Environmental Toxins and Metabolism Drive Leydig Cell Aging
When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk https://t.co/aCEQF1vYep @Cells_MDPI https://t.co/yu0DOE04dp
Reproductive Hormones Shorten Lifespan Across Vertebrates
Sterilization and contraception increase lifespan across vertebrates "... the hormonal drive to reproduce constrains adult survival across vertebrates, regardless of the environment in which an animal resides." https://t.co/gO0UflzgbW
Codon Bias Evolution Linked to Organism Longevity
Codon bias coevolves with longevity "Our finding is in harmony with the notion that one of the most important hallmarks of aging is loss of proteostasis, manifested in the accumulation of abnormal, misfolded proteins." https://t.co/6P7dB4KQXA
No RCTs for BPC‑157: Patent Dead, Profit Absent
Correct. There will likely be no RCTs on BPC. Unless a new variant can perform better and be patented and Rx’d… and THATs happening.
Senescent Cells Fuel Atherosclerosis; Senolytics Offer Hope
The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases "Cellular senescence and SASP drive chronic inflammation and vascular dysfunction central to atherosclerosis pathogenesis, with senescent endothelial cells, VSMCs,...
Diet and Exercise May Modify CNS Demyelinating Disease
Targeting Lifestyle in CNS Inflammatory Demyelinating Diseases: Insights from Diet and Exercise as Potential Disease Modifiers https://t.co/UyTxyZ85Ez @BrainSci_MDPI https://t.co/xTbie198cv
Melatonin Improves Multiple Cardiometabolic Risk Factors
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis 🫀 Author conclusion: Melatonin supplementation “significantly ameliorated” multiple Cardiometabolic Risk Factors. https://t.co/SapRrA0RDa
Bodyweight HIIT Lowers BP, Glucose, TyG in Seniors
Low-cost bodyweight callisthenic-based HIIT improves blood pressure, glucose control, and TyG in older adults with metabolic syndrome https://t.co/oa7ZJpk0Ld https://t.co/xKAFxvJPIz
B‑vitamins Lower Homocysteine, Slow Brain Atrophy in MCI
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial https://t.co/Xt9HqmmyGi
Melatonin Shields Mitochondria, Offering Neurodegenerative Therapy
Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases https://t.co/kp4LZEbZzN https://t.co/boWzW7fcjM
Walk 20k Steps, Transform Health and Creative Work
I used to walk under 4,000 steps per day—and I was miserable. I thought everything had to be done at my desk. Now I take 20,000 steps a day—and it's the *single* best thing I've done for my health & creativity. Here are...
Post‑Workout Sauna Supercharges Endurance and Strength Gains
Using the sauna after aerobic exercise improves VO₂ max more than training alone. People who performed 30 minutes of cycling and then sat in a sauna for ~15 minutes afterward saw greater gains in their VO₂ max after 8 weeks of...
5-MeO-DMT: Potential Longevity Molecule Revitalizing Brain
I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. + Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable...
Weight‑loss Meds Cut Alcohol Use in Half of Users
Study shows nearly half of weight loss participants reduced alcohol use after starting anti-obesity medication (GLP-1 agonists, metformin, naltrexone). https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827069 https://www.gatlan.com/ @GatlanHealth
Slight Effort Rise Shifts Fuel, Boosts Appetite
Energy and Exercise I've been writing about this a lot since the start of the year. Here's a snapshot from Bek's recent bike test from Elias' lab in Helsinki Don't get wrapped up in the exact numbers - it's the concept I...
Time-Restricted Eating May Extend Healthy Lifespan
Time-restricted eating as a potential strategy for healthy lifespan: an evaluation of current evidence https://t.co/wuXCFoZi1f https://t.co/mgFWzcFmSZ
Glycine Halves Glucose Spike without Extra Insulin
Adding 5 g of glycine to 25 g of glucose lowered the glucose response by >50% compared with glucose alone, without increasing total insulin secretion. PMID: 12450897 Why glycine is a blood sugar and glycation powerhouse: https://t.co/fEVjzefmyI https://t.co/dPaspTRBHF
Eight Hours Sitting Increases Mortality—Stand Now
Sitting for over 8 hours daily raises mortality risk. Stand up. Now. (And get a standing desk)
Estradiol Decline Weakens Workout Adaptation
Estradiol is not just a reproductive hormone. It is an anabolic signal. It drives muscle protein synthesis. It activates satellite cells after training. It controls how your body responds to the stress of a hard workout. When it declines, the same...
CRISPR's Natural Blueprint Powers Gene‑Therapy Breakthroughs
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
Recovery, Not Stress, Drives Fitness Gains
This is common sense. You don't get healthier/fitter from the exercise stressor. You get healthier/fitter from the supercompensation effect of the body during *recovery*. No recovery. No fitness. You need both.
Four Ways Glucose Monitoring Boosts Athletic Performance
In our blog we discuss four potential applications: https://t.co/i88WCldGot • Preventing hypoglycaemia during exercise • Improving pre competition fuelling strategies • Learning how different foods influence glucose levels • Understanding glucose regulation during sleep and stress
Daily Ketone Supplements Boost Brain Power, Lower Glucose
Daily exogenous ketone consumption enhances cognitive function 🧠📈 This new study investigated the effects of 90 g/day (3 x 30g) ketone monoester supplementation in recreational runners Analysed outcomes included… 🏃 Running performance 🧠 Cognitive function 🔥 Metabolism 🩻 Body composition 🩸 Hemodynamics 🎭 Mood Results 📊 Ingesting ketones led to...
Health Roadmap Adds Evidence Tags, Unit Switching, Bug Fixes
Health Roadmap Updates: 1. Clinical evidence for every suggestion — guideline tags + DOI references 2. Per-field unit switching (SI / conventional) 3. Fixed LDL suppression bug and HDL threshold rounding 4. Cleaner inputs https://t.co/wwMaIyXtzB
PCSK9 Drives Vascular Aging, Offers New Therapeutic Targets
PCSK9 in Vascular Aging and Age-Related Diseases Comprehensive summary of PCSK9's regulatory functions in vascular aging, highlighting potential therapeutic targets for combating age-related cardiovascular diseases. https://t.co/uo3PaSJLCb https://t.co/w8UZgIduPV
AI‑Driven Health Tools May Extend Lifespan to 100
How New Longevity Tech Could Help You Reach 100 Daily biometrics, smart scales and AI companions are quietly rewriting the rules of aging. https://t.co/lAmYntfSP5 https://t.co/YYo4tWkgMg
Future Tech Will Write to the Brain via Eyes
Most people are now comfortable with the idea of “reading” the nervous system, hormone, sleep tracking, etc., but writing to the nervous system, obviously is the next step. The eyes are going to be the entry point b/c they are...
Future Wearables Promise On‑Demand Control of Brain States
Sleep masks that induce sleep (exist not released yet), glasses to ramp up specific brain states etc (early versions look promising), and vagal micro stim with specificity… have tried several, and the engineers behind the soon to come tech are...
Contralateral vs Non‑local Fatigue Distinguishes CNS Mechanisms
CNS fatigue occurs during exercise due to supraspinal and spinal mechanisms. Supraspinal is likely global in nature, while spinal is not. Differences between contralateral muscle fatigue and entirely non-local muscle fatigue may help separate the two fatigue mechanisms. https://t.co/Ytl8WnBxFU
FDA Drugs Show Promise as Future Geromedicines
Check out this article I was apart of @MensHealthMag where I discuss currently approved FDA drugs that are potential geromedicines and our work on centenarians. https://t.co/e95XvnY9fb
Tailored Plan Cuts 5K Time by 90 Seconds
Nearly 90 secs off his 5k… in just a few weeks Ross was already training when he came to me. He also owns a busy cafe in Dublin so didn’t have endless hours to train So we designed a plan that hit the mark...
Wearables Transform Sleep Awareness Into Measurable Wellness
Sleep Awareness Week is a great reminder that getting better rest starts with understanding how we actually sleep. What I find fascinating is how wearable technology is turning sleep into something we can truly measure and improve. Today’s smartwatches and health...
Combat Aging Now: Common Longevity Concerns Overstated
Why is it vital for humanity to fight aging? Why are common longevity worries not big problems? My new review: https://t.co/tIcXYBFE7U a preprint of a book chapter for the upcoming radical longevity book that many in the field have contributed to. https://t.co/NFTYSMALzD
Low‑Dose Lithium Orotate May Counteract Alzheimer’s Deficiency
We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport...
New $8M Funding Enables Aging Biomarker Trials
A much needed effort that @Danbelsky and I have now been funded for to support the FAST initiative ($8 million over 18 months): https://t.co/aZsaZuEpoo The goal of this is to provide a set of biomarkers that will tell a person if...
Multivitamin Modestly Slows Epigenetic Aging; Cocoa Doesn’t
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Regular Bloodwork Is Essential, Even Without Symptoms
A while back I encouraged folks on twitter to get bloodwork 2x a year. A doctor friend of mine started arguing with me. "No need for this. If there are no symptoms, why look for problems?" I asked him when the last time...
Balancing Muscle Reserves and VO2max in Aging
In my view, the competing forces when it comes to health/longevity... 1/ Having sufficient reserves (both energy and muscle) so that you're not frail. 2/ Having very strong aerobic/metabolic fitness. These start to go against each other as you age. For example, for an...
Heart Rate Data Boosts Race-Day Performance Insights
I’ve had a few ask why this matters. It depends. If you’re a new runner just trying to get in shape, this doesn’t really matter. For those who are training for a race and trying not to blow up on...
Harnessing Immune System: New Frontiers in Cancer Therapy
The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T...
15% Body Fat: Optimal, Not Normal, Achieve via Deficit
On 15% BF... A lot of talk on whether 15% BF (for men) is "normal" at the moment. Statistically... No, not normal. Yes, optimal. The 10-step process to getting there... Step 1/ A 250-500 kcal deficit each day. Steps 2 - 10/ See step 1. Things...
Rewire Your Brain at Any Age: 8 Key Insights
Andrew Huberman just hosted one of the world's leading neuroscientists. Dr. David Eagleman shared the science behind brain plasticity—diving deep into how to rewire it to become a better person at any age. Here are 8 takeaways that could reshape your life:...
Sodium: Key to Hydration and Performance – Register Now
Sodium leads the way in controlling osmolality. That is why it sits at the centre of hydration and performance. LAST CHANCE to register: https://t.co/6IKMRNDI7X https://t.co/Khn3sEOM19
Supramaximal Isometric RDL Boosts Posterior Chain Strength
𝐒𝐮𝐩𝐫𝐚𝐦𝐚𝐱𝐢𝐦𝐚𝐥 𝐈𝐬𝐨𝐦𝐞𝐭𝐫𝐢𝐜 𝐑𝐃𝐋 A supramaximal Romanian Deadlift (RDL) held at the knee is an advanced strength training variation that uses loads exceeding your one-rep maximum (1RM), typically 105-125% or more, to target the posterior chain, primarily the hamstrings, glutes, erectors, and...
More Capillaries Don’t Boost Muscle Growth, Study Finds
One popular idea among fitness influencers is that training blocks of light loads could increase capillary content and then permit greater muscle growth in subsequent blocks. This study shows that increasing capillarization does not facilitate hypertrophy. https://t.co/SyMoaYcHWE
Exercise Slows Aging—Only with 7+ Hours Sleep
Regular exercise is linked to slower biological aging - but only in people sleeping 7+ hours. People who slept under 6 hours and exercised actually aged faster.
Mitochondrial Quality Control Drives Senolytic Resistance
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance "findings suggest that mitochondrial quality control is a key determinant of resistance to ABT263-induced and ARV825-induced senolysis, providing a possible framework for rational combination senotherapies." https://t.co/xB0wFkzIW9
Constant Phone Checks Erode Deep Thinking Capacity
Ave person checks their phone 186x a day. That's an interruption every 5 min. This shrinks the brain, causing lost capacity for deep reasoning and sustained thought. Deep focus strengths neural networks for complex thought.
WiFi Maps Your Body Pose Without Cameras
This is unsurprising. We are swimming in signals that we haven't learned how to read yet. Modern society creates a digital ledger. Our bodies generate similar data, just waiting to be read. Anti-aging progress accelerates when we learn how...
Stress Stops Nighttime Cooling, Sabotaging Deep Sleep
A close friend called me a few months ago. Sleeping 8 hours, waking up destroyed. I told him to check his data. REM gone, light sleep up, wake-ups all night. Classic stress pattern. How many of you have felt this? Stress physically...