HIIT Boosts Brain Health in Heart Disease Patients
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients “the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more optimal stimulus for improving cognitive aging in this population. physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more optimal stimulus for improving cognitive aging in this population. https://t.co/m4tE3wxXRp
Low Post‑Surgery Klotho Predicts Inflammation and Cognitive Decline
Lower levels of the anti-aging protein Klotho after surgery were strongly linked to higher inflammation and worse cognitive function in patients with postoperative cognitive dysfunction (POCD). This suggests Klotho could be a useful early biomarker—and possibly a treatment target—for predicting...
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Prevention Beats Treatment: NYC Smoking Ban Saves Lives
"How can medicine save the most lives?" Most people ask this rhetorically. @Farzad_MD and Tom Frieden took it literally. From banning smoking in NYC bars to cutting teen smoking in half in 5 years, this is what happens when you stop treating diseases...
Shared Pathways Link Gut Aging and IBD; Target Early
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging "this article highlights both the shared and distinct pathways driving gut dysfunction in aging and IBD, and underscores the importance of early recognition and targeted...
ACC Endorses Universal CRP Screening for Heart Risk
I've been waiting for this for a long time... The American College of Cardiology now recommends universal screening for a marker I've been writing about since 2011 - and most doctors still don't order it. The American College of Cardiology now highlights inflammation...
Pinealon Boosts Sleep, HRV, and Lowers Resting Heart Rate
Pinealon has been an awesome peptide for sleep: +1 hr sleep + HRV (up to 105-110) - RHR (down to 40-43) Thanks to @AbudBakri for these. https://t.co/YcwfPO9ebD
Injury Prevention Is Simply Optimized Performance Through Discipline
“Injury prevention is performance optimization in disguise.” These 7 words delivered Friday by Dan Fichter was a revelation; an epiphany of why a Feed the Cats approach creates HEALTHY athletes… seemingly bulletproof. When we get fit by repeating low-dose, performance-level work...
Skipping After‑Dinner Snacks May Drive Early TRF Benefits
From 2.6M time-stamped diet records, we identified 5 clusters of commonly consumed items: Breakfast | All-day | Lunch | Dinner | After-dinner After-dinner: popcorn, beer, wine, ice cream. So when people stop eating early, they also (inadvertently) cut out this cluster—potentially explaining some...
Carbs Aren’t One Tank: Muscle Glycogen Drives Performance
Let me dump some carbs on you... Someone said yesterday that thinking about CHO intake in terms of stores, output and "bonking" is the "old way" of looking at carbs in sport. That pissed me off. So, let's start with... Only those with...
Sodium Fuels Glucose Uptake, but Excess Clogs Absorption
Yes, it is a confounding factor, but a necessary one. To get carbs from the gut across the intestinal wall requires the SGLT1 transporter... Sodium-Glucose-Linked-Transporter Sodium is the driver, glucose is a passenger. So, you do need ample sodium to get high levels...
Cold Plunge Activates Vagus Nerve, Cuts Inflammation
Are you a cold plunge person — or does the idea make you want to close the app? For the full 10percenthappier podcast episode with Dr. Kevin J. Tracey — neurosurgeon, president and CEO of the Feinstein Institutes for Medical Research,...
Heart‑Metabolic Risks Accelerate Cognitive Decline in Indian Seniors
Cardiometabolic-Inflammatory Risk Factors and Cognitive Decline Among Older Indians—Report From a Nationally Representative, Longitudinal Study 'Longitudinal data provided by LASI-DAD study shed light on how cardiometabolic risk factors may influence decline of cognitive function and development of dementia in older adults...
AI Accelerates Longevity Science at London Tech Show
AI is reshaping longevity science faster than ever. At the Health + AI Insiders Tech Show, I'll be discussing how computational biology is transforming our understanding of ageing. 📍 London | 29 April 2026 🔗 Complimentary tickets: https://t.co/4XipXYfWcc
Static Stretching Boosts Flexibility and Pain Tolerance Alike
Long-term static stretching produces improvements in flexibility (by increasing stretch tolerance) but also increases pain tolerance more generally (as measured by pressure-pain thresholds). This shows that stretch tolerance and pain tolerance are very similar in nature. https://t.co/XEAOVCPQWi
Post‑marathon Reflections: Shoes, Fuel, and Doping Insights
I have some morning-after thoughts on that 1:59:30 performance and the marathon generally, ranging from shoes to doping via fuel, so let's see how it goes. And we'll explore them (and your thoughts) in the next podcast. So here goes......
Swedish Clinic Finds Limited Eligibility for New Alzheimer Drugs
Preparing for the implementation of anti-amyloid therapies in Europe: Assessing real-world eligibility for lecanemab and donanemab in a Swedish memory clinic https://t.co/H3TgYvgVSk
Uridine Boosts Synapse Formation in Aging Brains
Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses https://t.co/bOoaNebYmn
Air Pollution Fuels Sarcopenic Obesity via Inflammation
Air pollution and muscle-fat imbalance: How PM2.5 components and ozone drive sarcopenic obesity through inflammation "This study provides novel insights into environmental triggers of SO, highlighting the need for integrated air quality policies targeting specific PM2.5 components and personalized prevention strategies...
Both Poor and Great Sleep Scores Skew Performance—Prioritize Quality Rest
Yes a poor sleep score can bias your performance as can a great one (discussed in detail w/@AliaCrum @Stanford expert on science of belief & mindsets on the HLP (link below) but there are obvious limits on this. Tracked or...
Ageing Is a Multilevel Network; Target Central Hubs
Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions 👉 “Because molecular, cellular, tissue and organismal levels retain partial autonomy, human ageing can be viewed as a multilevel phenomenon. 🔬Geroscience may therefore advance by mapping this network...
Epigenetic Clocks Predict Lung Cancer Risk Beyond Self‑reports
New paper: Epigenetic age clocks help predict lung cancer risk & mortality by estimating smoke exposure. Is independent of self-reported smoking history, so people probably lie about it. Clocks could help doctors predict lung cancer risk & decide on...
Six Hours of Sleep Equals 48 Hours Awake
Use your illusion well. While mindset and optimism are fantastic, the truth is always hidden in physiology for some reason… The problem w/ poor sleep habits is while you can convince yourself <6hrs is fine the reality is you perform like...
Raw Peptides Degrade Instantly, Never Achieve Effect
Hi @MartinShkreli - if as you say at https://t.co/qJh2vgV0Wm that "raw peptides have a half-life measured in seconds or minutes, meaning your body destroys them almost instantly after you inject them. They never get a chance to do anything."...
MIB‑626 NMN Shows Lifespan Boost and New Mechanism
1. No living forever 🙈 2. Some MIB-626 (crystaline polymorph, pure NMN) human clinical trial results are in 😀 3. About to resubmit a revised mouse MIB-626 paper with Alice Kane, showing improved health measures + lifespan & a putative new mechanism...
Oral Health May Influence Alzheimer’s Risk—Floss Daily
Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s. Either way, to reduce overall inflammation, maintain oral heath by: 1. Flossing daily 2. Using an electric toothbrush 3. Seeing a dentist >2x a year 4. Chewing oral probiotics 🦷🧠💪
Allulose and Tagatose Lower Post‑Meal Blood Sugar
Glycemic and Cardiometabolic Effects of Rare Sugars Allulose and Tagatose: A Systematic Review and Meta-Analysis of Controlled Human Intervention Trials 👉"Supplementation of allulose or tagatose attenuates postprandial glycemic and insulin responses..." https://t.co/nqQTlk20m4 https://t.co/jRzp9Hrssy
Track and Treat Silent Blood Pressure for Lifelong Health
High blood pressure is one of the quietest threats in medicine. You can feel completely fine while it silently damages the heart, brain, blood vessels and kidneys for years. The good news: it’s measurable, trackable, and highly modifiable. Check it...
Ergothioneine Ties Blood Metabolome To
Ergothioneine. The blood metabolome of cognitive function and brain health in middle-aged adults – influences of genes, gut microbiome, and exposome https://t.co/H8tWyRhswR
Heat Therapy Mimics Exercise Through Shear Stress and Genes
Best review yet: We have identified plausible ways heat therapy works, such as shear stress and heat-sensitive genes “We find heat therapy to be analogous to exercise in many respects” 💪 https://t.co/RAFMTK8j3S https://t.co/iTVyZZuFZc
Midlife Fitness Proven to Boost Longevity and Health Span
A new JACC study from the Cooper Institute (April 22, 2026) followed nearly 25,000 adults for 30 years. As a medical school professor, I teach that the strongest longevity drug we have is not on a prescription pad. This study makes...
Nasal Microbiome Imbalance Fuels Neuroinflammation and Brain Disease
Nose-to-brain axis: mechanistic links between nasal microbiome dysbiosis, neuroinflammation, and brain disorders "Nasal dysbiosis promotes neuroinflammation and blood–brain barrier disruption... Microbial imbalance is linked to Alzheimer’s, Parkinson’s, MS, and psychiatric disorders." https://t.co/3OHivYYz2E
BMI Alone Misses Long‑term Heart Risk, Study Shows
A new Mass General Brigham study of 136,498 adults rewrites how we should screen cardiovascular risk. As a medical school professor, I teach that one lab number rarely tells the long-term story. This study (PLOS One, April 2026) shows the same...
Nesprin‑2 Protein Blocks Heart Cancer, May Aid Other Tumors
Wondered why we don’t hear about heart cancer? Contraction-sensing Nesprin-2 protein is discovered to prevent heart cancer By causing cells to pulse (or adding in Nespirin) we might be able to treat cancer in other organs 👏 @ScienceMagazine https://t.co/A8fOuw31N2
High LDL Remains Dangerous, Even for Lean Responders
There is no safe gamble with high LDL cholesterol The pitfalls of the lipid energy model and why “lean mass hyper-responders” should still take high LDL cholesterol seriously. https://t.co/lbRnOfe2py
UCI Sports Nutrition Project Delivers 10 Reviews, 4 Consensus Statements
The UCI Sports Nutrition Project was a massive undertaking by large and dedicated international team. Here are the the results of this effort, 10 reviews and 4 consensus statements, all open access: https://t.co/GgAmy3nZLK
H. Pylori and T. Gondii Infections Accelerate Frailty in Aging
Associations of common infections with frailty and mortality in two UK cohort studies "Our results indicate that infection with H. pylori and T. gondii, and the combined burden of infection may detrimentally impact ageing health. These pathogens may warrant targeting beyond...
Sleep, Mind, and Muscles Linked via Neuroimmune Pathways
Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective https://t.co/MvUvzmQ9Mb https://t.co/mhgfxBfzg6
Doctors Warn DIY Peptide Injections Cause Serious Injuries
People are injecting DIY peptides for weight loss and longevity. Doctors are alarmed at the side effects. “Doctors working on the bleeding edge of longevity care in high-end clinics around the globe — from concierge practices in wealthy enclaves of California...
Anecdotes Aren’t Data: Call for Rigorous Rapamycin Trials
Table updates worth noting 🔎 🔘 @bryan_johnson stopped it 🔘Alan Green died at 80 from hereditary cardiomyopathy 🫀 🔘Misha Blagosklonny died at 63 from cancer 👉These are cases, not data. Instead of adjusting the tally, what we actually need are rigorous human trials. Is rapamycin...
Eight Healthy Habits by 40 Add 24 Years
👉Adopting all eight healthy lifestyle habits by age 40 can increase life expectancy by an average of 24 years for men and up to 23 years for women compared to individuals who adopt none of these habits. 👨🏻⚕️ •Being physically active •Not...
Your Face Mirrors Health—Change Habits, Rejuvenate Quickly
True. The face is the most honest biomarker we have. Sleep, stress, food, exercise, and sun all show up within weeks. The good news is it runs in reverse just as fast. Better inputs, younger face.
Russia Claims Progress on 150‑year Human Lifespan Plan
Vladimir Putin's plan to make humans live for 150 years is in process under supervision of Russian scientists 🔎 “ Denis Sekirinsky, a Russian science and education minister, claimed his country's researchers are on course…” https://t.co/tVx2REdovu https://t.co/1WCXvDFWnf
Power Nap After Sauna Boosts Recovery and Longevity
Loved this morning. Included a nap in today's routine. May start napping more. > asleep before 9 pm > up at 5 am > 8h sleep, no wake events > work 2 hrs with fresh mind > 50 min strength > 12...
Every 1,000 Steps Cuts Mortality Risk by 15%
The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis A 1000-step increment was associated with a 15% decreased risk of all-cause mortality... with significant benefits starting event at 2500/4000 steps/day. https://t.co/8d6VGnP0Dg https://t.co/f9h0D5dWlV
Facial Age Acceleration Predicts Earlier Death, Varies by Job
Face photo-based age acceleration predicts all-cause mortality and differs among occupations "We found that face photo-based age predicts all-cause mortality for middle-aged and older individuals meaning that those age faster based on their face photo die sooner." https://t.co/QUUzK4fe9G
Metabolic, Epigenetic, Immune Links Drive Ovarian Aging
Metabolic, epigenetic, and immune crosstalk in ovarian aging "This work provides a conceptual foundation for developing personalized strategies to mitigate reproductive aging and its systemic health impacts..." https://t.co/IgYU6f36nP https://t.co/rRgC7Dh65g
Meditation Rewires Brain for Focus, Memory, Calm
Meditation literally reshapes your brain. Research shows it: Thickens the prefrontal cortex → better focus, decision-making and emotional control. Grows gray matter in the hippocampus → improved memory and learning. Shrinks the amygdala → less stress, anxiety and reactivity. https://t.co/5onewk01zW
Sodium's Role in Boosting Endurance Performance Explained
Could sodium intake influence endurance performance? Explore the science in our lecture with Dr Alan McCubbin, now available with supporting learning materials. 20% off with code: sodium https://t.co/w1wzklTgyn https://t.co/BSntORLKB9
Most Athletes Don't Need Extra Electrolytes, Study Shows
Electrolytes are heavily marketed to athletes, but does the science support the hype? This blog examines sodium’s role in hydration, why most athletes do not need targeted replacement, and when it may matter in very long events. Click here: https://t.co/Vsibe6dOrB...