Better Cardio Fitness Reduces Anger, Anxiety, Boosts Resilience
Cardiorespiratory fitness is associated with lower anger and anxiety and higher emotional resilience https://t.co/PPVmVFPPS1 https://t.co/sDI77TfjiO
Centenarians Share Simple Habits for Lasting Health
What do the oldest people in the world have in common? Longevity expert explains ☝🏼 #longevity #doctor #health #wellness #diet
Veteran Male Athletes Face Heightened Ventricular Tachycardia Risk
Protecting older male athletes’ heart health “Veteran male athletes who have spent years training at high intensity may be at greater risk of serious heart problems while exercising, new University of Leeds research shows… Over the two years of the study, around...
Nine-Year Skin Age Reversal Using Multi‑Depth Therapy
Results from my Feb 23 skin therapy: Improvements since treatment: > Brown spots: +71 percentile points (20th → 91st) ✅ > Pores: +25 percentile points ✅ > Spots: +25 percentile points✅ My skin age is 9 years younger than my chronological age (39 vs...
Polyphenols and Exercise Shield Fruit Flies From Alzheimer’s
Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease https://t.co/oNhsshekPa https://t.co/o0Yltk6fMc
3 AM Wake‑Ups Signal Cortisol, Not Melatonin
Your 3AM wake-ups aren't random. They're not a sleep problem they're a cortisol problem. Your nervous system is stuck in survival mode, and melatonin won't fix that. Swipe to learn what's really happening in your body at 3AM — and how...
Cures Emerge From Incremental Advances, Not Single Breakthroughs
The media makes it seem like cures are one breakthrough away. In reality, cures come from smaller breakthroughs and improvements made by the work of thousands of scientists, drug developers and doctors. We’re witnessing this evolution in real time with...
Attia Endorses Statins for 30‑year‑olds Despite Modest Benefits
So @PeterAttiaMD really loves statins and now leans into it for 30YO. This stance always surprised me given the low improvement rates of death and statin side effects. https://t.co/hV3kF44fr2
Prioritize Aerobic Training, Periodic Races Reveal True Fitness
Yes, but... 1/ Going along with @hjluks most recent post... "Aerobic Deficiency Syndrome" is a freaking epidemic. That is, most of us have aerobic fitness orders of magnitude worse than our anaerobic fitness. This should be reflected in how much training time/emphasis...
One Daily Drink Ages Brain by Two Years
As a medical school professor, I need to be honest: there is no safe level of alcohol for your brain. A landmark study of 36,000 brain scans found that even one drink per day shrinks your brain -- and the damage...
Extra Virgin Olive Oil Shields Brain via Gut Microbiome
As a medical school professor, I used to tell patients to "eat healthy fats." But the type of olive oil matters more than we ever taught. A new study in Microbiome (Feb 2026) tracked 650 adults for 2 years and found...
AI Health Data Uncovers Hidden Sinus Issue Affecting Sleep
I was always a believer that AI could radically improve health. When you see it in action in your own life, it’s amazing and gives clarity about the future. One, new learning for me is a thesis that my oddly...
Risk-Weighted ApoB Outperforms LDL in CVD Prediction
LDL is only part of the equation. What's your Lp(a), VLDL, ApoB? Risk-weighted ApoB, which incorporates all of the above, is a better measure than LDL for predicting CVD risk: https://t.co/y5Hc9ZXIWG
Time Your Fitness Boosters for Peak Performance
Fitness isn’t one engine. It’s a sequence of boosters - each one timed to fire at exactly the right moment 🚀 Get the sequence right → you peak on race day. Get it wrong → you never leave the ground. My latest: Building your season...
Women Need Their Own Longevity Blueprint, Not Male Models
Women are not “mini-men.” That line from Dr. Jennifer Pearlman MD CCFP NCMP FAARM ABAARM stuck with me from our @Optispan_Inc Podcast conversation—and it sets the stage for a much bigger issue. For decades, medicine and biomedical research have often treated...
Seeing Biological Age Data Drives Real Health Improvements
Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...
High-Performing Athletes Suffer More Health Issues Than Elite
Fascinating review on the relationship between level of training/performance and immune function. I would agree that "high" performing athletes generally have worse health than "elite" performing athletes. Because... 1/ They have less control over life stress (often global "Type A" personalities) 2/ They train...
Elevate Your Feet for a Healthier Squat Toilet
Toilet PSA: Take the tiny trash bin in most toilets Put it in front of the toilet and put your feet on the trash bin Much healthier and more natural way to sit, giving natural pressure We've designed toilets wrong and your feet should...
Early Heart Rate Spike Is Normal, Not a Problem
Aerobic base building - the Cliff Notes version. This is for two groups: those just starting out and those who've been sidelined for a while. You lace up, head out, and ten minutes in, your heart is pounding, and you're breathing...
Statins Now Recommended for Patients as Young as 30
Updated cardiovascular guidelines—statin use in patients as young as 30 Recommendations still may not be aggressive enough, but the needle is moving https://t.co/HS9PtEdrsU https://t.co/d9YcDAFH2N
Carb Mouth Rinse Boosts Reps by 12% in Combat Athletes
Carbohydrate mouth rinse enhances repeat high-intensity efforts 🥤 This new study recruited 14 combat sports athletes (Judo + BJJ) to complete 3 x judogi grip test separated by 3-mins under two conditions… 1️⃣ Carb mouth rinse (6.4% maltodextrin) 2️⃣ Placebo Interventions were used pre-warm-up...
Best Diet Scores Add up to Three Extra Years
Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study "Compared with the bottom quintile, achieving the top quintile of dietary scores was associated with 1.9 to 3.0 years of life gained at 45 years in men and 1.5...
Targeted Antivirals and Vaccines Needed for CMV-Linked Cognitive Decline
Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies 🔎"We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration." https://t.co/b7Qx9aj0K3 https://t.co/KMB9ITLEzW
Machine Learning Links Spironolactone to Reduced Fibrosis Risk
Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics https://t.co/Ho2RL0RhO4 https://t.co/cHkogagDTt
Aging? Keep Your Brain Sharp with Novel Challenges
As people get older and have less energy, there's often a drive to make things more predictable. But the most important thing you can do for your brain: put it in novel situations and give it novel challenges. #Livewired https://t.co/1PKvPkClbI
Greens Boost Gut Microbiome and Epigenetics in Obese Seniors
Epigenetic and microbiome responses to greens supplementation in obese older adults: results from a randomized crossover-controlled trial https://t.co/Sz8ZmAUnxh https://t.co/zgpLh0dYG6
Exercise Mitigates Motor Unit Decline During Bedrest in Seniors
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans https://t.co/LOCU5ppBxh @ExpPhysiol https://t.co/0sdUCLOqP7
Intranasal EV Vaccine Shields Mice From H5N1, H7N9
A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9 https://t.co/WroXpi6YP3 https://t.co/umAPlnRjbF
Intermittent Fasting Cuts Crohn’s Disease Activity by 40%
As a medical school professor, I was never taught this: meal timing may be more powerful than medication for gut disease. A new clinical trial in Gastroenterology found that intermittent fasting reduced Crohn's disease activity by 40%. Patients who restricted eating to...
Precision Analytics Cut Inflammation, Boost Function in Seniors
Leveraging Precision Medicine Analytics to Optimize Inflammation Reduction and Enhance Physical Function in Older Adults https://t.co/BSSN0SwK8a https://t.co/yRxbhtHG5r
Silicon Valley's Immortality Bet Reaches 91‑year‑old
Longevity treatments for a 91-year-old. That's the kind of story that captures where Silicon Valley's immortality bet is actually heading. Great piece by @AmyDMarcus, who I had the chance to meet in Boston recently. She brings serious depth to this beat,...
Pre‑sleep Protein Boosts Muscle Mass and Strength
This study found that adding protein before sleep during a 12 week resistance training programme increased muscle mass and strength gains. Read the blog: https://t.co/f7Xyv1KzlZ https://t.co/r3am4gpDIK
Diet Sodas Raise Liver Disease Risk as Much as Sugar
As a medical school professor, I need to warn you: "diet" drinks may be just as dangerous as sugary ones for your liver. A major UK Biobank study of 124,000 people found: -- Artificially sweetened drinks raised liver disease risk by 60% --...
FGF21 Boosts Lactate Metabolism For
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice https://t.co/WInPF6Nm1C https://t.co/f9BxVAApln
Epigenetic Aging Markers Predict Dementia Risk Beyond Age
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study 🧠"These findings provide evidence linking epigenetic biomarkers of biological aging with MCI and dementia development, independent of chronological age." https://t.co/GKmn44gsqj
Incretin Modulators Boost Health, Happiness, and Longevity
Life is a marshmallow test. Incretin modulators help you win while staying happy. I often ask big audiences - "how many of you are on GLP1?" and only a couple hands go up. Sometimes, none. That's when I understood that...
Your Easy Runs Are Already Threshold Workouts
"Coach, after reading Bakken's book, I think I need to add some threshold runs to my week" "Are you lactate testing your easy runs?" "No." "Good news: You're already doing them."
Exercise Boosts NAD+, Enhancing Muscle Function in Aging
Healthy aging and muscle function are positively associated with NAD+ abundance in humans “… conversely, exercise-trained older individuals had NAD+ levels that were more similar to those found in younger individuals. NAD+ abundance positively correlated with average number of steps per day...
Lifestyle Factors Modulate Autophagy in Alzheimer’s
Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease https://t.co/aFGuo2R84Y https://t.co/vu2Jt7OvuZ
Food-Derived Bacterium Boosts Nanoplastic Excretion in Mice
Efficient biosorption of nanoplastics by food-derived lactic acid bacterium 👉 Strain CBA3656 enhanced fecal excretion of nanoplastics from the germ-free mouse intestine. 🔎 CBA3656 as a food-derived microbial biosorbent for NP mitigation https://t.co/eweZxEKYwL https://t.co/UbEYXADXwq
NMN and NR Show No Benefit for Elderly Muscle
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis “… In conclusion, current evidence does not support the use of NMN and NR as effective interventions for improving muscle function and mass...
Therapeutic SASP Targets Halt Brain Cell Senescence Spread
Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types "we identified specific SASP targets for therapeutic intervention in the context of human brain cells and thereby informed the SASP-dependent reaction of immune cells and age-related tissue dysfunction across...
More Athletes Testing Rotation and Abduction in Hip Extensions
Love this unique spin. People doing much more experimentation this past year on slight rotation, abduction, and abduction during hip extension exercises.
NR & NMN Boost Blood NAD+ via Gut Microbiome
The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans “Collectively, the clinical data combined with the ex vivo human microbiota and human whole-blood experiments led us to propose a human model where NR and...
Ice on Face Delays Sauna-Induced Core Temperature Spike
Felt like I was going to die in the sauna this morning. Experiment: time to reach a core body temp of 102.2°F (39°C) > with ice on face and neck: 38 min > no ice on face and neck: 33 min Dry sauna...
Wearables Distinguish Real Fatigue From Cat‑like Laziness
Wearables (can) help with that eternal question... "I feel kinda tired today. Am I really tired, or am I just being a 🐱?" That question is a very stressful question for athletes. It can rattle around in your head for days. And...
Oral NR/NMN Boosts Blood and Brain NAD in Two Weeks
The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation 🔎 “… oral NR or NMN in humans produces a slow but robust and sustained elevation of systemic and cerebral NAD that stabilizes after ∼2 weeks…” https://t.co/Hvp1NvRwl0
Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy
This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...
Evidence‑Heavy Statins Still Outpace Unproven Peptides
There is a fascinating op-ed piece in STAT from a doctor whose patient rejected a statin -- one of the most tested drug classes in existence -- but chose to take an untested peptide for cardiovascular risk. "My patient is intelligent,...
Nutrition Hacks to Boost Sleep, Recovery, Performance
Can you improve sleep with nutrition? Learn how to optimise sleep for better recovery, adaptation and performance. Early-bird rate ends soon: https://t.co/6Nswtdw8XP https://t.co/GceImySM7b