Five Hidden Lab Numbers Reveal Your True Health
Your labs are "normal." But you haven't felt normal in years. There are 5 numbers your doctor probably isn't checking — and they tell a very different story. Free live webinar: May 5, 5 PM PT → 30dayhealth.co/webinar
Pain Signals Bad Choices; Discomfort Signals Growth
Pain and discomfort are not the same. Pain is what your bad choices are doing to you. Discomfort is what change feels like on the way out.
Sugar: Not All Bad—Boosts Performance When Used Strategically
Sugar is often labelled as “bad” for health, but it’s also promoted as beneficial for athletes during exercise. This blog examines the evidence to answer the key question: is sugar actually harmful or helpful for athletic performance? https://t.co/eyhnVny8Am https://t.co/Ogq9bDJbXg
Sinclair Explains GLP‑1’s Role in Longevity Protocols
David Sinclair just did a 25-minute live Q&A on aging, longevity and AI. Here are the top 9 questions the audience asked him and his answers to each one: 1) How can GLP-1 drugs be used in longevity protocols? https://t.co/q5V2fyfFnq
Glial Senescence Drives Neuroinflammation and Brain Degeneration
Disentangling causality in brain aging: The complex interplay between glial senescence, neuroinflammation, and neurodegeneration https://t.co/kiLXyxFUL0 https://t.co/XmyARd1bst
Depression Reduces Chances of Exceptional Longevity in Older Women
Prospective association of depression symptoms with exceptional longevity among older women "...Depression symptoms associated with lower odds of healthy longevity..." https://t.co/RnVcQs7XG4
One Hour Screen‑free Before Bed Restores Sanity
For real, turn screens off 60 min before bed. I know it feels like death at first. Do it for a few days, and you’ll realize that it was slowly chipping away your sanity.
Epigenetic Reprogramming Enters Human Trials for Vision
Aging biotech has made TIME's "New Frontiers" list. @lifebiosciences is using Yamanaka factors, and the FDA just cleared their first-in-human trial for optic neuropathies. Partial epigenetic reprogramming is no longer theoretical. It's in human trials. https://t.co/ZtVT5PxbHZ https://t.co/OhqLtNfqGT
Low Leukocyte mtDNA and High Inflammation Predict Elderly
Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults https://t.co/AeqAZIv3er
5‑MeO‑DMT Cuts Measurable Brain Noise for Weeks
I measured my brain when taking 5-MeO-DMT. Interestingly, pre-dose my brain noise spiked 7.6%. Must have known what was coming lol. Then it dropped 10.9% and stayed down for weeks. Brain noise (anxiety, rumination, stress) is measurable and reducible. The reduction was an...
Daily Brain Boost: Exercise, Hydration, Sleep, Supplements
3 things I’ve started to do for my brain health daily: Trying to incorporate more walking (and working out) Drinking enough water Less alcohol Sleep Creatine Lion’s Mane Methyl B-12
Blood Factors Drive Aging or Rejuvenation; Therapies Emerging
Aging is increasingly understood as a system-wide process shaped by factors in the blood, which can actively drive either decline or rejuvenation rather than just reflect it. Emerging therapies that modify the circulatory environment show promise in reversing aspects of...
NMN Curbs Antibody Attacks, Eases Bleeding Disorder
NEW CLINICAL TRIAL RESULT: NMN suppresses harmful antibody-driven immune attacks to alleviate a common bleeding disorder. Authors suggest it may help other autoimmune diseases like lupus and rheumatoid arthritis 🙏🧵 https://t.co/eMvefTFxZo
Natural Supplements Boost Stress Resilience When Used Wisely
Stress is part of life, but how we respond to it matters. In my practice, I often recommend starting with simple, natural supports. Adaptogens like ashwagandha can help the body build resilience. Magnesium plays a role in relaxation and sleep. L-theanine,...
Fever‑level Sauna Spikes Heat‑shock Proteins, May Boost Longevity
3x this week I sat in 200°F (93°C) dry sauna for 55 min to get my core body temp to 102.4°F (39°C) That temp, at that duration, triggers primal panic. Took blood samples before and after each session to measure heat shock protein...
Morning Coffee Shown to Protect Brain Health
Your morning coffee is protecting your brain. JAMA just confirmed it with 131,821 people and 43 years of data...
Melatonin Shields Mitochondria From Radiation Damage
Melatonin as a radioprotectant against mitochondrial damage 🤔"Melatonin can protect against irradiation-induced mitochondrial damage, suggesting utility for mitigating the health effects of accidental radiation exposure." https://t.co/XHZYDE916a
It's Never Too Late to Transform Your Health
If you’re in your 50s or 60s and feel like it’s too late to start prioritising your health, take it from a bioscientist who studies aging: it’s not. Start the resistance training. Fix up your diet. Limit the harmful habits....
US Phone Radiation Limits Stuck in 1996 Era
The safety limits on cell phone radiation in the US haven't been updated since 1996. That was before smartphones, before 5G, before kids carried glowing rectangles in their pockets all day. The standard was set assuming a 6-foot-tall man holding the...
AI Links Healthy Thymus to Longer Lifespan
As a medical school professor, I've taught that the thymus shrinks and fades after puberty. A new Nature paper says we should start watching it again. Researchers applied deep learning to routine chest CTs across 25,031 participants in the National Lung...
SIRT1 Emerges as Exercise‑driven Exerkine Boosting Longevity
Sirtuin 1 as an emerging exerkine in the aging process: unveiling its multifaceted biological roles "Taken together, these observations support the notion that SIRT1 functions as a potential exerkine, and understanding its role in exercise-induced adaptations offers new insights into non-pharmacological...
Boosting NAD+ May Restore Sleep in Dementia
NAD+‒circadian rhythm coupling in dementia "Pharmacological and lifestyle-based strategies targeting NAD+ restoration are outlined as potential approaches to improve sleep and circadian rhythm integrity..." https://t.co/qQXLHS8nou https://t.co/te8QGUftC4
AGEs Trigger SIRT1 Loss, Accelerating Osteoarthritis via RANKL
SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL-Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development "Targeting this mechanism may offer new therapeutic opportunities for delaying age-related OA progression." https://t.co/HB2nmyZ43u
Lifestyle Signals Misaligned: 90% of Heart Disease Preventable
Cardiovascular disease is the leading cause of death globally. Yet up to 90% of cases are linked to lifestyle-related risk factors we can influence. As a longevity scientist, this points to a simple information problem: the daily signals we give our...
Train With Age, Not Against It
Midlife and Master's Athlete Training: The Biological Realities We Face For the better part of 15 years, I have been training in the gym, running, cycling, climbing, and more. But the biology of aging and the physiological changes that come with...
Microplastics Threaten Longevity: One Health Perspective
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity https://t.co/CAs0yrtcQy https://t.co/rzXoOMwI40
Start Strength Training in Your 30s to Preserve Muscle Quality
Muscle loss can begin as early as your 30s, with measurable declines in muscle mass and function occurring well before old age. The study also found that women may lose strength and fitness faster than muscle mass itself, highlighting the...
Energy Balance Isn't Simple: CICO Overlooks Metabolic Variability
Energy Uptake In Athletes Decades ago, Andrew Coggan berated me for making a point that energy eaten via sugar wasn't the same as energy eaten via real food. CICO makes sense, but we are not a closed system. ✅There are heat and...
Nattokinase Lacks Evidence; Choose Omega‑3 or Berberine
Nattokinase isn’t high on my list for cardiovascular prevention. I don’t see convincing evidence that it should be a primary strategy for cardiovascular disease or stroke risk reduction. If the goal is cardiovascular prevention, there are options with much stronger support. Omega-3...
HDL Inflammatory Markers Predict Mortality in Elderly
High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANES data https://t.co/WdNtpIgGpI https://t.co/cM0LeTv7io
Protein Powers Recovery, Adaptation, and Performance, Not Just Hypertrophy
Protein is often framed around hypertrophy, but its role is broader. Explore evidence based advice on protein use for recovery, adaptation, and performance in this 2H masterclass with Dr Oliver Witard. https://t.co/X2jF4hM5UH https://t.co/a9kpTqLyQH
CNS Gene Therapies Showcase Tau-Targeted VY170
CNS Gene Therapies Featured in Multiple Presentations at ASGCT 2026, Including Late Breaker on Tau-Targeted VY1706 for Alzheimer’s Disease https://t.co/oQ5MCd5piS https://t.co/8KeWSTJ1q7
Intensity Is Fine; Insufficient Recovery Is the Problem
Intensity remains highly trainable... But the dose matters. Intensity isn’t the enemy. Frequency without adequate recovery is. https://t.co/drZfgaCvpJ
L-Glutamine May Cut Sugar Cravings, Boost Gut Health
In addition to some evidence that it can improve gut health, supplementing with L glutamine may reduce sugar cravings. Need more data but anecdotally, it works. Specifics in this short 30 minute episode of Huberman Lab essentials.
Your Egg's Final Months, Not Years, Determine Quality
A 34 year old woman is ovulating a 34 year old egg. That egg has been sitting in her ovaries since before she was born. She started with 6 to 7 million of them. By birth, she had 1 to...
One Year Training Cuts HR 25 Beats, Boosts Efficiency
A very interesting question that we did a deep data dive on the #MADcrew forum about... https://t.co/GjhhFK2p7c Average improvement in E.F. across the entire group over 1 year was 0.21. At typical training paces (and, of course, assuming volume builds), this would be...
Maternal Polyphenols Boost Fetal Brain Development in Rodents
New review: The effect of the mother's consumption of polyphenols (resveratrol, curcumin, quercetin, naringin, ferulic acid, genistein) on fetal neurodevelopment in rodents & improvements in brain development 🧠🧠🧠 https://t.co/xN2GISamzy https://t.co/bVFiIjoZem
Warm‑ups Activate Your Nervous System, Not Just Muscles
How and why I warm up : Most people think of a warm-up as something you do to “get loose.” That’s not really the point. The real goal is to wake up the systems that control movement, coordination, and energy delivery...
Aging Science Promising Yet Still Lacks Core Understanding
Aging biology is full of promise, but the reality is that it's still a nascent field. Great to be back at the @MPIAGE speaking with students and researchers about some uncomfortable truths in geroscience: We still don't understand the drivers of aging. And...
Animal Protein Edge Limited to Older Adults, Leucine Key
Our recently published meta-analysis found that animal-based proteins confer a modest advantage in stimulating muscle protein synthesis (MPS) compared to plant-based proteins (PMID: 42055214). At first glance, this might suggest a benefit to prioritizing animal protein for muscle building. However, the...
Decoding Ovarian Aging to Extend Reproductive Lifespan
Ovarian aging: Mechanisms and strategies to extend reproductive lifespan Core mechanisms include genomic instability, epigenetic noise, mitochondria, inflammation, senescence & fibrosis PhD student Maria Lopez @sinclarfriends is working on it https://t.co/tuJbQb2Xcu https://t.co/K1GlXY4KsY
Semaglutide Cuts Heavy Drinking and Cravings in AUD
GLP-1 Drug Semaglutide (Ozempic, Wegovy) Reduced Heavy Drinking & Craving in Adults with Alcohol Use Disorder https://t.co/FYRkjWYhJQ https://t.co/cGtEajk9lp
Calorie Restriction Deactivates Complement C3a, Slowing Inflammaging
"complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging" Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging https://t.co/FxGHE6Obm0
Unified Redox Strategy Prevents Multiple Diseases Simultaneously
The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity https://t.co/TaDq4wbrH7 https://t.co/P8QYDgcmiH
Organelles Drive Aging: Metabolic Engines and Signaling Hubs
Cellular organelles play a central role in aging by acting as both metabolic engines and signaling hubs that coordinate processes within and between cells. Their dynamic interactions influence lifespan, health, and even inheritance, making them key targets for interventions aimed...
Mitochondria Shape Immune Landscape: Clinical Insights
Mitochondria orchestrated immune microenvironment and response in health and disease-clinically relevant outlook and recommendations https://t.co/bI64EK9zdf https://t.co/0UV2mkcRiP
Follow Basic Guidelines, Not Complex Solutions, to Prevent Pitching Injuries
With pitching injuries, many people like to chase complex physics/sports medicine solutions. Instead, they should start with rigorous adherence to basic protective guidelines. >100 IP/yr = 350% increase in risk of youth arm injury. Anyone who can count can prevent...
Age Can't Be Stopped, But Slowing Down Can Be
Getting older is not optional. But getting slower is. Power declines faster than strength with age. The fast-twitch fibers go first and athleticism follows. Most people accept it as inevitable and stop training the one thing that could slow it down....
Punch Power Is Learned, Not Born: Master Biomechanics
This article will teach you how to make your punches hard, faster, and more powerful, along with giving you exercises that aren’t commonly taught to fighters to increase their punching ability. I have never believed in the old boxing adage that...
Irisin Hormone Reverses Obesity and Insulin Resistance
Irisin, a hormone released by muscle during exercise, reverses obesity and insulin resistance in mice -- without cutting food intake or causing muscle loss. As a medical school professor, I find this striking. We have spent a decade asking how to...