Exercise Cuts Visceral Fat, Boosts Insulin Sensitivity in NIDDM
Mobilization of Visceral Adipose Tissue Related to the Improvement in Insulin Sensitivity in Response to Physical Training in NIDDM: Effects of branched-chain amino acid supplements 🔘"Patients who exercised increased their VO2 peak by 41% and their insulin sensitivity by 46%... 🔘with a greater loss of visceral adipose tissue (VAT) (48%) in comparison with the loss of subcutaneous adipose tissue (18%), but did not significantly affect body weight." 🚴"Physical training consisted of a supervised 45-min cycling exercise at 75% of their oxygen uptake peak (VO2 peak) two times per week and an intermittent exercise one time per week for 2 months." https://t.co/gyV8ssP9FQ
Four‑Month MDF Cuts NAFLD Liver Fat by 24%
"The 4-month intervention with this MDF was effective in reducing IHTC in patients with NAFLD by an absolute reduction of −5.89% and a relative reduction of −24.30% after adjusting for weight loss. Such effect was partly mediated by altered composition...
Test Your Physiology, Train at the Right Intensity
Physiological testing isn’t about geeking out on numbers. It’s about *intensity discipline*... Knowing where you should be training & sticking to it! I spent years training at the wrong intensity. And it was my ultimate limiter.
Prioritize Peakspan Over Healthspan in Drug Discovery
I think that it is easier to measure Peakspan than Healthspan. And something we should study hard. I don't want just healthspan - I want to be at my peak. Not for myself but for all of you - we...
Essential Low-Cost Tests for Longevity Baseline
Longevity testing starter pack: 1. VO2 max/Cooper test - cardiorespiratory fitness 2. Grip strength - muscle mass and strength 3. Blood pressure - cardiovascular disease risk 4. DEXA scan - muscle and bone density 5. Blood panel - a dozen most common blood markers 6. Waist...
Ultra-Endurance Running May Speed Up Aging, RBC Damage
Ultra-Endurance Running May Accelerate Aging and Breakdown of Red Blood Cells | @ASH_hematology https://t.co/aYbsblfTwZ https://t.co/NYSKw0843c
Bootstrapped Cryo‑AI: LLMs Power Life‑Saving Freeze Tech
Meet Dr. Mark Woodward, undergrad and grad from Stanford, PhD from Harvard, Many years at Google as part of Google brain. One day he realizes that we need the enabling technology to pause biological time for patients that are about...
Carb Mouth Rinse Boosts Reps, Reveals CNS Fatigue
Carbohydrate mouth rinsing increases the number of reps to failure across multiple sets of multiple exercises, revealing that supraspinal CNS fatigue is a common effect in strength training workouts. https://t.co/Nj0JxgJIRs
Lower Cholesterol Linked to Reduced Dementia Risk
Does lowering cholesterol harm the brain? A large genetic study suggests lifelong reductions in atherogenic lipoproteins are associated with lower—not higher—dementia risk. https://t.co/QutNZzb4PH https://t.co/T84ZLIKq4A
Move More: Strengthen Core to Combat Sedentary Harm
We weren’t built to sit all day. Sedentary life weakens the core, changes how gravity acts on the body, and can contribute to pain, bloating, and gut issues. Movement + core strength + better nutrition go a long way. More in the video...
Creating Autonomous Health via Real-Time Multi‑Omic Monitoring
I've measured my body a lot. I'm about to dwarf what we've done by building real-time continuous multi-omic monitoring and intervention. Cars drive themselves. Software writes itself. I'm building Autonomous Health. First for me, then for you. > Peptides...
Food Ingredients Combine to Supercharge Anti-Inflammatory Effects
Powerful Synergies Between Plant Compounds Can Dramatically Reduce Inflammation Researchers discover that familiar food ingredients can work together inside immune cells to drastically boost each other's anti-inflammatory effects. https://t.co/CfZ8b8fjw1 https://t.co/S3ZJeOWy7z
One Psychedelic Dose Quickly Eases Depression, Trial Shows
Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests https://t.co/c72qpfwQPm https://t.co/xR7hbj4v8e
Experts Weigh Pros and Cons of At‑home Biological Age Tests
What's your biological age? Experts explain the benefits and risks of at-home tests https://t.co/NSr8O4EGnU via @nbcnews
Immune Training Against Senescent Cells Reduces Tumor Growth
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Stay Strong: Don't Apologize, Shrink, or Fawn
The best way to respond to difficult or combative people is to never fawn, apologize, or shrink. A complete guide to not having a cortisol spike:
Three Weekly Weight Sessions Transform Health and Metabolism
Lifting weights burns calories during the workout. Lifting weights burns calories for 24 to 48 hours after. Lifting weights builds muscle that burns fat while you sleep. Lifting weights protects your bones as you age. Lifting weights improves how your...
Key Aging Factors That Matter After 40
I’m a bioscientist studying aging. 🧬 If you’re 40+, this is what actually matters ↓
232 Saunas Reveal 20‑Minute Sessions Miss Heat‑Shock Threshold
I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in...
Diabetes Drug Replicates Exercise Effects in Prostate Cancer Patients
How a Diabetes Drug May Echo the Benefits of Exercise in Prostate Cancer Care “From a clinical standpoint, seeing a metabolic signal that mirrors what we associate with intense exercise was striking… For patients whose treatments or symptoms limit physical activity,...
Resveratrol Alters Sperm Epigenetics, Boosts Offspring Metabolism
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications"...
Indoor Eye Use May Drive Myopia, New Study Finds
New Research Suggests Myopia Could Be Caused By How We Use Our Eyes Indoors https://t.co/UTBhiAeP8v https://t.co/U0wlBGLvUz
Vitamin D3 Preserves Telomeres, Slowing Cellular Aging
As a medical school professor, I have watched vitamin D research for decades. This trial finally delivers causal evidence. The VITAL randomized controlled trial -- the gold standard -- followed nearly 1,000 adults aged 50+ for 4 years and found that...
Short Rest Intervals Boost Pace Work Efficiency
I couldn't find the original post but a ways back @StephenSeiler asked the community why swimmers do so many intervals, rather than continuous work sets The new Bakken book makes a strong case for the benefit of interval training. The key...
From Burnout to Action: Prioritize Five Daily Health Behaviors
Nineteen years ago today, I collapsed from sleep deprivation and burnout and broke my cheekbone. That day changed my life. I started learning all I could about the science of how our five key daily behaviors — food, movement, sleep, stress management and...
AI-Powered Full-Body Scan Gives Me a Pocket Doctor
I did a prenuvo full body scan and function blood test and now I have a doctor in my pocket I have seen friends and peers pass early so wanted to be proactive vs reactive like most of the US...
Prioritize Sleep, Movement, Nutrition Over Fancy Biohacks
Speaking as a scientist in the longevity space: Too many people “major in the minors” when it comes to health. They obsess over biohacks — cold plunges, supplement stacks, red light panels — and neglect the fundamentals that drive most...
Theanine Plus Caffeine Outperforms Each Alone
Theanine and caffeine work better for cognition than either one alone🍵☕ The combination of theanine 🍵(97 mg) and caffeine ☕(40 mg) improves cognitive performance and subjective alertness compared to placebo (PMID: 21040626). A 2021 review saw that theanine alone has mild cognitive...
Promoting OSKM Therapy with MYC Is Borderline Criminal
The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal
Early Time-Restricted Eating Beats All Fasting Strategies
As a medical school professor, I used to think all fasting windows were created equal. This massive analysis proves they are not. A network meta-analysis of 113 trials published in BMJ Medicine found that early time-restricted eating -- finishing food by...
A Single Nerve Links Brain, Heart, Gut, Immunity, Longevity
What if one small nerve quietly connects your brain to your heart, your gut, your immune system — and even how long you live? That was the question I brought to Dr. Elisabetta Burchi, a clinical psychiatrist, neuroscience researcher, and Head...
Optimal Sleep for Insulin Resistance: 7 Hours 18 Minutes
As a medical school professor, I teach that sleep matters for metabolism. But now we have the precise number. A study of 23,475 adults published in BMJ Open Diabetes Research & Care found the optimal sleep duration for preventing insulin resistance:...
Aging Gut Loses Magnesium, Boosting Inflammation Risk
As a medical school professor, I never imagined a single mineral could be this important to gut health. But the data is staggering. A new study in Aging Cell found that magnesium levels decline specifically in the gut as we age...
Bones Remodeled Constantly: Your Skeleton Evolves
The skeleton you are walking around in today is not the one you had ten years ago. Most of it isn’t even the one you had three years ago. Your bones are continuously being broken down and rebuilt by an...
Ketogenic Diet May Counteract Genetic Lp(a) Vascular Damage
Can you fix Lp(a) With Diet? Let's go inside the artery... 1/2) Lp(a) is a genetically determined risk factor for cardiovascular disease. But that doesn't mean you can't change your risk. In today's deep-dive video (21 minutes, just released and linked...
Ginseng Boosts Mitochondria via AMPK/PGC‑1α Pathway
Ginseng for exercise and injury recovery 🍃 Panax ginseng is a well-known traditional medicine which has been gathering data for it’s ergogenic and antioxidative properties 📚 This new review highlighted it’s primary mechanisms and benefits 🔍 Here are the key takeaways...
Aging Science Reveals How to Extend Dogs' Lifespans
Dr. Daniel Promislow has spent 30+ years studying the biology of aging and has published 180+ papers. Now he’s applying that science to something millions of people care about personally: Why do dogs age the way they do, and can we help...
Static Stretching Boosts Whole-Body Flexibility via Tolerance
Static stretching doesn't just temporarily increase the flexibility of the stretched muscle. It also increases the flexibility of other, unstretched muscles. This is because the mechanism by which flexibility increases is an increase in stretch tolerance, which is a global...
Breakfast, Sleep, Exercise Boost Psychological Flexibility
Want to handle stress better? Start with breakfast, sleep, and exercise New study shows healthy habits build ‘psychological flexibility’ https://t.co/WGaecPUetj https://t.co/k4rgATDX4Q
Processed Foods Impair Aged Brain’s Emotional Memory via Low Fiber
Emotional memory region of aged brain is sensitive to processed foods "Lack of fiber is linked to cognitive problems, animal study suggests..." https://t.co/q6EbUnLkWc
AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation
New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd
Daily Multivitamins May Slow Aging, Especially in Older Bodies
Daily multivitamin may slow biological aging Greatest gains for participants who were biologically older, researchers say https://t.co/GhRJHwgr9B https://t.co/OxfNd0ZmEE
Consistent Workouts May Preserve Fitness Better Than Constant Switching
In terms of slowing the age-related loss of fitness, I'd bet the same is true for those who standardize their workouts, when compared with those who "switch it up"
Psilocybin Single Dose Beats Nicotine Patches for Quitting
A single dose of psilocybin is more effective than nicotine patches for quitting smoking, study suggests https://t.co/APDQt1WYxp https://t.co/zDnXcUjFyG
Exercise‑linked Protein Target Could Rejuvenate Aging Blood‑brain Barrier
Scientists Find a Mechanism for How Exercise Protects the Brain 🗣️Finding drugs to trim proteins like TNAP could be a new way to rejuvenate the blood-brain barrier, even after it’s been degraded by age. “We’re uncovering biology that Alzheimer’s research has largely...
Genomic Instability and Epigenetic Reprogramming Drive Vascular Aging
DNA repair-driven epigenetic changes as a cause of disease is going mainstream. A general medical review on CVD says: Genomic instability & epigenetic reprogramming are the deep mechanisms of vascular aging. Intervention strategies are the most promising & complex interventions https://t.co/xbEytAnIUH
AI Model Maps Cell Trajectories Driving Human Aging
Impressive temporal AI model of aging by @GladstoneInst Based on ~175M single-cell transcriptomes, the model predicts drivers of cell trajectories across human aging. Also great that the first author, Javier, trained in our lab. Always rewarding to see our alumni flourish.
SIRT1 Activation Shows Promise for Age‑related Brain Disorders
SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential "...SIRT1 could be a promising pharmacological target for age-associated brain disorders, warranting more robust translational studies to validate these findings in humans..." https://t.co/hGVxZ4RErM
Balanced Hormones Boost Longevity, Backed by Research
New research confirms: optimal hormone levels don't just make you feel better, they help you live longer. Everything you need to support your hormones in one place. Biolongevity Labs, where all supplements and compounds are USA-made, third-party tested, with 99% purity....
Block Night Light, Boost Sleep, Transform Your Life
If you prioritize one thing to completely change your life, focus on your sleep. For less than $200, you can block junk light and repair your circadian rhythm. Studies show that even a small amount of streetlight pollution at night...