Systems Thinking Unlocks Leverage to Slow Aging
The breakthrough in longevity science is systems thinking. When we map how aging actually works, we gain leverage to slow it down. https://t.co/hheOmHsWX7
Time‑restricted Eating Cuts Glucose, Insulin Resistance, HbA1c
Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis "Compared with a CON, TRE resulted in a larger reduction in fasting glucose... insulin resistance... HbA1c..." https://t.co/Jq9EpoAy3u
Peptides Are Potent Therapeutics, yet only a Few Qualify.
“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia 👨🏻⚕️
Same DEXA Score, Different Fracture Risks Explained
Your DEXA scan gives you a number, your doctor gives you a category, but the conversation often ends there... there's so much more nuance. Two people with the exact same T-score can have completely different fracture risk, and DEXA...
Caffeine Boosts Performance, Disrupts Sleep—Timing Is Key
Caffeine can enhance performance and impair sleep. Learn how dose and timing matter in sport. Sign up: https://t.co/0PJC4DLDwV https://t.co/PHd1LGS0UD
Keep Moving: Rest Worsens Knee Osteoarthritis
Knee Osteoarthritis... Thread #2 ! Your knee hurts. Your instinct is to rest it. Please don't. That instinct is very often wrong — and following it makes osteoarthritis worse, not better. Movement is one of the best evidence-based primary treatments for...
Morning Hormone Peaks, Evening Temperature Rise: Body Clock Overview
The human body has a circadian rhythm with fluctuations in hormones, body temperature, and blood pressure Here's a graph for the most important diurnal rhythms in the human body: - cortisol rises in the morning and peaks around 9 AM - testosterone also...
Creatine Plus Resistance Training Boosts Healthy Aging
Is there a role for creatine in healthy ageing? This blog reviews the evidence on creatine supplementation, especially when combined with resistance training, as a strategy to promote healthy ageing. Click here: https://t.co/3sLdyAxgJL https://t.co/ZbTLlZxubR
Cold Exposure Boosts Pain Tolerance and Flexibility
Cold application is used in research to create a temporary increase in pain tolerance. Interestingly, applying cold water to an upper body limb causes an immediate increase in lower body flexibility. This shows how stretch tolerance is close in nature...
EKF Acquires Real‑Time Glucose Tracker, P/E Declines
#EKF buying "Real-time glucose and lactate tracking for sports performance monitoring" from Beep Insights AB. ShareScope has fwd p/e 15.1 falling to 13.4 but no Dividend. Worth investigating. I don't hold.
Vitamin D Overdose Cases Surge, Kids at Risk
Taking Too Much Vitamin D Can Backfire, Scientists Warn “From 2000 to 2014, there were more than 25,000 cases of vitamin D toxicity reported in the US. From 2005 to 2011, these cases increased by 1600 percent, and many involved children...
Repairing Aging Blood‑Brain Barrier to Halt CNS Disease
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders "We discuss interventions focused on barrier repair and immune recalibration, including the reinforcement of tight junctions, restoration of pericyte homeostasis, and modulation of...
Pets May Shield Against Cognitive Decline, Review Finds
The protective role of companion animal ownership in cognitive aging: current status of the literature https://t.co/TKXjlA0FTR https://t.co/kmWE6BHeQm
Discrepancy in Mouse Counts Raises Partial Reprogramming Concerns
okay, tell me why you think browder et al had 21 mice in -dox and only 15 mice in the +dox group when they did partial reprogramming? https://t.co/gedJiKSRKo 6 more mice in the dox group got tummy aches and asked out of...
OSK Reprogramming Triggers Tumors, Undermining Mouse Study Confidence
OSK reprogramming also produces tumors see https://t.co/dNhcHVSBf3 cancer is a selective process clones grow out because they have a proliferative advantage or apoptotic disadvantage when mouse papers say no cancer despite the fact that half of lab mice die from cancer, i don't feel...
Appendix Presence Linked to Longer Lifespans Across Mammals
The cecal appendix is correlated with greater maximal longevity in mammals “We found, through analyses of data on 258 mammalian species, that cecal appendix presence is correlated with increased maximal observed longevity… . In addition, we show that the cecal appendix...
Singaporeans Increasingly Aware of Healthspan and Longevity Medicine
Knowledge of lifespan and healthspan and interest in Healthy Longevity Medicine among the general population in Singapore: the Singapore HEalthy LOngevity (HELO) survey https://t.co/urqgBWfzIW https://t.co/y6skIWdASG
Aging Opens Chromatin, Altering Cell Behavior
The researchers then looked into the changes in the old cells that might explain such pronounced differences in behavior compared with the young cells. Liao Says "It seems as though chromatin opens up with age, so to speak." https://t.co/1kdRDunTea
Give Your Body What It Needs, Period Returns Naturally
Things I did to get my period back after 16 years: - Gained 25 pounds on purpose - Stopped running - Ate 2,500+ calories a day - Added carbs back - 7-8 hours of sleep - Reduced my exercise intensity (temporarily) - Stopped fasting - Worked on...
Higher Albumin Levels Linked to Longer Lifespan
High albumin is associated with longevity Association between age and malnutrition in oldest-old and centenarian populations https://t.co/0denO96lEh
Healthy Diet Cuts Mortality Risk Among Chinese Elderly
Association between Dietary Patterns and All-Cause Mortality in the Chinese Old: Analysis of the Chinese Longitudinal Healthy Longevity Survey Cohort https://t.co/4FoNf4WnRt #mdpinutrients
Garlic Intake Linked to Lower Mortality in Chinese Elders
Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study https://t.co/Oda8CifdOX #mdpinutrients
IPSC Therapies Succeed; In‑vivo Reprogramming Remains Hype
your regular reminder that Yamanaka factor-driven production of iPSCs is already producing real medicine (eg dopaminergic neural progenitor for Parkinson's, cardiomyocyte sheets for heart failure & more) iPSC tech is not done in vivo... ppl isolate the well behaved cells away...
Daily Evoked Gamma Therapy Shows Safety and Cognitive Benefit
Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease 👉 “Our results demonstrate that 1-h daily treatment with [CogTx-001] was safe and well-tolerated and demonstrated potential clinical benefits in mild to moderate AD.” 🔘 Participants underwent...
Deep Focus Restores Mood and Sharpens Cognition
12 hrs of focused work yesterday. Surprised by the level of cognitive and mood lift. Context switching 300x/day creates a noise floor of attention reside and chronic nervous system arousal. Microdosing cortisol. Extended focus resensitizes, making the world interesting again
Drugs May Slow, but Not Fully Reverse Aging
Just like we can't turn a human into a naked mole rat with drugs (requires too many specific molecular changes), I don't think we will fully reverse ageing pharmacologically. We may be able to slow human ageing with drugs, but reversing...
Total Protein, Not Timing, Drives Muscle Growth
Some 20+ years ago, when I was studying exercise science, nutrient timing was viewed as a cornerstone of muscle growth. We were taught about the so-called “anabolic window,” which suggested that protein needed to be consumed within ~45 minutes after...
Prioritize the Fitness Type You Need Most
Aerobic fitness & Metabolic fitness are two separate things. If you are a time-limited athlete, prioritize that precious time according to what you need the most.
Why Standard Health Tips Miss Neurodivergent Realities
I'm a neurodivergent health researcher. Here are 12 health tips that are correct in theory but often fail in real life (especially for NDs): (and what actually works better)
Vitamin C May Halt Aging for Just Cents Daily
Vitamin C for Anti-Aging? New 2026 Science (Human and Monkey) 1/2) Could you really slow aging for as little as 6.2 cents per day? Based on new human and primate data published in Cell Metabolism, it might actually be possible. TL;DR: Vitamin...
Rebalancing Autonomic Nervous System May Slow Aging
“We propose that, at the core of aging, there is an imbalance between the SNS and PNS, which provides opportunities for therapeutic intervention.” How? Read more below👇 👨🏻⚕️ 🔎 “Hand-held, non-invasive wellness devices are being deployed in the U.S. military to enhance...
Aging Shares Disease Hallmarks, May Be Treatable
Is aging a disease? These authors reflect: “Disease is commonly defined as an abnormality of bodily structure or function, distinct from direct physical injury (Bulterijs et al., 2015). Whether ageing itself constitutes a disease has long been debated in the fields of...
Heat + Altitude Training Boosts Hemoglobin Mass in Athletes
Heat training augments haemoglobin mass during altitude camp in endurance athletes 🌡️⛰️ This new study recruited 45 cross-country skiers and biathletes (VO2max ~69.1) to one of three 3-week interventions… 1️⃣ Train and reside at moderate altitude with three weekly heat-suit cycling sessions 2️⃣...
Sleep, Sprint, Mediterranean Diet Top Health Priorities
Health habits tierlist: - Sleep 7-8h: 10/10 - Sprinting: 9.5/10 - Mediterranean or Japanese diet: 9/10 - Sauna: 8.5/10 - Education: 8/10 - Consistent daily rhythms: 7.5/10 - Coffee and teas: 7/10 - Supplements: 5/10 - Walking <8k steps: 3/10 - Drinks 1-2/day: 2/10 - Snus: 1/10
Aerobic System Dominates Events over 78.6 Seconds
If your event lasts longer than 78.6 seconds, your Aerobic Energy system is the dominant contributor. #BuildThatBase
Therapeutic Phlebotomy Restores Bone Marrow, Reverses Aging
Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function “our work provides preliminary evidence suggesting that periodic therapeutic phlebotomy exerts anti-aging effects by restoring bone marrow function and mitigating aging phenotypes, subsequently driving peripheral blood functional restoration.” 👉 “...
Safe Cell Reprogramming Restores Identity, Nature Reports
You're confused. Let me explain: My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed We tried innumerable combos to find the solution Story is @Nature...
The 1:10 Protein Rule Sticks in Your Mind
POV: you learned the 1:10 protein rule and now you can’t unsee it Follow @trizzlemanfitness for more
NMN Reverses Ovarian Aging in Mice, Human Trials Needed
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓 https://t.co/oVeGUZSaQ0
Basic Sleep, Exercise, Nutrition Trump Extreme Longevity Hacks
After almost a decade studying the biology of aging, I hate to break it to you: Consistency with the basics — sleep, movement, and nutrition — outperforms most extreme protocols when it comes to longevity.
Four Essential Weekly Movements for Longevity
As a bioscientist studying aging, these are 4 types of movement I try to include each week: 👉 Walking 👉 Strength training 👉 Higher-intensity cardio 👉 Mobility work
Seeking Experiences with GTWY Peptide From Β‑Lactolin
New smart drug peptide alert… (Possibly): who has experience with GTWY peptide isolated from β-lactolin? Research here: https://t.co/Sg7twStXvr
High‑carb, Low‑fat Diets Boost Triglycerides and Fatty‑acid Synthesis
Effect of high-carbohydrate feeding on triglyceride and saturated fatty acid synthesis "The results of a series of studies in lean and obese weight-stable volunteers showed that very-low-fat (10%), high-carbohydrate diets enriched in simple sugars increased the fraction of newly synthesized fatty...
Cut Inflammatory Foods, Add Creatine for Joint Health
Superfoods could be fueling your arthritis. When you remove inflammatory foods and upgrade your supplements and protocols, you can support collagen synthesis to lower your risk. I recommend creatine from Qualia. It is doctor-formulated, helps promote strength, build lean muscle,...
Potatoes Omitted From Healthy Plate Due to Sugar Risks
"The School’s Healthy Eating Plate does not include potatoes in its vegetable recommendations given their negative impact on blood sugar. Researchers at the School and elsewhere have found that diets high in potatoes and similarly rapidly digested, high-carbohydrate foods can...
The Cholesterol Myth: How Doctors Misled Heart Health
Cholesterol and heart disease- how we got to the crazy place we are today with unhealthy recommendations by doctors and the AHA: https://mindandmatter.substack.com/p/the-cholesterol-cult-and-heart-mafia https://x.com/trikomes
Erythritol Not Proven Cardiovascular Threat, Evidence Shows
The totality of evidence does not support the conclusion that dietary erythritol drives cardiovascular harm. The paper referenced claims erythritol “adversely affects brain microvascular endothelial cell function,” but it’s an in VITRO study bathing isolated cells in erythritol for 3...
One Year of Training at 63 Reveals Surprising Aging Insights
Interesting post today. I’ve written about how and why I trained at 62. Now I’m turning 63 and I always look back… But this post is different. It isn’t a rehash of the same program with a new number...
Epigenetic Clock Detects Aging and Cancer via Blood Test
This is the future: An epigenetic clock for the simultaneous assessment of biological aging and cancer from a simple, cheap blood test 👏 https://t.co/uzGoZWos9C
Your N=1 Outweighs Any Randomized Controlled Trial
Your N = 1 is more relevant to you than any RCT will ever be.