CJC‑1295 Extends Sauna Heat‑Shock Time, Delays Threshold
Bodybuilders use the peptide CJC-1295 to grow muscle. I tried it for two weeks. Unexpectedly, it changed how my body responded to 200°F sauna protocol. First, the good. I spent more total time above the heat shock protein (HSPs) threshold. This is when my core body temperature reaches 102.2°F and heat shock proteins are released. Before CJC, total time in HSP land was 9 minutes (with face cooling). On day 9 of CJC, it rose to 15 minutes. Resulting in more HSP exposure per session. Now the bad. It took me 13 minutes longer to reach the target heat shock threshold of 102.2°F. From 41 minutes to reach threshold at baseline to 53 minutes on day 9. This is an insane level of primal panic to be in 200°F for 53 min. Max core temperature remained below the 103°F mark (39.4°C) The sauna session went from 41 minutes total to 56 minutes total to get the HSP benefit. CJC raises growth hormone which causes the body to retain more water and sodium. More water means more thermal mass which means core temperature rises slower. The body is harder to heat up. A second interesting data point. My max sauna heart rate dropped from 135 to 128 bpm while the core body temp remained the same. For a bodybuilder, this water retention helps performance and physique. For someone using sauna for HSP activation, it is a tradeoff. You bank more HSP time per session, but you pay for it with substantially longer sessions. I've stopped CJC-1295 DAC. The side effect burden outweighed the benefit. A 6 minute gain in HSP exposure is not worth 14 extra minutes in the sauna plus the unknowns of sustained GH elevation. It disrupted my REM sleep and caused clear blood sugar disruption with early insulin resistance signals (posting soon). In 2 weeks I will retest after washout. If time to threshold returns to 40 minutes, the GH mechanism is confirmed. If it stays elevated, what I observed was heat acclimation. Peptides are great, we just don't know much about them.
Aged Male Mice Stay Glucose Tolerant Despite Obesity
Aged Male Mice Remain Glucose Tolerant Despite Increased Energy Storage Efficiency Favoring Diet-Induced Obesity https://t.co/PzeRMKqvKw https://t.co/mUihjmGsSG
Brain IGF-1 Shields Male Mice From Age‑Related Decline
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice https://t.co/7U25aLdLFv
Nastent Nasal Insert Outperforms CPAP in Compliance
Your doctor will not tell you this. Most CPAP patients hate it and abandon it within months. Their oxygen crashes at night. Their mitochondria suffer. Their glymphatic system cannot clear amyloid beta. A clinical trial just completed on Nastent. It is...
Blocking IGF1 Senescence Reverses Hair Follicle Aging
Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging - Wang - 2025 - Aging Cell - Wiley Online Library https://t.co/LwbNFih66G
Hip Mobility Scores Predict Lifespan, Assess With Simple Moves
Hip mobility is essential for healthy and pain-free movement. And it might even predict how long you'll live. What does that look like? According to Dr. Kelly Starrett (@thereadystate), you should be able to squat with your hip crease below your knee,...
Eat 0.18‑0.25 G Protein per Pound per Meal
How much protein per meal should you eat for maximizing muscle protein synthesis, based on your body weight? .18-.25g/lb. More here: https://t.co/KqtDMSO4iI
Exercise Decline Accelerates Aging—New Review Offers Solutions
We now exercise five times less than we did 100 years ago. Our lifestyles are accelerating aging New review @Cell_Metabolism how to counter it https://t.co/rmb527oP0Y
FDA Approvals for Aging Therapies: Updated Insights
My 20min talk on FDA approvals of aging therapies & more coming soon from the Dec 2025 Longevity Summit at the Buck Institute is now on YouTube: https://t.co/L024jUz9iT It's an updated version of the one I gave at Vitalist Bay May'25. I'll be...
Time‑Restricted Eating Counteracts Hypoxia‑Induced Glucose Dysregulation
Time-restricted eating improves intermittent hypoxia-induced dysglycemia "In IH, TRE mitigates adverse hypoxic effects on glucose homeostasis, via improvements in pancreatic insulin secretion. Some beneficial glycemic effects of TRE are accentuated in IH. TRE may represent a novel therapeutic strategy in OSA" https://t.co/SQgSGnX6Ay
Moderate Training Boosts Brain Metabolism; HIIT Adds Benefits
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats "These findings suggest that MICT is the preferred regimen for enhancing cerebral metabolic function and neurovascular adaptation, while HIIT serves as a complementary strategy to involve other brain...
Sleep Deprivation Leads to Major Muscle Atrophy in Rodents
Lack of sleep directly produces substantial muscular atrophy in rodent models (although it is not always easy to disentangle the effects of stress and sleep loss in such cases). https://t.co/ah019I6zNw
Sweat Sodium Varies Beyond Salt Intake: Diet, Rate, Acclimation
Is the sodium in your sweat simply a reflection of how much salt you eat? This blog explores why sweat sodium concentrations vary between and within individuals, and how factors such as diet, sweat rate and heat acclimation influence losses....
Chemical Reprogramming Triggers Toxic Lipid Droplets In Vivo
https://t.co/F6dZ4lFcUZ problem is that most groups don't publish negative results here's a recent paper from @gladyshev_lab showing that chemical reprogramming (yes, different thank OSKM) causes lipid droplet formation and significant in vivo toxicity
Reading Books Adds Years to Your Life
Reading books can help you live longer. Here are 5 studies that show how: 1) Researchers followed 3,635 adults aged 50 and older over 12 years and examined how reading habits related to survival. They found that people who regularly read books...
Build a Body You Trust: Actionable Movement Strategies
I had so much fun sitting down with the incredible Dr. Kelly Starrett (@thereadystate) for the latest episode of the FoundMyFitness podcast. He frames fitness and movement in a way that really resonates and cuts through trends and metrics. The goal...
Multivitamins Show No Overall BP Benefit, Help Low‑Diet Individuals
Long-Term Effect of Multivitamin Supplementation on Incident Self-Reported Hypertension and Blood Pressure Changes in the COSMOS Trial "MVM supplementation versus placebo did not reduce hypertension incidence or lower BP overall. Exploratory analyses showed greater reduction in hypertension risk and BP changes...
Boost Focus by Harnessing Your Brain’s Beta Bursts
Maintaining Focus Using Brain Science Staying focused today has become a neurological challenge. In a world full of notifications, noise, and constant demands, maintaining focus can feel like an uphill battle. Yet focus means more than discipline or willpower. It is...
Build Aerobic Base Before Intensity for Long-Term Gains
Most athletes are in awful metabolic shape... And they don't know it. Then they skimp on the low zones because they're "time-crunched" and go straight to intensity. All that does? Reinforce the limiter. Want to really improve over long time horizons? Build the aerobic base...
Genetic Variant Determines Individual GLP‑1 Drug Response
As a medical school professor, I get asked why GLP-1 drugs work miracles for some and barely budge for others. A new Nature paper from 23andMe gives part of the answer: your genes. Researchers ran a genome-wide association study in 27,885...
ApoB, Not LDL, Predicts True Heart Attack Risk
Lie I was taught in medical school: your LDL cholesterol number is the gold standard for heart attack risk. Reality: a normal LDL with high ApoB is far more dangerous than a "high" LDL with low ApoB. ApoB counts the actual...
RAGE Gene Therapy Cuts Inflammation, Not Lifespan
It's a gene therapy that targets the RAGE pathway (Receptor for Advanced Glycation End-Products) that mediates inflammation and oxidative stress signaling. So far, the mice data doesn't show significant longevity benefits and mostly reduced inflammation and vascular stiffness and kidney damage. On...
Male‑dominant Dementia Risks Highlighted in 2024 Lancet Report
Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework Your dementia risk profile may differ by sex. Which risk factors matter most for you? 🤔👇👨⚕️ "The 2024 report identifies 14 modifiable risk factors for...
Astaxanthin's Lifespan Boost Hinges on Dose and Timing
Astaxanthin was tested for lifespan in mice. In 2023, it increased lifespan by ~12% in male mice But a new 2026 study found no effect. The big difference: dose and timing. Full video breakdown: https://t.co/6r7rqMc8jw https://t.co/Lm8ApCG64t
Sunlight: The Original Natural Nootropic Stack
UV exposure → vitamin D → dopamine & serotonin. The original nootropic stack was just... going outside.
Sunlight Boosts Heart Health Beyond Vitamin D
Sunlight: Time for a Rethink? 🤔 “Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as...
Creatine Boosts Complex Cognitive Tasks, Not Daily Alertness
Yes, creatine helps with sleep deprivation issues, but mainly for performance of complex central executive tasks - probably not gonna keep you “awake” during your normal rote daily activities: https://t.co/6XoKTvZXbu https://t.co/g4rbS3XiHh
Healthy Habits Boost Odds of Living Past 100
Healthy lifestyles and survival beyond age 100: Evidence from a national cohort of Chinese centenarians https://t.co/FsfcGUzlFV
New Toolkit Maps Human Ageing Hallmarks for Translation
🔬 Excited to share our new preprint on a translational toolkit for ageing research. We present a multi-modal approach to profile key hallmarks of human ageing, from immune function to mitochondrial activity and mTOR/autophagy. Our aim is to improve standardisation, reproducibility, biomarker...
Train to Live: Practical Mobility for Lifelong Performance
Dr. Kelly Starrett has a simple philosophy. We should train to live, not live to train. He's helped athletes, teams, and everyday people build bodies that can handle the real demands of life. In this episode, Kelly (@thereadystate) breaks down how to...
Blue Zones After 25 Years: Mixed Evidence on Longevity
What is the status of the Blue Zones 25 years after they were claimed? @ShelleyWood2 and I did an extensive look into this question, one of the forces behind the current longevity movement @statnews https://t.co/avrbAbgr90
Cultivate Agency and Healing Through Self‑Reflection Tools
The new Huberman Lab episode is out: Tools to Bolster Your Mental Health & Confidence | Dr. Paul Conti 0:00 Paul Conti 2:51 Self View; Tool: What's Going Right?; State Dependence 10:03 Sponsors: Helix Sleep & BetterHelp 12:44 Tool: Compassionate Curiosity; Falseness; Social Media 21:00...
Data Settles Diet Debate: Clinical Trials Reveal Best Patterns
🍽️ The Diet Debate, Settled by Data: What Clinical Trials Tell Us About Popular Eating Patterns 🔗https://t.co/Cs6ri3rFqL 🌐 #INPST #Longevity #Health https://t.co/HubIzIwEk0
Bigger VO2max, Not Tiny Lactate Tweaks, Drives Speed
Many athletes are focused on the little stuff - tweaking or shaping the lactate curve. A timely reminder that the vast majority of the difference in speed at *any* point on the curve comes from building a bigger engine - a...
ML Model Shows CPAP Cuts Heart Risk in Sleep Apnea
As a medical school professor, I've long argued sleep apnea is undertreated metabolic disease in disguise. A new Mount Sinai study in Nature Communications Medicine adds a wrinkle... https://www.youtube.com/@RobertLufkinMD https://www.mountsinai.org/about/newsroom/2026/mount-sinai-researchers-develop-machine-learning-model-to-predict-how-cpap-affects-cardiovascular-disease-risk-in-patients-with-obstructive-sleep-apnea SleepApnea #CPAP #MetabolicHealth #PrecisionMedicine #HealthLongevitySecrets
Higher Carb Intake Boosted Sub‑2‑Hour Marathon Success
Did higher carb intake win the day in the battle of the sub 2-hr marathons?
Evidence‑Backed Supplements Boost Cycling Performance
Supplements to improve cycling performance 🚴♂️💊 This new paper from the UCI Sports Nutrition Project outlined considerations and applications of sports foods and supplements to improve cycling performance 📝 Here are the primary supplements including their dose/form (🎯), timing (⏱️), half-life/washout...
Tech-Based Programs Boost Activity in Adults 55+
Interventions for promoting physical activity and reducing sedentary time among people aged 55 years and older: an overview of systematic reviews "Consistent evidence suggests that technology-based interventions are effective in increasing physical activity, step counts and MVPA, whereas inconsistent findings support...
Bathroom Vent Halves Bedroom CO2, Boosts Sleep Quality
🌡️ Update on the CO2 bedroom saga I tried this tip by @jesper_bee We have a bathroom in the bedroom with a vent (for removing humidity after showering), so I kept the door open and vent on Anyway it worked CO2 at...
Older Adults' Muscle Gains May Vary by Muscle Type
It is well-known that elderly people experience smaller gains in muscle size as a result of following the same strength training program as younger people. Whether this problem is universal or muscle-specific, however, is less clear. https://t.co/e1CMXYMDt0
Klotho Buffers Age‑Related Brain Atrophy Effects in Seniors
Serum Klotho Levels, Brain Structure, and Cognitive Performance "Results suggest that circulating serum klotho levels modified the known adverse association between age-related brain atrophy and cognition in older, but not younger, adults at risk for AD, suggesting that the neuroprotective effects...
Mitochondrial Dysfunction Drives Frailty; Biomarkers Needed for Precision Therapy
The mitochondrial side of frailty "Mitochondrial dysfunction lies at the intersection of musculoskeletal, metabolic, and immune changes underpinning frailty. While integrative biomarker panels have defined metabolic signatures, early diagnosis and personalized therapies remain unmet needs. Longitudinal studies are required to establish...
Phone Light Blocks Melatonin, Disrupts Sleep
If you're on your phone during the night, you're allowing blue wavelength light to influence your pineal gland in your brain. The impact is to prevent your own melatonin from rising. This can make it hard to sleep. Try to...
Sleep: The Ultimate Performance Boost Society Overlooks
Sleep is the most potent performance & health enhancement that we have, and once society is ready to see it— the medical estb. will follow. This doesn’t mean movement, nutrition, or light aren’t vital. Until it is understood, the 7...
Glucagon Signaling Required for Caloric Restriction Benefits
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice https://t.co/xZYiHWkw5s @GeroScienceAGE https://t.co/WcZgdHgsG2
Higher‑intensity Aerobic Exercise Cuts Loneliness in Older Adults
Effects of aerobic exercise of different intensities on the social, emotional, and financial functioning of healthy older adults: results from a 16-week exercise randomized control trial https://t.co/SePImekLGY Interaction plot depicting change across time in loneliness by condition:
Three Key Nutrients for Brain Longevity, Plus Polyphenols
As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.
Mitochondrial Health Drives Egg Quality and Fertility
The largest cell in your body is your egg. It is one of the only cells you can see with the naked eye. It also contains more mitochondria than any other cell in your body. Hundreds of thousands per egg compared...
Small Daily Habits Compound Into Lifelong Longevity
As a scientist studying aging, I can’t stress this enough: You don’t need to optimise everything. What really moves the needle is the compounding effect of small habits repeated over years. The 20-minute daily walks. The nutrient-dense, fibre-rich breakfast bowl...
App Boosts HRV 30% and Lowers Resting Heart Rate
So this really worked for me. Use the https://t.co/XdKb719aG9 app HRV up by 30% on average Resting heart rate down