Hindbrain Neurons Directly Sense FGF21, Regulating Appetite
Researchers identified a specific group of neurons in the hindbrain that respond directly to FGF21, acting as a key pathway through which the hormone influences eating behavior and energy balance. https://t.co/ISa30OdrM5
HDAC9 Deletion Reverses Age‑Related Fat Cell Decline
Histone Deacetylase 9 Gene Deletion Ameliorates Aging-Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice ...suggesting that targeting HDAC9 may be a promising strategy to maintain healthy adipose tissue during aging." https://t.co/pi1aXAEoeB https://t.co/IB1yUwCaGC
IL-15 Super‑Agonist ANKTIVA: Longevity’s Hidden Cancer Breakthrough
In 2024 the FDA approved a drug for bladder cancer. It is now the most interesting molecule in longevity medicine that no one is talking about. The drug is ANKTIVA - an IL-15 super-agonist. IL-15 is the body's signal for keeping...
Chronic NSAIDs May Hinder Muscle Growth, Occasional Use Safe
Millions of people routinely take nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil and Motrin, with usage being especially common among individuals who exercise. Emerging research shows that NSAIDs effectively reduce pain and inflammation, but may influence muscle-building processes. Here are some...
Sleep Deprivation Disrupt
Sleep loss reshapes not only the brain, but also the chemistry of the gut–microbiome axis. Restricted sleep disrupted daily rhythms of microbial metabolites in human blood—including butyrate and indole-3–propionic acid—linking poor sleep to altered metabolism and potential long-term health risks....
NAD⁺ Depletion Drives Heart Disease; Supplementation Shows Promise
Role of nicotinamide adenine dinucleotide in cardiovascular disease "This review explains how nicotinamide adenine dinucleotide (NAD⁺), a central redox cofactor in energy metabolism, is involved in cardiovascular diseases. It summarizes evidence that NAD⁺ levels are reduced in cardiovascular diseases, including heart failure,...
Suppressing GCN2‑ATF4 Pathway Extends Fly Lifespan
Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly https://t.co/3VBtZMHIsy https://t.co/ZAdJTc0bvL
Oxygenated Water Boosts Cycling Performance, Study Shows
Can oxygenated water improve athletic performance? In this blog, Dr Nick Tiller and I discuss findings from a study showing oxygenated water improves cycling performance... Read here: https://t.co/CdDx9avfs2 https://t.co/cYjadZ75cr
Hypoxic Training Cuts Fat, Boosts VO₂max
Does hypoxic training improve athletic performance outcomes? New meta-analysis 😮💨 This new meta-analysis compiled data from 43 studies (1154 participants) to establish the effects of hypoxic vs normoxic training on… 🩻 Body composition 🫀Cardiometabolic health ⚡️ Functional performance Results 📊 Overall, compared to normoxia, hypoxic training...
Visceral Fat Loss Reduces Brain Atrophy, Boosts Cognition
Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife https://t.co/gavVmRAAgh
Key Molecules for Alzheimer’s Prevention: A Deep Dive
Comment “Curious” for the deep dive Today’s letter is a deep dive into the molecules I find most interesting and promising for Alzheimer’s prevention — including several I take myself or recommend to people predisposed to Alzheimer’s disease. This carousel is just...
Targeting Gut‑Microbiota‑Senescence Axis to Combat Degeneration
Regulatory Mechanisms of Age-related Degenerative Diseases: Insights from the Gut Microbiota-Cellular Senescence Interaction Network "This review systematically dissects this [brain-gut] interaction network and its pathogenic role in major degenerative diseases, and highlights precision targeting of this network as a promising strategy...
Targeting Inflammaging to Predict and Prevent Chronic Disease
Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions "...opportunities and limitations of these approaches for identifying individuals at risk for chronic disease..." https://t.co/ClCxPi6sQx https://t.co/Tz6OTxUONS
Just 2–3 Sprints Enough; More Reduces VO2 Gains
Just 2–3 all-out sprints may be enough to get most of the cardio fitness benefits of sprint interval training. A meta-analysis of 34 studies found that: - Sprint interval training increased VO2 max by ~8% overall - Doing MORE sprint repetitions did not...
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Elite Athletes Win by Optimizing Every Performance Pillar
⚡️Elite & high performers invest in way more than just training. They treat their body and mind like a high-performance machine. They prioritize: • World-class trainers • Cognitive & vision training • Dedicated physical therapists • Advanced Recovery protocols • Sleep optimization & hygiene • Cutting-edge tech...
Boosting TTP Reverses Frailty and Bone Loss in Elderly Mice
New in Aging and Disease: scientists boosted a single protein in elderly mice and the animals got measurably stronger, less frail, and built denser bones. The protein is tristetraprolin, or TTP. Its job is to silence inflammatory messages inside cells before...
Zone 2 Pushes Mitochondria to Peak Capacity for Adaptation
At Zone 2, mitochondria are at metabolic equilibrium and at the highest operating capacity. This is why it is a challenging intensity for well-trained athletes (it must be). Lactate is being produced at a meaningful rate as glycolytic rate is...
Rare Gut Bacterium Can Rapidly Dominate Healthy Microbiome
A rare gut bacterium under 1% of a community can swing into dominance overnight when conditions change. A new Mount Sinai study just rewrote how we think about a "good" microbiome. (1/4)
2 Extra Weekend Hours Cut Aging Risk 23%
Catching up on lost sleep might be possible to a certain extent. Moderate weekend catch-up sleep (CUS) - sleeping 0-2 extra hours on weekends - was seen to be associated with a 23% lower risk of accelerated aging compared to no...
Gut FGF15 Shapes Lean Mass, Bone, Bile Acid Changes
Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss https://t.co/bIet15YkyC https://t.co/bMdqiWtLmu
New Study Debunks NAD+ Supplement Anti‑Aging Claims
As a medical school professor, I have watched the NAD+ supplement market explode on the promise that boosting your blood NAD+ slows aging. A new Nature Metabolism paper just punched a hole in the premise. (1/4)
Aging Athletes: Key Adjustments to Preserve Peak Performance
I turned 45 this week, and it was a good reminder that older athletes need specific adjustments to stay the course with training goals. As such, in the latest podcast, I share insights for aging athletes who want to preserve...
Moderate Exercise Lowers Cortisol, Boosts Metabolic Health
This is important. He's almost entirely wrong, but not quite. Cortisol release is intensity-dependent. While work >~60% VO2max increases cortisol, work <50-60% VO2max decreases cortisol below baseline levels. That is, it's a de-stressor that stabilizes your metabolism. In other words, the metabolic health of...
Lactate Reveals Distinct Metabolic States and Balance
30 years ago I was working with elite athletes and drawing training zones on paper based on blood lactate curves. No substrate data. No indirect calorimetry. Just the conviction that something metabolically distinct was happening at each intensity — and that...
Bicarbonate Boosts Heat Sprint Power, No Side Effects
Sodium bicarbonate improves sprints in the heat 🌡️ This new study recruited 10 endurance trained participants to take either… 1️⃣ 0.2 g/kg sodium bicarbonate 2️⃣ Placebo …prior to repeated max cycling sprints at 40°C. Results 📊 Sodium bicarbonate led to significantly improved… 💥 Peak power 💥 Average...
Berberine’s Weight Benefits Are Modest, Inconsistent, Context‑dependent
Is berberine really “nature’s Ozempic”? "...its effects on anthropometric outcomes are small, inconsistent, and context dependent..." @Examinecom https://t.co/Q3a27r89sP
Mitochondrial DNA Stability Crucial for IGF‑1 Longevity Benefits
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome [ "These observations suggest that mtDNA mutations represent a major barrier to life span extension and that mitochondrial function is required for the successful activation of...
Your 20s Can Heal Pandemic Damage Through New Inputs
If you're in your 20s and you want to feel unstoppable, this is for you... Let's be honest. Your generation got screwed. More anxiety, more depression, less fertility, lower IQ than any generation before you. And most of it traces back...
Leukemia Drug HHT Delays Aging, Extends Mouse Lifespan
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [an FDA-approved anti-leukemic drug; authors found that "HHT treatment delays aging and extends the lifespan in progeroid and aged mice"] https://t.co/LEegM8XUtR
Semaglutide Drives Significant Fat Loss in Bariatric Non‑responders
For patients who did not respond well to bariatric surgery, semaglutide shifted weight loss far beyond placebo over 68 weeks. Most of that loss came from body fat rather than muscle. obesity
Moderate Sex Frequency Minimizes Heart Risk, Extremes Harmful
Americans who had sex 1-3x/week (52–103x/year) had the lowest risk of cardiovascular disease and death. Both very low frequency (<12x/year) and extremely high frequency (≥365x/year) were linked to a higher risk. Low sexual activity might suggest cardiovascular problems (ED), hormonal dysfunction, or...
Natural Killer Cells: The Cleanest Senescent Cell Eraser
As a medical school professor, I have watched senolytics shift from drug discovery to immune engineering. A new review in Immunity & Ageing argues your own natural killer cells may be the cleanest eraser of senescent cells we have. (1/4)
Omics and AI Build Precise Biological Age Clocks
Predicting healthspan and disease risks through biological age "...Advances in omics technologies and machine learning enable the development of sophisticated aging clocks that can track aging at the molecular, cellular, and organ levels...." https://t.co/irxSfuy6qJ https://t.co/AJf53HWR3O
Longevity Expert Dr. Charlop Joins FOX Business Roundtable
Dr. Gregory Charlop here. I’m excited to announce I’m a featured longevity expert on FOX Business. I’ll be appearing on the Barron’s Roundtable to discuss common-sense health solutions for executives and family offices.
Bright and Near‑Infrared Light Reduce Insomnia in Seniors
Effects of bright light and near-infrared light on insomnia symptoms in community-dwelling older adults: a randomized clinical trial https://t.co/NmZvFlV7qy
New Cohort Study Refutes GLP‑1 Muscle‑Loss Claims
As a medical school professor, I have watched the "GLP-1 causes muscle loss" narrative drive headlines. A new real-world cohort presented at ECO 2026 pushes back. (1/4)
Centenarians Retain Youthful Immune Profile, Hinting at Longevity
Centenarians show immune function found in younger individuals. Their immune system show reduced inflammatory signaling, enhanced autophagy, and controlled cellular senescence. They have low or no autoimmune disease, robust immunity against cancer and a distinct immune cell profile. Together, these...
Fish Oil Boosts Skin Resilience, Cuts Sunburn Risk
3 months of fish oil made people significantly more resilient to UV-induced sunburn and light-sensitive skin reactions. They also had lower levels of inflammatory prostaglandin E2 (PGE2) in the skin. On social media, omega-3s are claimed to increase sunburn risk, but...
2026‑2035 Longevity Metatr
I've spent decades studying exponential tech, and this longevity report is one of the most important I've done. My 2026–2035 Longevity Metatrends Report covers the breakthroughs that will redefine healthspan, performance, and the meaning of aging. Read it here: https://t.co/mLVBlpmmCg
Optimal Heart Health Needs 4× Current Activity Guidelines
The current physical activity guidelines are too low. I've been saying this for a while. And a new study confirms it. Meeting the standard 150 minutes/week was associated with only a modest ~8–9% lower cardiovascular risk. The biggest protection occurred at roughly 560–610...
Test for Hidden Mold Toxins to Restore Energy
Mold hides in walls, vents, coffee, and even furniture, but your body still reacts. Mold toxins attack your mitochondria, disrupt your brain, and trigger chronic inflammation. They drain energy, lower resilience, and block recovery. Testing your home and your body...
Low Protein Boosts Functional Decline Risk in Seniors
Low Protein Intake Is Associated with the Risk of Functional Impairment in Older Adults in an Age- and Gender-Specific Manner: A SHARE-Based Study "...Low protein intake is associated with modest but consistent increases in the risk of reduced muscle strength and...
Methylene Blue: From Dye to Mitochondrial Therapeutic Breakthrough
As a medical school professor, I have watched methylene blue go from a 19th-century dye to a serious mitochondrial story. A new paper adds a striking chapter. (1/4)
Weekend Warrior Exercise Cuts Mortality in Early CKD
Accelerometer-derived “Weekend Warrior” physical activity and all-cause and cardiovascular mortality across CKM stages 0–3 "...while regular activity confers the greatest longevity advantage in early CKM syndrome, a WW pattern still offers meaningful protection and may be a practical alternative for individuals...
Lifestyle Interventions Lower Cardiometabolic Risk in Young Cancer Survivors
Diet and Exercise Interventions in Pediatric Cancer Survivors and Effects on Cardiometabolic Disease Risk and Inflammaging Biomarkers: A Systematic Review https://t.co/HT1V5Agx2Q https://t.co/0hVvIf2CYb
Cold Exposure Disrupts Nighttime Feeding Muscle Growth
Cold exposure impairs the muscle growth-promoting effect of nighttime-restricted feeding by desynchronizing mitochondrial energy supply rhythm in rabbits https://t.co/620Fi7oKG8 https://t.co/yaoPNNz83T
Meet Kate Tolo: First Ultra‑Measured Woman for Free Health Data
We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline....
LDL <55 Mg/dL Cuts 3‑year CV Events vs <70
Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease 👉"Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per...
Strength Training Twice Weekly Halts Age‑Related Muscle Loss
When we reach the age of 30, we start to experience age-related sarcopenia--loss of muscle mass. We can lose up to 3-5% each decade, which means by 50, we might lose 10% of our muscle mass. To prevent this, we...