Booster Speed-Processing Training Cuts Dementia Risk 25%
This one type of cognitive training might delay dementia.🧠🧠 In the ACTIVE randomized controlled trial, older adults were assigned to memory, reasoning, or speed training — then they were followed for 20 years. Standard memory and reasoning training didn't reduce dementia risk. Speed-of-processing training alone didn't either. However, those who did speed-of-processing training and received booster sessions every few years had ~25% lower risk of dementia. Full video: https://t.co/XB5PQfTm2E Study: https://t.co/IE5CBGzn66
Statins Don't Harm Muscle Health in Older Adults
Statin use does not impair muscle health in older adults: findings from the SCOPE study https://t.co/WKjk9Ov0rG https://t.co/xTo9mk3vbw
Recovery Becomes Your Superpower as Performance Slows
Recovery is a superpower... A thread... 1/There's a moment most aging athletes eventually hit. You finish a routine workout, but the next day, something is off. You're not just tired. You're slower. Less inclined to train. Your body is responding differently to...
Feel First, Think Second, Let Performance Follow
In physical training most coaches lead with the performance results. I think about those last. My prescription follows: Feel first. Mind second. Performance third. Performance is almost always a byproduct of getting the first two right.
Muscle Atrophy Driven by Intrinsic Aging, Not Nerve Damage
I teach medical students that nerve damage causes muscle wasting. New research says we had it backwards. Scientists at MDI Biological Lab engineered "atrofish" -- zebrafish that compress DECADES of human muscle aging into weeks by activating the Atrogin-1 gene. What they...
AI Tackles Tough Challenges, Shaping Science, Health, Humanity
Solving a hard problem with AI… and next steps A high quality discussion with @demishassabis Thoughtful approaches to harnessing AI for better science, health, and personal welfare across humanity. https://t.co/Uyz6BpuWCi https://t.co/Uv2DyyPXES
AI-Driven Global Collaboration Needed for Longevity Research
Great speaking with @SpeakerPelosi at @semafor . In my opinion, drug discovery for cancer and age-related diseases should be a global effort. Nations need to strive to collaborate to extend healthy productive life. Please through longevity. It is the best...
Electromagnetic Gene Switch Extends Lifespan in Progeroid Mice
Wow, a technique that allows electromagnetic control of gene expression in vivo 🤯 And they tested their system with OSK partial reprogramming, showing it extends lifespan in progeroid mice. In normal mice, they report health improvements and a small reduction in mortality...
Hit 50g Protein by Noon to Boost Performance
If you haven’t hit at least 50g of protein in by 12:30 pm you’re already behind. Yes, you should be eating 20–40g of protein at each meal. Skipping or under-eating earlier in the day is a big reason why you’re struggling. You’re...
Modern Health Advances Make 60‑year‑olds Feel Younger
Look at photos of 60 year olds from 1985. Then look at 60 year olds today. It's not even close. Something fundamentally shifted -- and it's not just skincare or fashion. We know more about sleep, metabolic health, strength training, and inflammation...
MRNA Nanoparticles Teach Beta Cells to Prevent Type 1 Diabetes
As a medical school professor, I can tell you: what we've been doing for type 1 diabetes is managing, not curing. University of Chicago scientists just changed the game. They developed mRNA-loaded nanoparticles that deliver genetic instructions directly to insulin-producing beta cells,...
Today's Teen Could Become First 150‑year‑old
David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has...
Energy Levels Reveal Early Healthspan Decline Signals
Energy isn't just a feeling. It may be one of the earliest biological windows into healthspan decline. New from @BuckInstitute's Healthspan Horizons, led by @NathanPriceSci, exploring how mitochondrial function, sleep, glucose stability, and inflammation converge as early warning signals. This matters for...
Molecular Signature Differentiates Aging Cognitive Resilience vs Decline
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease 👉"Together, our study points to a multiomic molecular signature of the hippocampus that distinguishes cognitive resilience and deterioration with ageing." https://t.co/rRkFg6HKO0
Strength Training Beats Pills, Injections, Surgery for Knee OA
Knee Osteoarthritis: Thread Number 3 The most powerful intervention for knee osteoarthritis is not a pill, not an injection, and not a surgery. It's not PRP and certainly not stem cells. It is the muscle above and below the joint. If you...
Balanced Nutrition: Plants, Fiber, Carbs, and Flexibility
Unpopular truths about nutrition: - You need plants in your diet and probably more servings than you think. - Fiber is good for your gut and heart health. It also plays a role in satiety. - Carbs aren’t the enemy. They’re...
Fiber Size, Not Type, Drives Unloading Atrophy Rates
Whether fiber type affects atrophy rates when all fibers in a muscle are unloaded is contentious. Yet, we can explain even the most confusing results if we make the assumption that fiber size determines atrophy rates and that fiber type...
Brain Age Gap Predicts Lifestyle Impact on Mental Health
Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health https://t.co/kgvgyZ9v4S
Depleting Microbiome Restores
Microbiome depletion rejuvenates the aging brain "Our findings demonstrate that age-associated microbial inflammation contributes to brain aging and that its attenuation can restore youthful features at the molecular, cellular, and functional levels." https://t.co/GuBPBxxzeH
Young Microbiota Restores Cognition and Sperm Health via Bifidobacterium
Young Human-Derived Microbiota Ameliorates Cognitive Decline and Reproductive Senescence in Aged Mice This approach "increased intestinal Bifidobacterium levels and effectively restored hippocampal metabolomic profiles and cognitive behavior." Additionally, yFMT-based treatments "mitigated structural damage to the seminiferous tubules [and] improved sperm quality. 👉These findings...
Build Zone 1 Reserve Before Hard Training
Zone 1 is an investment. It builds your fat-burning engine and expands your energy reserves. Zone 3/4 is a withdrawal. It spends from that reserve. Want your hard training to actually work? Build the reserve first. #Base
Natural Compounds Boost Gut Butyrate, Increase Muscle Mass
Computational Screening and Experimental Validation of Natural Compounds that Enhance Butyrate Production in Gut Bacteria and Promote Muscle Cell Mass https://t.co/YgZdtWly4n
EMF‑Controlled Gene Switch Reverses Aging In Vivo
EMF-inducible gene switch gene switch enables in vivo rejuvenation by reversing aging phenotypes Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression https://t.co/yeIDzXChWV
One Injection Restores Hearing via OTOF Gene Therapy
A single injection uses an engineered AAV virus to deliver a healthy OTOF gene into cochlear cells, enabling them to produce otoferlin and restore the ear’s ability to convert sound vibrations into signals the brain can interpret. https://t.co/Lk34jpnRBe
Test, Target, and Clear Oxalates with Lemon & Biotin
Do you know what oxalates are actually doing to your body? Did you know lemon juice breaks them down and biotin clears them out? Most people only know half the protocol, which is why you should get a urine organic acid...
Peak Span May Outweigh Health Span for Longevity
Experts say your ‘peak span’ could be more important than your ‘health span’ – here’s why, and what it really means for health https://t.co/YVulQ49Zvh @StylistMagazine Featuring work by @biogerontology, @KejunYing, and @DomiWilczok 🔬💻⚕️ https://t.co/basWzeHBi6
18‑Minute Sinus Surgery Aims to Boost Sleep Health
Had four sinus treatments today. Amazingly enough, the surgery took 18 minutes under general with a 27 minute recovery. Here’s what I had done: 1.Septoplasty: straightened the right deviated septum that was blocked 90% 2.Balloon Sinuplasty: dilated sinus outflow tracts, removed infection,...
Design Smarter HIIT Workouts with Our Free Guide
With so much junk out there on HIIT and other interval training... I put together a free guide: How to Design Better Workouts. Filled with insights on writing creative workouts that get the right stimulus for the desired adaptation. Sign...
Moderate Coffee Intake Cuts Stress and Anxiety Risk
Scientists Identify Coffee 'Sweet Spot'–Here's How Much to Drink Each Day for Lower Risk of Stress and Anxiety https://t.co/DohCegVD51 https://t.co/N6P8qAxfr2
Barley Leaf–Derived Gut Microbes Boost Mouse Cognition, Slow Aging
Bizarre experiment, but OK... Middle-aged mice were given human fecal samples from young people taking barley leaf (BL), rich in dietary fiber, chlorophyll & polyphenols. Bifidobacterium in the mice rose, along with restored cognition & slower testicular aging 🧠🥜
Targeting Aging: Epigenetic Reprogramming Tackles Disease Root
Aging is arguably the root cause of most major diseases. Our cells lose function as we age, allowing various conditions to manifest, which is why most major diseases correlate with age. Yes, it is more complex than this, but this is...
Coaches Craft Personalized Plans Using Your Data, Schedule, Demands
https://t.co/dPuUxiaqfE The coaches I have personally trained at TRIUMPH Coaching don’t hand out generic plans. They build around your data, your schedule, and your actual demands: https://t.co/Mmwq3Iqn6o
Choose Fragrance‑free; Scented Products Increase Hormone Disruption
WILD (& devious). When it comes to hormone disruptors, frequency of exposure matters & generally anything scented is worse than not. But “unscented” is a scent (!) designed to mask other scents. “Fragrance free” is what you want. Dr Natalie...
Aging May Be a Software Issue, New Primate Study Shows
Cool new paper: Cellular aging biomarkers in primates - increasingly supportive of aging being a software problem But what kind of software? And can an update be reinstalled? 🧵 https://t.co/1CKLNtHwZ4
Age Spots Linked to Epigenetic Drift, Potentially Reversible
Could age spots be due to a suspected cause of aging? New paper says: "Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation of methylation states." If so, they are reversible. Can't wait to...
AI‑designed Sensors Promise Earlier Cancer Detection
As a medical school professor, I can tell you: we catch most cancers too late. MIT and Microsoft may have just changed that forever. They built an AI system called CleaveNet that designs molecular sensors detecting cancer enzymes called proteases --...
Low HRV Significantly Increases Heart Attack and Death Risk
1/2) Heart rate variability (HRV). You’ve probably heard of it—but do you actually understand it? It’s incredibly important metric. Low HRV is associated with ~50% higher risk of heart attack, even after accounting for common confounders. And... In people who’ve already had...
SGLT2 Inhibitors Protect Kidneys, Yet Raise Non‑Renal Risks
Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury Risk: A Systematic Review and Meta-Analysis of Randomized Trials "SGLT2is conferred substantial renoprotective benefits but increases the risk of certain nonrenal AEs." https://t.co/n0yhZgcShy
Carb Mouth Rinse Boosts Heavy‑Lift Performance, Shows CNS Fatigue
Carbohydrate mouth rinsing increases work done during a strength training workout involving a small number of reps with a heavy load, showing that exercise need not be long-duration in order for supraspinal CNS fatigue to occur. https://t.co/Q11E9Ep6bb
Elite Athletes Blend Hard Sessions with Abundant Easy Miles
You can argue threshold vs high-intensity all day. Both have produced world-class athletes. What hasn’t? Skipping the easy miles. Almost everyone at the top: *Something* hard + a lot of easy aerobic work That’s the recipe.
One Drink Harms Health: Quit Alcohol Now
Friends, stop drinking alcohol. Not cut back. Eliminate. > alcohol increases cortisol > disrupts REM sleep > accelerates epigenetic aging > shrinks hippocampal volume > elevates resting heart rate > raises inflammatory markers > impairs glucose metabolism for 16 hrs One drink does that.
Cross‑correlating 1.9M Health Data Points Reveals Hidden Cause‑effects
My home brew health app. 1.9M personal health data points. The most valuable thing has been finding cross correlations in all the data between cause and effect. Exercise. Sleep. Diet. Prescriptions. Work. Stress. Flying. Activity. Supplements. Surgeries. Meetings. Workouts. Chelations....
Serum Proteomics Distinguishes Endurance versus Strength Adaptations
Adaptations to endurance vs strength training in elite athletes revealed by serum proteomics https://t.co/ii3xAiNEcT https://t.co/hBfQ0E0v9W
Rory McIlroy’s Diet: High Protein
If you want to fuel like Rory McIlroy, it’s actually pretty consistent with my recommendations as a registered dietitian and certified sports nutritionist. He prioritizes protein first (around 170–180g daily) to support muscle, recovery, and stable energy. Then he adds in...
Optimize Fertility: Hormone Health, Testing, and Lifestyle Choices
The new Huberman Lab episode is out: How Women Can Improve Their Fertility & Hormone Health | Dr. Natalie Crawford (@ncrawfordmd) 0:00 Natalie Crawford 2:26 Fertility as a Health Marker, Infertility 5:34 Perimenopause, Menopause, Hormone Replacement Theory 11:01 Sponsors: David & BetterHelp 13:35 Hormone Therapy,...
Skip Meals Around Sleep to Improve Metabolism
If you are struggling with the symptoms of metabolic issues, such as blood glucose fluctuations, high body fat percentage/inability to lose weight, low heart rate variability, high heart rate, etc., then it’s pretty likely you would benefit from not eating...
Health Thrives Through Social Co‑Regulation, Not Solo Optimization
Co-regulation is the most effective biohack. Your body feels safest when you are surrounded by people you love. Stop trying to optimize in a vacuum. Health is a social sport. DNA doesn't lie. We need each other.
Calorie Cutting Lowers Epigenetic Age and Inflammaging Protein C3a
Caloric restriction (CR) slows aging in rodents. People who cut calories by 14% over 2 years had lower epigenetic ages of some tissues & inflammatory protein C3a, regardless of BMI. In mice, lowering C3a levels reduced inflammaging, especially in fat....
30‑Minute Sauna Spike Boosts Immune Cells
Sauna bathing mobilizes circulating immune cells. A single 30-minute session at ~165°F (enough to elevate body temperature to 101°F) increased levels of several immune cells including lymphocytes and neutrophils for up to 30 minutes. This occurred in non-users and people who used...
Boost Athletic Recovery: Nutrition-Optimized Sleep Workshop
LAST CHANCE to register https://t.co/6Nswtdw8XP Can you improve sleep with nutrition? Learn how to optimise sleep for better recovery, adaptation and performance in sport. https://t.co/OaGTE28Goh