension: The “North Star” of Geroscience🌟| @AgingJrnl 🩺 - David Barzilai MD PhD | @agingdoc1👨⚕️ 🔗https://t.co/JqhGgOe3nA https://t.co/ieBQZ6pAQd
Humming Boosts Nitrous Oxide, Health, and Heart Variability
Did you know humming producing nitrous oxide which is anti-inflammatory, anti-viral and a vasodilator for the blood vessels? It also tones the vagus nerve and improves heart rate varialbity, a marker of good health. Inhale and then hum as...
Complement Proteins Predict Dementia Risk over a Decade
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY
Cochrane Review Misses Intermittent Fasting’s Metabolic Benefits
A new Cochrane review claims intermittent fasting "doesn't work." But it only measured weight loss - not insulin sensitivity, autophagy, inflammation, or gene expression. Here's what the science actually shows. The 2026 Cochrane systematic review analyzed 22 randomized controlled trials and...
Creatine Supports Muscle, Bone, and Brain Health in Aging
Creatine supplementation and healthy ageing: https://t.co/NDGrsIncs2 This blog outlines the potential role of creatine for combating age-related changes in skeletal muscle and bone health, as well as cognitive function and memory. https://t.co/gVxO9C1mit
GIP Drives Subcutaneous Fat Storage; Tirzepatide Leverages This
GIP preferentially enhances glucose storage and triglyceride deposition in healthier subcutaneous fat, particularly under conditions of hyperinsulinemia and hyperglycemia. Tirzepatide contains a GIP agonist. https://doi.org/10.2337/db10-0098 https://www.gatlan.com/ @GatlanHealth
Beyond VO₂max: Rethinking Performance and Longevity
Working on a new article for my Substack. Those of us working with elite athletes have relied on our good old friend VO₂max for decades. It’s essential, but it’s not the full picture. Now that VO₂max has re-emerged in the world of longevity,...
Believing You’re on Steroids Increases Strength Significantly
You should placebo yourself into thinking you’re on steroids. Athletes given a placebo they thought was Dianabol added ~8.5 kg to their bench, ~7 kg to their military press, and ~16 kg to their squat in 4 weeks compared to when...
Speed Work Beats Long Runs for Aging Athletes
“A lot of people tend to drift up in distance as they age, thinking, “well, if I can’t go faster, I’ll just go longer.” I believe dropping down is underrated and probably provides more bang for your buck as you...
Can NAD⁺ Manipulation Extend Human Healthspan?
NAD for Health: Opportunities & Challenges 2026 This international conference will explore a central question in aging research: can manipulation of nicotinamide adenine dinucleotide (NAD⁺) metabolism enhance human healthspan and prevent age-related diseases? https://t.co/bEtQPmUnSh
Master CGM Data Interpretation – Early Bird Ends Soon
Learn how to interpret CGM data correctly during training. 24h left to use the early bird discount. Webinar 25 March | 16:00-18:00 CET https://t.co/eN6PetWMGW https://t.co/1HxlnKcV5K
Non‑local Fatigue Stems From Central Nervous System Fatigue
Non-local fatigue is closely associated with reductions in voluntary activation of the untrained limb, indicating that it is caused by central nervous system fatigue mechanisms. https://t.co/BSr0Cw5Qz6
Exploring Known and Unknowns in NAD Coenzyme Research
looking forward to concluding next week's NAD for Health conference in Copenhagen with a talk on Known Knowns and Known Unknowns in NAD Coenzyme Research.... see you there https://t.co/hLAnAq7Fay