DASH and Anti‑inflammatory Diets Lower SCD Risk, Boost Cognition
Dietary Patterns and Indicators of Cognitive Function “healthy diets, exemplified by the DASH diet for blood pressure control and diets with lower hyperinsulinemia and inflammation potentials, were associated with a lower SCD risk and better cognitive function” https://t.co/Km7DxqqtJa
Rejuvenation Stems From Removing Old Blood, Not Young Transfusions
Munger was right to “avoid crazy” regarding young blood transfusions. While animal data is compelling, evidence shows rejuvenation (in mice) comes mostly from removing old blood components to dilute age-elevated factors. 🩸
Explore the Ubiquity of Peptides with Expert Jon Slotkin
Peptides are everywhere. Don’t miss this conversation with clinical expert @slotkinjr if you’re curious. Jon is my go to on this topic. Link here: https://t.co/luQcHXz3cQ https://t.co/FhsQNVv1Hp
Creatine Boosts Power Output, Not Cognition, in Active Adults
Creatine is still primarily a physical performance supplement 💊 This new study recruited 40 active participants to complete physical (Wingate) and cognitive testing after either… 1️⃣ Creatine (20 g/day for 7-days) 2️⃣ Placebo (7-days) Cognitive testing was performance before and after the Wingate...
Early Detection Tools Exist—Yet Prostate Cancer Screening Lags
Prostate cancer: a PSA on PSA We have the tools to catch prostate cancer early—why aren’t we using them? https://t.co/w8lN6rfNmO https://t.co/dapKLiI4aX
21st‑Century Models Show Longevity Escape Velocity
Life expectancy is rising across the world. Some people think we’re on the verge of “longevity escape velocity” — where medical progress starts extending life faster than aging takes it away. But what do the actual models for the 21st century predict?...
Sleep, Cardio, Meditation, Whole Foods: Real Nootropics
I've experimented with nootropics my whole life, The best ones are; -Perfect sleep -Intense cardio -Meditation -Whole foods diet Anything else is a waste of time if you don't sort these. 0 side effects, pure upside.
CGM Can't Accurately Predict Endurance Fuel Needs
Continuous glucose monitoring (CGM) is increasingly used in sport, but can it tell athletes how much fuel is left in the tank? This blog explores whether CGM can provide meaningful guidance on fuelling strategies for endurance performance. Click here: https://t.co/j4V3cTKttl...
MIND Diet Slows Brain Atrophy Over Ten Years
Adherence to the MIND diet and longitudinal brain structural changes over a decade: evidence from the Framingham heart study offspring cohort “In this prospective cohort study, greater adherence to the MIND diet was associated with slower brain structural atrophy, particularly...
Refined Diets Damage Amygdala Memory in Aging Rats
The aged amygdala’s unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis 👉 “Refined diets impaired amygdalar memory in aged rats, regardless of fat or sugar…” https://t.co/GfWLeVTb9z https://t.co/xLCIniZq5B
Science Shows Seed Oils Aren’t the Health Villains Claimed
How Seed Oils Became Controversial—And What the Science Really Says A food scientist debunks the vilification of seed oils on social media and explains what research says about them. https://t.co/3vkvSpmBod | @sciam https://t.co/MuRLtmBi7U
Regular Resistance Training Boosts Muscle Function, Hypertrophy, Performance
American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews 👇 FIGURE 2: Schematic representation of the modes of RT and the outcomes that are positively influenced...
Whey Protein Boosts Weight Loss in Obesity, Review Finds
Effectiveness of Whey Protein Supplementation in Weight Loss Interventions for Patients with Obesity: A Systematic Review https://t.co/aWeSqmYfFL
Monitor Heart Rate: Ignoring It Leads to Bad Outcomes
This is exactly why you *should* pay attention to heart rate. A lot of variables beyond the pace/power you're pushing go into the mix to determine physiological stress at any point in time. You can't ignore those variables. I mean, you can, but...
Sinclair's 1g NMN: Myth Vs. Cellular Reality
David Sinclair is one of the smartest longevity researchers on the planet. I interviewed him here: https://t.co/dZCOAD5PLU and recently @tombilyeu released an interview with him here: https://t.co/F2pHBy9xuw... ...in which @davidsinclair says he takes 1g of NMN every morning. But some people say...
Late‑stage Oral Cocktail Adds 33% Lifespan in Obese Mice
An oral drug combination, including a senolytic (quercetin), NR, urolithin A, and alpha-lipoic acid, extended median remaining lifespan in mice by 33%. Important to note, however, that the mice were fed a high-fat "Western Diet" and the intervention started at 18...
Neuroplastogens: The Next Frontier Beyond Peptides
Peptides are old news tbh. I was taking noopept and mk-677 in 2015. The next big thing will be neuroplastogens
Doctor Says 100 Daily Jumps Offer Limited Benefits
Is jumping 100 times every day good for you? Doctor breaks down TikTok trend A new TikTok fitness trend involves jumping 100 times each day, and a doctor has explained whether this viral exercise routine actually delivers health benefits https://t.co/8LhdDx4ei2 https://t.co/jstsaJ3hte
Oliver Zolman Discusses Cutting‑Edge Aging Research Insights
New interview, by the terrific Oliver Zolman who was for a time Bryan Johnson's main doctor and who knows a great deal about aging research too: https://t.co/LCenNXC9xg
NAD+ Rhythms Drive Sleep, Aging; Resetting Delays Decline
NEW PAPER: Ups & downs in NAD+ over 24 h dictates our body's clock & sleep but declines with age. Disrupting the cycle promotes mouse aging & restoring it improves fitness & metabolic function, pointing to "circadian reprogramming" as a...
Lower Resting Heart Rate Lets You Work Harder
One thing I like about a fixed HR cap... It naturally grows with your fitness. 120 bpm is a much higher relative effort for someone with a resting heart rate of 40bpm, than it is for someone with a resting heart rate...
Walking Reduces Calorie, Hydration, and Heat Limits
95% Calories, fluid & heat management are 3 of the biggest limiters to marathon performance. All go down a lot easier when walking.
Androgen Receptor Density Drives Muscle Gains, Not Testosterone
Muscle androgen receptor density, but not testosterone, predicts muscle growth from resistance training In this 2018 study, testosterone, IGF-1, growth hormone, DHEA, LH, or DHT predicted muscle hypertrophy - muscle androgen receptor content did Muscles have androgen receptors that mediate hypertrophy through...
Optimized Type 2 Diabetes Care Boosts Health and Savings in Spain
Estimating the Clinical, Quality-of-Life and Economic Impact of Optimized Management of Type 2 Diabetes Patients in Spain https://t.co/L3QB4MJf57 https://t.co/pot0usHX7f
Supplements Offer Small Endurance Gains, Unclear Adaptation Benefits
Supplements like sodium bicarbonate, beta-alanine, beetroot juice, and caffeine can boost endurance by ~1-3%. What about their impact on adaptation? Read the blog: https://t.co/nOvClAp15h https://t.co/R0OaDs8m92
Keto Diet Induces Ulcerative Colitis Remission, Challenges Conventional Care
A ketogenic diet put his ulcerative colitis into complete remission — off all medications, confirmed on colonoscopy. Dr. Nick Norwitz (PhD Oxford, MD Harvard) explains why "evidence-based" care isn't always optimal care, how keto rewires the gut and brain, and...
Longevity Obsession Ignoring Youth Health Crisis
Yesterday I published my latest Substack article and went to bed feeling something was missing. This morning I realized what it was. I had left out two key sections: • One for the hundreds of millions of people with real metabolic dysfunction...
Extreme Glycogen Loading Can Accelerate Breakdown, Not Boost Performance
Is it necessary to follow an extreme glycogen loading protocol? Or will you simply accelerate glycogen breakdown? Read the blog to find out: https://t.co/4tRxNEPTAA https://t.co/Grta1nNNWy
Protein‑rich Breakfast
Big breakfast diet composition impacts on appetite control and gut health: a randomized weight loss trial in adults with overweight or obesity "The HPWL diet was superior to the HFWL diet for suppressing subjective appetite (P=0.003). The faecal microbiota analysis showed beneficial...
Pre‑Sleep Nutrition Boosts Muscle Recovery and Next‑Day Performance
In this live webinar, we will explore whether pre sleep nutrition can affect muscle protein synthesis, glycogen restoration, sleep, body composition, and next day readiness. Find out more: https://t.co/UXBWDt3JIP https://t.co/7uocd3yDXB
PFAS Exposure Linked to Faster Biological Aging in Men
Aging process could accelerate due to 'forever chemicals' exposure, study finds Higher concentrations of PFAS chemicals were associated with faster biological aging in men of certain age groups https://t.co/ZClEw0Gj1p https://t.co/tYBTJTmlt9
Exercise Activates Hypothalamic SF1 Neurons, Boosting Endurance
Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance 👉 “ These results demonstrate that exercise-induced hypothalamic SF1 neuron activity is essential for the coordination of physiological improvements following exercise training.” https://t.co/qLowm6sETh
Peptides: Unregulated, Risky, and Growing in Popularity
"What's your star sign?" "I'm a Taurus." "Cool, and what's your peptide stack?" Special Lifers episode on Peptides Part 1 with Sunita Mohanty Spotify: https://t.co/nRCBnLOjqm Apple: https://t.co/iibWpZHNZ7 Youtube: https://t.co/ijtPosgt4t Timestamps: (00:00) Intro (00:04) Peptides everywhere (00:42) Meet Sunita and Ultralight (01:08) Regulatory whiplash explained (01:58) Stacks and the gray area (03:34) Black market...
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative "Genetic IL6R blockade was not associated with incident chronic-disease risk, including invasive cancer and longevity, in a large, ethnically diverse cohort of postmenopausal women. No significant...
Two Weeks Offline Boosts Mental Health, Reverses Decline
Two weeks without mobile internet improved mental health more than antidepressants and reversed roughly 10 years of attentional decline. Screen time dropped 49% (314 to 161 min/day). https://t.co/9sU6ZFXDCr
Blood‑based ECM Protein Clock Predicts Biological Age and Disease
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease https://t.co/3VOwhGCz5S
Nocebo's Power Equals Placebo in Health Education
Nocebo deserves as much airtime as placebo in patient education and provider training It matters as much for diets: tell someone a food is harmful and their body will often cooperate, which "confirms" the belief and pushes them to cut foods...
Pregnancy's Neglect Sparks Women’s Self‑Experimentation for Empowerment
Pregnancy is severely underappreciated in our society. Most women don't get the guidance they need from doctors. Self experimentation gives the power back.
Sex Differences Crucial for Glucagon Obesity Drug Efficacy
Male and female bodies respond differently to glucagon-based obesity drugs, and FGF21 plays an important role—especially in females. This means future treatments need to account for sex differences to be effective and safe. https://t.co/Z9gllk02Dj
Moderate Calorie Restriction Lowers Fat C3, Slowing Aging
Moderate calorie restriction in humans reduces levels of the immune protein C3 in fat tissue, potentially slowing aging and inflammation without the negative effects of severe dieting or weight loss. aging
Childhood NAD+ Deficiency Triggers Lifelong Muscle Aging
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood https://t.co/K0MAkv7hIB https://t.co/eRCOesGwL5
Exercise Aligned with Your Chronotype Reduces Heart Disease Risk
Timing exercise to match body clock chronotype may lower cardiovascular disease risk https://t.co/RhtM0ZlW1k via @medical_xpress #exercise #CardioTwitter #MedTwitter #health #lifestylemedicine
Superfoods May Deplete Minerals—Supplements Fill the Gap
What if the superfoods you eat every day are actually stealing minerals from your body? Spinach, kale, sweet potatoes, almonds, and raspberries are all designed by nature to limit how much you consume, and glyphosate-sprayed foods make it worse. That's exactly...
Why Female Influencers Rarely Promote Peptide Stacks
It was on this day that I learned what a Wolverine Peptide stack is! I spoke to @sunitasmohanty on the market demand for peptides, how she's experimenting with them & why we don't see as many female influencers hawking them. Full...
Data Isn't Steroids: WHOOP Defends Athlete Insight Rights
At @WHOOP, we will always stand by our members’ right to understand their health and performance. Data is not steroids. Access to accurate, non-invasive insights does not undermine competition—it strengthens the sport and supports players. https://t.co/9s6c3ifw9N
Stop Eating Three Hours Before Bed for Better Sleep
One of the simplest things I do for sleep is to stop eating about 3 hours before bed. It's something that’s supported pretty consistently in the research. When you eat (especially a large meal), you’re activating the sympathetic nervous system... not what...
Creatine: Most Studied Supplement Still Sparks Debate
People are still debating creatine use when it's the most researched supplement in history? https://t.co/lIOlNTG713
New Delivery Bypasses Diet, Fuels Cells with Urolithin A
Only 30% of people can actually produce Urolithin A from food. And even if you are one of them, you would need six cups of pomegranate juice a day to hit the minimum effective dose. Scientists have found a way...
Blood Test Identifies Molecules Predicting Short‑term Survival
New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe
Wheat Bran Plus Resistant Starch Improves Fecal Health Markers
Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone https://t.co/c5q4PlNB2l