Syringic Acid Shields Rodents From Neurotoxicity and Inflammation
Syringic acid is a naturally occurring molecule in grapes, olives, pumpkins & herbs with antiinflammatory, anti-microbial & anticancer properties. New study finds it prevents rodent neurotoxicity & inflammation. Not yet sold widely but will be I expect https://t.co/3XtSesFb9I https://t.co/C3RqjvK6NY
Epigenetic Therapy Marks New Era in Glaucoma Treatment
Great to see ophthlamologists adopting epigenetic modifications and resets to treat eye diseases like glaucoma. A paradigm shift in medicine https://t.co/g2gr3WVpkf https://t.co/6gbBVHJuXI
Sauna Use Cuts Cardiac Death 22% and Mortality 40%
The wellness industry loves the word "detox." Doctors prefer the word "data." In this recent episode, we look at why sauna use is linked to a 22% drop in cardiac death and a 40% reduction in all-cause mortality. Is the heat shock...
Aging Linked to Naive CD8 T‑cell Shortage
Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging https://t.co/NSDiR30N6W
Ice Face Extends Sauna Session, Slows Core Heat
My dry sauna session today: . 38 min at 200°F . inner ear temp 102.8°F . longer duration than usual as have been experimenting with icing face and neck to avoid MMPs thermal aging, eroding collagen. The icing slows my core temp rise....
Midlife Joint Pain Signals Systemic Decline, Not Isolated Injury
I’ve been an orthopedic surgeon for nearly 30 years, and a few patterns have become impossible to ignore. One is that many musculoskeletal problems in adults aren’t sudden injuries. They’re the moment when declining capacity and awful metabolic health finally...
Adding Load Can Enhance Movement Quality in Certain Cases
In the latest podcast, I look at how adding load can actually improve movement quality for certain individuals in specific situations, as counterintuitive as it may seem. https://t.co/nAcesV7bCd https://t.co/xCCRVH5sYE
Just 8 Minutes of Exercise Cuts Mortality 36%
Get off dat ass. 8 minutes a day of vigorous exercise linked to a 36% lower mortality risk. Benefits start at 2.2 min/day. https://t.co/UQlUv8NHI7
Gut Microbiome Proteins Influence Aging Speed, Metabolic Disease
Links between gut microbiome proteins and pace of aging, metabolic diseases, and medications @Cell_Metabolism https://t.co/Vg6vMPjnXm https://t.co/3SKNH6IEhJ
Master CGM for Athletes: Science, Myths, Practical Tips
Clear science. Practical guidance. Common myhts challenged. Join us to learn how to use CGM effectively and responsively with atheletes. https://t.co/q43bbIu6Me https://t.co/Yl2muIZiGN
5‑Minute Calcium Scan Beats Cholesterol for Heart Risk
The Coronary Artery Calcium Scan - The Heart Disease Test You've Never Heard Of There's a 5-minute heart scan… No needles. No treadmill. No contrast dye. And it predicts heart attack risk better than cholesterol alone. https://youtu.be/XVNLubDAE-M
CBD and CBG Reverse Fatty Liver in Mice
I teach medical students that fatty liver disease (MASLD) affects 1 in 3 adults and has limited approved drug treatments. That may be changing. Hebrew University researchers found CBD and CBG -- two non-psychoactive cannabis compounds -- reversed fatty liver in mice...
Choir Singing Boosts Memory, Speed, and Brain Youth
Singing in a choir is linked to sharper memory, faster thinking, and a younger-looking brain. Your grandma dragging you to church every Sunday might have been the original biohacker.
Heat Therapy Triggers Heart‑Protective Cellular Repair Proteins
Heat therapy activates proteins that repair cells and protect the heart [PODCAST] http://dlvr.it/TRSXny Podcast #PrimaryCare
Relationships Matter More Than Wealth for Healthy Aging
80 years. 724 people. One finding. The quality of your relationships predicts your health in old age more than wealth, class, or genetics. https://t.co/RhHGOhY3S8
Extending Peakspan Crucial for Aging Economy Growth
👉 “humans now spend the majority of their adult lives in a "healthy but declined" state, characterized by a significant "functional gap." 👉 We argue that extending Peakspan and developing strategies to restore function in post-peak individuals is the functional manifestation...
No‑Fluff Sleep Advice I Give My Family
What I actually tell my family about sleep (no filter) I see thousands of patients. I'm polite, professional, clinical. But at family dinners? I say what I really think. Here's the unfiltered advice I give the people I love—because sugar-coating doesn't save lives. Swipe...
Track Everything, Unlock Performance Through Self‑
When I have my clients and athletes consistently document: ✅ Sleep ✅ Training ✅ Nutrition & hydration ✅ Reading/studying ✅ Time spent on apps/video games It builds powerful self-awareness around their daily habits what’s truly serving their goals and what’s quietly holding them back. You can’t correct...
Prioritize Sleep: The Ultimate Weapon Against Societal Chaos
Everything in society attacks sleep. It’s humanity's greatest risk because it strips clear thinking. Build your life around sleep. It’s worth it. Of all the longevity stuff I’ve done, I’m most proud of my learned ability to sleep. It represents overcoming...
Low‑dose Rapamycin Eases Fatigue and PEM in ME/CFS
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem disorder characterized by profound fatigue… 👉 “Low-dose rapamycin effectively reduced PEM and other key...
Ken & Dawn Discuss AI, Anti‑aging, and Psychedelics
Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide-ranging AMA https://t.co/PtZVCoRpUy
Deliberate Heat Boosts Health, Performance—Sauna Preferred, De‑Frag Effective
30 min key takeaways on deliberate heat exposure for health and performance. And unlike the cold plunge, nobody seems to mind the sauna. Then again, hardly anyone is doing the de-frag protocol… which is brutal but very effective. https://t.co/dFR0wVdSpn
Psychedelics Boost Exercise Habits and Stress Resilience
psychedelics appear to facilitate the adoption or maintenance of physical activity habits, increase psychological flexibility, emotional resilience to acute stress, exercise and psychedelics have numerous potential complementary mechanisms https://t.co/gl4YK8bqaE
Probiotics: Benefits Questioned, Potential Explored
We know the microbiome plays an important role in health. Probiotics may play a role in the microbiome, but are they really as positive as they seem? This blog explores the potential of probiotics. Read now: https://t.co/EEXKgILfH7 https://t.co/5lwReH5Q2a
Marathons Unhealthy Only When Poorly Prepared or Mis‑paced
Two things that make marathons unhealthy IMO: 1. Inadequate preparation. 2. Inappropriate pacing (for your fitness). Both are very common, but that doesn't make running a marathon inherently unhealthy.
Personalized, Periodized Nutrition Drives Peak Athletic Performance
The 4Ps of Performance Nutrition⚡️ This new review outlined an evidence-based framework for achieving optimal performance via nutrition 📝 Focusing on the following 4Ps… 1️⃣ Personalise 2️⃣ Periodise 3️⃣ Prefuel 4️⃣ Prepare Here are the details ⬇️ Personalise 🧬 👤 Tailor diet and supplement plans to the individual athlete 📊...
Pre‑exhaustion Offers No Advantage over Straight Sets
A common bodybuilding strategy is to perform a single-joint exercise for a given muscle group immediately before a multi-joint exercise that targets the same muscle group. The rationale is that pre-fatiguing the target muscle may allow it to receive...
Smart, Hard Training Beats Injury‑Prevention Exercises in Golf
Golfers often train neither smart nor hard. Golf fitness and its ‘injury prevention’ frame has a lot to answer for. Often repurposed rehab. ‘Injury prevention exercises’ are often not performance enhancing but performance enhancing training is often injury preventing.
Oxytocin Loss Accelerates Epigenetic Aging and Inflammation
Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings "The elegant work by Maejima et al. recently published in Aging Cell reveals a previously unrecognized mechanism linking age-related oxytocin (OXT) decline to epigenetic remodeling,...
Glymphatic Dysfunction Connects Vascular Disease to Alzheimer Biomarkers
Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline "These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes." 🧠 https://t.co/YUCjeay0kr
Probiotic L. Paracasei DG I1572 Combats Vascular Inflammaging
Gut Microbiota Manipulation by Probiotic Lacticaseibacillus paracasei DG I1572 as New Therapeutical Strategy to Counteract Vascular Inflammaging https://t.co/91dumlTNgU https://t.co/tkL0m8P6nd
Thick Achilles Tendon Doubles Post‑Stent Cardiac Risk
Your ankle is a window into your heart. A new study found that patients with a thickened Achilles tendon were nearly twice as likely to experience a major cardiovascular event within three years of a coronary stent procedure. An observational study...
4-2-1
🍉NWW “4-2-1; Chew- Nibble- Sip” Fueling Strategy™ to optimize athletic performance: Pick a food from each category on game or training day 👇 4⃣Hrs. out CHEW ✔️25-30g protein ✔️50-75g carbs ✔️20-30 oz fluid 2⃣Hrs.. out NIBBLE ✔️10-15g protein ✔️20-30 g carbs *as needed ✔️10-15 oz...
Niclosamide Combats Frailty by Dampening mTORC1 Hyperactivation
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models https://t.co/U8LALaiz9D https://t.co/67rsM0g0pP
Quarterly 72‑Hour Fasts Boost Metabolism and Cut Cancer Risk
I’ve done 4 72+ hour fasts with no calories. Will do them quarterly for the rest of my life. I think it will dramatically improve metabolic health and reduce cancer risk. (Your body eats the cells that are weak and likely to morph...
Exercise Boosts Circular RNAs to Protect Aging Muscles
The role of circular RNAs in mediating the protective effects of exercise against muscle degeneration and aging https://t.co/pdRwgTkuCj https://t.co/EaEhZfDCNi
Gut‑brain Signaling Fixes Age‑related Memory Loss
Intestinal interoceptive dysfunction drives age-associated cognitive decline "We leverage this pathway to define interventions that enhance memory in aged mice, such as phage targeting of Parabacteroides, GPR84 inhibition and restoration of vagal activity. These findings indicate a key role for interoceptive dysfunction...
Aging Happens Asynchronously: Different Systems Peak at Different Ages
Instead of "healthspan," we should be thinking about "Peakspan." How long can you maintain ~90% of your peak physical or cognitive function? According to a new paper, different systems reach their “Peakspan” at very different times. Fluid cognitive abilities like processing speed...
Day 3 Tackles Extending Healthspan and Achieving Longevity Escape Velocity
The @abundance360 Day 3 is at full force, covering one of the most important topics for humanity: how do we extend human healthspan & achieve LEV. We have a powerful lineup of speakers, including my friend @davidasinclair ! https://t.co/SLfeDlbo5f
Herbal Terpenoids Boost Autophagy, Guard Against Aging
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging https://t.co/gtpKOmoxDS
Regular Sauna Use Lowers Cardiovascular Mortality Risk
Heat exposure through sauna bathing is associated with reduced cardiovascular mortality. JAMA Internal Medicine, 2015. Laukkanen et al. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2130724
Training Load Predicts VO2max, Aerobic Gains Ahead
A little #ProjectUnreasonable predictive modeling this morning - Training Load + Time In Zone vs predicted VO2max. Still a whole lot of pretty aerobic colors ahead for @JohnGoldman https://t.co/noj8ztob5u
Just a Few Flights Daily Cuts Mortality Risk
Even small amounts of stair climbing can provide great health benefits Climbing 6–10 flights/day (~60–100 steps) is associated with: - 10% lower all-cause mortality - Lower cardiovascular disease risk - Better metabolic health - Improved cognitive function Nobody deliberately climbs stairs - stairs add incidental physical...
Muscles Play a Crucial Role in Brain Health
Our muscles influence the health of our brains in ways we are only beginning to understand. The muscle-brain connection. Post #3 in my series. https://t.co/IPMvZ5weLG
Targeting Mitochondrial Redox Balance to Create Geroprotectors
Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects) https://t.co/TcG9GjMVg7 @IJMS_MDPI https://t.co/gxCC9SsO7z
Vitamin D Triggers Autophagy, Improves Diabetes Metabolism
As a medical school professor, I teach students that vitamin D does far more than build bones. This new study shows just how much more. Researchers found that vitamin D supplementation significantly improved glucose tolerance, lowered fasting blood sugar, and reduced...
Heart‑rate Recovery Outperforms VO₂max for Metabolic Health
Everyone obsesses over VO₂max. But this paper found heart rate recovery to be more strongly tied with metabolic health metabolites than VO₂max. Peak capacity is nice. But how well you recover after a hard effort may tell us more about your metabolic health.
Prescribing Mood-Boosting Probiotics Feels Like Magic
Me, during a patient appointment, going over probiotic strains that are evidence-based for mood/anxiety: "I feel like I'm casting Harry Potter spells right now" 🪄
Low‑Carb/Ketogenic Diets Mostly Preserve VO2max in Athletes
Ketogenic diets for endurance performance in trained athletes 🥑 This new meta-analysis compiled data from 33 studies (409 athletes) to establish the effects of… 1️⃣ Low carbohydrate (≤130 g/day or ≤25% total energy) 2️⃣ Ketogenic diet (<50 g/day or <10% total energy) …on aerobic...
New ACSM Guidelines Elevate Evidence‑Based Resistance Training
Honored to have contributed to the updated ACSM Position Stand on Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults. This was a major undertaking that synthesized findings from all related systematic reviews to develop recommendations...