Insilico Launches First Longevity Board to Accelerate AI Aging Research
Insilico Medicine Announces Industry's First Longevity Board to Accelerate AI-Driven Aging Research for Drug Discovery https://t.co/Xd8GpDTVjW
Circadian Discipline: The Longevity Hack Behind a 100‑Year‑Old Scientist
Dr. G.P. Talwar turns 🎂100🎂 this year — founder of the National Institute of Immunology, India. Still shows up to work daily at the Talwar Foundation. Sharp mind, strong memory, fully independent. His secret? Circadian Discipline. A lifelong commitment to circadian rhythm—fixed sleep,...
Genetic Bridge Links Ageing Theory to Lifespan Interventions
Dynamics of genetic and somatic trade-offs in ageing and mortality “These findings provide a genetic bridge between evolutionary theories of ageing and molecular mechanisms that can guide interventions to extend healthy lifespan.” https://t.co/HFGnELAIqH https://t.co/gAlE7D4OCh
Crowdfunded Rapamycin‑Exercise Trial Shows Promising Aging Data
Five years ago, @BradStanfieldMD reached out with an idea: a crowdfunded clinical trial testing rapamycin combined with exercise in older adults. The results are now published — and Brad and I just sat down for a full 42-minute breakdown...
Scrotal Sun Myths Debunked: UV Boosts Testosterone Generally
Sorry to be the bearer of bad news but this is bullshit. The 1939 paper referenced is a study conducted on institutionalized men with documented depression, measuring a urinary testosterone byproduct, not serum levels, and without a control group. There...
Increase Training Volume for Sustainable Performance Gains
Your training volume sets your performance limit. Sure you can do intervals for a couple of months to get a temporary boost. But, for lasting, sustained improvement, the only way forward is to figure out how you can do (and absorb) more.
Sleep Loss Damages Brain, Fuels Anxiety and Depression
Hard truth: Sleep deprivation isn't just making you tired—it's causing brain damage, anxiety, and depression that doctors are missing. Your body doesn't adapt to sleep loss. It breaks. Slowly, then all at once. Stop treating sleep like it's optional in 2026. Comment SLEEPFIX...
Age‑and Sex‑Specific Genes Shape Lifespan Trade‑offs
Delighted to have contributed to this new study @Nature on the genetics of ageing and mortality 🧬 Using a large mouse cohort, we uncover age- and sex-specific genetic effects, including trade-offs where variants are beneficial early in life but detrimental later.
Reverse Osmosis Cuts Microplastics, Add Mineral Drops
One of my first recommendations for people wanting to reduce their microplastic exposure at home is a reverse osmosis filter. They remove 99%+ of microplastic particles and other contaminants. But they also remove trace minerals, so adding them back with mineral...
Intense Exercise Boosts Belief, Cuts Depression and Anxiety
Physical Activity and Mental Health of Employed Adults: Mediation and Moderation Effects of Beliefs in the Benefits of Physical Activity “more intensive PA was related to a stronger belief in PA benefits, subsequently leading to reduced levels of depression and anxiety.” https://t.co/JBF1kDolZa
Tailor Your Training: Athlete Types Guide Updated
Updated my latest article on "What Type of Athlete Are You?" I wasn’t satisfied with just explaining the athlete types… So I added a NEW section on how to actually adjust training for each one... - What to emphasize through the season - How...
Believing You Exercised Boosts Health, Mindset Matters
Mind-set matters: Why Thinking You Got a Workout may Actually Make You Healthier 👉 “ “Whether the change in physiological health was brought about directly or indirectly, it is clear that health is significantly affected by mind-set…” https://t.co/gVlr8q4jzL
Bitter Foods Linked to Better Blood Sugar Control
Eating more bitter foods (including dark chocolate and broccoli, which I never thought bitter but…whatever…) might be associated with better blood sugar outcomes: https://t.co/fKgAK7GsLw. Here’s my go-to bitters capsule “pre-carb”: @GetKion https://t.co/5qCmeOjebh https://t.co/pCTeB5YT1W
Understanding CGM: What It Measures and Its Accuracy in Sports
There are many questions around the use of CGM in sport. What does CGM measure? How accurate is it? What can it tell us? etc. In this blog, Professor Michael Riddell and I provide an overview of CGM. Read here: https://t.co/shkcDJqVnW...
Longevity Linked to Ion Transport, Not Cell Division Genes
Why some species age slower than others remains a mystery. This is an impressive analysis of genes linked to longevity evolution in mammals. Genes associated with cell division & DNA repair show negative correlations with lifespan evolution, while positively correlated genes are...
Understanding Broad Aging Slowdown vs Targeted Rejuvenation
The 2 Longevity Fields... New post on a topic of great importance. Long, but something I feel strongly about. Broadly Slowing Aging vs. Divide-and-Conquer Rejuvenation: How to tell the difference and why acknowledging both matters (link in next post) https://t.co/khHlClSAWo
Sleep: A Modifiable Key to Aging and Alzheimer’s
“If sleep is a missing piece in the explanatory puzzle of aging and Alzheimer’s disease, then maybe we can do something about it. Sleep is a modifiable factor.” — Dr. Matthew Walker Listen to my interview with sleep expert Dr. Matthew Walker:...
Skipping Breakfast Undermines Athlete Performance and Recovery
Breakfast isn’t optional it’s essential for optimal health and performance. The average person is on their phone > 5 hours per day. You have time for a 5-min breakfast that you can prepare the night before or wake up 10-min...
Oxygenated Water Boosts Cycling Performance, Study Shows
Can oxygenated water improve athletic performance? In this blog, Dr Nick Tiller and I discuss findings from a study showing oxygenated water improves cycling performance... Read here: https://t.co/pqgFyUWJSv https://t.co/qNDIecK4Pj
Belief in Treatment Lowers Brain Pain Activity
Simply believing you’re being treated can measurably reduce the brain’s pain processing. MRI scans across 20 studies show that placebo treatment reduces activity in pain-processing brain regions. The effect is small, but consistent. Full video on placebo: https://t.co/l1PV2LNyhA Study: PMID: 33654105
Postural Slow‑twitch Muscles Atrophy Faster when Immobilized
Slow twitch muscles (like the calves) atrophy more during immobilization. This might be explained by their postural role, since they tend to contain more hypertrophied fibers due to the activities of daily life, leading to greater atrophy during disuse. https://t.co/lDSyXbYdC3
Melatonin Spikes Growth Hormone, Amplified by Resistance Training
Taking 5 mg of melatonin raised growth hormone by 157% within 40 minutes. When resistance training was performed 60 minutes after ingestion, GH rose again - reaching a 132% increase by the 83rd minute. Exercise alone (placebo group) likely increased GH by...
Blocking PGAM‑Chk1 Kills Senescent Cells, Eases Lung Fibrosis
Researchers found that senescent cells depend on a PGAM–Chk1 interaction to boost glycolysis and survive, and blocking this interaction selectively kills these cells and reduces disease effects like lung fibrosis. https://t.co/VTsHTkBcad
SIRT6 Controls Brain Protein Homeostasis, Slowing Aging
SIRT6 Regulates Brain Protein Balance and Aging https://t.co/prPtswc8kh @bengurionu Further reading (primary source) @Aging_Cell: SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling https://t.co/w1SfUiUxg4 https://t.co/TA9UjYkxvN
World's First Longevity Board Launched to Accelerate Aging Therapies
I am very happy to report that we formed the world's first Longevity Board at the public biotechnology company. Our objective is to discover and develop longevity therapeutics with pipeline-in-a-product potential. GLP-1 therapeutics paved the way and demonstrated the path...
One Week Plastic-Free Diet Slashes Hormone Disruptors 60%
A “plastic-free diet” cut endocrine-disrupting chemicals in the body by up to 60% in just 1 week. Participants in a recent study switched to low-plastic food, plastic-free kitchenware, and screened personal care products for 7 days. Urinary BPA fell by 59%, and...
Lilly's Retatrutide Achieves 28.7% Weight Loss, Higher Dropouts
Lilly’s triple G agonist boasts 28.7% weight loss in Phase III trial Lilly is investigating retatrutide in seven other Phase III trials, which are due to read out in 2026. 👨🏻⚕️“Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide...
NMN Eases Liver ER Stress, Resets Circadian Rhythm
Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity https://t.co/mXbwdQlAzt https://t.co/iQxPG0NKYf
Diet Can Reverse Phosphatidylcholine‑driven Mitochondrial Aging
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging "a previously unrecognized natural driver of mitochondrial decline in aging that is malleable by dietary interventions." https://t.co/jICV37bT1N https://t.co/DxBCO7WXJa
Coffee Regularly Improves Mood, Cuts Anxiety, Enhances Memory
Regular consumption of coffee ‘significantly’ boosts mood and reduces anxiety Benefits were also recorded in non-caffeinated coffee, found to improve learning and memory https://t.co/vWQOtWxObh https://t.co/iPzyyxbe2W
Senolytics Fail to Reset Senescence DNA Methylation Marks
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment https://t.co/uemETuWkqI H/T @NataliaMitin
Three Key Nutrients for Brain Longevity, Plus Polyphenols
As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.
Doctor’s Insider Tips to Ease NAD IV Experience
Feel “weird” during an NAD IV? Here are the insider tips from a top doctor, @joseph_purita, to make things smoother:
When Recovery Fails, Overtraining Triggers Injury
A 47-year-old runner came to see me many months after surgery. His knee hurt. We dove deeper. He had returned to training, but recently his times had slowed, his heart rate had risen, and his legs had felt heavy. What...
High Sodium Accelerates Memory Decline in Older Men
Higher sodium intake is associated with episodic memory decline in cognitively unimpaired older males: A 6-year longitudinal study https://t.co/8snYRP7sRR https://t.co/kDhs9b2Y8s
AI-Driven Medicine and Cars to Extend Productive Life
Extending human productive life and restoring lost function should be the ultimate objective of AI-powered discovery medicine. It was a great pleasure to share some the story, current progress and long-term plans at one of the most impactful events of...
Curing Disease Adds Years; Slowing Aging Adds Decades
In the future, very few will die from cancer and heart disease. But it's estimated that eliminating both completely only increases life expectancy by ~5–10 years. The real dramatic gains in life expectancy will be achieved by figuring out how to slow...
Loading Speeds Creatine Saturation; Maintenance Works Too
Creatine loading is back, but there are some things you need to be aware of⬇️⬇️ Bodybuilders have been doing 'creatine loading' for decades: take 20-25 g/day for a week and then switch to a maintenance dose (3-5 g/day) Whereas over the...
Research Shows Nicotine May Boost Cognition, Guard Against Parkinson's
The New York Times mentioned me in an article about nicotine. They're skeptical. Here's what they didn't include... Dr. Paul Newhouse at Vanderbilt ran controlled trials showing nicotine improved concentration and cognitive function in people with mild cognitive impairment. Peer-reviewed, published...
High‑Intensity Training Linked to Greater Brain Atrophy in Seniors
🤔This study followed older adults for 9 years and found that those assigned to long-term high‑intensity interval training (HIIT) actually had slightly more hippocampal and thalamic atrophy than controls who just followed national physical activity guidelines, while higher baseline fitness...
APOE Ε4 Predicts Early Cognitive Decline in Midlife Adults
APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults 🗣️” In this study, APOE ε4 carrier status was associated with early cognitive decline, highlighting midlife risk awareness and lifestyle interventions, while non-APOE polygenic risk may require longer...
Skipping Nightly Brain Cleansing Compounds Mental Fatigue
“Night after night, if you’re not cleansing the brain, it becomes like compounding interest on a loan, that it continues to escalate time and time again, night after night. “ — Dr. Matthew Walker Listen to my interview with sleep expert Dr....
90% of Fitness Gains Come From Pure Base Work
(Sadly) leaving ice cream metaphors behind, the number is ~90/10. That is, you'll get ~90% of your fitness potential from pure base *work* (sub LT1) You'll get ~10% by adding "the fancy stuff" More concretely, your typical runner with the potential to run...
Inflammation, Not Cholesterol, Fuels Heart Disease
As a medical school professor, I have been saying this for years. Now Scientific American put it on the cover. "Your Heart In Flames" -- May 2026 issue. The argument: chronic inflammation, not cholesterol alone, is the real driver of cardiovascular disease. Up...
Self‑Experiment Shows High‑Dose Statins May Reduce Exercise Performance
1/2) Given emerging literature I decided to test, in a randomized, placebo-controlled crossover experiment conducted on myself whether high-dose statins would impair my exercise performance.
Nicotinamide Riboside Blocks Lasting Mitochondrial Damage Post‑asphyxia
Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach https://t.co/ZGyAxcnNAC https://t.co/w0VJkAmlHT
Metabolic Health Drives Knee Osteoarthritis Progression
Knee Osteoarthritis Thread 4: Metabolic Health and the Knee. Your metabolic health will directly impact how your knee feels more than you can imagine. Your metabolic health directly influences how quickly your arthritis progresses and how your cartilage responds to...
Tailored Training Guide for Midlife Athletes
I recently created the Midlife Athlete's Training Guide. Why? Because many of you have asked me to write these up. So... Here's my first guide. 36 pages... why we need to train differently than when we were 30. How to...
Wearables May Render Lab HR Max Tests Obsolete
In the age of wearables and digital platforms, are one-off lab test based HR max determinations a thing of the past? https://t.co/1xTqyugldW
Tailoring Nutrient Chemistry to Boost Exercise Performance
What if we could modify the chemical structure of nutrients to alter their digestion, absorption, and metabolic effects during exercise? Could this enhance performance? https://t.co/nEZAItsKo4 https://t.co/Xn7h1zbXwU